metronidazole has been researched along with Cerebellar Diseases in 20 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Cerebellar Diseases: Diseases that affect the structure or function of the cerebellum. Cardinal manifestations of cerebellar dysfunction include dysmetria, GAIT ATAXIA, and MUSCLE HYPOTONIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cerebellar syndrome or seizures are less frequently reported." | 5.35 | [Metronidazole-related polyneuritis, convulsive seizures, and cerebellar syndrome. Contribution of MRI]. ( Corpechot, C; Ferroir, JP; Freudenreich, A; Khalil, A, 2009) |
| " Lumbar spinal magnetic resonance imaging (MRI) revealed infective spondylitis, and metronidazole (1." | 4.31 | Metronidazole-induced encephalopathy delayed diagnosis due to cerebellar infarction: A case report. ( Cha, S; Cho, KH; Lee, BC; Moon, CW, 2023) |
| "Here, we report a case of cerebellar dysfunction in the form of slurring of speech and episodes of falls, in an elderly male following a three-week course of metronidazole therapy." | 1.51 | Cerebellar Dysfunction in an Elderly Male After a Brief Course of Metronidazole. ( Chakrabarti, SS; Kaur, U; Kumar, I; Kumar, M; Singh, A, 2019) |
| "Metronidazole can cause adverse effects both in the central and peripheral nervous system." | 1.40 | [Reversible neurotoxicity secondary to metronidazole: report of one case]. ( Galdames-Poblete, D; Retamal-Riquelme, E; Soto-San Martín, H; Vallejos-Castro, J, 2014) |
| "Linezolid was selected as a first-line antimicrobial drug." | 1.39 | Otogenic cerebellar abscess by Enterococcus avium, a very rare infectious agent. ( Escribano, JA; Lozano, J; Rivin, E; Solivera, J; Vidal, E, 2013) |
| "Metronidazole is a widely prescribed treatment for amoebic and anaerobic germ infections." | 1.35 | [Metronidazole-induced reversible cerebellar lesions and peripheral neuropathy]. ( Essid, A; Hammouda, M; Laouani-Kechrid, C; Medimagh, L; Slamia, LB; Toumi, S, 2009) |
| "Cerebellar syndrome or seizures are less frequently reported." | 1.35 | [Metronidazole-related polyneuritis, convulsive seizures, and cerebellar syndrome. Contribution of MRI]. ( Corpechot, C; Ferroir, JP; Freudenreich, A; Khalil, A, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (15.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (25.00) | 29.6817 |
| 2010's | 7 (35.00) | 24.3611 |
| 2020's | 5 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cha, S | 1 |
| Lee, BC | 1 |
| Moon, CW | 1 |
| Cho, KH | 1 |
| Yoon, HJ | 1 |
| Lee, JH | 1 |
| Lee, SU | 1 |
| Kim, JS | 1 |
| Tomoda, Y | 1 |
| Kagawa, S | 1 |
| Miyasato, K | 1 |
| Kurata, S | 1 |
| Tanaka, K | 1 |
| Roig-Martí, C | 1 |
| Pérez-Catalán, I | 1 |
| Palomo-De la Sota, D | 1 |
| Esteve-Gimeno, MJ | 1 |
| Ornador-Gaya, N | 1 |
| Usó-Blasco, J | 1 |
| John, KJ | 1 |
| P Pillai, D | 1 |
| Pillai, V | 1 |
| John, JK | 1 |
| Kaur, U | 1 |
| Kumar, I | 1 |
| Singh, A | 1 |
| Kumar, M | 1 |
| Chakrabarti, SS | 1 |
| Escribano, JA | 1 |
| Solivera, J | 1 |
| Vidal, E | 1 |
| Rivin, E | 1 |
| Lozano, J | 1 |
| Ng, PS | 1 |
| Saini, M | 1 |
| Retamal-Riquelme, E | 1 |
| Soto-San Martín, H | 1 |
| Vallejos-Castro, J | 1 |
| Galdames-Poblete, D | 1 |
| Ward, F | 1 |
| Crowley, P | 1 |
| Cotter, PE | 1 |
| Toumi, S | 1 |
| Hammouda, M | 1 |
| Essid, A | 1 |
| Medimagh, L | 1 |
| Slamia, LB | 1 |
| Laouani-Kechrid, C | 1 |
| Ferroir, JP | 2 |
| Corpechot, C | 1 |
| Freudenreich, A | 1 |
| Khalil, A | 1 |
| Sarna, JR | 1 |
| Brownell, AK | 1 |
| Furtado, S | 1 |
| Chatzkel, JA | 1 |
| Vossough, A | 1 |
| Etxeberria, A | 1 |
| Lonneville, S | 1 |
| Rutgers, MP | 1 |
| Gille, M | 1 |
| Ito, H | 1 |
| Maruyama, M | 1 |
| Ogura, N | 1 |
| Fujioka, T | 1 |
| Iwasaki, Y | 1 |
| Aikawa, A | 1 |
| Hasegawa, A | 1 |
| Bonkowsky, JL | 1 |
| Sondrup, C | 1 |
| Benedict, SL | 1 |
| Dubois, A | 1 |
| Raffanel, C | 1 |
| Pignodel, C | 1 |
| Janbon, C | 1 |
| Marty-Double, C | 1 |
| Balmes, P | 1 |
| Tokatli, A | 1 |
| Kanra, G | 1 |
| Ayhan, Z | 1 |
| Koçoğlu, T | 1 |
| Seçmeer, G | 1 |
| Oran, O | 1 |
| Roger, V | 1 |
| Mahieux, F | 1 |
| Guillard, A | 1 |
20 other studies available for metronidazole and Cerebellar Diseases
| Article | Year |
|---|---|
Metronidazole-induced encephalopathy delayed diagnosis due to cerebellar infarction: A case report.
Topics: Aged; Anti-Bacterial Agents; Brain Diseases; Brain Ischemia; Cerebellar Diseases; Delayed Diagnosis; | 2023 |
Metronidazole-induced cerebellar dysfunction preferentially involving the saccadic system.
Topics: Cerebellar Diseases; Humans; Metronidazole; Saccades | 2023 |
Metronidazole-induced cerebellar syndrome.
Topics: Cerebellar Diseases; Humans; Magnetic Resonance Imaging; Metronidazole | 2021 |
Cerebellar syndrome caused by metronidazole.
Topics: Cerebellar Diseases; Humans; Magnetic Resonance Imaging; Metronidazole | 2020 |
Metronidazole-induced reversible cerebellar dysfunction.
Topics: Aged; Anti-Bacterial Agents; Ataxia; Cerebellar Diseases; Cerebellar Nuclei; Duration of Therapy; Dy | 2021 |
Cerebellar Dysfunction in an Elderly Male After a Brief Course of Metronidazole.
Topics: Aged; Anti-Bacterial Agents; Cerebellar Diseases; Humans; Liver Abscess, Amebic; Male; Metronidazole | 2019 |
Otogenic cerebellar abscess by Enterococcus avium, a very rare infectious agent.
Topics: Acetamides; Anti-Bacterial Agents; Brain Abscess; Cerebellar Diseases; Ciprofloxacin; Enterococcus; | 2013 |
Reversible metronidazole-induced subacute cerebellar syndrome.
Topics: Acute Disease; Anti-Infective Agents; Cerebellar Diseases; Humans; Magnetic Resonance Imaging; Male; | 2014 |
[Reversible neurotoxicity secondary to metronidazole: report of one case].
Topics: Adult; Antiprotozoal Agents; Cerebellar Diseases; Female; Humans; Liver Abscess; Magnetic Resonance | 2014 |
Acute cerebellar syndrome associated with metronidazole.
Topics: Acute Disease; Adult; Anti-Infective Agents; Brain Stem; Cerebellar Diseases; Humans; Magnetic Reson | 2015 |
[Metronidazole-induced reversible cerebellar lesions and peripheral neuropathy].
Topics: Adult; Brain Abscess; Cerebellar Diseases; Consciousness Disorders; Humans; Magnetic Resonance Imagi | 2009 |
[Metronidazole-related polyneuritis, convulsive seizures, and cerebellar syndrome. Contribution of MRI].
Topics: Aged; Cerebellar Diseases; Cerebellum; Epilepsies, Myoclonic; Humans; Liver Transplantation; Magneti | 2009 |
Cases: Reversible cerebellar syndrome caused by metronidazole.
Topics: Aged; Bronchiectasis; Cerebellar Diseases; Dose-Response Relationship, Drug; Drug Administration Sch | 2009 |
Metronidazole-induced cerebellar toxicity.
Topics: Adolescent; Anti-Infective Agents; Cerebellar Diseases; Crohn Disease; Female; Humans; Metronidazole | 2010 |
Metronidazole-cerebellopathy associated with peripheral neuropathy, downbeat nystagmus, and bilateral ocular abduction deficit.
Topics: Abducens Nerve Diseases; Accommodation, Ocular; Aged, 80 and over; Anti-Infective Agents; Cerebellar | 2012 |
Reversible cerebellar lesions induced by metronidazole therapy for helicobacter pylori.
Topics: Anti-Infective Agents; Cerebellar Diseases; Female; Helicobacter Infections; Helicobacter pylori; Hu | 2004 |
Acute reversible cerebellar lesions associated with metronidazole therapy.
Topics: Adult; Anti-Infective Agents; Brain Edema; Cerebellar Diseases; Humans; Male; Metronidazole | 2007 |
[Acute cerebellar syndrome associated with sensitive neuropathy in a patient treated with metronidazole].
Topics: Cerebellar Diseases; Humans; Male; Metronidazole; Middle Aged; Nervous System Diseases; Sensation; S | 1983 |
[A cerebellar abscess caused by anaerobic and aerobic (mixed) microorganisms].
Topics: Adolescent; Bacteria, Aerobic; Bacteria, Anaerobic; Bacteroides; Brain Abscess; Cerebellar Diseases; | 1984 |
[Polyneuritis, convulsive crises, and cerebellar syndrome, complications of treatment with metronidazole].
Topics: Cerebellar Diseases; Female; Humans; Metronidazole; Middle Aged; Polyneuropathies; Seizures | 1985 |