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metronidazole and Alcoholic Pancreatitis

metronidazole has been researched along with Alcoholic Pancreatitis in 2 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Research Excerpts

ExcerptRelevanceReference
"Pancreatitis is a very rare adverse effect of metronidazole with only six cases of metronidazole-induced pancreatitis reported in the English literature so far."8.82Metronidazole-induced pancreatitis. A case report and review of literature. ( Casey, KJ; Nigwekar, SU, 2004)
" Twenty-three consecutive patients suffering from acute alcoholic pancreatitis with computed tomography demonstrating two or more fluid collections were randomly assigned to one of two groups receiving either nonantibiotic treatment or prophylactic antibiotics (ceftazidime, amikacine, and metronidazole for 10 days)."5.08Prophylactic antibiotics in treatment of severe acute alcoholic pancreatitis. ( Delcenserie, R; Ducroix, JP; Yzet, T, 1996)
"Pancreatitis is a very rare adverse effect of metronidazole with only six cases of metronidazole-induced pancreatitis reported in the English literature so far."4.82Metronidazole-induced pancreatitis. A case report and review of literature. ( Casey, KJ; Nigwekar, SU, 2004)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's1 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Nigwekar, SU1
Casey, KJ1
Delcenserie, R1
Yzet, T1
Ducroix, JP1

Reviews

1 review available for metronidazole and Alcoholic Pancreatitis

ArticleYear
Metronidazole-induced pancreatitis. A case report and review of literature.
    JOP : Journal of the pancreas, 2004, Nov-10, Volume: 5, Issue:6

    Topics: Diagnostic Errors; Female; Humans; Metronidazole; Middle Aged; Pancreatitis; Pancreatitis, Alcoholic

2004

Trials

1 trial available for metronidazole and Alcoholic Pancreatitis

ArticleYear
Prophylactic antibiotics in treatment of severe acute alcoholic pancreatitis.
    Pancreas, 1996, Volume: 13, Issue:2

    Topics: Acute Disease; Adult; Amikacin; Anti-Bacterial Agents; Bacterial Infections; Ceftazidime; Female; Hu

1996