Page last updated: 2024-09-27

Tick Bites

The effects, both local and systemic, caused by the bites of TICKS.

Synonyms(1)

Synonym
Tick Bites

Research Excerpts

Overview

ExcerptReference
"Amblyomma tick bites are associated with this condition, but the pathophysiology is not understood."( Fujiyama, T; Hashizume, H; Kageyama, R; Satoh, T; Umayahara, T; Walls, AF, 2018)

Context

ExcerptReference
"Exposure to tick bites has been correlated with development of an allergic response to alpha-gal."( Apperson, CS; Commins, SP; Lin, FC; Meshnick, SR; Mitchell, CL; Vaughn, M, 2020)

Research

Studies (102)

TimeframeStudies, This Condition (%)All Conditions %
pre-19903 (2.94)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's66 (64.71)28.8240
2020's33 (32.35)9.53
DrugIndicatedRelationship StrengthStudiesTrials
beta-alanine0low10
salicylic acid0low60
ciprofloxacin0low10
fexofenadine0low10
metronidazole0low10
deet0low40
phenazopyridine0low10
terfenadine0low10
prednisolone0low30
chloramphenicol0low10
galactose0low250
methylprednisolone0low20
penicillin v0low10
trolamine salicylate0low10
triamcinolone0low10
amoxicillin0low50
ribavirin0low40
permethrin0medium93
cephalosporin c0low10
atovaquone0low20
fibrinogen0low10
ethyl-3-(n-n-butyl-n-acetyl)aminopropionate0low20
galactosyl-(1-3)galactose0low150
picaridin0low10
zithromax0low40
dinoprostone0low10
s 11080low10
bifenthrin0medium11
ants0low10
ro13-99040low80
glycolipids0low10
piperidines0low10
tetracycline0low10
oxytetracycline, anhydrous0low10
pyrethrins0medium11
exudates0low40
eye0low10

Protein Targets (489)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE6006
Chain A, Beta-lactamase2002
Chain A, 2-oxoglutarate Oxygenase4004
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
AR protein130013
apical membrane antigen 1, AMA13003
estrogen nuclear receptor alpha150015
Beta-lactamase 0001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 13003
DNA polymerase eta isoform 13003
DNA polymerase iota isoform a (long)4004
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
DNA polymerase kappa isoform 14004
ATP-binding cassette sub-family C member 3010010
Multidrug resistance-associated protein 4010011
Bile salt export pump0202
Bile salt export pump012012
Beta-lactamase SHV-10001
Beta-lactamase SHV-10001
Cytochrome P450 2C9 0606
Beta-lactamase0001
Kappa-type opioid receptor0001
Solute carrier family 15 member 10202
Solute carrier family 15 member 10101
Cytochrome P450 2J20505
B2 metallo-beta-lactamase 0001
Solute carrier family 15 member 20101
Beta-lactamase 0001
Beta-lactamase 0001
Solute carrier family 15 member 20101
Beta-lactamase 0001
Beta-lactamase 0001
Canalicular multispecific organic anion transporter 10909
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Chain A, Cruzipain3003
interleukin 84004
phosphopantetheinyl transferase3003
GLS protein3003
glucocorticoid receptor [Homo sapiens]9009
farnesoid X nuclear receptor8008
peroxisome proliferator-activated receptor delta6006
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
tumor necrosis factor1001
vitamin D3 receptor isoform VDRA4004
nuclear factor erythroid 2-related factor 2 isoform 1110011
peripheral myelin protein 226006
lamin isoform A-delta10110011
Cytochrome P450 1A20202
Cytochrome P450 3A40617
Cytochrome P450 2D60202
Cytochrome P450 2C190202
Nuclear receptor ROR-gamma3003
Potassium voltage-gated channel subfamily H member 20708
Aurora kinase B0101
Broad substrate specificity ATP-binding cassette transporter ABCG20202
RAR-related orphan receptor gamma8008
SMAD family member 25005
USP1 protein, partial5005
SMAD family member 35005
TDP1 protein9009
GLI family zinc finger 3100010
Microtubule-associated protein tau3003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)5005
thyroid stimulating hormone receptor5005
cytochrome P450 family 3 subfamily A polypeptide 46006
retinoid X nuclear receptor alpha9009
estrogen-related nuclear receptor alpha120012
pregnane X nuclear receptor100010
peroxisome proliferator activated receptor gamma6006
IDH14004
euchromatic histone-lysine N-methyltransferase 26006
aryl hydrocarbon receptor6006
activating transcription factor 64004
v-jun sarcoma virus 17 oncogene homolog (avian)3003
Dihydroorotate dehydrogenase 0101
cellular tumor antigen p53 isoform a1001
cytochrome P450 2C9 precursor3003
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 16006
potassium voltage-gated channel subfamily H member 2 isoform d2002
transcriptional regulator ERG isoform 32002
thyroid hormone receptor beta isoform 28008
heat shock protein beta-15005
ubiquitin carboxyl-terminal hydrolase 2 isoform a3003
nuclear receptor ROR-gamma isoform 14004
geminin140014
Vpr1001
histone acetyltransferase KAT2A isoform 15005
Voltage-dependent calcium channel gamma-2 subunit4004
Cytochrome b0101
Cellular tumor antigen p53100010
Integrin beta-31001
Integrin alpha-IIb1001
Glutamate receptor 24004
Dihydroorotate dehydrogenase (fumarate)0101
Histamine H2 receptor3003
Spike glycoprotein1012
Guanine nucleotide-binding protein G1001
Disintegrin and metalloproteinase domain-containing protein 172002
Dihydroorotate dehydrogenase (quinone), mitochondrial0102
TAR DNA-binding protein 433003
Dihydroorotate dehydrogenase 0202
Dihydroorotate dehydrogenase (quinone), mitochondrial0102
regulator of G-protein signaling 43003
lethal factor (plasmid)2002
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent betaine transporter0101
Glutamate receptor ionotropic, NMDA 1 0101
Sodium- and chloride-dependent GABA transporter 30101
Glutamate receptor ionotropic, NMDA 2A 0101
Glutamate receptor ionotropic, NMDA 2B0101
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, NMDA 2D0101
Proton-coupled amino acid transporter 10101
Glutamate receptor ionotropic, NMDA 3B0101
Sodium- and chloride-dependent GABA transporter 20101
Glutamate receptor ionotropic, NMDA 3A0101
hypoxia-inducible factor 1 alpha subunit4004
nuclear receptor subfamily 1, group I, member 35005
progesterone receptor4004
retinoic acid nuclear receptor alpha variant 19009
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a6006
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
aldehyde dehydrogenase 1 family, member A17007
EWS/FLI fusion protein4004
G2002
cytochrome P450 2D63003
streptokinase A precursor0022
Dihydroxyacetone phosphate acyltransferase0002
Interferon beta6006
HLA class I histocompatibility antigen, B alpha chain 2002
30S ribosomal protein S60303
30S ribosomal protein S70303
50S ribosomal protein L150303
50S ribosomal protein L100303
50S ribosomal protein L110303
50S ribosomal protein L7/L120303
50S ribosomal protein L190303
50S ribosomal protein L10303
50S ribosomal protein L200303
50S ribosomal protein L270303
50S ribosomal protein L280303
50S ribosomal protein L290303
50S ribosomal protein L310303
50S ribosomal protein L31 type B0303
50S ribosomal protein L320303
50S ribosomal protein L330303
50S ribosomal protein L340303
50S ribosomal protein L350303
50S ribosomal protein L360303
30S ribosomal protein S100303
30S ribosomal protein S110303
30S ribosomal protein S120303
30S ribosomal protein S130303
30S ribosomal protein S160303
30S ribosomal protein S180303
30S ribosomal protein S190303
30S ribosomal protein S200303
30S ribosomal protein S20303
30S ribosomal protein S30303
30S ribosomal protein S40303
30S ribosomal protein S50303
30S ribosomal protein S80303
30S ribosomal protein S90303
50S ribosomal protein L130303
50S ribosomal protein L140303
50S ribosomal protein L160303
50S ribosomal protein L230303
30S ribosomal protein S150303
50S ribosomal protein L170303
50S ribosomal protein L210303
50S ribosomal protein L300303
50S ribosomal protein L60303
30S ribosomal protein S140303
30S ribosomal protein S170303
30S ribosomal protein S10303
50S ribosomal protein L180303
50S ribosomal protein L20303
50S ribosomal protein L30303
50S ribosomal protein L240303
50S ribosomal protein L40303
50S ribosomal protein L220303
50S ribosomal protein L50303
30S ribosomal protein S210303
50S ribosomal protein L250303
50S ribosomal protein L36 20303
Inositol hexakisphosphate kinase 12002
Methionine--tRNA ligase, mitochondrial0011
cytochrome P450 2C9, partial2002
Gamma-aminobutyric acid receptor subunit pi4105
DNA gyrase subunit B0101
DNA gyrase subunit A0101
DNA gyrase subunit B0304
DNA gyrase subunit A0103
DNA gyrase subunit B0103
DNA topoisomerase 4 subunit A0101
DNA topoisomerase 4 subunit B0102
DNA topoisomerase 4 subunit A0102
DNA topoisomerase 2-alpha0104
Gamma-aminobutyric acid receptor subunit beta-14105
Gamma-aminobutyric acid receptor subunit delta4105
Gamma-aminobutyric acid receptor subunit gamma-24105
Gamma-aminobutyric acid receptor subunit alpha-54105
Gamma-aminobutyric acid receptor subunit alpha-34105
DNA gyrase subunit A0304
Gamma-aminobutyric acid receptor subunit gamma-14105
Gamma-aminobutyric acid receptor subunit alpha-24105
Gamma-aminobutyric acid receptor subunit alpha-44105
Gamma-aminobutyric acid receptor subunit gamma-34105
Gamma-aminobutyric acid receptor subunit alpha-64105
Multidrug resistance protein MdtK0011
Gamma-aminobutyric acid receptor subunit alpha-14105
Gamma-aminobutyric acid receptor subunit beta-34105
Gamma-aminobutyric acid receptor subunit beta-24105
DNA gyrase subunit B0101
DNA gyrase subunit A0101
Enoyl-[acyl-carrier-protein] reductase [NADH]0001
DNA topoisomerase 4 subunit A0101
DNA topoisomerase 4 subunit B0101
Integrase 0202
GABA theta subunit4105
Gamma-aminobutyric acid receptor subunit epsilon4105
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
Chain A, Ferritin light chain3003
Chain A, Odorant binding protein0011
Chain B, Odorant binding protein0011
chromobox protein homolog 18008
thyroid hormone receptor beta isoform a4004
thyroid stimulating hormone receptor5005
prostaglandin E2 receptor EP2 subtype1001
mitogen-activated protein kinase 13003
Solute carrier family 22 member 20001
Solute carrier family 22 member 1 0001
Solute carrier organic anion transporter family member 1A50001
Prostaglandin E2 receptor EP3 subtype0101
Prostaglandin E2 receptor EP4 subtype0101
Prostaglandin E2 receptor EP1 subtype0213
Prostaglandin E2 receptor EP1 subtype0101
Prostaglandin E2 receptor EP4 subtype0213
Prostaglandin F2-alpha receptor0011
Prostaglandin E2 receptor EP4 subtype0112
Prostaglandin E2 receptor EP3 subtype0213
Prostaglandin E2 receptor EP2 subtype0213
Prostacyclin receptor0213
Solute carrier organic anion transporter family member 2A10001
Solute carrier family 22 member 60102
Solute carrier family 22 member 70002
Prostaglandin E2 receptor EP2 subtype0101
Prostaglandin E2 receptor EP2 subtype0112
Solute carrier family 22 member 200202
Solute carrier family 22 member 80103
Solute carrier family 22 member 60202
Solute carrier family 22 member 70001
Solute carrier organic anion transporter family member 2A10001
Solute carrier family 22 member 110002
Solute carrier organic anion transporter family member 1B20001
Solute carrier family 22 member 70002
arylsulfatase A4004
Bloom syndrome protein isoform 13003
Solute carrier organic anion transporter family member 1A40001
Histamine H1 receptor0404
Solute carrier organic anion transporter family member 1A10001
Solute carrier organic anion transporter family member 1A20001
Histamine H4 receptor0101
ATP-dependent phosphofructokinase2002
importin subunit beta-1 isoform 12002
snurportin-12002
Beta-galactosidase0101
Lipopolysaccharide heptosyltransferase 10101
PA-I galactophilic lectin0011
Jacalin0011
acetylcholinesterase1001
PPM1D protein2002
nonstructural protein 11001
bromodomain adjacent to zinc finger domain 2B3003
nuclear receptor subfamily 1, group I, member 23003
nuclear factor erythroid 2-related factor 2 isoform 24004
muscleblind-like protein 1 isoform 14004
Nuclear receptor subfamily 1 group I member 20011
Glucocorticoid receptor06112
Glycine receptor subunit alpha-10606
Androgen receptor0303
Glycine receptor subunit beta0606
Glycine receptor subunit alpha-20606
Glycine receptor subunit alpha-30606
ATPase family AAA domain-containing protein 53003
Ataxin-25005
Nuclear receptor subfamily 1 group I member 20011
Thioredoxin reductase 0101
Histone H2A.x5005
Flavodoxin0001
Voltage-dependent L-type calcium channel subunit alpha-1F0303
Voltage-dependent L-type calcium channel subunit alpha-1D 0303
Voltage-dependent L-type calcium channel subunit alpha-1S0303
Voltage-dependent L-type calcium channel subunit alpha-1C0303
Lanosterol 14-alpha demethylase0101
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, JmjC domain-containing histone demethylation protein 3A2002
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
thioredoxin reductase3003
WRN1001
Valosin-containing protein0101
thioredoxin glutathione reductase2002
lysosomal alpha-glucosidase preproprotein2002
microphthalmia-associated transcription factor isoform 90101
DNA polymerase beta1001
flap endonuclease 11001
eukaryotic translation initiation factor 4 gamma 1 isoform 40101
serine/threonine-protein kinase PLK11001
eukaryotic translation initiation factor 4E isoform 10101
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
Rap guanine nucleotide exchange factor 32002
Neuronal acetylcholine receptor subunit alpha-42002
Neuronal acetylcholine receptor subunit beta-22002
Serum paraoxonase/arylesterase 10101
phosphoglycerate kinase1001
Solute carrier family 22 member 80101
Replicase polyprotein 1ab0213
Beta-lactamase OXA-70001
pregnane X receptor1001
serine-protein kinase ATM isoform a1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
lethal(3)malignant brain tumor-like protein 1 isoform I1001
Luciferase1001
hemoglobin subunit beta1001
cytochrome P450 2C19 precursor1001
cytochrome P450 3A4 isoform 14004
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Histamine H1 receptor0112
Prostaglandin G/H synthase 20202
Nociceptin receptor0011
Estrogen receptor beta0202
NS5 0011
Thrombopoietin2002
alpha-galactosidase1001
Spike glycoprotein0011
Replicase polyprotein 1ab0011
peripheral myelin protein 22 isoform 13003
glycogen synthase kinase-3 beta isoform 10011
survival motor neuron protein isoform d2002
muscarinic acetylcholine receptor M12002
Transmembrane protease serine 20011
Polymerase basic protein 20011
RNA-directed RNA polymerase catalytic subunit0011
Polymerase acidic protein0022
Procathepsin L0011
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Adenosine receptor A30101
Adenosylhomocysteinase0002
Adenosine receptor A2a0101
Adenosine receptor A10101
Adenosine receptor A10101
Genome polyprotein0011
Angiotensin-converting enzyme 2 0011
chaperonin-containing TCP-1 beta subunit homolog1001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Solute carrier family 22 member 60101
Polyphenol oxidase 20102
Carbonic anhydrase 120101
5'-AMP-activated protein kinase subunit beta-20001
Carbonic anhydrase 10202
Carbonic anhydrase 20202
Albumin0101
Carbonic anhydrase 30101
Stromelysin-10112
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Acetylcholinesterase0101
Carbonic anhydrase 40101
Prostaglandin G/H synthase 10101
Carbonic anhydrase 60101
Cystathionine gamma-lyase0101
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase 70101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase 90101
Carbonic anhydrase0101
Nicotinate phosphoribosyltransferase0101
Ubiquitin-like domain-containing CTD phosphatase 10101
Carbonic anhydrase 150101
Carbonic anhydrase 130101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
5'-AMP-activated protein kinase subunit beta-10001
endonuclease IV1001
ATAD5 protein, partial2002
caspase 7, apoptosis-related cysteine protease1001
estrogen receptor 2 (ER beta)1001
67.9K protein1001
glucocerebrosidase1001
Parkin1001
caspase-31001
XBP10101
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
Caspase-71001
NPC intracellular cholesterol transporter 1 precursor1001
D(1A) dopamine receptor1001
atrial natriuretic peptide receptor 1 precursor1001
caspase-31001
histone deacetylase 9 isoform 31001
huntingtin isoform 21001
ubiquitin-conjugating enzyme E2 N0101
ras-related protein Rab-9A1001
serine/threonine-protein kinase mTOR isoform 11001
DNA damage-inducible transcript 3 protein0101
M-phase phosphoprotein 81001
neuropeptide S receptor isoform A1001
5-hydroxytryptamine receptor 40202
Epidermal growth factor receptor0101
Tyrosine-protein kinase Fyn0101
ATP-dependent translocase ABCB10101
Aldo-keto reductase family 1 member B10202
ATP-dependent translocase ABCB10101
Muscarinic acetylcholine receptor M10101
Transcriptional activator protein LuxR0101
D(2) dopamine receptor0202
Dipeptidyl peptidase 40101
Alpha-1B adrenergic receptor0202
Alpha-2C adrenergic receptor0202
D0101
Alpha-2B adrenergic receptor0101
ATP-dependent translocase ABCB10101
Substance-K receptor0202
D(1A) dopamine receptor0202
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Alpha-1D adrenergic receptor0202
Sodium-dependent noradrenaline transporter 0202
Sodium-dependent dopamine transporter0101
Alpha-1D adrenergic receptor0101
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
Alpha-1A adrenergic receptor0101
Alpha-1B adrenergic receptor0101
D(3) dopamine receptor0202
5-hydroxytryptamine receptor 2B0202
Alpha-1A adrenergic receptor0202
D(1A) dopamine receptor1001
5-hydroxytryptamine receptor 60202
C-C chemokine receptor type 50202
Sodium-dependent dopamine transporter 0202
Sodium channel protein type 5 subunit alpha0101
90-kda heat shock protein beta HSP90 beta, partial0101
estrogen receptor beta isoform 10101
heat shock protein HSP 90-alpha isoform 20101
tyrosine-protein phosphatase non-receptor type 7 isoform 20101
Tetracycline resistance protein, class B0001
Muscarinic acetylcholine receptor M20101
72 kDa type IV collagenase0101
Multidrug transporter MdfA0101
Neutrophil collagenase0101
Alpha-synuclein0101
Collagenase 30101
Cannabinoid receptor 10101
P2Y purinoceptor 120101
Protein-arginine deiminase type-40202
glp-1 receptor, partial2002
NFKB1 protein, partial1001
Smad31001
procathepsin L isoform 1 preproprotein0101
twin arginine protein translocation system - TatA protein0001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]