metronidazole has been researched along with Allergic Reaction in 11 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronidazole desensitization is recommended in patients with trichomoniasis and history of an allergic reaction to metronidazole due to presumed cross reactivity with tinidazole and lack of reliably safe and effective alternative therapies." | 4.02 | Successful treatment of trichomoniasis with tinidazole following desensitization in a patient allergic to metronidazole. ( Biagi, M; Slipke, W; Smalley, A; Tsaras, G, 2021) |
| "pylori infection and penicillin allergy." | 3.30 | New regimens as first-line eradication therapy for Helicobacter pylori infection in patients allergic to penicillin: A randomized controlled trial. ( Li, C; Lu, H; Ren, X; Song, Z; Suo, B; Tian, X; Yao, X; Zhang, H; Zhang, Y; Zhou, L, 2023) |
| "Metronidazole-treated patients became 100% parasite free." | 2.71 | Serum cytokine changes in Turkish children infected with Giardia lamblia with and without allergy: Effect of metronidazole treatment. ( Bayraktar, MR; Durmaz, R; Mehmet, N, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (27.27) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 3 (27.27) | 2.80 |
| Authors | Studies |
|---|---|
| Adachi, K | 1 |
| Kato, S | 1 |
| Koshino, A | 1 |
| Nagao, K | 1 |
| Sugiyama, T | 1 |
| Yoshimine, T | 1 |
| Yamaguchi, Y | 1 |
| Izawa, S | 1 |
| Ohashi, W | 1 |
| Ebi, M | 1 |
| Funaki, Y | 1 |
| Ogasawara, N | 1 |
| Sasaki, M | 1 |
| Kasugai, K | 1 |
| Zhang, Y | 1 |
| Suo, B | 1 |
| Tian, X | 1 |
| Zhang, H | 1 |
| Lu, H | 1 |
| Yao, X | 1 |
| Li, C | 1 |
| Ren, X | 1 |
| Zhou, L | 1 |
| Song, Z | 1 |
| Biagi, M | 1 |
| Slipke, W | 1 |
| Smalley, A | 1 |
| Tsaras, G | 1 |
| Ono, S | 1 |
| Kato, M | 1 |
| Nakagawa, S | 1 |
| Mabe, K | 1 |
| Sakamoto, N | 1 |
| Selgrad, M | 1 |
| Bornschein, J | 1 |
| Malfertheiner, P | 1 |
| Bayraktar, MR | 1 |
| Mehmet, N | 1 |
| Durmaz, R | 1 |
| Shelanski, MV | 1 |
| Phillips, SB | 1 |
| Potts, CE | 1 |
| Lazar, AP | 1 |
| Lazar, P | 1 |
| Kohli, J | 1 |
| Bhattacharya, SK | 1 |
| Gupta, VS | 1 |
| Sen, P | 1 |
| Chakravarty, AK | 1 |
| Schneider, GT | 1 |
| Geary, WL | 1 |
| Karageosov, I | 1 |
| Mischev, D | 1 |
1 review available for metronidazole and Allergic Reaction
| Article | Year |
|---|---|
[Helicobacter pylori: an infection with local complications and systemic effects].
Topics: Amoxicillin; Anemia, Iron-Deficiency; Anti-Bacterial Agents; Asthma; Clarithromycin; Cross-Sectional | 2011 |
3 trials available for metronidazole and Allergic Reaction
| Article | Year |
|---|---|
New regimens as first-line eradication therapy for Helicobacter pylori infection in patients allergic to penicillin: A randomized controlled trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Bismuth; Cefuroxime; Drug Therapy, Combination; Helicobacter Inf | 2023 |
Serum cytokine changes in Turkish children infected with Giardia lamblia with and without allergy: Effect of metronidazole treatment.
Topics: Adolescent; Antiprotozoal Agents; Case-Control Studies; Child; Child, Preschool; Cytokines; Female; | 2005 |
Evaluation of cutaneous reactivity to recently marketed dermatologic products.
Topics: Adult; Aged; Aged, 80 and over; Allergens; Antifungal Agents; Calcitriol; Clobetasol; Dermatitis, Ir | 1996 |
7 other studies available for metronidazole and Allergic Reaction
| Article | Year |
|---|---|
A Vonoprazan, Clarithromycin, and Metronidazole Regimen as Helicobacter pylori Eradication Therapy for Patients with Penicillin Allergy in Light of Clarithromycin Resistance.
Topics: Amoxicillin; Anti-Bacterial Agents; Clarithromycin; Drug Therapy, Combination; Helicobacter Infectio | 2023 |
Successful treatment of trichomoniasis with tinidazole following desensitization in a patient allergic to metronidazole.
Topics: Adult; Antitrichomonal Agents; Drug Resistance; Female; Humans; Hypersensitivity; Metronidazole; Tin | 2021 |
Vonoprazan improves the efficacy of Helicobacter pylori eradication therapy with a regimen consisting of clarithromycin and metronidazole in patients allergic to penicillin.
Topics: Anti-Bacterial Agents; Breath Tests; Carbon Isotopes; Clarithromycin; Female; Helicobacter Infection | 2017 |
Giardiasis, cryofibrinogenemia, and cold sensitivity: a response to metronidazole.
Topics: Animals; Cold Temperature; Cryoglobulins; Female; Fibrinogen; Fibrinogens, Abnormal; Giardiasis; Hum | 1991 |
Effect of metronidazole on immune mechanism in experimental animals.
Topics: Anaphylaxis; Animals; Antibody Formation; Female; Hemagglutination; Hypersensitivity; Immunity; Male | 1987 |
Vaginitis in adolescent girls.
Topics: Adolescent; Boric Acids; Candida; Candidiasis, Vulvovaginal; Child; Enterobius; Female; Foreign Bodi | 1971 |
[Colpitis emphysematosa trichomonalis].
Topics: Adult; Blister; Colposcopy; Eosinophilia; Estriol; Female; Hemostatics; Humans; Hypersensitivity; Me | 1974 |