Any drug that binds to and activates cholinergic receptors.
ChEBI ID: 38324
| Member | Definition | Class |
|---|---|---|
| arachidonoylcholine | An acylcholine obtained by formal condensation of the carboxy group of arachidonic acid with the hydroxy group of choline. | arachidonoylcholine |
| methacholine | A quaternary ammonium ion in which the nitrogen is substituted with three methyl groups and a 2-acetoxypropyl group. Parasympathomimetic bronchoconstrictor drug used in clinical diagnosis. | methacholine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (5.26) | 18.7374 |
| 1990's | 1 (5.26) | 18.2507 |
| 2000's | 4 (21.05) | 29.6817 |
| 2010's | 6 (31.58) | 24.3611 |
| 2020's | 7 (36.84) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 20 (100.00%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 42.5615 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 2.8184 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 0.8437 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | IC50 | 2.7900 | 2 | 2 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | IC50 | 3.5933 | 2 | 3 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 0.0590 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | Ki | 0.0590 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | IC50 | 0.7000 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 1.6000 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | Ki | 1.6000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | EC50 | 0.4000 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | EC50 | 0.1200 | 1 | 1 |
| NPYLR7B | Aedes aegypti (yellow fever mosquito) | EC50 | 20.0000 | 1 | 1 |