metronidazole has been researched along with Megacolon, Toxic in 8 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Megacolon, Toxic: An acute form of MEGACOLON, severe pathological dilatation of the COLON. It is associated with clinical conditions such as ULCERATIVE COLITIS; CROHN DISEASE; AMEBIC DYSENTERY; or CLOSTRIDIUM ENTEROCOLITIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " difficile diarrhea with metronidazole or vancomycin is highly effective at relieving symptoms." | 4.80 | Treatment of Clostridium difficile-associated diarrhea and colitis. ( Gerding, DN, 2000) |
| "This study evaluated the incidence and treatment of pouchitis in Japanese ulcerative colitis patients." | 1.39 | Clinical features and management of pouchitis in Japanese ulcerative colitis patients. ( Bando, T; Ikeuchi, H; Matsuoka, H; Takesue, Y; Tomita, N; Uchino, M, 2013) |
| "The development of toxic megacolon as a complication of infectious colitis is rare." | 1.33 | Toxic megacolon complicating Escherichia coli O157 infection. ( Koerner, RJ; McElroy, J; Nayar, DM; Pai, P; Vetrivel, S, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Popa, D | 1 |
| Laszlo, M | 1 |
| Ciobanu, L | 1 |
| Ucenic, E | 1 |
| Mihalache, M | 1 |
| Pascu, O | 1 |
| Torrijo Gómez, I | 1 |
| Uribe Quintana, N | 1 |
| Catalá Llosa, J | 1 |
| Raga Vázquez, J | 1 |
| Sellés Dechent, R | 1 |
| Martín Dieguez, MC | 1 |
| Báguena Requena, G | 1 |
| Asencio Arana, F | 1 |
| Akamine, CM | 1 |
| Ing, MB | 1 |
| Jackson, CS | 1 |
| Loo, LK | 1 |
| Stallmach, A | 1 |
| Uchino, M | 1 |
| Ikeuchi, H | 1 |
| Matsuoka, H | 1 |
| Bando, T | 1 |
| Takesue, Y | 1 |
| Tomita, N | 1 |
| Nayar, DM | 1 |
| Vetrivel, S | 1 |
| McElroy, J | 1 |
| Pai, P | 1 |
| Koerner, RJ | 1 |
| Bouza, E | 1 |
| Burillo, A | 1 |
| Muñoz, P | 1 |
| Gerding, DN | 1 |
2 reviews available for metronidazole and Megacolon, Toxic
| Article | Year |
|---|---|
Antimicrobial therapy of Clostridium difficile-associated diarrhea.
Topics: Aged; Anti-Infective Agents; Bacterial Proteins; Bacterial Toxins; Clostridioides difficile; Clostri | 2006 |
Treatment of Clostridium difficile-associated diarrhea and colitis.
Topics: Abdomen, Acute; Anti-Bacterial Agents; Antidiarrheals; Clinical Trials as Topic; Clostridioides diff | 2000 |
6 other studies available for metronidazole and Megacolon, Toxic
| Article | Year |
|---|---|
Self-Administered Home Series Fecal "Minitransplants" for Recurrent Clostridium difficile Infection on a Rectal Remnant.
Topics: Aged; Anti-Infective Agents; Clostridioides difficile; Colectomy; Enterocolitis, Pseudomembranous; F | 2015 |
[Fulminant Clostridium difficile colitis].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Clostridioides difficile; Colectomy; Enterocol | 2016 |
The efficacy of intracolonic vancomycin for severe Clostridium difficile colitis: a case series.
Topics: Aged; Anti-Bacterial Agents; Clostridioides difficile; Colon; Drug Administration Routes; Enterocoli | 2016 |
[Clostridium difficile infection : What is currently available for treatment?]
Topics: Aminoglycosides; Anti-Bacterial Agents; Clostridioides difficile; Diarrhea; Enterocolitis, Pseudomem | 2016 |
Clinical features and management of pouchitis in Japanese ulcerative colitis patients.
Topics: Acute Disease; Adolescent; Adult; Age Factors; Age of Onset; Aged; Anti-Bacterial Agents; Asian Peop | 2013 |
Toxic megacolon complicating Escherichia coli O157 infection.
Topics: Adult; Anti-Infective Agents; Antibodies, Bacterial; Ciprofloxacin; Colitis; Colon; Escherichia coli | 2006 |