metronidazole has been researched along with Demyelinating Diseases in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Demyelinating Diseases: Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Demyelination is evident seven days later, and remyelination is observed 16 days after Mtz treatment." | 1.51 | A Drug-Inducible Transgenic Zebrafish Model for Myelinating Glial Cell Ablation. ( Karttunen, MJ; Lyons, DA, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Karttunen, MJ | 1 |
| Lyons, DA | 1 |
| Sekizar, S | 1 |
| Mannioui, A | 1 |
| Azoyan, L | 1 |
| Colin, C | 1 |
| Thomas, JL | 1 |
| Du Pasquier, D | 1 |
| Mallat, M | 1 |
| Zalc, B | 1 |
2 other studies available for metronidazole and Demyelinating Diseases
| Article | Year |
|---|---|
A Drug-Inducible Transgenic Zebrafish Model for Myelinating Glial Cell Ablation.
Topics: Animals; Animals, Genetically Modified; Demyelinating Diseases; Disease Models, Animal; Gene Express | 2019 |
Remyelination by Resident Oligodendrocyte Precursor Cells in a Xenopus laevis Inducible Model of Demyelination.
Topics: Animals; Animals, Genetically Modified; Anti-Infective Agents; Demyelinating Diseases; Disease Model | 2015 |