Central Pontine Myelinolysis

A demyelinating condition affecting the PONS and characterized clinically by an acute progressive QUADRIPLEGIA; DYSARTHRIA; DYSPHAGIA; and alterations of consciousness. Pathologic features include prominent demyelination in the central PONS with sparing of axons and neurons. This condition is usually associated with systemic disorders such as HYPONATREMIA; chronic ALCOHOLISM; LIVER FAILURE; severe BURNS; malignant NEOPLASMS; hemorrhagic PANCREATITIS; HEMODIALYSIS; and SEPSIS. The rapid medical correction of hyponatremia has been cited as a cause of this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1125-6)

Synonym
Extrapontine Myelinoclasis
Myelinolysis, Central Pontine
Myelinoclasis, Central Pontine
Pontine Myelinolysis, Central
Extrapontine Myelinolysis
Central Pontine Myelinolysis

Excerpt	Reference
"Two patients with central pontine myelinolysis are described for the peculiar mode of development."	( Gupta, S; Jha, R; Kher, V; Phadke, RV; Pradhan, S; Singh, MN, 1995)
"Central pontine myelinolysis is described in children, usually associated with rapid correction of hyponatremia."	( Duman, O; Haspolat, S; Senol, U; Yegin, O, 2004)
"Central pontine and extrapontine myelinolysis are uncommon disorders characterized by distinctive clinical features and typical findings on neuroimaging."	( Arlotta, A; Cefalo, MG; Cianfoni, A; Mastrangelo, S; Maurizi, P; Riccardi, R, 2009)
"Central pontine myelinolysis is a rare but devastating cause of morbidity and mortality after orthotopic liver transplant."	( Al-Sarraf, AJ; Haque, M; Pudek, M; Yoshida, EM, 2010)
"Central pontine myelinolysis is a serious condition that may result in neuropathological sequelae and mortality, and clinicians should be aware of its potential presence in patients with malignancies."	( Akaogi, T; Isa, R; Kawata, E; Kobayashi, Y; Nagakane, Y; Tanba, K; Tsutsumi, Y; Uchiyama, H; Uoshima, N; Yamaguchi, J, 2015)

Excerpt	Reference
"We report a patient who developed extrapontine myelinolysis in the cerebellum during treatment of hyponatremic dehydration."	( Duman, O; Haspolat, S; Senol, U; Yegin, O, 2004)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	2 (1.02)	23.3326
1990's	33 (16.84)	12.5806
2000's	79 (40.31)	18.1394
2010's	67 (34.18)	28.8240
2020's	15 (7.65)	9.53

Drug	Relationship Strength	Studies
ethylene glycol	low	2
ammonium hydroxide	low	1
choline	low	2
chlorine	low	1
creatine	low	3
glycerol	low	1
methanol	low	2
inositol	low	1
niacin	low	1
taurine	low	1
thiamine	low	3
toluene	low	1
homovanillic acid	low	1
phenytoin	low	1
hydroxyindoleacetic acid	low	1
baclofen	low	1
benserazide	low	2
caffeine	low	1
disulfiram	low	1
valproic acid	low	1
fluorouracil	low	1
fluoxetine	low	1
fomepizole	low	1
haloperidol	low	1
hydrochlorothiazide	low	2
methylphenidate	low	1
metronidazole	low	1
metyrapone	low	1
apnea	low	1
ofloxacin	low	1
risperidone	low	2
trihexyphenidyl	low	1
zolpidem	low	1
prednisolone	low	4
thyroxine	low	1
prednisone	low	1
aspartic acid	low	3
glutamine	low	1
levodopa	low	12
carbaryl	low	1
colchicine	low	2
arginine	low	2
methylprednisolone	low	10
diquat	low	1
thiophenes	low	1
evans blue	low	1
lithium carbonate	low	2
gadolinium	low	2
chromates	low	1
vasotocin	low	1
sodium bichromate	low	1
fludrocortisone	low	2
glutamic acid	low	1
torsemide	low	1
n 0437, (-)-isomer	low	1
n-acetylaspartic acid	low	2
fluorodeoxyglucose f18	low	3
carbidopa, levodopa drug combination	low	3
3-iodo-2-hydroxy-6-methoxy-n-((1-ethyl-2-pyrrolidinyl)methyl)benzamide	low	1
pramipexole	low	2
ro 8-0576	low	2
methotrexate	low	1
levofloxacin	low	2
tolvaptan	low	1
fludrocortisone acetate	low	1
inositol 3-phosphate	low	1
lignans	low	1
tacrolimus	low	7
cocaine	low	1
mycophenolic acid	low	2
sodium bicarbonate	low	1
arginine vasopressin	low	1
digoxin	low	1
lithium	low	1
sirolimus	low	2
topiramate	low	1
atosiban	low	1
deamino arginine vasopressin	low	9
fluvoxamine	low	1
n-(3-iodopropen-1-yl)-2-carbomethoxy-3-(4-chlorophenyl)tropane	low	1
phosphocreatine	low	1
2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane	low	1
lactulose	low	1
pituitrin	low	4
quetiapine fumarate	low	1
heme	low	1
lewis x antigen	low	1
cyclosporine	low	6
clozapine	low	1
heme arginate	low	1
carbidopa	low	3

Protein Targets (1,257)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Sodium-dependent dopamine transporter	0	11	1	12
D(2) dopamine receptor	0	12	4	21
D(4) dopamine receptor	0	10	2	16
D(3) dopamine receptor	0	11	3	19
D(2) dopamine receptor	0	13	1	14
thioredoxin reductase	22	0	0	22
ATAD5 protein, partial	11	0	0	11
TDP1 protein	31	0	0	31
Microtubule-associated protein tau	6	0	0	6
estrogen-related nuclear receptor alpha	28	0	0	28
arylsulfatase A	13	0	0	13
euchromatic histone-lysine N-methyltransferase 2	26	0	0	26
Bloom syndrome protein isoform 1	9	0	0	9
D(1A) dopamine receptor	7	0	0	7
lamin isoform A-delta10	22	0	0	22
neuropeptide S receptor isoform A	4	0	0	4
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	17	0	0	17
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
phosphopantetheinyl transferase	8	0	0	8
NFKB1 protein, partial	7	0	0	7
GLS protein	13	0	0	13
thyroid stimulating hormone receptor	13	0	0	13
alpha-galactosidase	4	0	0	4
cytochrome P450 2C19 precursor	7	0	0	7
chromobox protein homolog 1	15	0	0	15
flap endonuclease 1	9	0	0	9
DNA polymerase iota isoform a (long)	6	0	0	6
muscarinic acetylcholine receptor M1	11	0	0	11
lethal factor (plasmid)	10	0	0	10
Cytochrome P450 3A4	0	10	0	13
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	19	0	0	19
vitamin D3 receptor isoform VDRA	9	0	0	9
peripheral myelin protein 22	17	0	0	17
ATP-binding cassette sub-family C member 3	0	23	0	23
Multidrug resistance-associated protein 4	0	23	0	24
Bile salt export pump	0	29	0	29
Translocator protein	0	1	1	2
Vasopressin V2 receptor	0	6	2	9
Oxytocin receptor	0	3	2	5
Vasopressin V1a receptor	0	0	2	2
Vasopressin V1a receptor	0	5	2	7
Vasopressin V1b receptor	0	3	2	5
Vasopressin V2 receptor	0	0	1	1
Vasopressin V1b receptor	0	1	1	3
Translocator protein	0	2	0	3
Oxytocin receptor	0	3	1	4
Vasopressin V2 receptor	0	2	2	4
Canalicular multispecific organic anion transporter 1	0	23	0	23
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	8	0	0	8
Chain A, Ferritin light chain	7	0	0	7
aldehyde dehydrogenase 1 family, member A1	14	0	0	14
Metabotropic glutamate receptor 6	0	1	2	4
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
Carbonic anhydrase 1	0	7	0	12
Carbonic anhydrase 2	0	8	2	15
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	2
Glutamate receptor ionotropic, NMDA 1	0	5	1	7
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Glutamate receptor ionotropic, NMDA 2A	0	5	1	7
Glutamate receptor ionotropic, NMDA 2B	0	6	1	8
Glutamate receptor ionotropic, NMDA 2C	0	5	1	7
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Carbonic anhydrase-like protein, putative	0	0	0	4
Glutamate receptor ionotropic, NMDA 2D	0	5	1	7
Glutamate receptor ionotropic, NMDA 3B	0	5	1	7
Carbonic anhydrase 4	0	2	0	3
Glutamate receptor ionotropic, NMDA 3A	0	5	1	7
GLI family zinc finger 3	22	0	0	22
AR protein	30	0	0	30
regulator of G-protein signaling 4	12	0	0	12
67.9K protein	8	0	0	8
activating transcription factor 6	8	0	0	8
cytochrome P450 3A4 isoform 1	9	0	0	9
histone acetyltransferase KAT2A isoform 1	7	0	0	7
Gamma-aminobutyric acid receptor subunit pi	9	5	0	14
Gamma-aminobutyric acid type B receptor subunit 2	0	2	1	3
Gamma-aminobutyric acid type B receptor subunit 2	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	9	5	0	14
Gamma-aminobutyric acid receptor subunit delta	9	5	0	14
Gamma-aminobutyric acid receptor subunit gamma-2	9	5	1	15
Gamma-aminobutyric acid receptor subunit alpha-5	9	5	0	14
Gamma-aminobutyric acid receptor subunit alpha-3	9	5	0	14
Gamma-aminobutyric acid receptor subunit gamma-1	9	5	0	14
Gamma-aminobutyric acid receptor subunit alpha-2	9	5	0	14
Gamma-aminobutyric acid receptor subunit alpha-4	9	5	0	14
Gamma-aminobutyric acid receptor subunit gamma-3	9	5	0	14
Gamma-aminobutyric acid receptor subunit alpha-6	9	5	0	14
Gamma-aminobutyric acid receptor subunit alpha-1	9	5	1	15
Gamma-aminobutyric acid receptor subunit beta-3	9	5	0	14
Gamma-aminobutyric acid receptor subunit beta-2	9	5	1	15
GABA theta subunit	9	5	0	14
Gamma-aminobutyric acid receptor subunit epsilon	9	5	0	14
Gamma-aminobutyric acid type B receptor subunit 1	0	2	1	3
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
EWS/FLI fusion protein	14	0	0	14
serine/threonine-protein kinase mTOR isoform 1	5	0	0	5
M-phase phosphoprotein 8	7	0	0	7
Zinc finger protein mex-5	0	0	1	1
POsterior Segregation	0	0	1	1
Genome polyprotein	0	1	0	1
Replicase polyprotein 1ab	0	5	0	5
D(1A) dopamine receptor	3	1	0	4
Hexokinase-2	0	1	0	1
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
RAR-related orphan receptor gamma	15	0	0	15
nuclear receptor subfamily 1, group I, member 3	20	0	0	20
glucocorticoid receptor [Homo sapiens]	24	0	0	24
retinoic acid nuclear receptor alpha variant 1	21	0	0	21
retinoid X nuclear receptor alpha	14	0	0	14
farnesoid X nuclear receptor	10	0	0	10
pregnane X nuclear receptor	19	0	0	19
estrogen nuclear receptor alpha	34	0	0	34
thyroid stimulating hormone receptor	8	0	0	8
v-jun sarcoma virus 17 oncogene homolog (avian)	17	0	0	17
atrial natriuretic peptide receptor 1 precursor	4	0	0	4
thyroid hormone receptor beta isoform a	10	0	0	10
thyroid hormone receptor beta isoform 2	19	0	0	19
DNA polymerase beta	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 1	20	0	0	20
nuclear receptor ROR-gamma isoform 1	9	0	0	9
geminin	21	0	0	21
DNA polymerase kappa isoform 1	8	0	0	8
Voltage-dependent calcium channel gamma-2 subunit	15	0	0	15
Potassium channel subfamily K member 2	0	2	1	3
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	1	0	1
Cholinesterase	0	1	0	1
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	3	0	3
Adenosine receptor A3	0	3	0	3
Glutamate receptor 2	15	3	1	19
Amine oxidase [flavin-containing] A	0	2	0	2
Acetylcholinesterase	0	4	0	4
Adenosine receptor A1	0	4	0	6
Amine oxidase [flavin-containing] B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	3	0	3
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	2	1	4
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	2	0	3
Adenosine receptor A1	0	1	1	4
Adenosine receptor A2a	0	2	0	5
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	3	1	4
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	2	3
Endochitinase B1	0	1	0	1
Muscarinic acetylcholine receptor	0	0	0	1
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	0	4
Guanine deaminase	0	1	0	1
Chain A, HADH2 protein	9	0	0	9
Chain B, HADH2 protein	9	0	0	9
acetylcholinesterase	11	0	0	11
estrogen receptor 2 (ER beta)	14	0	0	14
progesterone receptor	16	0	0	16
cytochrome P450 family 3 subfamily A polypeptide 4	15	0	0	15
peroxisome proliferator-activated receptor delta	15	0	0	15
vitamin D (1,25- dihydroxyvitamin D3) receptor	14	0	0	14
aryl hydrocarbon receptor	11	0	0	11
Histone H2A.x	9	0	0	9
lysosomal alpha-glucosidase preproprotein	3	0	0	3
mitogen-activated protein kinase 1	3	0	0	3
kallikrein-5 preproprotein	0	1	0	1
Fatty-acid amide hydrolase 1	0	2	0	2
Acetylcholinesterase	0	1	0	1
Interferon beta	16	0	0	16
Cellular tumor antigen p53	19	0	0	19
Guanine nucleotide-binding protein G	2	0	0	2
Carbonic anhydrase 4	0	4	0	6
Carbonic anhydrase	0	3	0	4
Carbonic anhydrase 15	0	2	0	3
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	1	0	2
Solute carrier family 22 member 1	0	2	0	4
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	3	0	3
Solute carrier family 22 member 1	0	2	0	4
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Solute carrier family 22 member 2	0	2	0	4
Chain A, JmjC domain-containing histone demethylation protein 3A	6	0	0	6
5-hydroxytryptamine receptor 3E	0	1	0	1
Luciferase	10	0	0	10
hypoxia-inducible factor 1 alpha subunit	7	0	0	7
Fumarate hydratase	6	0	0	6
caspase 7, apoptosis-related cysteine protease	4	0	0	4
G	11	0	0	11
cytochrome P450 2D6	10	0	0	10
polyprotein	6	0	0	6
Beta-1 adrenergic receptor	0	1	0	1
glucocerebrosidase	4	0	0	4
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
caspase-3	4	0	0	4
IDH1	9	0	0	9
Adenylate cyclase type 1	0	2	0	2
cytochrome P450 2D6 isoform 1	4	0	0	4
peripheral myelin protein 22 isoform 1	9	0	0	9
cytochrome P450 2C9 precursor	8	0	0	8
potassium voltage-gated channel subfamily H member 2 isoform d	9	0	0	9
atrial natriuretic peptide receptor 2 precursor	5	0	0	5
short transient receptor potential channel 6 isoform 1	0	0	1	1
survival motor neuron protein isoform d	7	0	0	7
transient receptor potential cation channel subfamily V member 1	2	0	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
Voltage-dependent L-type calcium channel subunit alpha-1F	0	5	0	5
Bile salt export pump	0	4	0	4
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 4	0	8	0	8
5-hydroxytryptamine receptor 3B	0	1	0	1
HLA class I histocompatibility antigen, B alpha chain	11	0	0	11
Albumin	0	0	4	4
Aldo-keto reductase family 1 member B1	0	9	0	9
Muscarinic acetylcholine receptor M2	0	7	1	8
Muscarinic acetylcholine receptor M4	0	6	1	7
ATP-dependent translocase ABCB1	0	6	0	12
Muscarinic acetylcholine receptor M1	0	5	0	5
Muscarinic acetylcholine receptor M3	0	4	0	4
Muscarinic acetylcholine receptor M4	0	4	0	4
5-hydroxytryptamine receptor 1A	0	6	2	8
5-hydroxytryptamine receptor 2C	0	11	0	12
Muscarinic acetylcholine receptor M5	0	4	0	4
Muscarinic acetylcholine receptor M5	0	9	0	9
Alpha-2A adrenergic receptor	0	10	0	10
Calmodulin-1	0	1	0	1
Beta-2 adrenergic receptor	0	4	0	4
Cytochrome P450 2D6	0	5	0	6
Muscarinic acetylcholine receptor M2	0	4	0	4
Muscarinic acetylcholine receptor M1	0	10	1	11
Cytochrome P450 2C9	0	9	1	11
Angiotensin-converting enzyme	0	7	0	7
5-hydroxytryptamine receptor 2A	0	11	0	11
Alpha-1B adrenergic receptor	0	9	1	10
Alpha-2B adrenergic receptor	0	11	0	11
Beta-1 adrenergic receptor	0	3	0	3
Alpha-2C adrenergic receptor	0	7	0	7
D	0	8	0	8
D(3) dopamine receptor	0	7	1	8
5-hydroxytryptamine receptor 1A	0	8	0	8
Alpha-2B adrenergic receptor	0	6	1	7
D(2) dopamine receptor	0	5	0	5
Muscarinic acetylcholine receptor M3	0	10	1	11
Endothelin receptor type B	0	1	0	1
D(1A) dopamine receptor	0	9	2	13
D(1B) dopamine receptor	0	4	0	6
Adenylate cyclase type 3	0	2	0	2
Alpha-2C adrenergic receptor	0	6	1	7
UDP-glucuronosyltransferase 1A4	0	0	0	3
Alpha-2A adrenergic receptor	0	6	1	7
Alpha-1D adrenergic receptor	0	7	1	8
Sodium-dependent noradrenaline transporter	0	12	1	13
Sodium-dependent dopamine transporter	0	9	1	10
5-hydroxytryptamine receptor 3A	0	2	0	2
Endothelin receptor type B	0	1	0	1
Histamine H2 receptor	0	7	2	9
Alpha-1D adrenergic receptor	0	6	0	6
D(1B) dopamine receptor	0	5	0	5
Beta-3 adrenergic receptor	0	2	0	2
Adenylate cyclase type 2	0	2	0	2
Adenylate cyclase type 4	0	2	0	2
5-hydroxytryptamine receptor 2A	0	8	1	11
5-hydroxytryptamine receptor 2C	0	8	1	9
5-hydroxytryptamine receptor 1B	0	6	0	6
5-hydroxytryptamine receptor 1D	0	4	0	4
D(4) dopamine receptor	0	5	0	5
5-hydroxytryptamine receptor 1F	0	4	0	4
5-hydroxytryptamine receptor 2B	0	10	1	11
Histamine H1 receptor	0	2	1	3
Histamine H1 receptor	0	4	0	4
Sodium-dependent serotonin transporter	0	13	2	15
Sodium-dependent serotonin transporter	0	8	0	9
5-hydroxytryptamine receptor 7	0	4	0	4
Cytochrome P450 2C19	0	4	0	5
5-hydroxytryptamine receptor 2C	0	3	0	3
5-hydroxytryptamine receptor 7	0	4	0	4
Alpha-1A adrenergic receptor	0	5	0	5
5-hydroxytryptamine receptor 2A	0	3	0	3
Histamine H1 receptor	0	6	3	11
Alpha-1B adrenergic receptor	0	3	0	3
5-hydroxytryptamine receptor 3A	0	2	0	2
Adenylate cyclase type 8	0	2	0	2
5-hydroxytryptamine receptor 2B	0	8	1	9
Alpha-1A adrenergic receptor	0	9	1	10
5-hydroxytryptamine receptor 3A	0	2	0	2
Histamine H2 receptor	8	0	0	9
5-hydroxytryptamine receptor 5A	0	2	0	2
5-hydroxytryptamine receptor 6	0	9	0	10
Cytochrome P450 2J2	0	5	0	6
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
D(2) dopamine receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Gastrin/cholecystokinin type B receptor	0	2	0	2
Spike glycoprotein	12	1	0	13
D(2) dopamine receptor	0	2	0	2
Calmodulin	0	0	1	1
Inositol monophosphatase 1	4	0	0	4
Voltage-dependent L-type calcium channel subunit alpha-1D	0	5	0	5
5-hydroxytryptamine receptor 2B	0	3	0	3
Adenylate cyclase type 6	0	2	0	2
Adenylate cyclase type 5	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	14	0	14
5-hydroxytryptamine receptor 4	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1C	0	5	0	5
Transporter	0	4	0	4
Cholecystokinin receptor type A	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
Nuclear receptor subfamily 3 group C member 3	0	6	0	6
5-hydroxytryptamine receptor 3D	0	1	0	1
Adenylyl cyclase 7	0	2	0	2
5-hydroxytryptamine receptor 3C	0	1	0	1
Inositol hexakisphosphate kinase 1	11	0	0	11
D	0	5	0	5
ATPase family AAA domain-containing protein 5	14	0	0	14
Ataxin-2	17	0	0	17
Sigma non-opioid intracellular receptor 1	0	11	0	11
Histamine H4 receptor	0	2	2	4
5-hydroxytryptamine receptor 3B	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	5	0	5
Transporter	0	6	0	6
Histamine H3 receptor	0	3	0	3
cytochrome P450 2C9, partial	11	0	0	11
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	0	3	0	3
Amyloid-beta precursor protein	2	3	0	5
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Tryptophan 5-hydroxylase 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	4	1	5
Gamma-aminobutyric acid receptor subunit beta-1	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	4	1	5
Liver carboxylesterase 1	0	1	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	4	0	4
5-hydroxytryptamine receptor 6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	4	1	5
Gamma-aminobutyric acid receptor subunit alpha-3	0	4	1	5
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	4	1	5
Gamma-aminobutyric acid receptor subunit beta-2	0	4	1	5
Gamma-aminobutyric acid receptor subunit alpha-4	0	4	0	4
Gamma-aminobutyric acid receptor subunit epsilon	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	4	0	4
Sodium-dependent dopamine transporter	0	3	0	3
5-hydroxytryptamine receptor 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	0	3	0	3
Leukotriene B4 receptor 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	3	0	3
Chain A, Beta-lactamase	3	0	0	3
interleukin 8	3	0	0	3
endonuclease IV	4	0	0	4
PAX8	0	0	0	2
pregnane X receptor	5	0	0	5
USP1 protein, partial	8	0	0	8
PPM1D protein	4	0	0	4
Thrombopoietin	4	0	0	4
Smad3	6	0	0	6
peroxisome proliferator activated receptor gamma	10	0	0	10
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	20	0	0	20
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
nuclear receptor subfamily 0 group B member 1	0	1	0	1
cellular tumor antigen p53 isoform a	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 2	10	0	0	10
ras-related protein Rab-9A	3	0	0	3
steroidogenic factor 1	0	1	0	1
muscleblind-like protein 1 isoform 1	6	0	0	6
caspase-1 isoform alpha precursor	2	0	0	2
Solute carrier family 22 member 3	0	1	0	1
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	0	0	2
Tubulin beta-4A chain	0	3	2	6
ATP-dependent translocase ABCB1	0	2	0	2
Tubulin beta chain	0	3	2	6
Tubulin alpha-3C chain	0	3	2	6
Serine/threonine-protein kinase pim-1	0	1	1	2
ATP-dependent translocase ABCB1	0	2	0	2
Nuclear receptor ROR-gamma	4	1	1	6
Tubulin alpha-1B chain	0	3	2	6
Tubulin alpha-4A chain	0	3	2	6
Tubulin beta-4B chain	0	3	2	6
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	3	2	6
Tubulin beta-2A chain	0	3	2	6
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	3	2	6
Tubulin beta-2B chain	0	2	0	2
Tubulin alpha-3E chain	0	3	2	6
Tubulin alpha-1A chain	0	3	2	6
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	3	2	6
Tubulin beta-6 chain	0	3	2	6
Tubulin beta-2B chain	0	3	2	6
Tubulin beta-1 chain	0	3	2	6
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	2	0	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Chain A, Cruzipain	3	0	0	3
SMAD family member 2	3	0	0	3
SMAD family member 3	3	0	0	3
STAT3, partial	0	1	0	1
thioredoxin glutathione reductase	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	9	0	0	9
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
tumor necrosis factor	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	3
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-1	0	2	0	2
Integrin beta-3	3	0	1	4
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Integrin alpha-IIb	3	0	1	4
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	2
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1B3	0	1	0	2
Solute carrier organic anion transporter family member 1B1	0	3	0	4
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
15-lipoxygenase, partial	5	0	0	5
apical membrane antigen 1, AMA1	3	0	0	3
hypothetical protein, conserved	2	0	0	2
nonstructural protein 1	4	0	0	4
pyruvate kinase	2	0	0	2
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
LacZ protein (plasmid)	0	0	1	1
thyrotropin-releasing hormone receptor	2	0	0	2
Caspase-7	2	0	0	2
Spike glycoprotein	0	1	0	1
Replicase polyprotein 1ab	0	2	0	2
beta-2 adrenergic receptor	2	0	0	2
type-1 angiotensin II receptor	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	3	0	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	6	0	0	6
runt-related transcription factor 1 isoform AML1b	1	0	0	1
perilipin-5	0	1	0	1
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
perilipin-1	0	1	0	1
caspase-3	2	0	0	2
histone deacetylase 9 isoform 3	1	0	0	1
heat shock protein beta-1	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
huntingtin isoform 2	3	0	0	3
polypyrimidine tract-binding protein 1 isoform a	1	0	0	1
serine/threonine-protein kinase PLK1	2	0	0	2
apelin receptor	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
urokinase-type plasminogen activator precursor	4	0	0	4
plasminogen precursor	4	0	0	4
urokinase plasminogen activator surface receptor precursor	4	0	0	4
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Vpr	2	0	0	2
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase	0	1	0	1
pyruvate kinase PKM isoform b	1	0	0	1
Transmembrane protease serine 2	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Carbamate kinase	0	1	0	1
Retinal dehydrogenase 1	0	1	0	1
Aldehyde dehydrogenase, mitochondrial	0	1	0	1
Cytochrome P450 1A2	0	2	0	2
Procathepsin L	0	1	0	1
Ornithine decarboxylase	1	0	0	1
Fructose-1,6-bisphosphatase 1	0	1	0	1
Replicase polyprotein 1a	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
C-X-C chemokine receptor type 2	0	2	0	2
Mitogen-activated protein kinase 3	0	1	1	2
Protein-lysine 6-oxidase	0	1	0	1
Lysine-specific demethylase 5A	0	1	0	1
Caspase-1	0	1	0	1
Mu-type opioid receptor	0	4	1	5
Alpha-synuclein	3	0	0	3
Kappa-type opioid receptor	0	2	0	2
C-C chemokine receptor type 2	0	2	0	2
C-C chemokine receptor type 4	0	2	0	2
C-C chemokine receptor type 5	0	2	0	2
Gasdermin-D	0	1	0	1
Lysyl oxidase homolog 3	0	1	0	1
TAR DNA-binding protein 43	7	0	0	7
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Lysyl oxidase homolog 4	0	1	0	1
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
Monoglyceride lipase	0	1	0	1
Angiotensin-converting enzyme 2	0	1	0	1
Gasdermin-D	0	1	0	1
Histone-lysine N-methyltransferase EHMT1	0	1	0	1
Lysyl oxidase homolog 2	0	1	0	1
heat shock protein 90, putative	0	0	0	1
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
large T antigen	0	1	0	1
Albumin	0	1	3	4
Luciferin 4-monooxygenase	0	1	0	1
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	1
Nuclear factor NF-kappa-B p105 subunit	0	0	0	1
Tyrosine-protein phosphatase 1	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	0	2	0	2
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Vesicular glutamate transporter 3	0	1	0	1
GALC protein	3	0	0	3
Glucocorticoid receptor	0	8	2	15
Glycine receptor subunit alpha-1	0	8	0	8
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
glp-1 receptor, partial	5	0	0	5
Skn7p	0	0	0	1
hemoglobin subunit beta	1	0	0	1
Solute carrier family 22 member 8	0	0	0	1
Epidermal growth factor receptor	0	2	1	3
Thymidylate synthase	0	3	0	3
Aromatase	0	2	0	2
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Sodium-dependent noradrenaline transporter	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Cytochrome P450 2C8	0	3	0	3
Dipeptidyl peptidase 4	0	1	0	1
Acetylcholinesterase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Potassium voltage-gated channel subfamily C member 1	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Cytochrome P450 1B1	0	1	0	1
Sigma intracellular receptor 2	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	3	0	3
Sodium-dependent serotonin transporter	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	4	0	4
Alcohol dehydrogenase E chain	0	1	1	2
Alcohol dehydrogenase S chain	0	1	1	2
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	5	0	0	5
Metabotropic glutamate receptor 8	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	3	1	4
Glutamate receptor 3	0	3	1	4
Glutamate receptor 4	0	3	1	4
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	2	0	2
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Cocaine esterase	0	2	0	2
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
UDP-glucuronosyltransferase 1A9	0	1	0	4
Major prion protein	0	0	1	1
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	1	0	1
Integrin alpha-4	0	1	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
UDP-glucuronosyltransferase 2B7	0	2	0	5
C-8 sterol isomerase	0	1	0	1
Delta-type opioid receptor	0	4	0	4
Mu-type opioid receptor	0	5	0	5
Kappa-type opioid receptor	0	2	0	2
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	2	0	3
Kappa-type opioid receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
Sodium channel protein type 7 subunit alpha	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	2	0	2
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	1	0	1
Protease	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	2	0	2
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	2	0	2
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
ClpP	2	0	0	2
Solute carrier family 22 member 8	0	0	0	1
Carbonic anhydrase	0	3	0	3
Hsf1 protein	0	0	2	3
Carbonic anhydrase	0	2	0	2
Solute carrier family 22 member 6	0	1	0	1
Carbonic anhydrase 12	0	2	0	4
Carbonic anhydrase 3	0	2	0	3
Carbonic anhydrase 6	0	3	0	5
Delta-type opioid receptor	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	3	1	6
Carbonic anhydrase 7	0	2	0	4
Mu-type opioid receptor	0	2	0	2
Carbonic anhydrase 9	0	3	0	5
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	2	0	2
Delta carbonic anhydrase	0	2	0	2
Carbonic anhydrase 13	0	2	0	4
Carbonic anhydrase 14	0	2	0	4
Carbonic anhydrase 5B, mitochondrial	0	3	0	5
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Chain B, Pulmonary surfactant-associated protein D	0	1	0	1
Chain A, Pulmonary surfactant-associated protein D	0	1	0	1
Sodium/myo-inositol cotransporter 2	0	1	0	1
Chain A, 2-oxoglutarate Oxygenase	7	0	0	7
dopamine D1 receptor	2	0	0	2
WRN	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
importin subunit beta-1 isoform 1	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
snurportin-1	2	0	0	2
DNA polymerase eta isoform 1	3	0	0	3
Polyphenol oxidase 2	0	1	0	2
Tyrosine-protein kinase Lck	0	1	1	2
Tyrosine-protein kinase Fyn	0	1	1	2
Tyrosinase	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Carbonic anhydrase	0	1	0	2
Large neutral amino acids transporter small subunit 1	0	1	0	1
SLC16A10 protein	0	0	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	2
Monocarboxylate transporter 10	0	0	0	1
phosphoglycerate kinase	1	0	0	1
CAAX prenyl protease 2 isoform 2	0	0	0	1
streptokinase A precursor	0	0	2	2
DNA gyrase subunit A	0	2	0	3
DNA primase	0	1	0	1
Multidrug and toxin extrusion protein 1	0	3	0	3
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
acid sphingomyelinase	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
transcriptional regulator ERG isoform 3	4	0	0	4
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	2	2
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	2	2
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	2
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	0	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Solute carrier family 22 member 6	0	2	0	2
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	4	4
Androgen receptor	0	3	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	2	1	3
Inosine-5'-monophosphate dehydrogenase 1	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	2
Peroxisome proliferator-activated receptor gamma	0	0	3	3
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A7	0	0	0	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Cholesteryl ester transfer protein	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	1	3
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
STE24	0	0	0	1
CAAX prenyl protease	0	0	0	1
Trypsin	0	0	0	1
DNA gyrase subunit A	0	1	0	2
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit B	0	1	0	2
Gamma-aminobutyric acid	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Beta-3 adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	0	1
5-hydroxytryptamine receptor 1E	0	1	0	1
Delta-type opioid receptor	0	1	0	1
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Glycine receptor subunit alpha-1	0	0	1	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Bone morphogenetic protein receptor type-1B	0	0	1	1
Cell division cycle 7-related protein kinase	0	0	1	1
Serine/threonine-protein kinase PLK4	0	0	1	1
ATP-dependent RNA helicase DDX3X	0	0	1	1
Pyridoxal kinase	0	0	1	1
Citron Rho-interacting kinase	0	0	1	1
Serine/threonine-protein kinase Chk1	0	0	1	1
Aurora kinase A	0	0	1	1
Cyclin-G-associated kinase	0	0	1	1
Ephrin type-B receptor 6	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 3	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 2	0	0	1	1
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	1	1
Dynamin-like 120 kDa protein, mitochondrial	0	0	1	1
Tyrosine-protein kinase JAK2	0	0	1	1
Eukaryotic translation initiation factor 5B	0	0	1	1
Rho-associated protein kinase 2	0	0	1	1
Serine/threonine-protein kinase ULK1	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	1	1
Ribosomal protein S6 kinase alpha-5	0	0	1	1
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	1	1
Ribosomal protein S6 kinase alpha-4	0	0	1	1
Serine/threonine-protein kinase 16	0	0	1	1
Cyclin-dependent kinase-like 5	0	0	1	1
Serine/threonine-protein kinase 10	0	0	1	1
Serine/threonine-protein kinase D3	0	0	1	1
Structural maintenance of chromosomes protein 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 6	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	1	1
Serine/threonine-protein kinase LATS1	0	0	1	1
Serine/threonine-protein kinase PAK 4	0	0	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
High affinity nerve growth factor receptor	0	0	1	1
ADP/ATP translocase 2	0	0	1	1
Protein kinase C beta type	0	0	1	1
Insulin receptor	0	0	1	1
Cyclin-dependent kinase 1	0	0	1	1
Eukaryotic translation initiation factor 4E	0	0	1	1
Glycogen phosphorylase, liver form	0	0	1	1
Tyrosine-protein kinase Fes/Fps	0	0	1	1
Adenine phosphoribosyltransferase	0	0	1	1
Tyrosine-protein kinase Yes	0	0	1	1
Tyrosine-protein kinase Lyn	0	0	1	1
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	1	1
Insulin-like growth factor 1 receptor	0	0	1	1
Signal recognition particle receptor subunit alpha	0	0	1	1
Cytochrome c1, heme protein, mitochondrial	0	0	1	1
Hepatocyte growth factor receptor	0	0	1	1
Tyrosine-protein kinase HCK	0	0	1	1
Platelet-derived growth factor receptor beta	0	0	1	1
Tyrosine-protein kinase Fgr	0	0	1	1
Serine/threonine-protein kinase A-Raf	0	0	1	1
Glycogen phosphorylase, brain form	0	0	1	1
Breakpoint cluster region protein	0	0	1	1
Fibroblast growth factor receptor 1	0	0	1	1
DNA topoisomerase 2-alpha	0	0	1	1
Cyclin-dependent kinase 4	0	0	1	1
ADP/ATP translocase 3	0	0	1	1
Proto-oncogene tyrosine-protein kinase Src	0	0	1	1
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	1	1
Serine/threonine-protein kinase B-raf	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	1	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	0	1	1
Tyrosine-protein kinase Fer	0	0	1	1
Protein kinase C alpha type	0	0	1	1
cAMP-dependent protein kinase catalytic subunit alpha	0	0	1	1
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	1	1
Casein kinase II subunit alpha'	0	0	1	1
Ras-related protein Rab-6A	0	0	1	1
Ephrin type-A receptor 1	0	0	1	1
Multifunctional protein ADE2	0	0	1	1
cAMP-dependent protein kinase catalytic subunit beta	0	0	1	1
Ferrochelatase, mitochondrial	0	0	1	1
Ribosomal protein S6 kinase beta-1	0	0	1	1
Tyrosine-protein kinase JAK1	0	0	1	1
Beta-adrenergic receptor kinase 1	0	0	1	1
Probable ATP-dependent RNA helicase DDX6	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
MAP/microtubule affinity-regulating kinase 3	0	0	1	1
Deoxycytidine kinase	0	0	1	1
Mitogen-activated protein kinase 1	0	0	1	1
Ephrin type-A receptor 2	0	0	1	1
Ephrin type-B receptor 2	0	0	1	1
Non-receptor tyrosine-protein kinase TYK2	0	0	1	1
UMP-CMP kinase	0	0	1	1
Phosphatidylethanolamine-binding protein 1	0	0	1	1
Wee1-like protein kinase	0	0	1	1
Heme oxygenase 2	0	0	1	1
S-adenosylmethionine synthase isoform type-2	0	0	1	1
DnaJ homolog subfamily A member 1	0	0	1	1
RAC-alpha serine/threonine-protein kinase	0	0	1	1
RAC-beta serine/threonine-protein kinase	0	0	1	1
Dual specificity protein kinase TTK	0	0	1	1
DNA replication licensing factor MCM4	0	0	1	1
Myosin-10	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 2	0	0	1	1
Receptor-type tyrosine-protein kinase FLT3	0	0	1	1
Bone morphogenetic protein receptor type-1A	0	0	1	1
Activin receptor type-1B	0	0	1	1
TGF-beta receptor type-1	0	0	1	1
Serine/threonine-protein kinase receptor R3	0	0	1	1
TGF-beta receptor type-2	0	0	1	1
Electron transfer flavoprotein subunit beta	0	0	1	1
Tyrosine-protein kinase CSK	0	0	1	1
Glycine--tRNA ligase	0	0	1	1
Protein kinase C iota type	0	0	1	1
Exosome RNA helicase MTR4	0	0	1	1
Tyrosine-protein kinase Tec	0	0	1	1
Tyrosine-protein kinase ABL2	0	0	1	1
Tyrosine-protein kinase FRK	0	0	1	1
G protein-coupled receptor kinase 6	0	0	1	1
Tyrosine-protein kinase SYK	0	0	1	1
26S proteasome regulatory subunit 6B	0	0	1	1
Mitogen-activated protein kinase 8	0	0	1	1
Mitogen-activated protein kinase 9	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 3	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	1	1
Casein kinase I isoform alpha	0	0	1	1
Casein kinase I isoform delta	0	0	1	1
MAP kinase-activated protein kinase 2	0	0	1	1
Elongation factor Tu, mitochondrial	0	0	1	1
Choline-phosphate cytidylyltransferase A	0	0	1	1
Cysteine--tRNA ligase, cytoplasmic	0	0	1	1
Casein kinase I isoform epsilon	0	0	1	1
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	1	1
Dual specificity protein kinase CLK1	0	0	1	1
Dual specificity protein kinase CLK2	0	0	1	1
Dual specificity protein kinase CLK3	0	0	1	1
Glycogen synthase kinase-3 alpha	0	0	1	1
Glycogen synthase kinase-3 beta	0	0	1	1
Cyclin-dependent kinase 7	0	0	1	1
Cyclin-dependent kinase 9	0	0	1	1
Ras-related protein Rab-27A	0	0	1	1
Interleukin-1 receptor-associated kinase 1	0	0	1	1
Ribosomal protein S6 kinase alpha-3	0	0	1	1
Serine/threonine-protein kinase Nek2	0	0	1	1
Serine/threonine-protein kinase Nek3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 6	0	0	1	1
Serine/threonine-protein kinase PLK1	0	0	1	1
LIM domain kinase 1	0	0	1	1
LIM domain kinase 2	0	0	1	1
Mitogen-activated protein kinase 10	0	0	1	1
Tyrosine--tRNA ligase, cytoplasmic	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	1	1
Ephrin type-B receptor 3	0	0	1	1
Ephrin type-A receptor 5	0	0	1	1
Ephrin type-B receptor 4	0	0	1	1
Ephrin type-A receptor 4	0	0	1	1
Adenylate kinase 2, mitochondrial	0	0	1	1
Adenosine kinase	0	0	1	1
Ras-related protein Rab-10	0	0	1	1
Actin-related protein 3	0	0	1	1
Actin-related protein 2	0	0	1	1
GTP-binding nuclear protein Ran	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	4	2	6
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	2	2
Casein kinase I isoform gamma-2	0	0	1	1
Cyclin-dependent kinase 6	0	0	1	1
Cyclin-dependent-like kinase 5	0	0	1	1
Cyclin-dependent kinase 16	0	0	1	1
Cyclin-dependent kinase 17	0	0	1	1
ATP-dependent 6-phosphofructokinase, platelet type	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 1	0	0	1	1
DNA topoisomerase 2-beta	0	0	1	1
Protein kinase C theta type	0	0	1	1
Activin receptor type-1	0	0	1	1
Macrophage-stimulating protein receptor	0	0	1	1
Focal adhesion kinase 1	0	0	1	1
Protein kinase C zeta type	0	0	1	1
Protein kinase C delta type	0	0	1	1
Tyrosine-protein kinase BTK	0	0	1	1
Cyclin-dependent kinase 18	0	0	1	1
Activated CDC42 kinase 1	0	0	1	1
Epithelial discoidin domain-containing receptor 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	1	1
Tyrosine-protein kinase Mer	0	0	1	1
Serine/threonine-protein kinase 4	0	0	1	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase 7	0	0	1	1
Serine/threonine-protein kinase PAK 2	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 1	0	0	1	1
Integrin-linked protein kinase	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	2	0	2
Rho-associated protein kinase 1	0	0	1	1
Non-receptor tyrosine-protein kinase TNK1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	1	1
Activin receptor type-2B	0	0	1	1
Bone morphogenetic protein receptor type-2	0	0	1	1
Protein-tyrosine kinase 6	0	0	1	1
cGMP-dependent protein kinase 1	0	0	1	1
Cyclin-dependent kinase 13	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	1	1
Protein-tyrosine kinase 2-beta	0	0	1	1
Maternal embryonic leucine zipper kinase	0	0	1	1
Structural maintenance of chromosomes protein 1A	0	0	1	1
Chromodomain-helicase-DNA-binding protein 4	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 1	0	0	1	1
Delta(24)-sterol reductase	0	0	1	1
Ribosomal protein S6 kinase alpha-1	0	0	1	1
Dual specificity testis-specific protein kinase 1	0	0	1	1
Myosin light chain kinase, smooth muscle	0	0	1	1
Mitogen-activated protein kinase 11	0	0	1	1
Serine/threonine-protein kinase STK11	0	0	1	1
Serine/threonine-protein kinase N1	0	0	1	1
Serine/threonine-protein kinase N2	0	0	1	1
Mitogen-activated protein kinase 14	0	0	1	1
Calcium/calmodulin-dependent protein kinase type IV	0	0	1	1
Mitogen-activated protein kinase kinase kinase 11	0	0	1	1
Discoidin domain-containing receptor 2	0	0	1	1
AP2-associated protein kinase 1	0	0	1	1
Myosin light chain kinase 3	0	0	1	1
Uncharacterized aarF domain-containing protein kinase 5	0	0	1	1
Programmed cell death protein 4	0	0	1	1
Putative heat shock protein HSP 90-beta 2	0	0	1	1
Serine/threonine-protein kinase MRCK alpha	0	0	1	1
Serine/threonine-protein kinase MRCK gamma	0	0	1	1
Acyl-CoA dehydrogenase family member 10	0	0	1	1
Serine/threonine-protein kinase N3	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Uncharacterized protein FLJ45252	0	0	1	1
Acyl-CoA dehydrogenase family member 11	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	1	1
Serine/threonine-protein kinase MARK2	0	0	1	1
ATP-dependent RNA helicase DHX30	0	0	1	1
Serine/threonine-protein kinase TAO1	0	0	1	1
STE20-related kinase adapter protein alpha	0	0	1	1
Myosin-14	0	0	1	1
AarF domain-containing protein kinase 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	1	1
MAP kinase-activated protein kinase 5	0	0	1	1
Regulatory-associated protein of mTOR	0	1	0	1
Misshapen-like kinase 1	0	0	1	1
Atypical kinase COQ8A, mitochondrial	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	1	1
Mitogen-activated protein kinase 15	0	0	1	1
Serine/threonine-protein kinase Nek9	0	0	1	1
ATP-dependent RNA helicase DDX1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	1	1
Aurora kinase B	0	0	1	1
MAP/microtubule affinity-regulating kinase 4	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1G	0	0	1	1
Serine/threonine-protein kinase Nek1	0	0	1	1
PAS domain-containing serine/threonine-protein kinase	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	1	1
EKC/KEOPS complex subunit TP53RK	0	0	1	1
Dual specificity testis-specific protein kinase 2	0	0	1	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase kinase kinase 3	0	0	1	1
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	1	1
Target of rapamycin complex subunit LST8	0	1	0	1
Nucleolar GTP-binding protein 1	0	0	1	1
Serine/threonine-protein kinase D2	0	0	1	1
RNA cytidine acetyltransferase	0	0	1	1
Serine/threonine-protein kinase SIK2	0	0	1	1
STE20-like serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO3	0	0	1	1
dCTP pyrophosphatase 1	0	0	1	1
Dual specificity protein kinase CLK4	0	0	1	1
Casein kinase I isoform gamma-1	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Phenylalanine--tRNA ligase beta subunit	0	0	1	1
Isoleucine--tRNA ligase, mitochondrial	0	0	1	1
BMP-2-inducible protein kinase	0	0	1	1
Obg-like ATPase 1	0	0	1	1
Midasin	0	0	1	1
Interleukin-1 receptor-associated kinase 4	0	0	1	1
Mitogen-activated protein kinase kinase kinase 20	0	0	1	1
Cyclin-dependent kinase 12	0	0	1	1
Serine/threonine-protein kinase 26	0	0	1	1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	1	1
Serine/threonine-protein kinase NLK	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	1	1
Serine/threonine-protein kinase TBK1	0	0	1	1
Septin-9	0	0	1	1
Ribosomal protein S6 kinase alpha-6	0	0	1	1
TRAF2 and NCK-interacting protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO2	0	0	1	1
Serine/threonine-protein kinase ICK	0	0	1	1
RAC-gamma serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase SIK3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 2	0	0	1	1
Thyroid hormone receptor-associated protein 3	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 3	0	0	1	1
Serine/threonine-protein kinase MRCK beta	0	0	1	1
Interleukin-1 receptor-associated kinase 3	0	0	1	1
Serine/threonine-protein kinase 24	0	0	1	1
Casein kinase I isoform gamma-3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 4	0	0	1	1
Carbonic anhydrase	0	1	0	1
Cytochrome P450 3A5	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Transthyretin	0	1	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Endolysin	0	0	1	1
Chain A, Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	0	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Histone deacetylase 3	0	2	0	2
Cytochrome P450 2A6	0	1	0	1
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	0	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Histone deacetylase 4	0	2	0	2
Histone deacetylase 1	0	2	0	2
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
Histone deacetylase 7	0	2	0	2
Histone deacetylase 2	0	2	0	2
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	2	0	2
Histone deacetylase 8	0	2	0	2
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	2	0	2
Histone deacetylase 5	0	2	0	2
Sphingosine-1-phosphate lyase 1	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Central Pontine Myelinolysis

Synonyms(6)

Research Excerpts

Overview

Treatment

Research

Studies (196)

Protein Targets (1,257)

Central Pontine Myelinolysis

Synonyms(6)

Research Excerpts

Overview

Treatment

Research

Studies (196)

Drugs Studied (111)

Protein Targets (1,257)