metronidazole has been researched along with Cancrum Oris in 11 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Only few cases of noma infection in adults have been described." | 1.46 | Noma in an HIV infected patient in Guinea-Bissau: a case report. ( Hønge, BL; Jespersen, S; Madsen, T; Medina, C; Wejse, C, 2017) |
| "Necrotizing stomatitis is more commonly encountered in malnourished children in developing countries, and may subsequently result in devastating facial defects and death." | 1.33 | Necrotizing stomatitis in the developed world. ( Buchanan, JA; Cedro, M; Hodgson, TA; Joseph, T; Mirdin, A; Porter, SR, 2006) |
| "Cancrum oris (noma) is a gangrenous infection that develops in the mouth and spreads rapidly to other parts of the face." | 1.31 | Noma (cancrum oris): case report in a 4-year-old HIV-positive South African child. ( Chikte, UM; Naidoo, S, 2000) |
| "The first reported isolation from human noma lesions of F." | 1.30 | Isolation of Fusobacterium necrophorum from cancrum oris (noma). ( Enwonwu, CO; Falkler, WA; Idigbe, EO, 1999) |
| "Cancrum oris is predominantly seen in children in underdeveloped countries where widespread malnutrition, dehydration and epidemic infections are present." | 1.28 | Cancrum oris-like lesions. ( Cheng, LH; Nash, ES; Smart, K, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brotherton, BJ | 1 |
| Hatcher, J | 1 |
| Williamson, L | 1 |
| Madsen, T | 1 |
| Medina, C | 1 |
| Jespersen, S | 1 |
| Wejse, C | 1 |
| Hønge, BL | 1 |
| Oji, C | 1 |
| Naidoo, S | 1 |
| Chikte, UM | 1 |
| Van Damme, PA | 1 |
| Buchanan, JA | 1 |
| Cedro, M | 1 |
| Mirdin, A | 1 |
| Joseph, T | 1 |
| Porter, SR | 1 |
| Hodgson, TA | 1 |
| Falkler, WA | 1 |
| Enwonwu, CO | 1 |
| Idigbe, EO | 1 |
| Nash, ES | 1 |
| Cheng, LH | 1 |
| Smart, K | 1 |
| Sirol, J | 1 |
| Vedy, J | 1 |
| Sabrié, A | 1 |
| Lacour, M | 1 |
| Castets, M | 1 |
11 other studies available for metronidazole and Cancrum Oris
| Article | Year |
|---|---|
Visual Diagnosis: Rapidly Progressing Oral Ulcer in a 13-year-old Girl.
Topics: Adolescent; Anti-Bacterial Agents; Debridement; Diagnosis, Differential; Female; Humans; Metronidazo | 2019 |
Noma in a patient with HIV.
Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Anti-HIV Agents; Antire | 2017 |
Noma in an HIV infected patient in Guinea-Bissau: a case report.
Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Infective Agents; Diagnosis, Differential | 2017 |
Cancrum oris: its incidence and treatment in Enugu, Nigeria.
Topics: Adolescent; Adult; Anti-Infective Agents; Child, Preschool; Female; Humans; Incidence; Male; Metroni | 2002 |
Noma (cancrum oris): case report in a 4-year-old HIV-positive South African child.
Topics: AIDS-Related Opportunistic Infections; Anti-Infective Agents; Child, Preschool; Female; HIV Seroposi | 2000 |
Noma.
Topics: Africa; Anti-Bacterial Agents; Child; Diagnosis, Differential; Humans; Metronidazole; Noma; Postoper | 2004 |
Necrotizing stomatitis in the developed world.
Topics: Aged; Analgesics; Debridement; Deglutition Disorders; Developed Countries; Dietary Supplements; Ging | 2006 |
Isolation of Fusobacterium necrophorum from cancrum oris (noma).
Topics: Adolescent; Anti-Bacterial Agents; Bacteroidaceae Infections; Child; Child, Preschool; Clindamycin; | 1999 |
Cancrum oris-like lesions.
Topics: Ampicillin; Busulfan; Candida albicans; Chronic Disease; Diagnosis, Differential; Disease Susceptibi | 1991 |
[Noma or forgotten ugliness. Clinical study and pathogenesis apropos of 6 cases at Fort-Lamy (Chad)].
Topics: Anti-Bacterial Agents; Chad; Child; Child, Preschool; Female; Humans; Leishmaniasis, Mucocutaneous; | 1972 |
[On a case of noma treated by metronidazole].
Topics: Child; Humans; Male; Metronidazole; Noma | 1968 |