metronidazole has been researched along with Pilonidal Cyst in 10 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This pilot study examines whether single-dose intravenous metronidazole preoperatively is at least as effective as a broad-spectrum multi-drug regimen in preventing infection-related wound complications following excision of pilonidal sinuses with primary closure." | 9.10 | Single-dose metronidazole versus 5-day multi-drug antibiotic regimen in excision of pilonidal sinuses with primary closure: a prospective randomised controlled double-blinded study. ( Bekdash, BA; Chaudhuri, A, 2002) |
| "88 Patients who had previously been in a prospective random control trial of two regimens of antibiotic treatment (ampicillin and metronidazole for one compared with four days) before incision, curettage, and primary closure of perianal abscess or pilonidal sinus." | 9.07 | Outcome at three to five years of primary closure of perianal and pilonidal abscess. A randomised, double-blind clinical trial with a complete three-year followup of one compared with four days' treatment with ampicillin and metronidazole. ( Gottrup, F; Lundhus, E, 1993) |
| "This pilot study examines whether single-dose intravenous metronidazole preoperatively is at least as effective as a broad-spectrum multi-drug regimen in preventing infection-related wound complications following excision of pilonidal sinuses with primary closure." | 5.10 | Single-dose metronidazole versus 5-day multi-drug antibiotic regimen in excision of pilonidal sinuses with primary closure: a prospective randomised controlled double-blinded study. ( Bekdash, BA; Chaudhuri, A, 2002) |
| "88 Patients who had previously been in a prospective random control trial of two regimens of antibiotic treatment (ampicillin and metronidazole for one compared with four days) before incision, curettage, and primary closure of perianal abscess or pilonidal sinus." | 5.07 | Outcome at three to five years of primary closure of perianal and pilonidal abscess. A randomised, double-blind clinical trial with a complete three-year followup of one compared with four days' treatment with ampicillin and metronidazole. ( Gottrup, F; Lundhus, E, 1993) |
| "The best surgical technique for treating pilonidal sinus disease is controversial." | 2.71 | Modified lay-open (incision, curettage, partial lateral wall excision and marsupialization) versus total excision with primary closure in the treatment of chronic sacrococcygeal pilonidal sinus: a prospective, randomized clinical trial with a complete two ( Gencosmanoglu, R; Inceoglu, R, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ypsilantis, E | 1 |
| Carapeti, E | 1 |
| Chan, S | 1 |
| Kareem, T | 1 |
| Chaudhuri, A | 2 |
| Bekdash, BA | 2 |
| Gencosmanoglu, R | 1 |
| Inceoglu, R | 1 |
| Taylor, AL | 1 |
| Bunke, HJ | 1 |
| Schultheis, A | 1 |
| Meyer, G | 1 |
| Düsel, W | 1 |
| Collazo, E | 1 |
| Luna, M | 1 |
| Lundhus, E | 2 |
| Gottrup, F | 2 |
| Terpling, S | 1 |
| Marks, J | 1 |
| Harding, KG | 1 |
| Hughes, LE | 1 |
| Ribeiro, CD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomised, Double-blind, Placebo-controlled Trial Evaluating the Effects of Metronidazole Ointment in Facilitating Resolution of Non-healing Pilonidal Sinus Wounds.[NCT04273997] | Phase 2 | 80 participants (Anticipated) | Interventional | 2021-10-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 trials available for metronidazole and Pilonidal Cyst
| Article | Year |
|---|---|
The use of topical 10% metronidazole in the treatment of non-healing pilonidal sinus wounds after surgery.
Topics: Administration, Topical; Adolescent; Adult; Endpoint Determination; Female; Humans; Male; Metronidaz | 2016 |
Single-dose metronidazole versus 5-day multi-drug antibiotic regimen in excision of pilonidal sinuses with primary closure: a prospective randomised controlled double-blinded study.
Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Anti-Infective Agents; Cefurox | 2002 |
Modified lay-open (incision, curettage, partial lateral wall excision and marsupialization) versus total excision with primary closure in the treatment of chronic sacrococcygeal pilonidal sinus: a prospective, randomized clinical trial with a complete two
Topics: Adolescent; Adult; Anti-Bacterial Agents; Cefazolin; Chronic Disease; Curettage; Female; Follow-Up S | 2005 |
Single-dose metronidazole vs 5-day multi-drug antibiotic regimen in excision of pilonidal sinuses with primary closure: a prospective, randomized, double-blinded pilot study.
Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Double-Blind Method; Drug Therapy, Combination; | 2006 |
Obeid's technique for treatment of pilonidal sinus.
Topics: Adult; Ciprofloxacin; Escherichia coli Infections; Female; Humans; Male; Metronidazole; Pilonidal Si | 1994 |
Outcome at three to five years of primary closure of perianal and pilonidal abscess. A randomised, double-blind clinical trial with a complete three-year followup of one compared with four days' treatment with ampicillin and metronidazole.
Topics: Abscess; Ampicillin; Anus Diseases; Chi-Square Distribution; Combined Modality Therapy; Double-Blind | 1993 |
4 other studies available for metronidazole and Pilonidal Cyst
| Article | Year |
|---|---|
Outcomes of conservative treatment of 134 cases of umbilical pilonidal sinus.
Topics: Adolescent; Adult; Amoxicillin; Anti-Infective Agents; Combined Modality Therapy; Drainage; Drug The | 2013 |
[Surgical revision of the pilonidal sinus with single shot antibiosis].
Topics: Abscess; Adult; Bacterial Infections; Drug Therapy, Combination; Humans; Infusions, Intravenous; Mal | 1995 |
[Primary suture of perianal abscesses and infected pilonidal cysts under metronidazole and ampicillin cover for 4 days].
Topics: Abscess; Adolescent; Adult; Aged; Ampicillin; Drug Therapy, Combination; Female; Humans; Male; Metro | 1986 |
Pilonidal sinus excision--healing by open granulation.
Topics: Bacteria, Anaerobic; Erythromycin; Granulation Tissue; Humans; Metronidazole; Pilonidal Sinus; Prosp | 1985 |