metronidazole has been researched along with Ischemia in 5 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McDonald, NM | 1 |
| Piovezani Ramos, G | 1 |
| Sweetser, S | 1 |
| Englert, C | 1 |
| Aebert, H | 1 |
| Lenhart, M | 1 |
| Solleder, A | 1 |
| Nerlich, M | 1 |
| Neumann, C | 1 |
| Keighley, MR | 1 |
| Kerin, MJ | 1 |
| Greenstein, D | 1 |
| Chisholm, EM | 1 |
| Sheehan, SJ | 1 |
| Kester, RC | 1 |
| Plonka, AJ | 1 |
| Schentag, JJ | 1 |
| Messinger, S | 1 |
| Adelman, MH | 1 |
| Francis, KL | 1 |
| Williams, JS | 1 |
2 reviews available for metronidazole and Ischemia
| Article | Year |
|---|---|
60-Year-Old Man With Syncope, Abdominal Pain, and Hematochezia.
Topics: Abdominal Pain; Colon; Colonoscopy; Diagnosis, Differential; Emergency Service, Hospital; Follow-Up | 2019 |
["Pouchitis"; histology].
Topics: Crohn Disease; Diagnosis, Differential; Diarrhea; Fecal Incontinence; Humans; Ileitis; Ileum; Inflam | 1993 |
3 other studies available for metronidazole and Ischemia
| Article | Year |
|---|---|
Thoracic spondylitis from a mycotic (Streptococcus pneumoniae) aortic aneurysm: a case report.
Topics: Aneurysm, Infected; Anti-Bacterial Agents; Aortic Aneurysm, Thoracic; Blood Vessel Prosthesis Implan | 2004 |
Is antibiotic penetration compromised in the ischaemic tissues of patients undergoing amputation?
Topics: Aged; Amputation, Surgical; Cephradine; Female; Humans; Ischemia; Leg; Male; Metronidazole; Premedic | 1992 |
Effects of enteral and intravenous antimicrobial treatment on survival following intestinal ischemia in rats.
Topics: Animals; Anti-Bacterial Agents; Bacteria, Anaerobic; Drug Therapy, Combination; Gentamicins; Gram-Ne | 1989 |