metronidazole has been researched along with Colonic Polyps in 5 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Colonic Polyps: Discrete tissue masses that protrude into the lumen of the COLON. These POLYPS are connected to the wall of the colon either by a stalk, pedunculus, or by a broad base.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In most of the patients studied, ambulatory conservative management was safe and effective in the treatment of uncomplicated acute diverticulitis." | 2.74 | [Safety and efficiency of ambulatory treatment of acute diverticulitis]. ( García Marín, A; Martín Gil, J; Pérez Díaz, MD; Rey Valcárcel, C; Sanz Sánchez, M; Serralta De Colsa, D; Turégano Fuentes, F; Vaquero Rodríguez, A, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Okamoto, K | 1 |
| Watanabe, T | 1 |
| Komeda, Y | 1 |
| Okamoto, A | 1 |
| Minaga, K | 1 |
| Kamata, K | 1 |
| Yamao, K | 1 |
| Takenaka, M | 1 |
| Hagiwara, S | 1 |
| Sakurai, T | 1 |
| Tanaka, T | 1 |
| Sakamoto, H | 1 |
| Fujimoto, K | 1 |
| Nishida, N | 1 |
| Kudo, M | 1 |
| Martín Gil, J | 1 |
| Serralta De Colsa, D | 1 |
| García Marín, A | 1 |
| Vaquero Rodríguez, A | 1 |
| Rey Valcárcel, C | 1 |
| Pérez Díaz, MD | 1 |
| Sanz Sánchez, M | 1 |
| Turégano Fuentes, F | 1 |
| Shimizu, K | 1 |
| Koga, H | 1 |
| Iida, M | 1 |
| Yao, T | 1 |
| Hirakawa, K | 1 |
| Hoshika, K | 1 |
| Mikami, Y | 1 |
| Haruma, K | 1 |
| Conscience, I | 1 |
| Perceau, G | 1 |
| Le Berruyer, PY | 1 |
| Bernard, P | 1 |
| Menzel, J | 1 |
| Bauer, J | 1 |
| von Pritzbuer, E | 1 |
| Klempa, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Multicentric Controlled Clinical Trial of Parallel Groups to Evaluate the Non-therapeutic Inferiority of a Free Diet With a Progressive Diet, in the Treatment of Non-complicated Acute Diverticulitis[NCT03496090] | 134 participants (Actual) | Interventional | 2018-04-16 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for metronidazole and Colonic Polyps
| Article | Year |
|---|---|
[Safety and efficiency of ambulatory treatment of acute diverticulitis].
Topics: Abdominal Pain; Abscess; Acute Disease; Adenocarcinoma; Adult; Aged; Aged, 80 and over; Ambulatory C | 2009 |
[Perioperative use of ampicillin/sulbactam, cefoxitin and piperacillin/ metronidazole in elective colon and rectal surgery. A prospective randomized quality assurance study of 422 patients].
Topics: Aged; Ampicillin; Anti-Bacterial Agents; Bacterial Infections; Cefoxitin; Colitis, Ulcerative; Colon | 1993 |
3 other studies available for metronidazole and Colonic Polyps
| Article | Year |
|---|---|
Dysbiosis-Associated Polyposis of the Colon-Cap Polyposis.
Topics: Ampicillin; Anti-Bacterial Agents; Asymptomatic Diseases; Bacteria; Colon; Colonic Polyps; Dysbiosis | 2018 |
Does metronidazole cure cap polyposis by its antiinflammatory actions instead of by its antibiotic action? A case study.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Child; Colon; Colonic Polyps; Colonoscopy; Female; | 2002 |
[Bilateral breast bacterial cellulite secondary to Streptococcus agalactiae septicemia].
Topics: Adenocarcinoma; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Breast Diseases; Ce | 2006 |