metronidazole has been researched along with Jaw Diseases in 6 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Jaw Diseases: Diseases involving the JAW.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The preliminary results seem to suggest that biphosphonate-associated osteonecrosis can be well controlled by a nonsurgical protocol consisting in long-term administration of antibiotics." | 2.73 | Biphosphonate-associated osteonecrosis can be controlled by nonsurgical management. ( Felicetti, L; Gissi, DB; Marchetti, C; Montebugnoli, L; Pelliccioni, GA; Pizzigallo, A, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Montebugnoli, L | 1 |
| Felicetti, L | 1 |
| Gissi, DB | 1 |
| Pizzigallo, A | 1 |
| Pelliccioni, GA | 1 |
| Marchetti, C | 1 |
| Feki, A | 1 |
| Wilson, P | 1 |
| Taylor, MR | 1 |
| Keane, CT | 1 |
| English, L | 1 |
| Allen, M | 1 |
| Greenwood, AG | 1 |
| Taylor, DC | 1 |
| Bridgeman, A | 1 |
| Wiesenfeld, D | 1 |
| Hellyar, A | 1 |
| Sheldon, W | 1 |
| Chikhani, P | 1 |
1 trial available for metronidazole and Jaw Diseases
| Article | Year |
|---|---|
Biphosphonate-associated osteonecrosis can be controlled by nonsurgical management.
Topics: Aged; Amoxicillin-Potassium Clavulanate Combination; Analysis of Variance; Anti-Bacterial Agents; Bo | 2007 |
5 other studies available for metronidazole and Jaw Diseases
| Article | Year |
|---|---|
[Significance of a spiramycin-metronidazole combination in the treatment of acute, circumscribed perimaxillary cellulitis].
Topics: Acute Disease; Adult; Cellulitis; Drug Combinations; Drug Tolerance; Female; Humans; Jaw Diseases; L | 1981 |
Metronidazole in the treatment of lumpy-jaw in a Bennett's wallaby.
Topics: Ampicillin; Animals; Bacteroides Infections; Cloxacillin; Female; Jaw Diseases; Macropodidae; Marsup | 1980 |
Metronidazole in the treatment of lumpy-jaw.
Topics: Animals; Fusobacterium Infections; Jaw Diseases; Marsupialia; Metronidazole | 1980 |
Major maxillofacial infections. An evaluation of 107 cases.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacterial Infections; Clinical Pr | 1995 |
[A highly synergistic antibacterial combination].
Topics: Drug Synergism; Humans; Jaw Diseases; Leucomycins; Metronidazole; Mouth Diseases | 1971 |