metronidazole has been researched along with Alcoholic Pancreatitis in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pancreatitis is a very rare adverse effect of metronidazole with only six cases of metronidazole-induced pancreatitis reported in the English literature so far." | 8.82 | Metronidazole-induced pancreatitis. A case report and review of literature. ( Casey, KJ; Nigwekar, SU, 2004) |
| " Twenty-three consecutive patients suffering from acute alcoholic pancreatitis with computed tomography demonstrating two or more fluid collections were randomly assigned to one of two groups receiving either nonantibiotic treatment or prophylactic antibiotics (ceftazidime, amikacine, and metronidazole for 10 days)." | 5.08 | Prophylactic antibiotics in treatment of severe acute alcoholic pancreatitis. ( Delcenserie, R; Ducroix, JP; Yzet, T, 1996) |
| "Pancreatitis is a very rare adverse effect of metronidazole with only six cases of metronidazole-induced pancreatitis reported in the English literature so far." | 4.82 | Metronidazole-induced pancreatitis. A case report and review of literature. ( Casey, KJ; Nigwekar, SU, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nigwekar, SU | 1 |
| Casey, KJ | 1 |
| Delcenserie, R | 1 |
| Yzet, T | 1 |
| Ducroix, JP | 1 |
1 review available for metronidazole and Alcoholic Pancreatitis
| Article | Year |
|---|---|
Metronidazole-induced pancreatitis. A case report and review of literature.
Topics: Diagnostic Errors; Female; Humans; Metronidazole; Middle Aged; Pancreatitis; Pancreatitis, Alcoholic | 2004 |
1 trial available for metronidazole and Alcoholic Pancreatitis
| Article | Year |
|---|---|
Prophylactic antibiotics in treatment of severe acute alcoholic pancreatitis.
Topics: Acute Disease; Adult; Amikacin; Anti-Bacterial Agents; Bacterial Infections; Ceftazidime; Female; Hu | 1996 |