metronidazole has been researched along with Metaplasia in 16 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Metaplasia: A condition in which there is a change of one adult cell type to another similar adult cell type.
| Excerpt | Relevance | Reference |
|---|---|---|
| " pylori-positive duodenal ulcer patients before and 6 weeks after 'triple therapy' with bismuth, tetracycline and metronidazole." | 3.69 | Effect of eradication of Helicobacter pylori on gastric epithelial cell proliferation. ( Dhillon, AP; Fraser, AG; Pounder, RE; Sankey, EA; Sim, R, 1994) |
| "Cultured gastric cancer cell line SGC-7901 was infected with H." | 1.56 | Helicobacter pylori Infection Facilitates the Expression of Resistin-like Molecule Beta in Gastric Carcinoma and Precursor Lesions. ( Fang, EH; Li, HJ; Tong, QS; Wang, JQ; Zheng, LD, 2020) |
| "The cumulative 5-year incidences of gastric cancer were 3." | 1.43 | Histologic intestinal metaplasia and endoscopic atrophy are predictors of gastric cancer development after Helicobacter pylori eradication. ( Fukayama, M; Hayakawa, Y; Hirata, Y; Koike, K; Niikura, R; Shichijo, S; Ushiku, T; Yamada, A, 2016) |
| "Chronic gastritis was evaluated according to sydney system." | 1.33 | [Prospective study of 420 biopsies realised in patients with duodenal ulcer with positive Helicobacter pylori]. ( Ben Ayed, M; Ben Khelifa, H; Chedly-Debbiche, A; Gargouri, D; Ghorbel, AJ; Kharrat, J; Khayat, O; Kilani, A; Souissi, A; Zeddini, A, 2006) |
| "Gastric metaplasia was endoscopically and histologically evaluated before and after eradication of this bacterium." | 1.32 | Long-term follow-up of gastric metaplasia after eradication of Helicobacter pylori. ( Sano, T; Urakami, Y, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (43.75) | 18.2507 |
| 2000's | 5 (31.25) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 2 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Li, HJ | 1 |
| Fang, EH | 1 |
| Wang, JQ | 1 |
| Zheng, LD | 1 |
| Tong, QS | 1 |
| Kodama, M | 1 |
| Okimoto, T | 1 |
| Mizukami, K | 1 |
| Hirashita, Y | 1 |
| Wada, Y | 1 |
| Fukuda, M | 1 |
| Matsunari, O | 1 |
| Okamoto, K | 1 |
| Ogawa, R | 1 |
| Fukuda, K | 1 |
| Kudo, Y | 1 |
| Kawahara, Y | 1 |
| Murakami, K | 1 |
| Kim, SG | 1 |
| Jung, HK | 1 |
| Lee, HL | 1 |
| Jang, JY | 1 |
| Lee, H | 1 |
| Kim, CG | 1 |
| Shin, WG | 1 |
| Shin, ES | 1 |
| Lee, YC | 1 |
| Shichijo, S | 1 |
| Hirata, Y | 1 |
| Niikura, R | 1 |
| Hayakawa, Y | 1 |
| Yamada, A | 1 |
| Ushiku, T | 1 |
| Fukayama, M | 1 |
| Koike, K | 1 |
| Urakami, Y | 2 |
| Sano, T | 1 |
| Salih, BA | 1 |
| Abasiyanik, MF | 1 |
| Saribasak, H | 1 |
| Huten, O | 1 |
| Sander, E | 1 |
| Khayat, O | 1 |
| Kilani, A | 1 |
| Chedly-Debbiche, A | 1 |
| Zeddini, A | 1 |
| Gargouri, D | 1 |
| Kharrat, J | 1 |
| Souissi, A | 1 |
| Ghorbel, AJ | 1 |
| Ben Ayed, M | 1 |
| Ben Khelifa, H | 1 |
| Li, XB | 1 |
| Ge, ZZ | 1 |
| Chen, XY | 1 |
| Liu, WZ | 1 |
| Camargo, MC | 1 |
| Piazuelo, MB | 1 |
| Mera, RM | 1 |
| Fontham, ET | 1 |
| Delgado, AG | 1 |
| Yepez, MC | 1 |
| Ceron, C | 1 |
| Bravo, LE | 1 |
| Bravo, JC | 1 |
| Correa, P | 1 |
| Fraser, AG | 1 |
| Sim, R | 1 |
| Sankey, EA | 1 |
| Dhillon, AP | 1 |
| Pounder, RE | 1 |
| Solcia, E | 1 |
| Villani, L | 1 |
| Fiocca, R | 1 |
| Luinetti, O | 1 |
| Boldorini, R | 1 |
| Trespi, E | 1 |
| Perego, M | 1 |
| Alvisi, C | 1 |
| Lazzaroni, M | 1 |
| Bianchi Porro, G | 1 |
| Sobala, GM | 1 |
| Schorah, CJ | 1 |
| Shires, S | 1 |
| Lynch, DA | 1 |
| Gallacher, B | 1 |
| Dixon, MF | 1 |
| Axon, AT | 1 |
| Khulusi, S | 1 |
| Badve, S | 1 |
| Patel, P | 1 |
| Lloyd, R | 1 |
| Marrero, JM | 1 |
| Finlayson, C | 1 |
| Mendall, MA | 1 |
| Northfield, TC | 1 |
| Kimura, M | 1 |
| Seki, H | 1 |
| Rudnicka, L | 1 |
| Bobrzyński, A | 1 |
| Stachura, J | 1 |
| Tepes, B | 1 |
| Kavcic, B | 1 |
| Zaletel, LK | 1 |
| Gubina, M | 1 |
| Ihan, A | 1 |
| Poljak, M | 1 |
| Krizman, I | 1 |
4 trials available for metronidazole and Metaplasia
| Article | Year |
|---|---|
A follow-up study on the effect of Helicobacter pylori eradication on the severity of gastric histology.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Ulcer | 2005 |
Effects of eradication of Helicobacter pylori on gastritis in duodenal ulcer patients.
Topics: Amoxicillin; Double-Blind Method; Drug Therapy, Combination; Duodenal Ulcer; Gastric Mucosa; Gastrit | 1994 |
Effect of eradication of Helicobacter pylori on gastric juice ascorbic acid concentrations.
Topics: Aged; Ampicillin; Anti-Ulcer Agents; Ascorbic Acid; Drug Therapy, Combination; Duodenal Ulcer; Fasti | 1993 |
Pathogenesis of gastric metaplasia of the human duodenum: role of Helicobacter pylori, gastric acid, and ulceration.
Topics: Adult; Aged; Amoxicillin; Antacids; Anti-Ulcer Agents; Drug Therapy, Combination; Duodenal Ulcer; Du | 1996 |
12 other studies available for metronidazole and Metaplasia
| Article | Year |
|---|---|
Helicobacter pylori Infection Facilitates the Expression of Resistin-like Molecule Beta in Gastric Carcinoma and Precursor Lesions.
Topics: Adenocarcinoma; Adult; Aged; Amoxicillin; Cell Line, Tumor; Female; Gene Expression Regulation, Neop | 2020 |
Gastric mucosal changes, and sex differences therein, after Helicobacter pylori eradication: A long-term prospective follow-up study.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Atrophy; Clarithromycin; Female; Follow-Up Studies; | 2021 |
[Guidelines for the diagnosis and treatment of Helicobacter pylori infection in Korea, 2013 revised edition].
Topics: Amoxicillin; Anti-Bacterial Agents; Aspirin; Bismuth; Breath Tests; Clarithromycin; Gastroesophageal | 2013 |
Histologic intestinal metaplasia and endoscopic atrophy are predictors of gastric cancer development after Helicobacter pylori eradication.
Topics: Aged; Amoxicillin; Anti-Bacterial Agents; Atrophy; Breath Tests; Clarithromycin; Cohort Studies; Fem | 2016 |
Long-term follow-up of gastric metaplasia after eradication of Helicobacter pylori.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Amoxicillin; Cicatrix; Convalescence; Drug The | 2003 |
[Prospective study of 420 biopsies realised in patients with duodenal ulcer with positive Helicobacter pylori].
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Ulcer Agents; Biopsy; D | 2006 |
Duodenal gastric metaplasia and Helicobacter pylori infection in patients with diffuse nodular duodenitis.
Topics: Adult; Aged; Case-Control Studies; Chronic Disease; Clarithromycin; Drug Therapy, Combination; Duode | 2007 |
Effect of smoking on failure of H. pylori therapy and gastric histology in a high gastric cancer risk area of Colombia.
Topics: Amoxicillin; Anti-Infective Agents; Bismuth; Colombia; Drug Therapy, Combination; Female; Follow-Up | 2007 |
Effect of eradication of Helicobacter pylori on gastric epithelial cell proliferation.
Topics: Adult; Aged; Bismuth; Cell Division; Drug Therapy, Combination; Duodenal Ulcer; Female; Gastric Muco | 1994 |
Gastric metaplasia and Helicobacter pylori.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Amoxicillin; Anti-Infective Agents; Anti-Ulcer | 1997 |
Short-term eradication therapy for Helicobacter pylori does not reduce the incidence of gastric metaplasia in duodenal ulcer patients.
Topics: Adult; Aged; Amoxicillin; Anti-Ulcer Agents; Drug Therapy, Combination; Duodenal Ulcer; Female; Heli | 1997 |
Two- to four-year histological follow-up of gastric mucosa after Helicobacter pylori eradication.
Topics: Adult; Aged; Amoxicillin; Drug Therapy, Combination; Duodenal Ulcer; Female; Follow-Up Studies; Gast | 1999 |