metronidazole has been researched along with Carcinoma, Ductal, Breast in 1 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Carcinoma, Ductal, Breast: An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present study, plasma concentration of MTZ was measured in a breast cancer patient using MTZ ointment for cancerous malodor and basic research was also conducted with the objective of investigating the safety of topical MTZ from a pharmacokinetic perspective." | 1.39 | Investigation of the safety of topical metronidazole from a pharmacokinetic perspective. ( Hasegawa, S; Iida, J; Ike, H; Ito, K; Kagaya, H; Kudo, T; Sato, T; Shimada, K; Yamagishi, S; Yatsuno, Y, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Iida, J | 1 |
| Kudo, T | 1 |
| Shimada, K | 1 |
| Yatsuno, Y | 1 |
| Yamagishi, S | 1 |
| Hasegawa, S | 1 |
| Ike, H | 1 |
| Sato, T | 1 |
| Kagaya, H | 1 |
| Ito, K | 1 |
1 other study available for metronidazole and Carcinoma, Ductal, Breast
| Article | Year |
|---|---|
Investigation of the safety of topical metronidazole from a pharmacokinetic perspective.
Topics: Administration, Topical; Animals; Anti-Infective Agents; Anticoagulants; Breast Neoplasms; Carcinoma | 2013 |