metronidazole has been researched along with Liver Cirrhosis, Alcoholic in 1 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Liver Cirrhosis, Alcoholic: FIBROSIS of the hepatic parenchyma due to chronic excess ALCOHOL DRINKING.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronidazole was administered intravenously for 20 min to healthy volunteers, and to patients with alcohol-induced, non-cirrhotic hepatopathy and liver cirrhosis." | 1.30 | Plasma hydroxy-metronidazole/metronidazole ratio can detect early changes in hepatic function in ethanol-induced liver injury. ( Da Silva, CM; David, FL; De Nucci, G; Ferraz, JG; Muscará, MN; Pedrazzoli, J; Polimeno, NC; Sousa, SS, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Da Silva, CM | 1 |
| David, FL | 1 |
| Muscará, MN | 1 |
| Sousa, SS | 1 |
| Ferraz, JG | 1 |
| De Nucci, G | 1 |
| Polimeno, NC | 1 |
| Pedrazzoli, J | 1 |
1 other study available for metronidazole and Liver Cirrhosis, Alcoholic
| Article | Year |
|---|---|
Plasma hydroxy-metronidazole/metronidazole ratio can detect early changes in hepatic function in ethanol-induced liver injury.
Topics: Adolescent; Adult; Aged; Alcohol Drinking; Anti-Infective Agents; Chromatography, High Pressure Liqu | 1999 |