metronidazole has been researched along with Brain Swelling in 5 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronidazole was discontinued, and her condition improved rapidly." | 1.42 | [Reversible changes on MR images in a patient with metronidazole-induced encephalopathy]. ( Kanaya, Y; Kuriyama, M; Neshige, S; Takeshima, S; Tanaka, A; Yoshimoto, T, 2015) |
| "Multiple brain abscesses are serious neurological problems with high mortality and disabling morbidity." | 1.32 | Multiple brain abscesses caused by Fusobacterium nucleatum treated conservatively. ( Hartl, H; Heckmann, JG; Lang, CJ; Tomandl, B, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ulukan, C | 1 |
| Ekizoglu, E | 1 |
| Yesilot, N | 1 |
| Coban, O | 1 |
| Neshige, S | 1 |
| Kanaya, Y | 1 |
| Takeshima, S | 1 |
| Yoshimoto, T | 1 |
| Tanaka, A | 1 |
| Kuriyama, M | 1 |
| Desai, JA | 1 |
| Dobson, J | 1 |
| Melanson, M | 1 |
| Pari, G | 1 |
| Jin, AY | 1 |
| Heckmann, JG | 1 |
| Lang, CJ | 1 |
| Hartl, H | 1 |
| Tomandl, B | 1 |
| Bonkowsky, JL | 1 |
| Sondrup, C | 1 |
| Benedict, SL | 1 |
1 review available for metronidazole and Brain Swelling
| Article | Year |
|---|---|
Metronidazole-induced encephalopathy: case report and review of MRI findings.
Topics: Aged; Anti-Infective Agents; Brain Diseases; Brain Edema; Diffusion Magnetic Resonance Imaging; Huma | 2011 |
4 other studies available for metronidazole and Brain Swelling
| Article | Year |
|---|---|
Metronidazole-induced cytotoxic edema of corpus callosum: a case report.
Topics: Adenocarcinoma; Anti-Infective Agents; Brain Edema; Corpus Callosum; Diarrhea; Digestive System Surg | 2020 |
[Reversible changes on MR images in a patient with metronidazole-induced encephalopathy].
Topics: Aged; Anti-Infective Agents; Brain Abscess; Brain Edema; Cerebellar Nuclei; Corpus Callosum; Diffusi | 2015 |
Multiple brain abscesses caused by Fusobacterium nucleatum treated conservatively.
Topics: Anti-Bacterial Agents; Brain Abscess; Brain Edema; Ceftriaxone; Cytidine Diphosphate; Dexamethasone; | 2003 |
Acute reversible cerebellar lesions associated with metronidazole therapy.
Topics: Adult; Anti-Infective Agents; Brain Edema; Cerebellar Diseases; Humans; Male; Metronidazole | 2007 |