metronidazole has been researched along with Female Genital Neoplasms in 7 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The influence of clindamycin plus metronidazole therapy (group I) and cephazolin therapy (group II) on fibrinogen concentration, level of bFGF and fibrin viscosity was studied in women diagnosed with nonmalignant myomas and cysts." | 3.77 | Influence of antibiotic therapy on the level of selected angiogenic factors in patients with benign gynecologic tumors--preliminary report. ( Kaplińska, K; Lazarenkow, A; Michalska, M; Mirowski, M; Nawrot-Modranka, J; Palatyńska-Ulatowska, A; Palatyński, A, 2011) |
| "Most patients with odor had bacterial vaginosis and had an improvement in odor with topical metronidazole." | 1.31 | Bacteriology and treatment of malodorous lower reproductive tract in gynecologic cancer patients. ( Coleman, RL; Heard, MC; Hemsell, DL; Li, AJ; Miller, DS; Von Gruenigen, VE, 2000) |
| "The overall surgical site infection rate was 4." | 1.28 | Single-dose antibiotic prophylaxis for patients undergoing extended pelvic surgery for gynecologic malignancy. ( Barrett, JM; Ellington, JR; Jennings, RH; Orr, JW; Paredes, KB; Patsner, B; Roe, C; Sisson, PF; Soong, SJ; Taylor, DL, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Avila, M | 1 |
| Funston, JR | 1 |
| Axtell, AA | 1 |
| Lentz, SE | 1 |
| Michalska, M | 1 |
| Palatyńska-Ulatowska, A | 1 |
| Palatyński, A | 1 |
| Mirowski, M | 1 |
| Kaplińska, K | 1 |
| Nawrot-Modranka, J | 1 |
| Lazarenkow, A | 1 |
| Dankert, J | 1 |
| Holloway, Y | 1 |
| Bouma, J | 1 |
| van der Werf, J | 1 |
| Wolthers, BG | 1 |
| Goldobenko, GV | 1 |
| Kherkheulidze, ZSh | 1 |
| Shchebetenko, IuE | 1 |
| Polotskiĭ, BE | 1 |
| Von Gruenigen, VE | 1 |
| Coleman, RL | 1 |
| Li, AJ | 1 |
| Heard, MC | 1 |
| Miller, DS | 1 |
| Hemsell, DL | 1 |
| Orr, JW | 1 |
| Sisson, PF | 1 |
| Patsner, B | 1 |
| Barrett, JM | 1 |
| Ellington, JR | 1 |
| Jennings, RH | 1 |
| Paredes, KB | 1 |
| Taylor, DL | 1 |
| Soong, SJ | 1 |
| Roe, C | 1 |
| Pateisky, N | 1 |
| Schatten, C | 1 |
| Schieder, C | 1 |
| Rheinthaller, A | 1 |
1 review available for metronidazole and Female Genital Neoplasms
| Article | Year |
|---|---|
[Analysis of clinical experience in the use of metronidazole as a radiosensitizer of tumors].
Topics: Brain Neoplasms; Clinical Trials as Topic; Esophageal Neoplasms; Female; Genital Neoplasms, Female; | 1983 |
1 trial available for metronidazole and Female Genital Neoplasms
| Article | Year |
|---|---|
[Analysis of clinical experience in the use of metronidazole as a radiosensitizer of tumors].
Topics: Brain Neoplasms; Clinical Trials as Topic; Esophageal Neoplasms; Female; Genital Neoplasms, Female; | 1983 |
6 other studies available for metronidazole and Female Genital Neoplasms
| Article | Year |
|---|---|
Preoperative Vaginal Metronidazole Decreases the Risk of Pelvic Infections After Radical Robotic Hysterectomy.
Topics: Adult; Anti-Infective Agents; Antibiotic Prophylaxis; Female; Female Urogenital Diseases; Genital Ne | 2017 |
Influence of antibiotic therapy on the level of selected angiogenic factors in patients with benign gynecologic tumors--preliminary report.
Topics: Adult; Aged; Angiogenic Proteins; Anti-Bacterial Agents; Cefazolin; Cysts; Female; Fibrin; Fibrinoge | 2011 |
Metronidazole in smelly gynaecological tumours.
Topics: Adult; Aged; Female; Genital Neoplasms, Female; Humans; Metronidazole; Middle Aged; Odorants | 1981 |
Bacteriology and treatment of malodorous lower reproductive tract in gynecologic cancer patients.
Topics: Anti-Bacterial Agents; Female; Genital Neoplasms, Female; Humans; Metronidazole; Odorants; Quality o | 2000 |
Single-dose antibiotic prophylaxis for patients undergoing extended pelvic surgery for gynecologic malignancy.
Topics: Anti-Bacterial Agents; Cephalosporins; Drug Administration Schedule; Female; Genital Neoplasms, Fema | 1990 |
[Perioperative one-shot prevention with metronidazole in gynecology].
Topics: Female; Genital Neoplasms, Female; Humans; Metronidazole; Premedication; Surgical Wound Infection | 1987 |