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metronidazole and Acute Generalised Exanthematous Pustulosis

metronidazole has been researched along with Acute Generalised Exanthematous Pustulosis in 2 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Research Excerpts

ExcerptRelevanceReference
"Metronidazole is a synthetic nitroimidazole derivative with antimicrobial and antiinflammatory properties."2.46Innovative use of topical metronidazole. ( Zip, CM, 2010)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kostaki, M1
Polydorou, D1
Adamou, E1
Chasapi, V1
Antoniou, C1
Stratigos, A1
Zip, CM1

Reviews

1 review available for metronidazole and Acute Generalised Exanthematous Pustulosis

ArticleYear
Innovative use of topical metronidazole.
    Dermatologic clinics, 2010, Volume: 28, Issue:3

    Topics: Acute Generalized Exanthematous Pustulosis; Administration, Cutaneous; Adult; Anti-Infective Agents;

2010

Other Studies

1 other study available for metronidazole and Acute Generalised Exanthematous Pustulosis

ArticleYear
Acute localized exanthematous pustulosis due to metronidazole.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2019, Volume: 33, Issue:3

    Topics: Acute Generalized Exanthematous Pustulosis; Aged; Anti-Bacterial Agents; Facial Dermatoses; Humans;

2019