Page last updated: 2024-10-31

metronidazole and Brain Ischemia

metronidazole has been researched along with Brain Ischemia in 4 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

Research Excerpts

ExcerptRelevanceReference
" Lumbar spinal magnetic resonance imaging (MRI) revealed infective spondylitis, and metronidazole (1."4.31Metronidazole-induced encephalopathy delayed diagnosis due to cerebellar infarction: A case report. ( Cha, S; Cho, KH; Lee, BC; Moon, CW, 2023)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's2 (50.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Cha, S1
Lee, BC1
Moon, CW1
Cho, KH2
Takada, K1
Maki, Y1
Kinosada, M1
Ishibashi, R1
Chin, M1
Yamagata, S1
Kowar, M1
Frackowiak, M1
Friedrich, C1
Wilhelm, K1
Walger, P1
Jacobs, AH1
Song, HC1
Bom, HS1
Kim, BC1
Seo, JJ1
Kim, CG1
Yang, DJ1
Kim, EE1

Trials

1 trial available for metronidazole and Brain Ischemia

ArticleYear
Prognostication of recovery in patients with acute ischemic stroke through the use of brain SPECT with Technetium-99m--labeled metronidazole.
    Stroke, 2003, Volume: 34, Issue:4

    Topics: Acute Disease; Aged; Brain; Brain Ischemia; Cysteine; Diffusion Magnetic Resonance Imaging; Female;

2003

Other Studies

3 other studies available for metronidazole and Brain Ischemia

ArticleYear
Metronidazole-induced encephalopathy delayed diagnosis due to cerebellar infarction: A case report.
    Medicine, 2023, Feb-03, Volume: 102, Issue:5

    Topics: Aged; Anti-Bacterial Agents; Brain Diseases; Brain Ischemia; Cerebellar Diseases; Delayed Diagnosis;

2023
Metronidazole Induced Encephalopathy Mimicking an Acute Ischemic Stroke Event.
    Neurologia medico-chirurgica, 2018, Sep-15, Volume: 58, Issue:9

    Topics: Aged, 80 and over; Anti-Bacterial Agents; Brain Ischemia; Diagnosis, Differential; Female; Humans; M

2018
[Sensory aphasia during therapy with metronidazole--an important differential diagnosis of acute cerebral ischemia].
    Deutsche medizinische Wochenschrift (1946), 2014, Volume: 139, Issue:46

    Topics: Acute Disease; Aged; Anti-Infective Agents; Aphasia, Wernicke; Brain Ischemia; Diagnosis, Differenti

2014