2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole profile

ID Source	ID
PubMed CID	61205
CHEMBL ID	139005
CHEBI ID	82286
SCHEMBL ID	1997012

Synonym
triafur
asa-140
tiafur
nf-475
thiafur
ph/778
furidiazina
furidiazine
wln: t5otj bnw e- et5nn dsj cz
712-68-5
nsc-53279
5-(5-nitro-2-furyl)-2-amino-1,4-thiadiazole
1,4-thiadiazole, 5-amino-2-(5-nitro-2-furyl)-
5-amino-2-(5-nitro-2-furyl)-1,4-thiadiazole
2-(5-nitro-2-furyl)-5-amino-1,4-thiadiazole
1,4-thiadiazol-2-amine, 5-(5-nitro-2-furanyl)-
2-amino-5-(5-nitro-2-furyl)-1,4-thiadiazole
1,4-thiadiazole, 2-amino-5-(5-nitro-2-furyl)-
nsc53279
furidazina
mls002667577 ,
2-amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole
5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-amine ,
5-(5-nitro-2-furyl)-1,3,4-thiadiazol-2-amine
ccris 35
nsc 78274
5-(5-nitro-2-furyl)-1,3,4-thiadiazol-2-ylamine
nsc 53279
1,3,4-thiadiazole, 2-amino-5-(5-nitro-2-furyl)-
5-amino-2-(5-nitro-2-furyl)-1,3,4-thiadiazole
einecs 211-925-6
2-(5-nitro-2-furyl)-5-amino-1,3,4-thiadiazole
1,3,4-thiadiazole, 5-amino-2-(5-nitro-2-furyl)-
5-(5-nitro-2-furyl)-2-amino-1,3,4-thiadiazole
brn 0616834
1,3,4-thiadiazol-2-amine, 5-(5-nitro-2-furanyl)-
OPREA1_523685
nsc-78274
nsc78274
SR-01000644423-1
MAYBRIDGE1_002122
NCIOPEN2_004401
smr000684791
AKOS000224930
chebi:82286 ,
CHEMBL139005
HMS547I10
C19189
HMS3079O04
CCG-55397
4jj4coi21v ,
unii-4jj4coi21v
SCHEMBL1997012
triafur [mi]
SXZZHGJWUBJKHH-UHFFFAOYSA-N
DTXSID7020059
Q27155857

Class	Description
C-nitro compound	A nitro compound having the nitro group (-NO2) attached to a carbon atom.
furans	Compounds containing at least one furan ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
thioredoxin reductase	Rattus norvegicus (Norway rat)	Potency	1.1220	0.1000	20.8793	79.4328	AID588453
BRCA1	Homo sapiens (human)	Potency	35.4813	0.8913	7.7225	25.1189	AID624202
TDP1 protein	Homo sapiens (human)	Potency	13.7782	0.0008	11.3822	44.6684	AID686978; AID686979
Smad3	Homo sapiens (human)	Potency	35.4813	0.0052	7.8098	29.0929	AID588855
67.9K protein	Vaccinia virus	Potency	22.1061	0.0001	8.4406	100.0000	AID720579; AID720580
IDH1	Homo sapiens (human)	Potency	23.1093	0.0052	10.8652	35.4813	AID686970
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	Homo sapiens (human)	Potency	28.1838	3.5481	19.5427	44.6684	AID743266
DNA polymerase iota isoform a (long)	Homo sapiens (human)	Potency	39.8107	0.0501	27.0736	89.1251	AID588590
geminin	Homo sapiens (human)	Potency	27.5110	0.0046	11.3741	33.4983	AID624296; AID624297
Glycoprotein hormones alpha chain	Homo sapiens (human)	Potency	10.0000	4.4668	8.3448	10.0000	AID624291
Guanine nucleotide-binding protein G	Homo sapiens (human)	Potency	10.0000	1.9953	25.5327	50.1187	AID624287
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
G protein-coupled receptor signaling pathway	Glycoprotein hormones alpha chain	Homo sapiens (human)
positive regulation of cell population proliferation	Glycoprotein hormones alpha chain	Homo sapiens (human)
hormone-mediated signaling pathway	Glycoprotein hormones alpha chain	Homo sapiens (human)
regulation of signaling receptor activity	Glycoprotein hormones alpha chain	Homo sapiens (human)
positive regulation of steroid biosynthetic process	Glycoprotein hormones alpha chain	Homo sapiens (human)
positive regulation of cell migration	Glycoprotein hormones alpha chain	Homo sapiens (human)
thyroid gland development	Glycoprotein hormones alpha chain	Homo sapiens (human)
luteinizing hormone secretion	Glycoprotein hormones alpha chain	Homo sapiens (human)
organ growth	Glycoprotein hormones alpha chain	Homo sapiens (human)
follicle-stimulating hormone signaling pathway	Glycoprotein hormones alpha chain	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Glycoprotein hormones alpha chain	Homo sapiens (human)
negative regulation of organ growth	Glycoprotein hormones alpha chain	Homo sapiens (human)
follicle-stimulating hormone secretion	Glycoprotein hormones alpha chain	Homo sapiens (human)
thyroid hormone generation	Glycoprotein hormones alpha chain	Homo sapiens (human)
negative regulation of inflammatory response to antigenic stimulus	Guanine nucleotide-binding protein G	Homo sapiens (human)
renal water homeostasis	Guanine nucleotide-binding protein G	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Guanine nucleotide-binding protein G	Homo sapiens (human)
regulation of insulin secretion	Guanine nucleotide-binding protein G	Homo sapiens (human)
cellular response to glucagon stimulus	Guanine nucleotide-binding protein G	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
hormone activity	Glycoprotein hormones alpha chain	Homo sapiens (human)
protein binding	Glycoprotein hormones alpha chain	Homo sapiens (human)
follicle-stimulating hormone activity	Glycoprotein hormones alpha chain	Homo sapiens (human)
G protein activity	Guanine nucleotide-binding protein G	Homo sapiens (human)
adenylate cyclase activator activity	Guanine nucleotide-binding protein G	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
extracellular region	Glycoprotein hormones alpha chain	Homo sapiens (human)
extracellular space	Glycoprotein hormones alpha chain	Homo sapiens (human)
Golgi lumen	Glycoprotein hormones alpha chain	Homo sapiens (human)
follicle-stimulating hormone complex	Glycoprotein hormones alpha chain	Homo sapiens (human)
pituitary gonadotropin complex	Glycoprotein hormones alpha chain	Homo sapiens (human)
extracellular space	Glycoprotein hormones alpha chain	Homo sapiens (human)
plasma membrane	Guanine nucleotide-binding protein G	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (25)

Assay ID	Title	Year	Journal	Article
AID224390	Concentration that cause cytotoxicity at 25 uM concentration	2003	Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3	Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID318681	Anticarcinogenic activity in rat assessed as induction of tumors per day	2008	Bioorganic & medicinal chemistry, Mar-15, Volume: 16, Issue:6	QSAR modeling of the rodent carcinogenicity of nitrocompounds.
AID224388	Concentration that cause cytotoxicity at 12.5 uM concentration	2003	Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3	Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID224392	Concentration that cause cytotoxicity at 3.1 uM concentration	2003	Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3	Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID100905	In vitro percent inhibition against mouse peritoneal macrophages infected with Leishmania infantum at 6.2 uM concentration	2003	Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3	Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID214144	In vitro percent inhibition against mouse peritoneal macrophages infected with Trypanosoma cruzi at 6.2 uM concentration	2003	Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3	Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID100902	In vitro percent inhibition against mouse peritoneal macrophages infected with Leishmania infantum at 25 uM concentration	2003	Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3	Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID215851	In vitro percent inhibition against mouse peritoneal macrophages infected with Trypanosoma brucei at 6.2 uM concentration	2003	Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3	Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID215850	In vitro percent inhibition against mouse peritoneal macrophages infected with Trypanosoma brucei at 3.1 uM concentration	2003	Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3	Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID224394	Concentration that cause cytotoxicity at 6.2 uM concentration	2003	Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3	Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID215701	In vitro percent inhibition against mouse peritoneal macrophages infected with Trypanosoma brucei at 1.5 uM concentration	2003	Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3	Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845	Primary qHTS for Inhibitors of ATXN expression
AID651635	Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1159607	Screen for inhibitors of RMI FANCM (MM2) intereaction	2016	Journal of biomolecular screening, Jul, Volume: 21, Issue:6	A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
AID1794808	Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).	2014	Journal of biomolecular screening, Jul, Volume: 19, Issue:6	A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808	Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (33.33)	29.6817
2010's	4 (44.44)	24.3611
2020's	2 (22.22)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	9 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
2-nitropropane 2-nitropropane: RN given refers to cpd with locant for nitro moiety in 2 position. 2-nitropropane : A secondary nitroalkane that is propane in which a hydrogen at position 2 has been replaced by a nitro group. Mainly used as a solvent (b.p. 120degreeC).	2.04	1	secondary nitroalkane	carcinogenic agent; hepatotoxic agent; polar aprotic solvent; xenobiotic
azathioprine Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed). azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.	2.04	1	aryl sulfide; C-nitro compound; imidazoles; thiopurine	antimetabolite; antineoplastic agent; carcinogenic agent; DNA synthesis inhibitor; hepatotoxic agent; immunosuppressive agent; prodrug
dimetridazole Dimetridazole: A compound used to treat histomoniasis in poultry.. dimetridazole : A C-nitro compound that is 5-nitroimidazole in which the hydrogens at positions 1 and 2 are replaced by methyl groups. An antiprotozoal drug, it has been banned by both the Government of Canada and the European Union as a livestock feed additive owing to suspicions of it being carcinogenic.	2.04	1	C-nitro compound; imidazoles	antiparasitic agent; antiprotozoal drug
metronidazole Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.. metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.	2.04	1	C-nitro compound; imidazoles; primary alcohol	antiamoebic agent; antibacterial drug; antimicrobial agent; antiparasitic agent; antitrichomonal drug; environmental contaminant; prodrug; radiosensitizing agent; xenobiotic
nitroglycerin Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.. nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.. nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.	2.04	1	nitroglycerol	explosive; muscle relaxant; nitric oxide donor; prodrug; tocolytic agent; vasodilator agent; xenobiotic
suramin Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.. suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.	2.01	1	naphthalenesulfonic acid; phenylureas; secondary carboxamide	angiogenesis inhibitor; antinematodal drug; antineoplastic agent; apoptosis inhibitor; EC 2.7.11.13 (protein kinase C) inhibitor; GABA antagonist; GABA-gated chloride channel antagonist; purinergic receptor P2 antagonist; ryanodine receptor agonist; trypanocidal drug
trifluralin Trifluralin: A microtubule-disrupting pre-emergence herbicide.. trifluralin : A substituted aniline that is N,N-dipropylaniline substituted by a nitro groups at positions 2 and 6 and a trifluoromethyl group at position 4. It is an agrochemical used as a pre-emergence herbicide.	2.04	1	(trifluoromethyl)benzenes; C-nitro compound; substituted aniline	agrochemical; environmental contaminant; herbicide; xenobiotic
chloramphenicol Amphenicol: Chloramphenicol and its derivatives.	2.04	1	C-nitro compound; carboxamide; diol; organochlorine compound	antibacterial drug; antimicrobial agent; Escherichia coli metabolite; geroprotector; Mycoplasma genitalium metabolite; protein synthesis inhibitor
nitroethane nitroethane : A nitroalkane that is ethane substituted by a nitro group.	2.04	1	primary nitroalkane
2-nitroanisole 2-nitroanisole : A member of the class of 2-nitroanisoles that is anisole in which one of the hydrogens ortho to the methoxy group is replaced by a nitro group.	2.04	1	2-nitroanisoles	carcinogenic agent
nitrobenzene nitrobenzene : A nitroarene consisting of benzene carrying a single nitro substituent. An industrial chemical used widely in the production of aniline.	2.04	1	nitroarene; nitrobenzenes
4-nitroaniline [no description available]	2.04	1	nitroaniline	bacterial xenobiotic metabolite
2,4-dinitrotoluene 2,4-dinitrotoluene : A dinitrotoluene in which the methyl group is ortho to one of the nitro groups and para to the other. It is the most common isomer of dinitrotoluene.	2.04	1	dinitrotoluene
2-amino-5-nitrothiazole 2-amino-5-nitrothiazole: RN given refers to cpd without isomeric designation	2.04	1	C-nitro compound; thiazoles
tetranitromethane [no description available]	2.04	1	organonitrogen compound
furothiazole furothiazole: carcinogen for mouse, rat, dog, hamster; structure	2.04	1	aromatic amide
5-nitroacenaphthene [no description available]	2.04	1	nitronaphthalene
n-methylamino-2-nitro-4-n',n'-bis(2-hydroxyethyl)aminobenzene N-methylamino-2-nitro-4-N',N'-bis(2-hydroxyethyl)aminobenzene: structure	2.04	1	C-nitro compound
dimethylnitramine [no description available]	2.04	1
1-nitropyrene [no description available]	2.04	1	nitroarene	carcinogenic agent
cl 64855 [no description available]	2.01	1
fanft FANFT: A potent nitrofuran derivative tumor initiator. It causes bladder tumors in all animals studied and is mutagenic to many bacteria.	2.04	1
anft ANFT: RN given refers to unlabeled cpd	2.04	1
nefurthiazole nefurthiazole: structure	2.04	1	C-nitro compound; furans
furylfuramide Furylfuramide: Used formerly as antimicrobial food additive. It causes mutations in many cell cultures and may be carcinogenic.. (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide : A member of the class of acrylamides that is acrylamide which is substituted at positions 2 and 3 by 2-furyl and 5-nitro-2-furyl groups, respectively (the trans isomer). Formerly used as a food preservative, it was withdrawn from the market following suspicions of carcenogenicity.	2.04	1	acrylamides; C-nitro compound; nitrofuran antibiotic; primary carboxamide
nitrofurazone Nitrofurazone: A topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial WOUNDS AND INJURIES and skin infections. Nitrofurazone has also been administered orally in the treatment of TRYPANOSOMIASIS.. nitrofurazone : A semicarbazone resulting from the formal condensation of semicarbazide with 5-nitrofuraldehyde. A broad spectrum antibacterial drug, although with little activity against Pseudomonas species, it is used as a local application for burns, ulcers, wounds and skin infections.	2.43	2
nitrofurantoin Nitrofurantoin: A urinary anti-infective agent effective against most gram-positive and gram-negative organisms. Although sulfonamides and antibiotics are usually the agents of choice for urinary tract infections, nitrofurantoin is widely used for prophylaxis and long-term suppression.. nitrofurantoin : An imidazolidine-2,4-dione that is hydantoin substituted at position 1 by a [(5-nitro-2-furyl)methylene]amino group. An antibiotic that damages bacterial DNA.	2.04	1	imidazolidine-2,4-dione; nitrofuran antibiotic; organonitrogen heterocyclic antibiotic; organooxygen heterocyclic antibiotic	antibacterial drug; antiinfective agent; hepatotoxic agent
furaltadon monohydrochloride, (s)-isomer [no description available]	2.04	1
methylnitronitrosoguanidine Methylnitronitrosoguanidine: A nitrosoguanidine derivative with potent mutagenic and carcinogenic properties.. N-methyl-N'-nitro-N-nitrosoguanidine : An N-nitroguanidine compound having nitroso and methyl substituents at the N'-position	2.04	1	nitroso compound	alkylating agent

Condition	Relationship Strength	Studies
Trypanosomiasis Infection with protozoa of the genus TRYPANOSOMA.	2.01	1
Benign Neoplasms [description not available]	2.04	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.04	1
Innate Inflammatory Response [description not available]	2.05	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.05	1
Plasmodium falciparum Malaria [description not available]	2.1	1
Malaria, Falciparum Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.	2.1	1
Anemia, Fanconi [description not available]	2.13	1
Fanconi Anemia Congenital disorder affecting all bone marrow elements, resulting in ANEMIA; LEUKOPENIA; and THROMBOPENIA, and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes. Spontaneous CHROMOSOME BREAKAGE is a feature of this disease along with predisposition to LEUKEMIA. There are at least 7 complementation groups in Fanconi anemia: FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, and FANCL. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227650, August 20, 2004)	2.13	1

2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole

Cross-References

Synonyms (57)

Drug Classes (2)

Protein Targets (11)

Potency Measurements

Biological Processes (18)

Molecular Functions (5)

Ceullar Components (6)

Bioassays (25)

Research

Studies (9)

Market Indicators

Research Demand Index: 12.04

Study Types

2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole

Cross-References

Synonyms (57)

Drug Classes (2)

Protein Targets (11)

Potency Measurements

Biological Processes (18)

Molecular Functions (5)

Ceullar Components (6)

Bioassays (25)

Research

Studies (9)

Market Indicators

Research Demand Index: 12.04

Study Types

Related Drugs (29)

Related Conditions (9)