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metronidazole and Cancer of Duodenum

metronidazole has been researched along with Cancer of Duodenum in 2 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's1 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yousfi, MM1
el-Zimaity, HM1
Cole, RA1
Genta, RM1
Graham, DY1
Nakamura, S2
Matsumoto, T1
Kusano, Y1
Esaki, M1
Kurahara, K1
Fukuda, T1

Other Studies

2 other studies available for metronidazole and Cancer of Duodenum

ArticleYear
Resolution of a metaplastic duodenal polyp after cure of Helicobacter pylori infection.
    Journal of clinical gastroenterology, 1996, Volume: 23, Issue:1

    Topics: Anti-Bacterial Agents; Anti-Ulcer Agents; Clarithromycin; Duodenal Neoplasms; Helicobacter Infection

1996
Duodenal mucosa-associated lymphoid tissue lymphoma treated by eradication of Helicobacter pylori: report of 2 cases including EUS findings.
    Gastrointestinal endoscopy, 2001, Volume: 54, Issue:6

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Amoxicillin; Benzimidazoles; Biopsy, Needle; Clarithr

2001