metronidazole has been researched along with Colon Diverticula in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fingerhut, A | 1 |
| Hay, JM | 1 |
| O'Sullivan, GC | 1 |
| Murphy, D | 1 |
| O'Brien, MG | 1 |
| Ireland, A | 1 |
| Balikian, JP | 1 |
| Uthman, SM | 1 |
| Khouri, NF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Laparoscopic Lavage for Acute Non-Faeculant Diverticulitis[NCT01019239] | 300 participants (Anticipated) | Interventional | 2010-01-31 | Enrolling by invitation | |||
| Management and Evolution of Acute Diverticulitis With Pericolic Free Gas - a Multicentre Observational Study[NCT04311385] | 1,000 participants (Actual) | Observational | 2020-06-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for metronidazole and Colon Diverticula
| Article | Year |
|---|---|
Single-dose ceftriaxone, ornidazole, and povidone-iodine enema in elective left colectomy. A randomized multicenter controlled trial. The French Association for Surgical Research.
Topics: Adult; Aged; Aged, 80 and over; Anastomosis, Surgical; Cefotaxime; Ceftriaxone; Colectomy; Colonic N | 1993 |
2 other studies available for metronidazole and Colon Diverticula
| Article | Year |
|---|---|
Laparoscopic management of generalized peritonitis due to perforated colonic diverticula.
Topics: Adult; Aged; Anti-Bacterial Agents; Cephalosporins; Diverticulum, Colon; Female; Follow-Up Studies; | 1996 |
Laparoscopic management of generalized peritonitis due to perforated colonic diverticula.
Topics: Adult; Aged; Anti-Bacterial Agents; Cephalosporins; Diverticulum, Colon; Female; Follow-Up Studies; | 1996 |
Laparoscopic management of generalized peritonitis due to perforated colonic diverticula.
Topics: Adult; Aged; Anti-Bacterial Agents; Cephalosporins; Diverticulum, Colon; Female; Follow-Up Studies; | 1996 |
Laparoscopic management of generalized peritonitis due to perforated colonic diverticula.
Topics: Adult; Aged; Anti-Bacterial Agents; Cephalosporins; Diverticulum, Colon; Female; Follow-Up Studies; | 1996 |
Intestinal amebiasis. A roentgen analysis of 19 cases including 2 case reports.
Topics: Abscess; Aged; Cecal Diseases; Colitis, Ulcerative; Colonic Diseases; Colonic Neoplasms; Diagnosis, | 1974 |