Assay ID | Title | Year | Journal | Article |
AID1683168 | Selectivity index, ratio of IC50 for human DU145 cells under normoxic condition to IC50 human PC-3 cells under hypoxia condition incubated for 2 hrs followed by washed with fresh media incubated for 3 days by alamar blue assay | 2021 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 31 | Synthesis and evaluation of new dinitrobenzamide mustards in human prostate cancer. |
AID1683173 | Lipophilicity, logD of compound at pH 7.4 by microscale shake flask method | 2021 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 31 | Synthesis and evaluation of new dinitrobenzamide mustards in human prostate cancer. |
AID1683169 | Cytotoxicity against human DU145 cells assessed as reduction in cell viability incubated for 2 hrs under hypoxic condition followed washed with fresh media incubated for 3 days by alamar blue assay | 2021 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 31 | Synthesis and evaluation of new dinitrobenzamide mustards in human prostate cancer. |
AID1683170 | Cytotoxicity against human DU145 cells assessed as reduction in cell viability incubated for 2 hrs under normoxic condition followed by washed with fresh media incubated for 3 days by alamar blue assay | 2021 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 31 | Synthesis and evaluation of new dinitrobenzamide mustards in human prostate cancer. |
AID1581891 | Substrate activity at Escherichia coli nitroreductase nfsB assessed as ratio of Kcat/Km using NADH as cofactor in Tris-Cl buffer at pH 7.5 by spectrophotometric method based Michaelis-Menten plot analysis relative to CB1954/NfsB | 2020 | European journal of medicinal chemistry, Feb-01, Volume: 187 | Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer. |
AID1683172 | Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 2 hrs under hypoxic condition followed by washed with fresh media incubated for 3 days by alamar blue assay | 2021 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 31 | Synthesis and evaluation of new dinitrobenzamide mustards in human prostate cancer. |
AID1581890 | Substrate activity at Escherichia coli nitroreductase nfsA assessed as ratio of Kcat/Km using NADH as cofactor in Tris-Cl buffer at pH 7.5 by spectrophotometric method based Michaelis-Menten plot analysis relative to CB1954/NfsB | 2020 | European journal of medicinal chemistry, Feb-01, Volume: 187 | Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer. |
AID1683167 | Selectivity index, ratio of IC50 for human PC-3 cells under normoxic condition to IC50 human PC-3 cells under hypoxia condition incubated for 2 hrs followed by washed with fresh media incubated for 3 days by alamar blue assay | 2021 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 31 | Synthesis and evaluation of new dinitrobenzamide mustards in human prostate cancer. |
AID1595314 | Substrate activity at Escherichia coli nitroreductase nfsB assessed as Kcat using NADH as cofactor at 0 to 800 mM in Tris-Cl buffer at pH 7.5 by spectrophotometric method | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | PRODRUGS FOR NITROREDUCTASE BASED CANCER THERAPY- 2: Novel amide/Ntr combinations targeting PC3 cancer cells. |
AID1683166 | Cytotoxicity against human PC-3 cells assessed as reduction in cell viability preincubated for 4 hrs in hypoxia and further incubated for 5 days in fresh medium by SRB assay | 2021 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 31 | Synthesis and evaluation of new dinitrobenzamide mustards in human prostate cancer. |
AID1683171 | Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 2 hrs under normoxic condition followed by washed with fresh media incubated for 3 days by alamar blue assay | 2021 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 31 | Synthesis and evaluation of new dinitrobenzamide mustards in human prostate cancer. |
AID1595320 | Substrate activity at Escherichia coli nitroreductase nfsB assessed as ratio of Kcat/Km up to 80 mM using NADH as cofactor relative to CB1954/NfsB | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | PRODRUGS FOR NITROREDUCTASE BASED CANCER THERAPY- 2: Novel amide/Ntr combinations targeting PC3 cancer cells. |
AID1581877 | Substrate activity at Escherichia coli nitroreductase nfsB assessed as Km using NADH as cofactor in Tris-Cl buffer at pH 7.5 by spectrophotometric method based Michaelis-Menten plot analysis | 2020 | European journal of medicinal chemistry, Feb-01, Volume: 187 | Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer. |
AID1581869 | Substrate activity at Escherichia coli nitroreductase nfsA assessed as Kcat using NADPH as cofactor in Tris-Cl buffer at pH 7.5 by spectrophotometric method | 2020 | European journal of medicinal chemistry, Feb-01, Volume: 187 | Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer. |
AID1581883 | Substrate activity at Escherichia coli nitroreductase nfsA assessed as ratio of Kcat/Km using NADPH as cofactor in Tris-Cl buffer at pH 7.5 by spectrophotometry based Michaelis-Menten plot analysis | 2020 | European journal of medicinal chemistry, Feb-01, Volume: 187 | Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer. |
AID1581876 | Substrate activity at Escherichia coli nitroreductase nfsA assessed as Km using NADPH as cofactor in Tris-Cl buffer at pH 7.5 by spectrophotometry based Michaelis-Menten plot analysis | 2020 | European journal of medicinal chemistry, Feb-01, Volume: 187 | Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer. |
AID1595316 | Substrate activity at Escherichia coli nitroreductase nfsB assessed as ratio of Kcat/Km using NADH as cofactor in Tris-Cl buffer at pH 7.5 by spectrophotometric method | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | PRODRUGS FOR NITROREDUCTASE BASED CANCER THERAPY- 2: Novel amide/Ntr combinations targeting PC3 cancer cells. |
AID1581870 | Substrate activity at Escherichia coli nitroreductase nfsB assessed as Kcat using NADH as cofactor in Tris-Cl buffer at pH 7.5 by spectrophotometric method | 2020 | European journal of medicinal chemistry, Feb-01, Volume: 187 | Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer. |
AID1581884 | Substrate activity at Escherichia coli nitroreductase nfsB assessed as ratio of Kcat/Km using NADH as cofactor in Tris-Cl buffer at pH 7.5 by spectrophotometric method based Michaelis-Menten plot analysis | 2020 | European journal of medicinal chemistry, Feb-01, Volume: 187 | Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer. |
AID1595315 | Substrate activity at Escherichia coli nitroreductase nfsB assessed as Km using NADH as cofactor in Tris-Cl buffer at pH 7.5 by spectrophotometric method | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | PRODRUGS FOR NITROREDUCTASE BASED CANCER THERAPY- 2: Novel amide/Ntr combinations targeting PC3 cancer cells. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |