Conjunctivitis, Bacterial

Purulent infections of the conjunctiva by several species of gram-negative, gram-positive, or acid-fast organisms. Some of the more commonly found genera causing conjunctival infections are Haemophilus, Streptococcus, Neisseria, and Chlamydia.

Synonym
Conjunctivitis, Bacterial

Excerpt	Reference
"Acute bacterial conjunctivitis is a prevalent infection in the population."	( Erdal, JE; Fiskaadal, HJ; Laerum, E; Løberg, RM, 1994)
"Bacterial conjunctivitis is the most common type of this infection for which emperical treatment is started without knowing the etiological agents because prior cultures are generally not taken."	( Kumar, P; Malhotra, S; Mehta, DK, 2005)
"Bacterial conjunctivitis is characterized by hyperemia and discharge of one or both eyes."	( Amraoui, A; Bhagat, Y; Bourcier, T; Cochereau, I; Khairallah, M; Meddeb-Ouertani, A; Pop, M; Robert, PY; Zaghloul, K, 2010)
"Bacterial conjunctivitis is generally self-limiting, resolving within 1-2 weeks."	( Benitez-Del-Castillo, J; Kodjikian, L; Stroman, D; Verboven, Y, 2011)
"Bacterial conjunctivitis is a contagious infection of the surface of the eye usually treated empirically with topical antibiotics."	( Gearinger, LS; Haas, W; Hesje, CK; Morris, TW; Sanfilippo, CM, 2012)
"Acute bacterial conjunctivitis is a common infection of the ocular surface."	( Blondeau, J; Deschênes, J, 2015)
"Bacterial conjunctivitis is a major problem in ocular health."	( Pier, GB; Zaidi, T; Zaidi, TS, 2018)
"Currently, bacterial conjunctivitis is treated by frequent administration of antibiotic eye drop solutions, which is tedious and patient noncompliant."	( Desai, AR; Maulvi, FA; Ranch, KM; Shah, DO; Shukla, MR; Singhania, SS; Tannk, AS; Vyas, BA, 2018)
"Acute bacterial conjunctivitis is an acute conjunctivitis that is frequently transmitted in summer and autumn."	( Feng, J; Xu, J, 2018)

Excerpt	Reference
"Bacterial conjunctivitis has high impact on the health of the population, since it represents more than a third of ocular pathologies reported by health services worldwide."	( Salgado, HRN; Tótoli, EG, 2018)

Excerpt	Reference
"Purulent bacterial conjunctivitis affects all ages with high frequency in newborns and children."	( Beresniak, A; Bhagat, Y; Bingen, E; Bremond-Gignac, D; Cochereau, I; Delval, L; El Fekih, L; Goldschmidt, P; Mariani-Kurkdjian, P; Pouliquen, P, 2010)

Excerpt	Reference
"The indicated use is generally for the treatment of bacterial conjunctivitis and/or blepharoconjunctivitis, especially that caused by Staphylococcus, but not Streptococcus or Haemophilus sp."	( Doughty, MJ; Dutton, GN, 2006)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	46 (14.29)	23.3326
1990's	64 (19.88)	12.5806
2000's	104 (32.30)	18.1394
2010's	94 (29.19)	28.8240
2020's	14 (4.35)	9.53

Drug	Relationship Strength	Studies	Trials
histamine	low	1	0
nitrites	low	1	0
pyrazinamide	low	1	0
pyridoxal	low	1	0
taurine	medium	1	1
acetazolamide	low	1	0
benzethonium	medium	1	1
cefixime	medium	2	1
ciprofloxacin	medium	20	3
clofazimine	low	1	0
flurbiprofen	low	1	0
gentamicin	medium	15	4
isoniazid	low	1	0
2-propanol	low	1	0
lomefloxacin	medium	5	3
metronidazole	low	1	0
norfloxacin	medium	7	5
sulfacetamide	medium	4	2
sulfanilamide	low	1	0
sulfapyridine	low	1	0
sulfathiazole	low	1	0
triclosan	low	1	0
trimethoprim	medium	9	5
corticosterone	low	1	0
prednisolone	low	2	0
cephaloridine	low	2	0
hydroxyproline	low	1	0
prednisone	low	3	0
penicillin g	low	4	0
biguanides	medium	1	1
chloramphenicol	medium	33	12
cephalothin	low	1	0
bromodeoxyuridine	low	1	0
carbostyril	medium	4	3
methicillin	medium	8	1
oxacillin	low	1	0
ampicillin	low	1	0
mannitol	low	1	0
triamcinolone acetonide	low	1	0
n-vinyl-2-pyrrolidinone	low	2	0
furaldehyde	low	1	0
framycetin	medium	5	3
nafcillin	low	1	0
dexamethasone 21-phosphate	low	1	0
fusarium	low	1	0
gentian violet	low	1	0
erythromycin	medium	22	2
5-nitro-2-furaldehyde	low	1	0
ethambutol	low	1	0
dicloxacillin	low	1	0
streptomycin	low	1	0
acetylglucosamine	low	1	0
silver nitrate	medium	11	2
trolamine salicylate	low	2	0
cromolyn sodium	low	1	0
amoxicillin	medium	4	1
timolol	low	1	0
ticarcillin	low	1	0
amikacin	low	2	0
propiconazole	low	1	0
cefaclor anhydrous	low	1	0
pefloxacin	medium	1	1
sparfloxacin	low	2	0
marbofloxacin	low	1	0
trazodone hydrochloride	low	1	0
glucose, (beta-d)-isomer	medium	1	1
cephalosporin c	medium	4	1
enrofloxacin	medium	2	1
miramistin	low	1	0
clarithromycin	low	2	0
tebuconazole	low	1	0
n-chlorotaurine	medium	1	1
methotrexate	low	1	0
trimethoprim, sulfamethoxazole drug combination	low	2	0
povidone-iodine	medium	12	3
netilmicin	medium	2	2
linezolid	low	2	0
erythromycin ethylsuccinate	medium	2	1
mupirocin	low	1	0
clindamycin	low	1	0
fosfomycin	low	1	0
diethylstilbestrol	low	1	0
bromochloroacetic acid	low	1	0
diethylstilbestrol dipropionate	low	1	0
fusidic acid	medium	13	7
rivoglitazone	low	1	0
hydroxyethylcellulose	low	1	0
dinoprostone	low	1	0
clavulanic acid	low	1	0
miocamycin	low	1	0
rokitamycin	low	1	0
phenylephrine hydrochloride	low	2	0
nitrofurazone	low	1	0
cefotaxime	low	4	0
brl 28500	low	1	0
chlorhexidine	medium	1	1
amoxicillin-potassium clavulanate combination	low	7	0
mocetinostat	low	2	0
rifamycins	medium	1	1
gramicidin a	medium	3	2
oligonucleotides	low	1	0
cellulose	low	1	0
chitosan	low	4	0
ro13-9904	low	10	0
interleukin-8	low	5	0
methylcellulose	low	1	0
tetracycline	medium	9	2
oxytetracycline, anhydrous	medium	1	1
minocycline	low	2	0
cyclosporine	low	2	0
muramidase	low	1	0
acyclovir	low	1	0
rifampin	low	5	0
eye	medium	26	1

Protein Targets (946)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Putative fructose-1,6-bisphosphate aldolase	8	0	0	8
Chain A, Ferritin light chain	12	0	0	12
acid sphingomyelinase	6	0	0	6
thioredoxin reductase	21	0	0	21
hypoxia-inducible factor 1 alpha subunit	10	0	0	10
SMAD family member 2	10	0	0	10
SMAD family member 3	10	0	0	10
TDP1 protein	37	0	0	37
GLI family zinc finger 3	32	0	0	32
AR protein	38	0	0	38
estrogen receptor 2 (ER beta)	17	0	0	17
nuclear receptor subfamily 1, group I, member 3	21	0	0	21
progesterone receptor	18	0	0	18
glucocorticoid receptor [Homo sapiens]	30	0	0	30
retinoic acid nuclear receptor alpha variant 1	31	0	0	31
retinoid X nuclear receptor alpha	27	0	0	27
farnesoid X nuclear receptor	16	0	0	16
estrogen nuclear receptor alpha	49	0	0	49
G	13	0	0	13
glucocerebrosidase	4	0	0	4
peroxisome proliferator-activated receptor delta	18	0	0	18
peroxisome proliferator activated receptor gamma	15	0	0	15
vitamin D (1,25- dihydroxyvitamin D3) receptor	17	0	0	17
alpha-galactosidase	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	31	0	0	31
activating transcription factor 6	13	0	0	13
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	11	0	0	11
v-jun sarcoma virus 17 oncogene homolog (avian)	12	0	0	12
Stimulator of interferon genes protein	0	0	1	1
chromobox protein homolog 1	23	0	0	23
thyroid hormone receptor beta isoform 2	27	0	0	27
heat shock protein beta-1	14	0	0	14
importin subunit beta-1 isoform 1	10	0	0	10
flap endonuclease 1	9	0	0	9
snurportin-1	10	0	0	10
nuclear factor erythroid 2-related factor 2 isoform 1	29	0	0	29
GTP-binding nuclear protein Ran isoform 1	3	0	0	3
geminin	34	0	0	34
peripheral myelin protein 22	14	0	0	14
Trypsin	0	0	0	2
Interferon beta	17	0	0	17
HLA class I histocompatibility antigen, B alpha chain	13	0	0	13
Cellular tumor antigen p53	25	0	0	25
TAR DNA-binding protein 43	14	0	0	14
Stimulator of interferon genes protein	0	0	1	1
Inositol hexakisphosphate kinase 1	13	0	0	13
cytochrome P450 2C9, partial	13	0	0	13
RAR-related orphan receptor gamma	27	0	0	27
aldehyde dehydrogenase 1 family, member A1	25	0	0	25
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	15	0	0	15
Histone H2A.x	12	0	0	12
thyroid hormone receptor beta isoform a	12	0	0	12
lamin isoform A-delta10	25	0	0	25
Voltage-dependent calcium channel gamma-2 subunit	14	0	0	14
Glutamate receptor 2	14	0	0	14
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	11	0	0	11
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	10	0	0	10
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	2	0	2
GALC protein	5	0	0	5
cytochrome P450 family 3 subfamily A polypeptide 4	21	0	0	21
estrogen-related nuclear receptor alpha	27	0	0	27
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
arylsulfatase A	7	0	0	7
Carbonic anhydrase	0	2	0	2
Bloom syndrome protein isoform 1	7	0	0	7
survival motor neuron protein isoform d	10	0	0	10
muscleblind-like protein 1 isoform 1	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	10	4	1	16
ATP-binding cassette sub-family C member 3	0	34	0	34
Multidrug resistance-associated protein 4	0	34	0	37
Carbonic anhydrase	0	2	0	2
Solute carrier family 22 member 6	0	6	0	7
Carbonic anhydrase 12	0	4	1	8
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	45	0	45
Glycogen phosphorylase, muscle form	0	2	0	2
Renin	0	2	0	2
Carbonic anhydrase 1	0	10	1	17
Carbonic anhydrase 2	0	10	3	19
Carbonic anhydrase 2	0	3	1	4
Cytochrome P450 1A2	0	4	0	5
Carbonic anhydrase 3	0	4	1	8
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	13	1	15
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	3	0	4
Polyunsaturated fatty acid 5-lipoxygenase	0	3	0	3
Cytochrome P450 2C8	0	2	0	2
Cytochrome P450 2D6	0	6	0	7
Cytochrome P450 2A6	0	2	0	2
Cytochrome P450 2C9	0	10	0	11
5-hydroxytryptamine receptor 2A	0	5	0	5
Androgen receptor	0	6	0	6
Gamma-aminobutyric acid receptor subunit beta-1	10	4	1	16
Translocator protein	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	10	4	1	16
Gamma-aminobutyric acid receptor subunit gamma-2	10	4	1	16
Gamma-aminobutyric acid receptor subunit alpha-5	10	4	1	16
Gamma-aminobutyric acid receptor subunit alpha-3	10	4	1	16
Cannabinoid receptor 1	0	2	0	2
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	2	1	3
Carbonic anhydrase 4	0	5	1	8
Carbonic anhydrase 6	0	7	1	10
Gamma-aminobutyric acid receptor subunit gamma-1	10	4	1	16
Gamma-aminobutyric acid receptor subunit alpha-2	10	4	1	16
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Adenosine receptor A1	0	1	0	2
Serum paraoxonase/arylesterase 1	0	3	0	3
Dipeptidyl peptidase 4	0	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	10	4	1	16
Gamma-aminobutyric acid receptor subunit gamma-3	10	4	1	16
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	10	4	1	16
Adenosine receptor A2a	0	1	0	2
5-hydroxytryptamine receptor 2B	0	3	0	3
Sodium-dependent serotonin transporter	0	2	0	2
Delta-type opioid receptor	0	2	0	2
Cytochrome P450 2C19	0	5	0	6
Delta-type opioid receptor	0	3	0	3
Mu-type opioid receptor	0	3	0	3
Carbonic anhydrase 5A, mitochondrial	0	5	1	10
Carbonic anhydrase	0	3	0	4
Kappa-type opioid receptor	0	1	0	7
Carbonic anhydrase 7	0	4	1	7
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	2	0	4
D(2) dopamine receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	10	4	1	16
Gamma-aminobutyric acid receptor subunit beta-3	10	4	1	16
Gamma-aminobutyric acid receptor subunit beta-2	10	4	1	16
Cholinesterase	0	1	0	1
Carbonic anhydrase	0	2	0	2
Mu-type opioid receptor	0	3	0	3
Fatty-acid amide hydrolase 1	1	3	0	4
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	1	0	2
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Carbonic anhydrase 9	0	5	1	9
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	2	0	4
Carbonic anhydrase 3	0	2	0	2
Carbonic anhydrase	0	2	0	5
Carbonic anhydrase	0	2	0	5
Carbonic anhydrase	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Delta carbonic anhydrase	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
Renin	0	1	0	1
Carbonic anhydrase	0	2	0	4
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	4	1	7
GABA theta subunit	10	4	1	16
Canalicular multispecific organic anion transporter 1	0	32	0	32
Carbonic anhydrase 4	0	3	0	4
Carbonic anhydrase 15	0	3	0	5
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	3	0	5
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	10	4	1	16
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 14	0	4	1	8
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	4	1	9
Putative glycosyltransferase WbgO	0	0	0	1
Killer cell lectin-like receptor subfamily B member 1A	0	1	0	1
Early activation antigen CD69	0	1	0	1
Microtubule-associated protein tau	11	0	0	12
Smad3	7	0	0	7
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	15	0	0	15
DNA polymerase iota isoform a (long)	12	0	0	12
DNA topoisomerase 2-alpha	0	1	0	7
Acetylcholinesterase	0	4	0	4
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	12	0	0	12
Chain B, HADH2 protein	12	0	0	12
Chain A, ATP-DEPENDENT DNA HELICASE Q1	5	0	0	5
Thymidine kinase	0	1	0	1
phosphopantetheinyl transferase	15	0	0	15
GLS protein	11	0	0	11
thyroid stimulating hormone receptor	16	0	0	16
EWS/FLI fusion protein	19	0	0	19
hemoglobin subunit beta	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	5	0	0	5
Solute carrier family 22 member 1	0	4	0	8
Bile salt export pump	0	12	0	12
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	1	0	2
POU domain, class 2, transcription factor 2	0	0	0	1
Cytochrome P450 2J2	0	7	0	7
Disintegrin and metalloproteinase domain-containing protein 17	4	0	0	4
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	6	0	9
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	6	0	10
Thymidine kinase	0	1	0	1
histone acetyltransferase KAT2A isoform 1	12	0	0	12
Aminoglycoside 3'-phosphotransferase	0	0	0	2
ATP-dependent phosphofructokinase	5	0	0	5
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	20	0	0	20
Chain A, 2-oxoglutarate Oxygenase	19	0	0	19
Beta-lactamase	0	1	0	6
Beta-lactamase	0	1	0	7
Beta-lactamase	0	0	0	6
Beta-lactamase	0	1	0	8
apical membrane antigen 1, AMA1	5	0	0	5
Beta-lactamase	0	0	0	5
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	5	0	0	5
DNA polymerase eta isoform 1	6	0	0	6
urokinase-type plasminogen activator precursor	7	0	0	7
plasminogen precursor	7	0	0	7
urokinase plasminogen activator surface receptor precursor	7	0	0	7
DNA polymerase kappa isoform 1	12	0	0	12
Beta-lactamase SHV-1	0	1	0	7
Beta-lactamase SHV-1	0	2	0	9
Beta-lactamase	0	1	0	7
Solute carrier family 15 member 1	0	13	0	13
Solute carrier family 15 member 1	0	2	0	2
B2 metallo-beta-lactamase	0	0	0	5
Solute carrier family 15 member 2	0	9	0	9
Beta-lactamase	0	1	0	7
Beta-lactamase	0	1	0	7
Solute carrier family 15 member 2	0	9	0	9
Beta-lactamase	0	1	0	7
Beta-lactamase	0	0	0	5
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, Cruzipain	9	0	0	9
Beta-lactamase	0	1	0	5
Beta-lactamase	0	2	0	7
Beta-lactamase	0	0	0	6
Metallo-beta-lactamase type 2	0	0	0	5
Metallo-beta-lactamase VIM-11	0	0	0	4
Metallo-beta-lactamase VIM-2	0	0	0	4
Beta-lactamase	0	0	0	6
Metallo-beta-lactamase	0	0	0	5
Beta-lactamase	0	2	0	7
DNA polymerase beta	5	0	0	5
60 kDa heat shock protein, mitochondrial	0	5	0	5
Beta-lactamase OXA-7	0	0	0	4
Spike glycoprotein	12	0	0	12
10 kDa heat shock protein, mitochondrial	0	5	0	5
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	1	0	4
Beta-lactamase	0	1	0	4
Beta-lactamase	0	1	0	4
Thiosulfate sulfurtransferase	0	5	0	5
Metallo-beta-lactamase VIM-13	0	0	0	5
Efflux transporter	0	0	0	4
Beta-lactamase	0	0	0	4
Beta-lactamase Toho-1	0	0	0	5
Beta-lactamase	0	0	0	4
Class D beta-lactamase	0	1	0	5
60 kDa chaperonin	0	5	0	5
Metallo-beta-lactamase	0	0	0	3
Beta-lactamase	0	1	0	5
Beta-lactamase	0	0	0	2
10 kDa chaperonin	0	5	0	5
Metallo-b-lactamase	0	0	0	7
Carbapenem-hydrolyzing beta-lactamase KPC	0	2	0	8
Histamine H3 receptor	0	1	0	5
Beta-lactamase class B VIM-2	0	0	0	7
Beta-lactamase VIM-1	0	0	0	5
USP1 protein, partial	14	0	0	14
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11	0	0	11
cytochrome P450 2D6 isoform 1	5	0	0	5
interferon gamma precursor	0	0	0	1
nuclear receptor ROR-gamma isoform 1	10	0	0	10
Polyunsaturated fatty acid lipoxygenase ALOX15B	6	0	0	6
Histamine H2 receptor	8	0	1	9
thyroid stimulating hormone receptor	13	0	0	13
Nuclear receptor ROR-gamma	11	0	0	11
interleukin 8	9	0	0	9
pregnane X receptor	8	0	0	8
ATAD5 protein, partial	6	0	0	6
pregnane X nuclear receptor	26	0	0	26
bromodomain adjacent to zinc finger domain 2B	7	0	0	7
IDH1	12	0	0	12
nuclear receptor subfamily 1, group I, member 2	6	0	0	6
cellular tumor antigen p53 isoform a	6	0	0	6
Nuclear hormone receptor family member daf-12	0	0	1	1
nuclear factor erythroid 2-related factor 2 isoform 2	9	0	0	9
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
oxysterols receptor LXR-beta isoform 1	0	0	1	1
muscarinic acetylcholine receptor M1	3	0	0	3
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
ATPase family AAA domain-containing protein 5	8	0	0	8
Ataxin-2	8	0	0	8
Chain A, serum paraoxonase	0	1	0	1
Neutrophil cytosol factor 1	0	1	0	1
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	9	0	0	9
aryl hydrocarbon receptor	15	0	0	15
vitamin D3 receptor isoform VDRA	15	0	0	15
serine/threonine-protein kinase PLK1	5	0	0	5
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1	0	2	0	2
streptokinase A precursor	0	0	16	16
Estrogen receptor	0	0	5	5
Estrogen receptor beta	0	0	5	5
Luciferase	7	0	0	7
cytochrome P450 2D6	13	0	0	13
Solute carrier family 22 member 11	0	4	0	7
Solute carrier family 22 member 8	0	5	0	6
Beta-lactamase	0	1	0	5
Beta-lactamase	0	1	0	4
Metallo-beta-lactamase VIM-19	0	0	0	3
Beta-lactamase	0	1	0	6
Albumin	0	1	7	8
Beta-lactamase	0	0	0	3
Beta-lactamase	0	1	0	6
Metallo-beta-lactamase VIM-2	0	0	0	4
Solute carrier family 22 member 7	0	3	0	4
BlaVIM-1	0	0	0	3
Beta-lactamase	0	0	0	3
Beta-lactamase	0	1	0	4
Solute carrier family 22 member 7	0	3	0	5
Beta-lactamase	0	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	12	0	0	12
Beta-lactamase	0	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	1	2	3
Solute carrier family 22 member 5	0	1	0	1
Beta-lactamase	0	1	0	4
Beta-lactamase	0	1	0	4
Beta-lactamase OXA-10	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase TEM	0	3	0	7
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase IMP-1	0	0	0	2
Beta-lactamase	0	0	0	2
endonuclease IV	3	0	0	3
WRN	2	0	0	2
DNA (cytosine-5)-methyltransferase 1 isoform b	0	1	0	1
Solute carrier family 22 member 8	0	7	0	8
Beta-lactamase OXA-1	0	1	0	2
Beta-lactamase	0	0	0	4
phosphoglycerate kinase	2	0	0	2
lethal factor (plasmid)	5	0	0	5
Dihydroxyacetone phosphate acyltransferase	0	0	0	2
30S ribosomal protein S6	0	7	1	8
30S ribosomal protein S7	0	7	1	8
50S ribosomal protein L15	0	7	1	8
50S ribosomal protein L10	0	7	1	8
50S ribosomal protein L11	0	7	1	8
50S ribosomal protein L7/L12	0	7	1	8
50S ribosomal protein L19	0	7	1	8
50S ribosomal protein L1	0	7	1	8
50S ribosomal protein L20	0	7	1	8
50S ribosomal protein L27	0	7	1	8
50S ribosomal protein L28	0	7	1	8
50S ribosomal protein L29	0	7	1	8
50S ribosomal protein L31	0	7	1	8
50S ribosomal protein L31 type B	0	7	1	8
50S ribosomal protein L32	0	7	1	8
50S ribosomal protein L33	0	7	1	8
50S ribosomal protein L34	0	7	1	8
50S ribosomal protein L35	0	7	1	8
50S ribosomal protein L36	0	7	1	8
30S ribosomal protein S10	0	7	1	8
30S ribosomal protein S11	0	7	1	8
30S ribosomal protein S12	0	7	1	8
30S ribosomal protein S13	0	7	1	8
30S ribosomal protein S16	0	7	1	8
30S ribosomal protein S18	0	7	1	8
30S ribosomal protein S19	0	7	1	8
30S ribosomal protein S20	0	7	1	8
30S ribosomal protein S2	0	7	1	8
30S ribosomal protein S3	0	7	1	8
30S ribosomal protein S4	0	7	1	8
30S ribosomal protein S5	0	7	1	8
30S ribosomal protein S8	0	7	1	8
30S ribosomal protein S9	0	7	1	8
50S ribosomal protein L13	0	7	1	8
50S ribosomal protein L14	0	7	1	8
50S ribosomal protein L16	0	7	1	8
50S ribosomal protein L23	0	7	1	8
30S ribosomal protein S15	0	7	1	8
50S ribosomal protein L17	0	7	1	8
50S ribosomal protein L21	0	7	1	8
50S ribosomal protein L30	0	7	1	8
50S ribosomal protein L6	0	7	1	8
30S ribosomal protein S14	0	7	1	8
30S ribosomal protein S17	0	7	1	8
30S ribosomal protein S1	0	7	1	8
50S ribosomal protein L18	0	7	1	8
50S ribosomal protein L2	0	7	1	8
50S ribosomal protein L3	0	7	1	8
50S ribosomal protein L24	0	7	1	8
50S ribosomal protein L4	0	7	1	8
50S ribosomal protein L22	0	7	1	8
50S ribosomal protein L5	0	7	1	8
30S ribosomal protein S21	0	7	1	8
50S ribosomal protein L25	0	7	1	8
50S ribosomal protein L36 2	0	7	1	8
Methionine--tRNA ligase, mitochondrial	0	0	1	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
acetylcholinesterase	6	0	0	6
PAX8	0	0	0	1
glp-1 receptor, partial	7	0	0	7
15-lipoxygenase, partial	5	0	0	5
caspase 7, apoptosis-related cysteine protease	4	0	0	4
PINK1	2	0	0	2
67.9K protein	8	0	0	8
Parkin	2	0	0	2
heat shock protein 90	0	0	2	2
caspase-3	4	0	0	4
calcineurin A1, putative	0	0	1	1
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
cytochrome P450 2C19 precursor	3	0	0	3
cytochrome P450 2C9 precursor	3	0	0	3
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
transcriptional regulator ERG isoform 3	5	0	0	5
huntingtin isoform 2	3	0	0	3
mitogen-activated protein kinase 1	9	0	0	9
ubiquitin-conjugating enzyme E2 N	0	1	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	2	0	0	2
protein AF-9 isoform a	0	0	0	1
melanocortin receptor 4	0	1	0	1
CAAX prenyl protease	0	0	0	2
bcl-2-related protein A1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
cytochrome P450 3A4 isoform 1	10	0	0	10
glycogen synthase kinase-3 alpha	0	0	0	1
hexokinase HKDC1	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
bcl-2-like protein 11 isoform 1	0	0	1	1
Synaptojanin-2	0	1	0	1
Solute carrier family 22 member 2	0	2	0	4
Synaptojanin-1	0	1	0	1
Solute carrier family 22 member 3	0	3	0	4
Glutathione reductase, mitochondrial	0	1	0	2
Integrin beta-3	5	0	0	5
72 kDa type IV collagenase	0	2	0	2
Integrin alpha-IIb	5	0	0	5
Matrix metalloproteinase-9	0	2	0	2
Trypanothione reductase	0	1	0	1
Alpha-synuclein	3	2	0	5
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Multidrug and toxin extrusion protein 1	0	4	0	4
Spermine oxidase	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	2	0	4
DNA gyrase subunit A	0	8	0	12
DNA gyrase subunit B	0	8	0	12
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	3
DNA topoisomerase 4 subunit A	0	4	0	6
DNA gyrase subunit A	0	2	0	4
Multidrug resistance protein MdtK	0	0	2	2
DNA gyrase subunit B	0	5	0	7
DNA gyrase subunit A	0	7	0	9
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	4	0	9
Potassium voltage-gated channel subfamily H member 2	0	14	0	17
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	2	0	2
ATP-dependent translocase ABCB1	0	4	0	5
Solute carrier organic anion transporter family member 1B3	0	5	0	7
Solute carrier organic anion transporter family member 1B1	0	5	0	6
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Neutrophil elastase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Protein-arginine deiminase type-4	0	10	0	10
mitogen-activated protein kinase kinase kinase kinase 2 isoform 1	0	0	1	1
eyes absent homolog 2 isoform a	1	0	0	1
mitogen-activated protein kinase kinase kinase 3 isoform 1	0	0	1	1
Spike glycoprotein	0	0	1	1
5-hydroxytryptamine receptor 1A	0	2	2	4
Cruzipain	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	5	0	6
NFKB1 protein, partial	3	0	0	3
Thrombopoietin	1	0	0	1
nonstructural protein 1	5	0	0	5
Solute carrier family 22 member 3	0	1	0	1
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	2	0	2
Mineralocorticoid receptor	0	2	2	4
C-8 sterol isomerase	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Solute carrier family 22 member 1	0	3	0	4
Sigma non-opioid intracellular receptor 1	0	1	0	1
Solute carrier family 22 member 2	0	3	0	4
Alkaline phosphatase, germ cell type	0	1	0	1
G protein-coupled receptor GPR35	0	0	1	1
G-protein coupled receptor 35	0	0	1	1
G-protein coupled receptor 35	0	0	1	1
regulator of G-protein signaling 4	6	0	0	6
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
high affinity choline transporter 1 isoform a	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	3	0	0	3
neuropeptide S receptor isoform A	2	0	0	2
5-hydroxytryptamine receptor 4	0	2	0	2
Estrogen receptor	0	4	1	5
Glucocorticoid receptor	0	8	2	15
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Tyrosine-protein kinase Fyn	0	2	0	2
Glycine receptor subunit alpha-1	0	8	0	8
Aldo-keto reductase family 1 member B1	0	2	0	2
Beta-1 adrenergic receptor	0	4	0	4
Alpha-2A adrenergic receptor	0	5	0	5
Adenosine receptor A3	0	4	0	4
Muscarinic acetylcholine receptor M1	0	4	0	4
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
D(2) dopamine receptor	0	4	0	4
Alpha-1B adrenergic receptor	0	6	0	6
Alpha-2B adrenergic receptor	0	4	0	4
Alpha-2C adrenergic receptor	0	4	0	4
Muscarinic acetylcholine receptor M3	0	4	0	4
Glycine receptor subunit beta	0	8	0	8
Substance-K receptor	0	4	0	4
D(1A) dopamine receptor	0	4	0	4
Glycine receptor subunit alpha-2	0	8	0	8
Prostaglandin G/H synthase 1	0	3	0	3
Sodium-dependent noradrenaline transporter	0	2	0	2
Glycine receptor subunit alpha-3	0	8	0	8
Thromboxane-A synthase	0	1	0	1
Alpha-1D adrenergic receptor	0	4	0	4
5-hydroxytryptamine receptor 2A	0	4	0	4
5-hydroxytryptamine receptor 2C	0	2	0	2
Adenosine receptor A2a	0	4	0	4
Adenosine receptor A1	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Mu-type opioid receptor	0	4	0	4
D(3) dopamine receptor	0	4	0	4
Vasopressin V1a receptor	0	2	0	2
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	4	0	4
5-hydroxytryptamine receptor 2B	0	2	0	2
Alpha-1A adrenergic receptor	0	6	0	6
5-hydroxytryptamine receptor 6	0	2	0	2
Estrogen-related receptor gamma	0	0	1	1
Inositol monophosphatase 1	2	0	0	2
Sodium-dependent dopamine transporter	0	4	0	4
Aldehyde oxidase	0	2	0	2
UDP-glucose 4-epimerase	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Estrogen receptor beta	0	4	1	5
Cysteinyl leukotriene receptor 1	0	2	0	2
Estrogen receptor 1	0	0	1	1
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Prostacyclin receptor	0	2	1	3
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 6	0	3	0	3
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Motilin receptor	0	0	1	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
Motilin receptor	0	1	1	2
Rap guanine nucleotide exchange factor 3	2	0	0	2
ATP-dependent translocase ABCB1	0	2	0	2
60 kDa chaperonin	0	2	0	2
Chitinase B	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Cytochrome P450 1B1	0	1	0	1
Lanosterol 14-alpha demethylase	0	3	0	3
exodeoxyribonuclease V subunit RecD	0	2	0	2
exodeoxyribonuclease V subunit RecB	0	2	0	2
exodeoxyribonuclease V subunit RecC	0	2	0	2
Pantothenate synthetase	0	2	0	2
PPM1D protein	3	0	0	3
histone deacetylase 9 isoform 3	2	0	0	2
Acid-sensing ion channel 3	0	1	0	1
Fatty acid-binding protein, liver	0	2	0	2
Amyloid-beta precursor protein	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Fatty acid-binding protein, intestinal	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	0	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
UDP-glucuronosyltransferase 1A3	0	0	0	1
Aldo-keto reductase family 1 member C3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0	1	0	1
UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0	1	0	1
Menin	0	0	1	1
Lecithin retinol acyltransferase	0	1	0	1
Lethal factor	0	1	0	1
Protein Rev	0	0	2	2
Tyrosyl-DNA phosphodiesterase 1	0	2	0	2
Caspase-7	3	0	0	3
caspase-3	3	0	0	3
Polyphenol oxidase 2	0	2	0	2
Chain A, Type Iii Chloramphenicol Acetyltransferase	0	1	0	1
thioredoxin glutathione reductase	5	0	0	5
Guanine nucleotide-binding protein G	3	0	0	3
Canalicular multispecific organic anion transporter 1	0	2	0	3
large T antigen	0	1	0	1
beta-amyloid peptide, A beta {N-terminal} [human, cerebrospinal fluid, conditioned medium of mixed-brain cell cultures, Peptide Partial, 33 aa]	1	0	0	1
alpha synuclein, partial	1	0	0	1
hypothetical protein, conserved	1	0	0	1
luciferase	1	0	0	1
thyrotropin-releasing hormone receptor	2	0	0	2
tumor necrosis factor	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
Epidermal growth factor receptor	0	1	0	1
Muscarinic acetylcholine receptor M2	0	3	0	3
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Glutamate receptor ionotropic, kainate 1	1	0	0	1
Histamine H2 receptor	0	3	2	5
Glutamate receptor ionotropic, kainate 2	1	0	0	1
Glutamate receptor ionotropic, kainate 3	1	0	0	1
Glutamate receptor ionotropic, kainate 4	1	0	0	1
Leukotriene B4 receptor 1	1	0	0	1
Glutamate receptor ionotropic, kainate 5	1	0	0	1
Leukotriene B4 receptor 2	1	0	0	1
Asialoglycoprotein receptor 1	0	1	1	2
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Plasma kallikrein	0	0	0	1
Macrophage migration inhibitory factor	0	3	0	3
5-hydroxytryptamine receptor 1D	0	0	0	1
Histamine H1 receptor	0	1	3	4
Histamine H1 receptor	0	2	1	3
Metabotropic glutamate receptor 5	0	3	1	4
Histamine H1 receptor	0	2	2	4
Glutamate receptor ionotropic, NMDA 1	0	0	0	1
Histamine H3 receptor	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	1
Glutamate receptor ionotropic, NMDA 2C	0	0	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
Equilibrative nucleoside transporter 4	0	0	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Histamine H4 receptor	0	1	2	3
Carboxylic ester hydrolase	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
Histamine H3 receptor	0	1	2	3
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Proton-coupled amino acid transporter 1	0	2	0	2
Amino acid transporter	0	1	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	2	0	2
N-glycosylase/DNA lyase	0	1	0	1
Myeloperoxidase	0	1	0	1
Formamidopyrimidine-DNA glycosylase	0	1	0	1
Endonuclease III-like protein 1	0	1	0	1
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	3	0	3
Endonuclease 8-like 1	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
CAAX prenyl protease 2 isoform 2	0	0	0	1
Tubulin beta-4A chain	0	1	0	1
Tubulin beta chain	0	1	0	1
Tubulin alpha-3C chain	0	1	0	1
Tubulin alpha-1B chain	0	1	0	1
Tubulin alpha-4A chain	0	1	0	1
Tubulin beta-4B chain	0	1	0	1
DNA primase	0	1	0	1
Tubulin beta-3 chain	0	1	0	1
Tubulin beta-2A chain	0	1	0	1
Tubulin beta-8 chain	0	1	0	1
Tubulin alpha-3E chain	0	1	0	1
Tubulin alpha-1A chain	0	1	0	1
Tubulin alpha-1C chain	0	1	0	1
Tubulin beta-6 chain	0	1	0	1
Tubulin beta-2B chain	0	1	0	1
Tubulin beta-1 chain	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	5	0	5
Amine oxidase [flavin-containing] B	0	1	0	1
Amine oxidase [flavin-containing] A	0	2	0	2
Amine oxidase [flavin-containing] B	0	1	0	1
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1S	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1C	0	6	0	6
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	0	1
Renin	0	1	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
dopamine D1 receptor	3	0	0	3
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
M-phase phosphoprotein 8	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	5	0	6
Dihydrofolate reductase	0	3	0	4
Dihydrofolate reductase	0	3	0	3
Dihydrofolate reductase	0	3	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	4	0	5
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	3	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	3	0	3
Thymidylate synthase	0	2	0	2
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	3	0	3
Thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	4	2	6
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	3	0	3
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	4	0	5
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	3	0	3
Dihydrofolate reductase	0	2	0	3
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Stromelysin-1	0	2	0	2
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	2	0	2
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Histone deacetylase 3	0	2	0	2
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Integrin alpha-4	0	1	0	1
Histone deacetylase 4	0	1	0	1
Histone deacetylase 1	0	2	0	2
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	2	0	2
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 5	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Replicase polyprotein 1ab	0	2	0	2
Replicase polyprotein 1ab	0	2	0	2
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Chain A, Isoleucyl-tRNA synthetase	0	1	0	1
twin arginine protein translocation system - TatA protein	0	0	0	3
Isoleucine--tRNA ligase	0	1	0	1
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase	0	1	0	1
Snake venom metalloproteinase BaP1	0	1	0	1
NAD(+) hydrolase SARM1	0	2	0	2
STE24	0	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
MecA	0	1	0	1
Valosin-containing protein	0	1	0	1
lysosomal alpha-glucosidase preproprotein	2	0	0	2
microphthalmia-associated transcription factor isoform 9	0	1	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	2	0	0	2
Neuronal acetylcholine receptor subunit beta-2	2	0	0	2
Beta-lactamase 1	0	0	0	1
beta-2 adrenergic receptor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	2	0	0	2
5-hydroxytryptamine receptor 2A	0	0	1	1
luciferase	0	0	0	1
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	3
heat shock protein 90, putative	0	0	0	2
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
Pyridoxal kinase	0	0	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
NH(3)-dependent NAD(+) synthetase	0	2	0	2
Arylacetamide deacetylase	0	1	0	2
Caspase-1	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Angiotensin-converting enzyme	0	2	0	2
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Cholinesterase	0	1	0	1
Protein argonaute-2	0	0	1	1
Cystine/glutamate transporter	0	1	0	1
Dihydropteroate synthase	0	1	0	1
Transcriptional activator protein LasR	0	1	0	1
Endothelin-1 receptor	0	1	0	1
Endothelin-1 receptor	0	1	0	1
Protein arginine N-methyltransferase 6	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Cytochrome P450 14alpha-demethylase	0	0	1	1
Sterol 14-alpha demethylase	0	1	0	1
Carnitine O-palmitoyltransferase 1, muscle isoform	0	1	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
Neutrophil collagenase	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Beta-1 adrenergic receptor	0	0	1	1
Beta-2 adrenergic receptor	0	2	0	2
Beta-3 adrenergic receptor	0	2	0	2
Beta-1 adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 1B	0	2	0	2
Beta-2 adrenergic receptor	0	0	1	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Chain A, enoyl-acyl carrier reductase	0	1	0	1
Chain C, enoyl-acyl carrier reductase	0	1	0	1
Chain A, enoyl-acyl carrier reductase	0	1	0	1
Chain C, enoyl-acyl carrier reductase	0	1	0	1
Chain A, enoyl-acyl carrier reductase	0	1	0	1
Chain C, enoyl-acyl carrier reductase	0	1	0	1
Chain A, Repressor	0	0	1	1
Fumarate hydratase	1	0	0	1
polyprotein	1	0	0	1
Transthyretin	0	1	1	2
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Endoplasmic reticulum chaperone BiP	0	1	0	1
Carbonyl reductase [NADPH] 1	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI	0	2	0	2
Enoyl-acyl carrier reductase	0	1	0	1
Enoyl-acyl-carrier protein reductase	0	2	0	2
Enoyl-ACP reductase II	0	1	0	1
Chain A, Dihydrofolate Reductase	0	0	1	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, dihydrofolate reductase (DHFR)	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase type 1	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase type 1 from Tn4003	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Dihydrofolate reductase	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Transporter	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Actions

Treatment

Research

Studies (322)

Protein Targets (946)

Conjunctivitis, Bacterial

Synonyms(1)

Research Excerpts

Overview

Context

Actions

Treatment

Research

Studies (322)

Drugs Studied (133)

Protein Targets (946)