Cockayne Syndrome

Type C is a rare form. Its genetic defect is not clear; appears to be a heterogeneous group. OMIM suggests that Type C should not be used anymore.

Synonym
Cockayne Syndrome, Group C
Cockayne Syndrome, Type A
Cockayne Syndrome, Type B
Cockayne Syndrome, Type I
Cockayne Syndrome, Type II
Cockayne Syndrome, Type III
Group C Cockayne Syndrome
Cockayne Syndrome, Type C
Type A Cockayne Syndrome
Type B Cockayne Syndrome
Type C Cockayne Syndrome
Type I Cockayne Syndrome
Type II Cockayne Syndrome
Group B Cockayne Syndrome
Type III Cockayne Syndrome
Group A Cockayne Syndrome
Progeroid Nanism
Progeria-Like Syndrome
Dwarfism-Retinal Atrophy-Deafness Syndrome
Cockayne Syndrome
Cockayne Syndrome Type 3
Cockayne Syndrome Type C
Cockayne Syndrome, Group A
Cockayne Syndrome, Group B

Excerpt	Reference
"Cockayne syndrome is a rare autosomal recessive disorder of childhood characterized by cachectic dwarfism with senile-like appearance, mental retardation, photosensitive dermatitis, loss of adipose tissue, pigmentary degeneration of retina, microcephaly, deafness, skeletal and neurologic abnormalities."	( Baek, HS; Chang, SH; Cho, SB; Lee, DY; Park, SK, 1994)
"Cockayne syndrome is an accelerated aging disorder, caused by mutations in the CSA or CSB genes."	( Babbar, M; Bohr, VA; Croteau, DL; De, S; Demarest, TG; Kim, EW; Lee, JH; Okur, MN, 2019)

Excerpt	Reference
"Patients We studied 3 patients with Cockayne syndrome, a rare autosomal recessive neurodegenerative disorder for which no known treatments are available."	( Delgado, MR; Donovan, MA; Jou, RL; Kang, PB; Kim, SY; Neilan, EG; Wu, BL, 2008)
"Through the Cockayne Syndrome Natural History Study, we have identified 8 cases of acute hepatic failure after metronidazole administration (8% of our cohort), 3 of which were fatal."	( Munkley, J; O'Kelly, S; Stark, Z; Strong, A; Wilson, BT, 2015)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	31 (17.22)	23.3326
1990's	50 (27.78)	12.5806
2000's	56 (31.11)	18.1394
2010's	33 (18.33)	28.8240
2020's	10 (5.56)	9.53

Drug	Relationship Strength	Studies
dinitrochlorobenzene	low	1
adenine	low	2
cadaverine	low	1
3-hydroxybutyric acid	low	1
cytosine	low	2
dihydrouracil	low	1
formaldehyde	low	1
melatonin	low	1
niacin	low	2
putrescine	low	1
thymine	low	3
toluene	low	1
uracil	low	1
3-aminobenzamide	low	1
hydroxyindoleacetic acid	low	1
amitriptyline	low	1
benzo(a)pyrene	low	1
caffeine	low	1
diazoxide	low	1
hydroxyurea	low	3
methyl methanesulfonate	low	1
metronidazole	low	2
nifedipine	low	1
pifithrin	low	1
pioglitazone	low	1
sevoflurane	low	1
mitomycin	low	3
prednisolone	low	1
thymidine	low	2
bromouracil	low	1
2-acetylaminofluorene	low	1
idoxuridine	low	1
serine	low	1
4-nitroquinoline-1-oxide	low	1
lysine	low	2
9,10-dimethyl-1,2-benzanthracene	low	1
methyltestosterone	low	3
uridine	low	1
bromodeoxyuridine	low	1
galactose	low	1
levodopa	low	1
tyrosine	low	1
methylene blue	low	1
cycloheximide	low	1
mannitol	low	1
cytarabine	low	4
arginine	low	1
picryl chloride	low	1
diethylhexyl phthalate	low	2
thiazoles	low	1
3-hydroxyflavone	low	1
glycopyrrolate	low	1
acetylcysteine	low	1
deoxycytidine	low	1
deoxycytidine monophosphate	low	1
d-alpha tocopherol	low	1
paraquat	low	2
thymine glycol	low	3
acetoxyacetylaminofluorene	low	3
camptothecin	low	1
ozone	low	1
glutamic acid	low	1
etoposide	low	1
7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	low	1
6-sulfatoxymelatonin	low	1
bromates	low	2
5-bromouridine	low	1
pyrimidine dimers	low	26
1,n(6)-ethenoadenine	low	1
ecteinascidin 743	low	1
peroxynitrous acid	low	1
imatinib mesylate	low	1
irofulven	low	1
paromomycin	low	1
biotin	low	1
3-nitrotyrosine	low	1
leupeptins	low	1
inositol 3-phosphate	low	1
dactinomycin	low	2
aphidicolin	low	1
benzyloxycarbonylleucyl-leucyl-leucine aldehyde	low	1
5-hydroxy-2'-deoxycytidine	low	1
potassium permanganate	low	1
isomethyleugenol	low	1
sesquiterpenes	low	1
nadp	low	1
amanitins	low	7
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3h)-quinazolinone	low	1
fisetin	low	1
4-hydroxy-2-octenal	low	1
4-hydroxy-2-nonenal	low	1
6,7-dihydroxyflavone	low	1
8-hydroxyadenine	low	1
arsenic	low	1
sulfur	low	2
8,5'-cyclo-2'-deoxyadenosine	low	1
dihydrotachysterol	low	4
nad	low	9
oligonucleotides	low	1
c-peptide	low	1
potassium bromate	low	2
sodium ethylxanthate	low	1
heme	low	1
epidermal growth factor	low	1
transforming growth factor beta	low	1
antipain	low	1
deoxyguanosine	low	7
2'-deoxyguanosine 5'-phosphate	low	1
deoxyguanosine triphosphate	low	1
guanine	low	13
guanosine	low	2
allopurinol	low	1
8-hydroxyguanosine	low	2
8-hydroxyguanine	low	13
8-hydroxy-2'-deoxyguanosine	low	5
3,n(4)-ethanocytosine	low	1
cytidylyl-3'-5'-guanosine	low	1
eye	low	2
carbidopa	low	1
concanavalin a	low	1
metallothionein	low	1

Protein Targets (1,015)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Luciferase	8	0	0	8
RAR-related orphan receptor gamma	23	0	0	23
AR protein	32	0	0	32
estrogen receptor 2 (ER beta)	14	0	0	14
nuclear receptor subfamily 1, group I, member 3	20	0	0	20
progesterone receptor	18	0	0	18
glucocorticoid receptor [Homo sapiens]	24	0	0	24
retinoic acid nuclear receptor alpha variant 1	25	0	0	25
estrogen-related nuclear receptor alpha	29	0	0	29
pregnane X nuclear receptor	19	0	0	19
estrogen nuclear receptor alpha	37	0	0	37
aryl hydrocarbon receptor	13	0	0	13
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	16	0	0	16
thyroid stimulating hormone receptor	9	0	0	9
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	11	0	0	11
thyroid hormone receptor beta isoform 2	21	0	0	21
histone deacetylase 9 isoform 3	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	19	0	0	19
5-hydroxytryptamine receptor 4	0	6	0	6
Voltage-dependent calcium channel gamma-2 subunit	19	0	0	19
Cytochrome P450 1A2	0	4	0	4
Aldo-keto reductase family 1 member B1	0	4	0	4
Alpha-2A adrenergic receptor	0	4	0	4
Glutamate receptor 2	20	2	1	25
Amine oxidase [flavin-containing] A	0	5	0	5
Sodium-dependent noradrenaline transporter	0	4	1	5
5-hydroxytryptamine receptor 2C	0	6	0	6
Sodium-dependent serotonin transporter	0	4	0	4
5-hydroxytryptamine receptor 2B	0	6	0	6
ATPase family AAA domain-containing protein 5	15	0	0	15
Ataxin-2	18	0	0	18
Chain A, Ferritin light chain	7	0	0	7
glp-1 receptor, partial	11	0	0	11
thioredoxin reductase	14	0	0	14
TDP1 protein	29	0	0	29
Smad3	8	0	0	8
nonstructural protein 1	3	0	0	3
67.9K protein	11	0	0	11
IDH1	12	0	0	12
euchromatic histone-lysine N-methyltransferase 2	22	0	0	22
polyunsaturated fatty acid lipoxygenase ALOX12	5	0	0	5
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	9	0	0	9
chromobox protein homolog 1	17	0	0	17
DNA polymerase eta isoform 1	4	0	0	4
nuclear receptor ROR-gamma isoform 1	10	0	0	10
geminin	29	0	0	29
neuropeptide S receptor isoform A	3	0	0	3
TAR DNA-binding protein 43	11	0	0	11
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	23	0	0	23
Chain A, HADH2 protein	11	0	0	11
Chain B, HADH2 protein	11	0	0	11
Chain A, 2-oxoglutarate Oxygenase	11	0	0	11
Chain A, Cruzipain	4	0	0	4
aldehyde dehydrogenase 1 family, member A1	17	0	0	17
cytochrome P450 2D6 isoform 1	5	0	0	5
cytochrome P450 2C9 precursor	4	0	0	4
lamin isoform A-delta10	17	0	0	17
Poly [ADP-ribose] polymerase 2	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	2	0	2
Poly [ADP-ribose] polymerase 1	0	1	0	1
Histamine H2 receptor	7	1	0	9
Transporter	0	1	0	1
ATP-dependent phosphofructokinase	11	0	0	11
Protein skinhead-1	0	1	0	1
Monocarboxylate transporter 2	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
USP1 protein, partial	12	0	0	12
apical membrane antigen 1, AMA1	6	0	0	6
cellular tumor antigen p53 isoform a	8	0	0	8
importin subunit beta-1 isoform 1	8	0	0	8
mitogen-activated protein kinase 1	7	0	0	7
snurportin-1	8	0	0	8
GTP-binding nuclear protein Ran isoform 1	5	0	0	5
DNA polymerase iota isoform a (long)	14	0	0	14
urokinase-type plasminogen activator precursor	12	0	0	12
plasminogen precursor	12	0	0	12
urokinase plasminogen activator surface receptor precursor	12	0	0	12
cytochrome P450 3A4 isoform 1	12	0	0	12
Gamma-aminobutyric acid receptor subunit pi	12	0	0	12
Polyunsaturated fatty acid lipoxygenase ALOX15B	5	2	0	7
Carbonic anhydrase 12	0	2	0	4
Carbonic anhydrase 1	0	3	0	6
Carbonic anhydrase 2	0	5	0	9
Integrin beta-3	6	0	1	7
ATP-dependent translocase ABCB1	0	3	1	6
Integrin alpha-IIb	6	0	1	7
Calmodulin-1	0	1	0	1
Androgen receptor	0	3	0	3
Pyruvate kinase PKM	0	3	1	4
Gamma-aminobutyric acid receptor subunit beta-1	12	0	0	12
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX12	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	12	0	0	12
Gamma-aminobutyric acid receptor subunit gamma-2	12	0	0	12
Gamma-aminobutyric acid receptor subunit alpha-5	12	0	0	12
Gamma-aminobutyric acid receptor subunit alpha-3	12	0	0	12
Gamma-aminobutyric acid receptor subunit gamma-1	12	0	0	12
Gamma-aminobutyric acid receptor subunit alpha-2	12	0	0	12
Gamma-aminobutyric acid receptor subunit alpha-4	12	0	0	12
Gamma-aminobutyric acid receptor subunit gamma-3	12	0	0	12
Gamma-aminobutyric acid receptor subunit alpha-6	12	0	0	12
Xanthine dehydrogenase/oxidase	0	6	0	6
Fatty acid synthase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	12	0	0	12
Gamma-aminobutyric acid receptor subunit beta-3	12	0	0	12
Gamma-aminobutyric acid receptor subunit beta-2	12	0	0	12
Cytochrome P450 1B1	0	2	0	2
Carbonic anhydrase 9	0	3	0	6
GABA theta subunit	12	0	0	12
Aurora kinase B	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	12	0	0	12
Dipeptidyl peptidase 3	0	2	0	2
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	5	0	0	5
Chain A, JmjC domain-containing histone demethylation protein 3A	11	0	0	11
phosphopantetheinyl transferase	13	0	0	13
bromodomain adjacent to zinc finger domain 2B	7	0	0	7
pyruvate kinase PKM isoform a	2	0	0	2
Glycoprotein hormones alpha chain	2	0	0	2
Guanine nucleotide-binding protein G	3	0	0	3
Tubulin--tyrosine ligase	0	2	0	2
Microtubule-associated protein tau	11	0	0	11
vitamin D3 receptor isoform VDRA	9	0	0	9
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
15-lipoxygenase, partial	7	0	0	7
DNA polymerase kappa isoform 1	7	0	0	7
survival motor neuron protein isoform d	13	0	0	13
caspase-1 isoform alpha precursor	4	0	0	4
Aromatase	0	3	0	3
Aldo-keto reductase family 1 member B1	0	1	0	1
Caspase-7	4	0	0	4
Chain A, Avidin	0	0	2	2
Chain A, Avidin	0	0	2	2
Chain B, Avidin	0	0	2	2
Olfactory receptor 51E2	0	0	1	1
Chain A, Beta-lactamase	4	0	0	4
acid sphingomyelinase	2	0	0	2
pregnane X receptor	7	0	0	7
hypoxia-inducible factor 1 alpha subunit	10	0	0	10
SMAD family member 2	8	0	0	8
ATAD5 protein, partial	10	0	0	10
SMAD family member 3	8	0	0	8
GLI family zinc finger 3	20	0	0	20
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	6	0	0	6
thyroid stimulating hormone receptor	12	0	0	12
retinoid X nuclear receptor alpha	18	0	0	18
farnesoid X nuclear receptor	14	0	0	14
glucocerebrosidase	4	0	0	4
P53	2	0	0	2
peroxisome proliferator-activated receptor delta	14	0	0	14
peroxisome proliferator activated receptor gamma	13	0	0	13
vitamin D (1,25- dihydroxyvitamin D3) receptor	14	0	0	14
activating transcription factor 6	9	0	0	9
v-jun sarcoma virus 17 oncogene homolog (avian)	13	0	0	13
Caspase-7	3	0	0	3
serine-protein kinase ATM isoform a	2	0	0	2
thyroid hormone receptor beta isoform a	13	0	0	13
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
caspase-3	3	0	0	3
heat shock protein beta-1	10	0	0	10
nuclear factor NF-kappa-B p105 subunit isoform 1	2	0	0	2
ras-related protein Rab-9A	5	0	0	5
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
Cellular tumor antigen p53	21	0	0	21
Nuclear receptor ROR-gamma	8	0	0	8
Chain A, ATP-DEPENDENT DNA HELICASE Q1	7	0	0	7
acetylcholinesterase	6	0	0	6
dopamine D1 receptor	2	0	0	2
NFKB1 protein, partial	8	0	0	8
Thrombopoietin	3	0	0	3
regulator of G-protein signaling 4	8	0	0	8
arylsulfatase A	4	0	0	4
Bloom syndrome protein isoform 1	9	0	0	9
D(1A) dopamine receptor	4	0	0	4
flap endonuclease 1	4	0	0	4
peripheral myelin protein 22	9	0	0	9
muscarinic acetylcholine receptor M1	9	0	0	9
Histone deacetylase 3	0	2	0	2
Solute carrier family 22 member 6	0	1	0	1
Histone deacetylase 4	0	2	0	2
Histone deacetylase 1	0	2	0	2
Histone deacetylase 7	0	2	0	2
Histone deacetylase 2	0	2	0	2
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	2	0	2
Histone deacetylase 8	0	2	0	2
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	2	0	2
Histone deacetylase 5	0	2	0	2
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
cytochrome P450 family 3 subfamily A polypeptide 4	11	0	0	11
nuclear factor erythroid 2-related factor 2 isoform 2	11	0	0	11
tumor susceptibility gene 101 protein	1	0	0	1
Bile salt export pump	0	16	0	16
Cyclin-dependent kinase 1	0	2	0	2
Heat shock protein HSP 90-beta	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
interleukin 8	6	0	0	6
transcriptional regulator ERG isoform 3	2	0	0	2
ATP-binding cassette sub-family C member 3	0	14	0	14
Multidrug resistance-associated protein 4	0	14	0	14
Polyphenol oxidase 2	0	2	0	4
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	2
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	0	1	0	1
Adenosine receptor A2a	0	3	2	6
Nuclear receptor ROR-gamma	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	1	4
Purine nucleoside phosphorylase	0	0	1	1
Canalicular multispecific organic anion transporter 1	0	14	0	15
Shiga toxin subunit A	0	2	0	2
Histamine H3 receptor	0	1	0	1
GLS protein	10	0	0	10
cytochrome P450 2D6	5	0	0	5
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	6	0	0	6
Solute carrier family 22 member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	4	0	4
Albumin	0	0	1	1
High affinity nerve growth factor receptor	0	1	2	3
Muscarinic acetylcholine receptor M2	0	4	0	5
Muscarinic acetylcholine receptor M4	0	3	0	4
Muscarinic acetylcholine receptor M1	0	1	1	2
Muscarinic acetylcholine receptor M3	0	1	1	2
Muscarinic acetylcholine receptor M4	0	1	1	2
5-hydroxytryptamine receptor 2C	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	1	2
Muscarinic acetylcholine receptor M5	0	3	0	4
Muscarinic acetylcholine receptor M2	0	1	1	2
Muscarinic acetylcholine receptor M1	0	3	0	4
Angiotensin-converting enzyme	0	2	0	2
D(2) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	3	0	3
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
Muscarinic acetylcholine receptor M3	0	4	0	5
D(1A) dopamine receptor	0	2	0	2
D(1B) dopamine receptor	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	1
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	0	2
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
5-hydroxytryptamine receptor 6	0	1	0	1
Histamine H1 receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
Histamine H1 receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	2	0	2
UDP-glucuronosyltransferase 1A3	0	0	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
Alpha-1A adrenergic receptor	0	5	0	5
D(1A) dopamine receptor	3	0	0	3
5-hydroxytryptamine receptor 6	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	4	0	4
Sodium-dependent dopamine transporter	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1S	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	5
Sodium channel protein type 5 subunit alpha	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	0	1	1
5-hydroxytryptamine receptor 4	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
5-hydroxytryptamine receptor 3B	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	2	0	2
Sodium channel protein type 11 subunit alpha	0	2	0	2
Sodium channel protein type 8 subunit alpha	0	2	0	2
Histamine H3 receptor	0	2	0	2
Sodium channel protein type 10 subunit alpha	0	2	0	2
huntingtin isoform 2	4	0	0	4
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase beta	0	1	0	1
DNA polymerase beta	0	1	0	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase alpha catalytic subunit	0	1	1	2
DNA polymerase delta catalytic subunit	0	1	0	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase subunit gamma-1	0	1	1	2
DNA polymerase lambda	0	1	0	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
alpha-galactosidase	3	0	0	3
cytochrome P450 2C19 precursor	3	0	0	3
lethal factor (plasmid)	8	0	0	8
Cytochrome P450 3A4	0	3	0	5
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	2	0	2
caspase 7, apoptosis-related cysteine protease	7	0	0	7
caspase-3	7	0	0	7
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	5	0	0	5
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Tyrosine-protein kinase Fyn	0	2	0	2
Acetylcholinesterase	0	5	0	5
Aryl hydrocarbon receptor	0	0	1	1
Proteasome subunit beta type-11	0	1	0	1
Fumarate hydratase	8	0	0	8
PPM1D protein	5	0	0	5
EWS/FLI fusion protein	11	0	0	11
polyprotein	8	0	0	8
Calpain-9	0	1	0	1
Proteasome subunit alpha type-7	0	1	0	1
Interferon beta	10	0	0	10
Cathepsin B	0	1	0	1
Replicase polyprotein 1ab	0	2	1	3
Replicase polyprotein 1ab	0	2	1	3
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Calpain-2 catalytic subunit	0	1	0	1
Proteasome subunit beta type-1	0	2	0	2
Proteasome subunit alpha type-1	0	1	0	1
Proteasome subunit alpha type-2	0	1	0	1
Proteasome subunit alpha type-3	0	1	0	1
Proteasome subunit alpha type-4	0	1	0	1
NF-kappa-B inhibitor alpha	0	0	1	1
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-9	0	1	0	1
Proteasome subunit alpha type-5	0	1	0	1
Proteasome subunit beta type-4	0	1	0	1
Proteasome subunit beta type-6	0	1	0	1
Proteasome subunit beta type-5	0	2	0	2
Proteasome subunit beta type-10	0	1	0	1
Cathepsin K	0	1	0	1
Proteasome subunit beta type-3	0	1	0	1
Proteasome subunit beta type-2	0	2	0	2
Proteasome subunit alpha type-6	0	1	0	1
Proteasome subunit alpha-type 8	0	1	0	1
Proteasome subunit beta type-7	0	1	0	1
Gamma-secretase subunit PEN-2	0	1	0	1
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
nonstructural protein 1	0	1	0	1
green fluorescent protein, partial	0	1	0	1
insulin-degrading enzyme isoform 1	0	0	1	1
Streptavidin	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
Nuclear hormone receptor family member daf-12	0	0	1	1
oxysterols receptor LXR-beta isoform 1	0	0	1	1
Thymidine kinase, cytosolic	0	6	0	9
Thymidine phosphorylase	0	0	0	3
Thymidylate kinase	0	2	0	2
Spike glycoprotein	7	0	1	8
Thymidine kinase	0	0	0	3
Thymidylate kinase	0	2	0	2
Carbonic anhydrase 3	0	1	0	3
Cannabinoid receptor 1	0	1	0	1
Carbonic anhydrase 4	0	2	0	4
Carbonic anhydrase 6	0	1	0	3
Carbonic anhydrase 5A, mitochondrial	0	2	0	4
Carbonic anhydrase 7	0	1	0	3
Carbonic anhydrase 15	0	1	0	3
Carbonic anhydrase 13	0	1	0	2
Carbonic anhydrase 14	0	1	0	3
Carbonic anhydrase 5B, mitochondrial	0	1	0	3
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
DNA polymerase beta	2	0	0	2
Potassium channel subfamily K member 2	0	0	2	2
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	1	0	1
Cholinesterase	0	2	0	2
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Adenosine receptor A3	0	3	0	3
Adenosine receptor A1	0	2	0	5
Amine oxidase [flavin-containing] B	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	2	0	3
Adenosine receptor A1	0	3	1	6
Adenosine receptor A2a	0	3	0	7
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	2	2	4
Endochitinase B1	0	1	0	1
Muscarinic acetylcholine receptor	0	0	0	1
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	2
Guanine deaminase	0	1	0	2
DNA topoisomerase	0	1	0	1
putative alpha-glucosidase	1	0	0	1
lysosomal alpha-glucosidase preproprotein	2	0	0	2
peripheral myelin protein 22 isoform 1	5	0	0	5
hemoglobin subunit beta	2	0	0	2
eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor	0	0	1	1
M-phase phosphoprotein 8	5	0	0	5
muscleblind-like protein 1 isoform 1	4	0	0	4
histone acetyltransferase KAT2A isoform 1	3	0	0	3
relaxin receptor 1 isoform 1	1	0	0	1
Telomerase reverse transcriptase	0	1	0	1
Serine/threonine-protein kinase Chk1	0	0	1	1
Type-2 restriction enzyme ScaI	0	1	0	1
Deoxyribonuclease-2-alpha	0	1	0	1
Tyrosyl-DNA phosphodiesterase 2	0	1	0	1
Deoxyribonuclease-1	0	1	0	1
Type-2 restriction enzyme PstI	0	1	0	1
Type-2 restriction enzyme EcoRI	0	1	0	1
Prothrombin	0	0	1	3
DNA ligase	0	1	0	1
Heterogeneous nuclear ribonucleoprotein A1	0	0	1	1
DNA topoisomerase 1	0	2	1	8
DNA topoisomerase 2-alpha	0	2	1	8
Type-2 restriction enzyme BamHI	0	1	0	1
Somatostatin receptor type 1	0	1	0	1
Somatostatin receptor type 2	0	1	0	1
Somatostatin receptor type 4	0	1	0	1
Somatostatin receptor type 3	0	1	0	1
Somatostatin receptor type 5	0	1	0	1
Type-2 restriction enzyme HindIII	0	1	0	1
Ribonuclease pancreatic	0	1	0	1
Inositol monophosphatase 1	5	0	0	5
DNA topoisomerase 2-beta	0	1	1	9
DNA topoisomerase 1	0	1	0	2
DNA topoisomerase 1	0	1	0	1
Integrase	0	3	0	3
DNA topoisomerase type IB small subunit	0	0	1	1
Tyrosyl-DNA phosphodiesterase 1	0	2	0	2
RPL19A	0	0	1	1
Histone H2A.x	11	0	0	11
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	3	0	3
COUP transcription factor 2 isoform a	0	1	0	1
Transmembrane protease serine 2	0	0	1	1
Glucose transporter	0	1	0	1
Hexose transporter 1	0	1	0	1
Procathepsin L	0	0	1	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 1	0	1	0	1
Alpha-synuclein	2	0	0	2
Eukaryotic initiation factor 4A-I	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	0	2
Peptidyl-prolyl cis-trans isomerase FKBP3	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP4	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	1	0	1
Endothelial PAS domain-containing protein 1	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP14	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4	0	1	0	1
heat shock protein 90, putative	0	0	0	1
endonuclease IV	3	0	0	3
G	4	0	0	4
LMP1 [Human herpesvirus 4]	0	0	0	3
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	2	0	2
nuclear receptor coactivator 3 isoform a	0	2	0	2
Thymidine kinase 2, mitochondrial	0	1	0	1
HLA class I histocompatibility antigen, B alpha chain	4	0	0	4
Thymidine kinase	0	2	0	3
Thymidylate synthase	0	0	0	2
Thymidine kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	3
Probable deoxycytidylate deaminase	0	0	0	2
Cytidine deaminase	0	2	0	4
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	2
Inositol hexakisphosphate kinase 1	4	0	0	4
Thymidine kinase	0	1	0	2
Deoxynucleoside kinase	0	1	0	1
cytochrome P450 2C9, partial	4	0	0	4
Deoxycytidine kinase	0	0	0	1
Rap guanine nucleotide exchange factor 3	3	0	0	3
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
RAD51	0	1	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	0	1	0	1
Growth factor receptor-bound protein 2	0	1	0	1
Pantothenate synthetase	0	1	0	1
Discoidin domain-containing receptor 2	0	1	0	1
Growth factor receptor-bound protein 2	0	1	0	1
Reverse transcriptase/RNaseH	0	1	2	4
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase	0	0	1	1
Thymidine kinase 2	0	1	0	1
AAA family ATPase	0	0	0	1
Chain A, Thymidylate Synthase	0	0	1	1
Chain A, Thymidylate Synthase	0	0	1	1
Chain A, Thymidylate Synthase	0	0	1	1
Chain A, Thymidylate Synthase	0	0	1	1
Chain A, Thymidylate Synthase	0	0	1	1
UMP-CMP kinase	0	0	0	1
Deoxycytidylate deaminase	0	0	0	1
AAA family ATPase	0	0	0	1
Sterol O-acyltransferase 1	0	2	0	2
Coagulation factor VII	0	1	0	1
Tissue factor	0	1	0	1
Glutamate receptor 1	1	2	1	6
Glutamate receptor 3	1	2	1	6
Glutamate receptor 4	1	2	1	6
Nicotinamide phosphoribosyltransferase	0	0	1	1
ATP-binding cassette sub-family C member 8	0	1	1	2
ATP-sensitive inward rectifier potassium channel 11	0	1	1	2
thioredoxin glutathione reductase	2	0	0	2
Vpr	3	0	0	3
Glutathione S-transferase omega-1	0	1	0	1
Regulatory protein E2	0	0	1	1
ATP-dependent translocase ABCB1	0	1	0	1
Cytochrome P450 2C9	0	4	1	5
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
DNA topoisomerase 2	0	0	0	1
ATP-dependent translocase ABCB1	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	0	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	1	6
Caspase-3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	1	6
Glutamate receptor ionotropic, NMDA 2B	0	2	1	6
Glutamate receptor ionotropic, NMDA 2C	0	2	1	6
DNA topoisomerase 2-alpha	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	2	1	6
Tubulin beta-2B chain	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	1	6
Solute carrier organic anion transporter family member 1B3	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	2	1	6
Chain B, Cell division protein kinase 6	0	1	0	1
G2/mitotic-specific cyclin-B2	0	1	0	1
Alpha-amylase 1A	0	1	0	1
Serine/threonine-protein kinase pim-1	0	1	0	2
G2/mitotic-specific cyclin-B1	0	1	0	1
G2/mitotic-specific cyclin-B	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
Casein kinase II subunit alpha'	0	2	0	2
Cyclin-dependent kinase 2	0	1	0	1
Cruzipain	0	2	0	2
Testosterone 17-beta-dehydrogenase 3	0	1	0	1
Tyrosine-protein kinase SYK	0	1	1	2
1-deoxy-D-xylulose 5-phosphate reductoisomerase	0	1	0	1
Glycogen synthase kinase-3 alpha	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
Mitogen-activated protein kinase 10	0	1	0	1
Casein kinase II subunit beta	0	2	0	2
Casein kinase II subunit alpha	0	2	0	2
Cyclin-dependent kinase 6	0	1	0	1
Cyclin-dependent-like kinase 5	0	1	0	1
Cyclin homolog	0	1	0	1
Lactoylglutathione lyase	0	1	0	1
Cyclin-dependent kinase 5 activator 1	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Casein kinase II subunit alpha 3	0	1	0	1
G2/mitotic-specific cyclin-B3	0	1	0	1
CREB-binding protein	1	0	0	1
Enoyl-acyl-carrier protein reductase	0	1	0	1
3-oxoacyl-acyl-carrier protein reductase	0	1	0	1
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)	0	1	0	1
Cyclin-dependent kinase 1	0	1	0	1
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	2	0	0	2
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutathione reductase, mitochondrial	0	7	0	8
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	2	1	3
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	1	0	1
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	3
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Purine nucleoside phosphorylase	0	2	0	3
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Adenosylhomocysteinase	0	1	0	2
hypothetical protein, conserved	3	0	0	3
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Stromelysin-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Urease subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Ribonucleoside-diphosphate reductase large subunit	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Urease subunit beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Thymidine kinase	0	2	0	3
DNA repair protein RAD52 homolog isoform a	0	0	0	2
Tyrosine-protein kinase ABL1	0	1	1	2
Cytochrome P450 2C8	0	0	0	1
Mast/stem cell growth factor receptor Kit	0	1	1	2
Breakpoint cluster region protein	0	0	1	1
Platelet-derived growth factor receptor alpha	0	1	1	2
Cytochrome P450 3A5	0	0	0	1
Prostaglandin reductase 1	0	1	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	4	0	0	4
WRN	1	0	0	1
integrase, partial	0	2	0	2
lens epithelium-derived growth factor p75	0	2	0	2
pyruvate kinase	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
Epidermal growth factor receptor	0	1	0	1
Plasma kallikrein	0	0	0	2
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosinase	0	1	0	1
Carbonic anhydrase	0	0	0	2
Solute carrier family 15 member 1	0	1	0	1
Carbonic anhydrase	0	0	0	2
Large neutral amino acids transporter small subunit 1	0	2	0	2
SLC16A10 protein	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Monocarboxylate transporter 10	0	0	0	2
phosphoglycerate kinase	2	0	0	2
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
ClpP	1	0	0	1
Cytochrome P450 1A1	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Myeloperoxidase	0	1	0	1
Cytochrome P450 2C11	0	1	0	1
Cytochrome P450 2D6	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Acetylcholinesterase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Carboxylic ester hydrolase	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Chain E, Fibrin beta chain	0	1	0	1
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
TSHR protein	1	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
luciferase	2	0	0	2
neutrophil cytosol factor 1	0	1	0	1
caspase-9 isoform alpha precursor	0	1	0	1
caspase-3 isoform a preproprotein	0	1	0	1
protein AF-9 isoform a	0	0	0	1
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
POsterior Segregation	0	0	1	1
Glutathione reductase	0	1	0	1
Albumin	0	0	0	1
Amyloid-beta precursor protein	0	2	0	2
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Microtubule-associated protein tau	0	1	1	2
Alpha-1B adrenergic receptor	0	3	0	3
Alpha-1D adrenergic receptor	0	1	0	1
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
Zinc finger protein mex-5	0	0	1	1
Glucocorticoid receptor	0	4	1	10
Sex hormone-binding globulin	0	0	1	1
Glycine receptor subunit alpha-1	0	4	0	4
Androgen receptor	0	3	0	3
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
thyrotropin-releasing hormone receptor	1	0	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Cholesteryl ester transfer protein	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
D-amino-acid oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	1	3
Multidrug and toxin extrusion protein 1	0	1	0	1
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
Parkin	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
tumor necrosis factor	1	0	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
eyes absent homolog 2 isoform a	1	0	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Bile salt export pump	0	2	0	2
Phospholipase A2, membrane associated	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Thromboxane-A synthase	0	1	0	1
Platelet-activating factor receptor	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
C-C chemokine receptor type 2	0	2	0	2
Cytochrome P450 2J2	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Leukotriene B4 receptor 1	0	0	0	1
Myosin light chain kinase, smooth muscle	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Potassium channel subfamily K member 2	0	1	0	1
Beta-2 adrenergic receptor	0	0	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Leukotriene B4 receptor 2	0	0	0	1
Chain A, ARGINASE 1	0	1	0	1
Chain A, Arginase 1	0	1	0	1
Chain A, ARGINASE 1	0	1	0	1
Chain A, L-ARGININE\\:GLYCINE AMIDINOTRANSFERASE	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Pyruvate kinase, M2 isozyme	0	1	0	1
Chain A, Phosphonopyruvate hydrolase	0	1	0	1
Chain A, Phosphoenolpyruvate-protein phosphotransferase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Photosystem I iron-sulfur center	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Luciferin 4-monooxygenase	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	1	0	1
tyrosine-protein kinase Yes	1	0	0	1
Free fatty acid receptor 1	0	0	1	1
Peroxisome proliferator-activated receptor gamma	0	1	0	1
Steryl-sulfatase	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	1
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Peroxisome proliferator-activated receptor alpha	0	1	0	1
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	2	2	5
Peroxisome proliferator-activated receptor gamma	0	1	1	2
Carnitine O-palmitoyltransferase 1, liver isoform	0	1	0	1
Peroxisome proliferator-activated receptor alpha	0	1	1	2
CDGSH iron-sulfur domain-containing protein 2	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Chain A, PUTRESCINE-BINDING PROTEIN	0	0	1	1
Chain A, S-ADENOSYLMETHIONINE DECARBOXYLASE ALPHA CHAIN	0	1	0	1
Chain B, S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN	0	1	0	1
Chain A, S-ADENOSYLMETHIONINE DECARBOXYLASE ALPHA CHAIN	0	1	0	1
Chain B, S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN	0	1	0	1
Ornithine decarboxylase	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
S-adenosylmethionine decarboxylase proenzyme	0	0	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Acetylcholinesterase	0	1	0	1
Neutral amino acid transporter A	0	1	0	1
Cholinesterase	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Proton-coupled amino acid transporter 1	0	1	0	1
Amino acid transporter	0	1	0	1
Thymidine phosphorylase	0	0	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	1	0	2
Thymidine kinase	0	0	0	1
Thymidine phosphorylase	0	1	0	1
Endolysin	0	0	1	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Taste receptor type 2 member 14	0	0	0	1
Chain A, Uracil-DNA Glycosylase	0	1	0	1
Protein cereblon	0	4	0	4
Chain A, Cytidine Deaminase	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Sodium/nucleoside cotransporter 2	0	2	0	2
Equilibrative nucleoside transporter 2	0	2	0	2
Equilibrative nucleoside transporter 1	0	2	0	2
Uridine-cytidine kinase 1	0	0	0	1
Solute carrier family 28 member 3	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(24)

Research Excerpts

Overview

Treatment

Research

Studies (180)

Protein Targets (1,015)

Cockayne Syndrome

Synonyms(24)

Research Excerpts

Overview

Treatment

Research

Studies (180)

Drugs Studied (139)

Protein Targets (1,015)