metronidazole has been researched along with Proctitis in 20 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Proctitis: INFLAMMATION of the MUCOUS MEMBRANE of the RECTUM, the distal end of the large intestine (INTESTINE, LARGE).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the effectiveness of metronidazole in combination with corticosteroids in enema and mesalazine (5-aminosalicylic acid) in comparison with the same protocol without metronidazole in the treatment of chronic radiation proctitis." | 9.09 | Metronidazole in the treatment of chronic radiation proctitis: clinical trial. ( Cavcić, J; Jelincić, Z; Martinac, P; Panijan-Pezerović, R; Turcić, J; Unusić, J; Zupancić, B, 2000) |
| "Twenty-two patients with chronic proctitis were treated with metronidazole for 28 days in a double-blind controlled trial, but they did not appear to benefit from the drug." | 9.04 | Metronidazole in the treatment of chronic proctitis: a controlled trial. ( Davies, PS; Heatley, RV; Owen, E; Rhodes, J, 1977) |
| "To evaluate the effectiveness of metronidazole in combination with corticosteroids in enema and mesalazine (5-aminosalicylic acid) in comparison with the same protocol without metronidazole in the treatment of chronic radiation proctitis." | 5.09 | Metronidazole in the treatment of chronic radiation proctitis: clinical trial. ( Cavcić, J; Jelincić, Z; Martinac, P; Panijan-Pezerović, R; Turcić, J; Unusić, J; Zupancić, B, 2000) |
| "Twenty-two patients with chronic proctitis were treated with metronidazole for 28 days in a double-blind controlled trial, but they did not appear to benefit from the drug." | 5.04 | Metronidazole in the treatment of chronic proctitis: a controlled trial. ( Davies, PS; Heatley, RV; Owen, E; Rhodes, J, 1977) |
| "Rectovaginal fistulas secondary to ulcerative colitis may be treated by ileoanal pouch anastomosis and primary repair." | 2.38 | Perianal inflammatory conditions in inflammatory bowel disease. ( Gordon, PH; Stein, BL, 1993) |
| "Four patients had had cervical cancer, five had uterine cancer, one had prostatic cancer, one had vesical cancer and one had vaginal cancer." | 1.37 | A novel treatment for haemorrhagic radiation proctitis using colonic irrigation and oral antibiotic administration. ( Atittharnsakul, P; Patiwongpaisarn, A; Rojanasakul, A; Sahakitrungruang, C; Thum-Umnuaysuk, S, 2011) |
| "Records of 217 patients with mucosal ulcerative colitis who underwent restorative proctocolectomy with a stapled ileal pouch-anal anastomosis without anal mucosectomy from 1987 through 1990 were retrospectively reviewed." | 1.29 | Anal canal inflammation after ileal pouch-anal anastomosis. The need for treatment. ( Fazio, VW; Lavery, IC; Sirimarco, MT; Ziv, Y, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (30.00) | 18.7374 |
| 1990's | 4 (20.00) | 18.2507 |
| 2000's | 4 (20.00) | 29.6817 |
| 2010's | 4 (20.00) | 24.3611 |
| 2020's | 2 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pui, WC | 1 |
| Chieng, TH | 1 |
| Siow, SL | 1 |
| Nik Abdullah, NA | 1 |
| Sagap, I | 1 |
| Babakhanlou, R | 1 |
| Larkin, K | 1 |
| Mamedov, MM | 1 |
| Mustafayeva, MF | 1 |
| Weiner, JP | 1 |
| Wong, AT | 1 |
| Schwartz, D | 1 |
| Martinez, M | 1 |
| Aytaman, A | 1 |
| Schreiber, D | 1 |
| Sahakitrungruang, C | 2 |
| Thum-Umnuaysuk, S | 1 |
| Patiwongpaisarn, A | 2 |
| Atittharnsakul, P | 2 |
| Rojanasakul, A | 1 |
| Kanjanasilp, P | 1 |
| Malakorn, S | 1 |
| Paul Turner, DA | 1 |
| Drenick, EJ | 1 |
| Wollman, JS | 1 |
| Stein, BL | 1 |
| Gordon, PH | 1 |
| Lavery, IC | 1 |
| Sirimarco, MT | 1 |
| Ziv, Y | 1 |
| Fazio, VW | 1 |
| Bourrat, E | 1 |
| Faure, C | 1 |
| Vignon-Pennamen, MD | 1 |
| Rybojad, M | 1 |
| Morel, P | 1 |
| Navarro, J | 1 |
| Simmonds, NJ | 1 |
| Millar, AD | 1 |
| Blake, DR | 1 |
| Rampton, DS | 1 |
| Cavcić, J | 1 |
| Turcić, J | 1 |
| Martinac, P | 1 |
| Jelincić, Z | 1 |
| Zupancić, B | 1 |
| Panijan-Pezerović, R | 1 |
| Unusić, J | 1 |
| Yar'mov, N | 1 |
| Gachev, N | 1 |
| Petkov, K | 1 |
| Denton, AS | 1 |
| Andreyev, HJ | 1 |
| Forbes, A | 1 |
| Maher, EJ | 1 |
| Feathers, RS | 1 |
| Sagor, GR | 1 |
| Lewis, AA | 1 |
| Amirak, ID | 1 |
| Noone, P | 1 |
| Davies, PS | 1 |
| Rhodes, J | 1 |
| Heatley, RV | 1 |
| Owen, E | 1 |
| Aukrust, P | 1 |
| Abeler, V | 1 |
| Gottrup, F | 1 |
| Lundhus, E | 1 |
| Terpling, S | 1 |
| Axton, JH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Postoperative or Salvage Radiotherapy for Node Negative Prostate Cancer Following Radical Prostatectomy[NCT00969111] | 70 participants (Anticipated) | Interventional | 2009-08-31 | Recruiting | |||
| An Expanded Phase II Study of Hypofractionated Dose Intense Image Guided Proton Radiation Therapy for Low and Intermediate Risk Adenocarcinoma of the Prostate[NCT01368055] | 361 participants (Actual) | Interventional | 2011-09-30 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for metronidazole and Proctitis
| Article | Year |
|---|---|
Endoscopic and non-endoscopic approaches for the management of radiation-induced rectal bleeding.
Topics: Endoscopy, Gastrointestinal; Gastrointestinal Hemorrhage; Humans; Hyperbaric Oxygenation; Metronidaz | 2016 |
Perianal inflammatory conditions in inflammatory bowel disease.
Topics: Abscess; Adult; Colitis, Ulcerative; Combined Modality Therapy; Crohn Disease; Female; Humans; Male; | 1993 |
Systematic review for non-surgical interventions for the management of late radiation proctitis.
Topics: Administration, Rectal; Anti-Inflammatory Agents; Chronic Disease; Combined Modality Therapy; Cross- | 2002 |
5 trials available for metronidazole and Proctitis
| Article | Year |
|---|---|
A Randomized Controlled Trial of Novel Treatment for Hemorrhagic Radiation Proctitis.
Topics: Administration, Oral; Adult; Aged; Anti-Infective Agents; Disinfectants; Electrocoagulation; Female; | 2020 |
A randomized controlled trial comparing colonic irrigation and oral antibiotics administration versus 4% formalin application for treatment of hemorrhagic radiation proctitis.
Topics: Administration, Oral; Administration, Rectal; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; | 2012 |
Metronidazole in the treatment of chronic radiation proctitis: clinical trial.
Topics: Aged; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Beta | 2000 |
Metronidazole in the treatment of chronic radiation proctitis: clinical trial.
Topics: Aged; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Beta | 2000 |
Metronidazole in the treatment of chronic radiation proctitis: clinical trial.
Topics: Aged; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Beta | 2000 |
Metronidazole in the treatment of chronic radiation proctitis: clinical trial.
Topics: Aged; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Beta | 2000 |
Prophylactic systemic antibiotics in colorectal surgery.
Topics: Abscess; Adult; Aged; Bacteroides fragilis; Clinical Trials as Topic; Colitis; Colon; Colonic Neopla | 1977 |
Metronidazole in the treatment of chronic proctitis: a controlled trial.
Topics: Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Humans; Metronidazole; Proctitis | 1977 |
12 other studies available for metronidazole and Proctitis
| Article | Year |
|---|---|
The value of Metronidazole in the management of acute radiation proctitis.
Topics: Gastritis; Humans; Metronidazole; Proctitis; Radiation Injuries | 2021 |
[New approaches in surgical treatment of acute paraproctitis].
Topics: Acute Disease; Adolescent; Adult; Aged; Drainage; Enzymes, Immobilized; Female; Humans; Low-Level Li | 2015 |
A novel treatment for haemorrhagic radiation proctitis using colonic irrigation and oral antibiotic administration.
Topics: Aged; Aged, 80 and over; Anti-Infective Agents; Ciprofloxacin; Combined Modality Therapy; Female; Ga | 2011 |
WD40-induced proctitis.
Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Humans; Lubrication; Male; Metronidazole; Oils | 2007 |
Treatment of proctitis after jejunoileal bypass operations.
Topics: Diarrhea; Female; Humans; Ileum; Jejunum; Male; Metronidazole; Obesity; Proctitis | 1980 |
Anal canal inflammation after ileal pouch-anal anastomosis. The need for treatment.
Topics: Administration, Rectal; Adolescent; Adult; Aged; Anal Canal; Biopsy; Ciprofloxacin; Colitis, Ulcerat | 1995 |
[Anitis, vulvar edema and macrocheilitis disclosing Crohn disease in a child: value of metronidazole].
Topics: Cheilitis; Child; Crohn Disease; Edema; Female; Granuloma; Humans; Metronidazole; Proctitis; Treatme | 1997 |
Antioxidant effects of aminosalicylates and potential new drugs for inflammatory bowel disease: assessment in cell-free systems and inflamed human colorectal biopsies.
Topics: Adrenal Cortex Hormones; Adult; Aged; Aminosalicylic Acid; Aminosalicylic Acids; Anti-Infective Agen | 1999 |
[Case of an HIV-patient with advanced form of perianal hidradenitis].
Topics: Adult; Anus Diseases; Hidradenitis; HIV Infections; Humans; Male; Metronidazole; Proctitis; Sigmoido | 2000 |
[Intestinal spirochaetosis].
Topics: Adult; Homosexuality; Humans; Intestinal Mucosa; Male; Metronidazole; Proctitis; Spirochaetales Infe | 1989 |
[Primary suture of perianal abscesses and infected pilonidal cysts under metronidazole and ampicillin cover for 4 days].
Topics: Abscess; Adolescent; Adult; Aged; Ampicillin; Drug Therapy, Combination; Female; Humans; Male; Metro | 1986 |
Amoebic proctocolitis and liver abscess in a neonate.
Topics: Colitis; Diarrhea, Infantile; Dysentery, Amebic; Female; Humans; Infant, Newborn; Infant, Newborn, D | 1972 |