metronidazole has been researched along with Brain Ischemia in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
Excerpt | Relevance | Reference |
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" Lumbar spinal magnetic resonance imaging (MRI) revealed infective spondylitis, and metronidazole (1." | 4.31 | Metronidazole-induced encephalopathy delayed diagnosis due to cerebellar infarction: A case report. ( Cha, S; Cho, KH; Lee, BC; Moon, CW, 2023) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (25.00) | 29.6817 |
2010's | 2 (50.00) | 24.3611 |
2020's | 1 (25.00) | 2.80 |
Authors | Studies |
---|---|
Cha, S | 1 |
Lee, BC | 1 |
Moon, CW | 1 |
Cho, KH | 2 |
Takada, K | 1 |
Maki, Y | 1 |
Kinosada, M | 1 |
Ishibashi, R | 1 |
Chin, M | 1 |
Yamagata, S | 1 |
Kowar, M | 1 |
Frackowiak, M | 1 |
Friedrich, C | 1 |
Wilhelm, K | 1 |
Walger, P | 1 |
Jacobs, AH | 1 |
Song, HC | 1 |
Bom, HS | 1 |
Kim, BC | 1 |
Seo, JJ | 1 |
Kim, CG | 1 |
Yang, DJ | 1 |
Kim, EE | 1 |
1 trial available for metronidazole and Brain Ischemia
Article | Year |
---|---|
Prognostication of recovery in patients with acute ischemic stroke through the use of brain SPECT with Technetium-99m--labeled metronidazole.
Topics: Acute Disease; Aged; Brain; Brain Ischemia; Cysteine; Diffusion Magnetic Resonance Imaging; Female; | 2003 |
3 other studies available for metronidazole and Brain Ischemia
Article | Year |
---|---|
Metronidazole-induced encephalopathy delayed diagnosis due to cerebellar infarction: A case report.
Topics: Aged; Anti-Bacterial Agents; Brain Diseases; Brain Ischemia; Cerebellar Diseases; Delayed Diagnosis; | 2023 |
Metronidazole Induced Encephalopathy Mimicking an Acute Ischemic Stroke Event.
Topics: Aged, 80 and over; Anti-Bacterial Agents; Brain Ischemia; Diagnosis, Differential; Female; Humans; M | 2018 |
[Sensory aphasia during therapy with metronidazole--an important differential diagnosis of acute cerebral ischemia].
Topics: Acute Disease; Aged; Anti-Infective Agents; Aphasia, Wernicke; Brain Ischemia; Diagnosis, Differenti | 2014 |