Compounds > tioxidazole
Page last updated: 2024-09-23

tioxidazole

Description

tioxidazole: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID72157
CHEMBL ID1371412
CHEBI ID188809
SCHEMBL ID23382
MeSH IDM0068780

Synonyms (63)

Synonym
CHEMDIVAM_000281
(6-propoxy-benzothiazol-2-yl)-carbamic acid methyl ester
OPREA1_503682
CHEMDIV1_000106
61570-90-9
tioxidazole (usan/inn)
tiox (tn)
D06158
tioxidazole
sch-21480
NCGC00160481-01
OPREA1_841146
STK832929
methyl (6-propoxy-1,3-benzothiazol-2-yl)carbamate
HMS587E18
AKOS000539060
CHEBI:188809
methyl n-(6-propoxy-1,3-benzothiazol-2-yl)carbamate
NCGC00160481-02
dtxsid7046178 ,
tox21_111843
cas-61570-90-9
dtxcid5026178
smr001353140
MLS004754522
CCG-103442
methyl 6-propoxy-2-benzothiazolecarbamate
tioxidazole [usan:inn]
einecs 262-854-2
tioxidazolum [inn-latin]
unii-nzw046ni85
tiox (veterinary)
carbamic acid, (6-propoxy-2-benzothiazolyl)-, methyl ester
nzw046ni85 ,
tioxidazol [inn-spanish]
tiox
sch 21480
tioxidazolum
tioxidazol
CHEMBL1371412
MLS006011641
SCHEMBL23382
tioxidazole [green book]
tioxidazole [usan]
tioxidazole [inn]
tioxidazole [mi]
methyl-6-n-propoxybenzothiazole-2-carbamate
HLLICFJUWSZHRJ-UHFFFAOYSA-N
methyl-6-n-propyloxybenzothiazole-2-carbamate
methyl (6-propoxybenzo[d]thiazol-2-yl)carbamate
sr-01000884010
SR-01000884010-1
DB11472
BRD-K08404405-001-01-0
nsc787556
nsc-787556
Q27285133
methyl(6-propoxybenzo[d]thiazol-2-yl)carbamate
tioxidazolum (inn-latin)
tioxidazol (inn-spanish)
methyl 6-n-propoxybenzothiazole-2-carbamate
tiox paste, tioxidazole paste
tiox granules

Drug Classes (1)

ClassDescription
benzothiazoles
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (16)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
LuciferasePhotinus pyralis (common eastern firefly)Potency1.14240.007215.758889.3584AID624030
TDP1 proteinHomo sapiens (human)Potency3.00540.000811.382244.6684AID686978; AID686979
AR proteinHomo sapiens (human)Potency3.11540.000221.22318,912.5098AID743035; AID743042; AID743054; AID743063
pregnane X nuclear receptorHomo sapiens (human)Potency10.00000.005428.02631,258.9301AID1346985
estrogen nuclear receptor alphaHomo sapiens (human)Potency1.50570.000229.305416,493.5996AID743079; AID743080; AID743091
aryl hydrocarbon receptorHomo sapiens (human)Potency3.60060.000723.06741,258.9301AID743085; AID743122
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency0.94390.001723.839378.1014AID743083
nuclear receptor subfamily 1, group I, member 2Rattus norvegicus (Norway rat)Potency2.51190.10009.191631.6228AID1346983
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency2.51570.000323.4451159.6830AID743065; AID743067
gemininHomo sapiens (human)Potency3.71140.004611.374133.4983AID624296; AID624297
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency0.22790.005612.367736.1254AID624032
lamin isoform A-delta10Homo sapiens (human)Potency2.51190.891312.067628.1838AID1487
Cellular tumor antigen p53Homo sapiens (human)Potency1.96810.002319.595674.0614AID651631; AID720552
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency39.81070.009610.525035.4813AID1479145
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency1.99830.011917.942071.5630AID651632; AID720516
Ataxin-2Homo sapiens (human)Potency1.88340.011912.222168.7989AID651632
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (141)

Processvia Protein(s)Taxonomy
negative regulation of cell population proliferationCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycleCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycle G2/M phase transitionCellular tumor antigen p53Homo sapiens (human)
DNA damage responseCellular tumor antigen p53Homo sapiens (human)
ER overload responseCellular tumor antigen p53Homo sapiens (human)
cellular response to glucose starvationCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
positive regulation of miRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
negative regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
mitophagyCellular tumor antigen p53Homo sapiens (human)
in utero embryonic developmentCellular tumor antigen p53Homo sapiens (human)
somitogenesisCellular tumor antigen p53Homo sapiens (human)
release of cytochrome c from mitochondriaCellular tumor antigen p53Homo sapiens (human)
hematopoietic progenitor cell differentiationCellular tumor antigen p53Homo sapiens (human)
T cell proliferation involved in immune responseCellular tumor antigen p53Homo sapiens (human)
B cell lineage commitmentCellular tumor antigen p53Homo sapiens (human)
T cell lineage commitmentCellular tumor antigen p53Homo sapiens (human)
response to ischemiaCellular tumor antigen p53Homo sapiens (human)
nucleotide-excision repairCellular tumor antigen p53Homo sapiens (human)
double-strand break repairCellular tumor antigen p53Homo sapiens (human)
regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
protein import into nucleusCellular tumor antigen p53Homo sapiens (human)
autophagyCellular tumor antigen p53Homo sapiens (human)
DNA damage responseCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorCellular tumor antigen p53Homo sapiens (human)
transforming growth factor beta receptor signaling pathwayCellular tumor antigen p53Homo sapiens (human)
Ras protein signal transductionCellular tumor antigen p53Homo sapiens (human)
gastrulationCellular tumor antigen p53Homo sapiens (human)
neuroblast proliferationCellular tumor antigen p53Homo sapiens (human)
negative regulation of neuroblast proliferationCellular tumor antigen p53Homo sapiens (human)
protein localizationCellular tumor antigen p53Homo sapiens (human)
negative regulation of DNA replicationCellular tumor antigen p53Homo sapiens (human)
negative regulation of cell population proliferationCellular tumor antigen p53Homo sapiens (human)
determination of adult lifespanCellular tumor antigen p53Homo sapiens (human)
mRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
rRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
response to salt stressCellular tumor antigen p53Homo sapiens (human)
response to inorganic substanceCellular tumor antigen p53Homo sapiens (human)
response to X-rayCellular tumor antigen p53Homo sapiens (human)
response to gamma radiationCellular tumor antigen p53Homo sapiens (human)
positive regulation of gene expressionCellular tumor antigen p53Homo sapiens (human)
cardiac muscle cell apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of cardiac muscle cell apoptotic processCellular tumor antigen p53Homo sapiens (human)
glial cell proliferationCellular tumor antigen p53Homo sapiens (human)
viral processCellular tumor antigen p53Homo sapiens (human)
glucose catabolic process to lactate via pyruvateCellular tumor antigen p53Homo sapiens (human)
cerebellum developmentCellular tumor antigen p53Homo sapiens (human)
negative regulation of cell growthCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
negative regulation of transforming growth factor beta receptor signaling pathwayCellular tumor antigen p53Homo sapiens (human)
mitotic G1 DNA damage checkpoint signalingCellular tumor antigen p53Homo sapiens (human)
negative regulation of telomere maintenance via telomeraseCellular tumor antigen p53Homo sapiens (human)
T cell differentiation in thymusCellular tumor antigen p53Homo sapiens (human)
tumor necrosis factor-mediated signaling pathwayCellular tumor antigen p53Homo sapiens (human)
regulation of tissue remodelingCellular tumor antigen p53Homo sapiens (human)
cellular response to UVCellular tumor antigen p53Homo sapiens (human)
multicellular organism growthCellular tumor antigen p53Homo sapiens (human)
positive regulation of mitochondrial membrane permeabilityCellular tumor antigen p53Homo sapiens (human)
cellular response to glucose starvationCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
entrainment of circadian clock by photoperiodCellular tumor antigen p53Homo sapiens (human)
mitochondrial DNA repairCellular tumor antigen p53Homo sapiens (human)
regulation of DNA damage response, signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of neuron apoptotic processCellular tumor antigen p53Homo sapiens (human)
transcription initiation-coupled chromatin remodelingCellular tumor antigen p53Homo sapiens (human)
negative regulation of proteolysisCellular tumor antigen p53Homo sapiens (human)
negative regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
positive regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
positive regulation of RNA polymerase II transcription preinitiation complex assemblyCellular tumor antigen p53Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
response to antibioticCellular tumor antigen p53Homo sapiens (human)
fibroblast proliferationCellular tumor antigen p53Homo sapiens (human)
negative regulation of fibroblast proliferationCellular tumor antigen p53Homo sapiens (human)
circadian behaviorCellular tumor antigen p53Homo sapiens (human)
bone marrow developmentCellular tumor antigen p53Homo sapiens (human)
embryonic organ developmentCellular tumor antigen p53Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylationCellular tumor antigen p53Homo sapiens (human)
protein stabilizationCellular tumor antigen p53Homo sapiens (human)
negative regulation of helicase activityCellular tumor antigen p53Homo sapiens (human)
protein tetramerizationCellular tumor antigen p53Homo sapiens (human)
chromosome organizationCellular tumor antigen p53Homo sapiens (human)
neuron apoptotic processCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycleCellular tumor antigen p53Homo sapiens (human)
hematopoietic stem cell differentiationCellular tumor antigen p53Homo sapiens (human)
negative regulation of glial cell proliferationCellular tumor antigen p53Homo sapiens (human)
type II interferon-mediated signaling pathwayCellular tumor antigen p53Homo sapiens (human)
cardiac septum morphogenesisCellular tumor antigen p53Homo sapiens (human)
positive regulation of programmed necrotic cell deathCellular tumor antigen p53Homo sapiens (human)
protein-containing complex assemblyCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressCellular tumor antigen p53Homo sapiens (human)
thymocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of thymocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
necroptotic processCellular tumor antigen p53Homo sapiens (human)
cellular response to hypoxiaCellular tumor antigen p53Homo sapiens (human)
cellular response to xenobiotic stimulusCellular tumor antigen p53Homo sapiens (human)
cellular response to ionizing radiationCellular tumor antigen p53Homo sapiens (human)
cellular response to gamma radiationCellular tumor antigen p53Homo sapiens (human)
cellular response to UV-CCellular tumor antigen p53Homo sapiens (human)
stem cell proliferationCellular tumor antigen p53Homo sapiens (human)
signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
cellular response to actinomycin DCellular tumor antigen p53Homo sapiens (human)
positive regulation of release of cytochrome c from mitochondriaCellular tumor antigen p53Homo sapiens (human)
cellular senescenceCellular tumor antigen p53Homo sapiens (human)
replicative senescenceCellular tumor antigen p53Homo sapiens (human)
oxidative stress-induced premature senescenceCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathwayCellular tumor antigen p53Homo sapiens (human)
oligodendrocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of execution phase of apoptosisCellular tumor antigen p53Homo sapiens (human)
negative regulation of mitophagyCellular tumor antigen p53Homo sapiens (human)
regulation of mitochondrial membrane permeability involved in apoptotic processCellular tumor antigen p53Homo sapiens (human)
regulation of intrinsic apoptotic signaling pathway by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of miRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
negative regulation of G1 to G0 transitionCellular tumor antigen p53Homo sapiens (human)
negative regulation of miRNA processingCellular tumor antigen p53Homo sapiens (human)
negative regulation of glucose catabolic process to lactate via pyruvateCellular tumor antigen p53Homo sapiens (human)
negative regulation of pentose-phosphate shuntCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to hypoxiaCellular tumor antigen p53Homo sapiens (human)
regulation of fibroblast apoptotic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of stem cell proliferationCellular tumor antigen p53Homo sapiens (human)
positive regulation of cellular senescenceCellular tumor antigen p53Homo sapiens (human)
positive regulation of intrinsic apoptotic signaling pathwayCellular tumor antigen p53Homo sapiens (human)
cell population proliferationATPase family AAA domain-containing protein 5Homo sapiens (human)
positive regulation of B cell proliferationATPase family AAA domain-containing protein 5Homo sapiens (human)
nuclear DNA replicationATPase family AAA domain-containing protein 5Homo sapiens (human)
signal transduction in response to DNA damageATPase family AAA domain-containing protein 5Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorATPase family AAA domain-containing protein 5Homo sapiens (human)
isotype switchingATPase family AAA domain-containing protein 5Homo sapiens (human)
positive regulation of DNA replicationATPase family AAA domain-containing protein 5Homo sapiens (human)
positive regulation of isotype switching to IgG isotypesATPase family AAA domain-containing protein 5Homo sapiens (human)
DNA clamp unloadingATPase family AAA domain-containing protein 5Homo sapiens (human)
regulation of mitotic cell cycle phase transitionATPase family AAA domain-containing protein 5Homo sapiens (human)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorATPase family AAA domain-containing protein 5Homo sapiens (human)
positive regulation of cell cycle G2/M phase transitionATPase family AAA domain-containing protein 5Homo sapiens (human)
negative regulation of receptor internalizationAtaxin-2Homo sapiens (human)
regulation of translationAtaxin-2Homo sapiens (human)
RNA metabolic processAtaxin-2Homo sapiens (human)
P-body assemblyAtaxin-2Homo sapiens (human)
stress granule assemblyAtaxin-2Homo sapiens (human)
RNA transportAtaxin-2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (40)

Processvia Protein(s)Taxonomy
transcription cis-regulatory region bindingCellular tumor antigen p53Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
cis-regulatory region sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
core promoter sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
TFIID-class transcription factor complex bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
protease bindingCellular tumor antigen p53Homo sapiens (human)
p53 bindingCellular tumor antigen p53Homo sapiens (human)
DNA bindingCellular tumor antigen p53Homo sapiens (human)
chromatin bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription factor activityCellular tumor antigen p53Homo sapiens (human)
mRNA 3'-UTR bindingCellular tumor antigen p53Homo sapiens (human)
copper ion bindingCellular tumor antigen p53Homo sapiens (human)
protein bindingCellular tumor antigen p53Homo sapiens (human)
zinc ion bindingCellular tumor antigen p53Homo sapiens (human)
enzyme bindingCellular tumor antigen p53Homo sapiens (human)
receptor tyrosine kinase bindingCellular tumor antigen p53Homo sapiens (human)
ubiquitin protein ligase bindingCellular tumor antigen p53Homo sapiens (human)
histone deacetylase regulator activityCellular tumor antigen p53Homo sapiens (human)
ATP-dependent DNA/DNA annealing activityCellular tumor antigen p53Homo sapiens (human)
identical protein bindingCellular tumor antigen p53Homo sapiens (human)
histone deacetylase bindingCellular tumor antigen p53Homo sapiens (human)
protein heterodimerization activityCellular tumor antigen p53Homo sapiens (human)
protein-folding chaperone bindingCellular tumor antigen p53Homo sapiens (human)
protein phosphatase 2A bindingCellular tumor antigen p53Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor bindingCellular tumor antigen p53Homo sapiens (human)
14-3-3 protein bindingCellular tumor antigen p53Homo sapiens (human)
MDM2/MDM4 family protein bindingCellular tumor antigen p53Homo sapiens (human)
disordered domain specific bindingCellular tumor antigen p53Homo sapiens (human)
general transcription initiation factor bindingCellular tumor antigen p53Homo sapiens (human)
molecular function activator activityCellular tumor antigen p53Homo sapiens (human)
promoter-specific chromatin bindingCellular tumor antigen p53Homo sapiens (human)
protein bindingATPase family AAA domain-containing protein 5Homo sapiens (human)
ATP bindingATPase family AAA domain-containing protein 5Homo sapiens (human)
ATP hydrolysis activityATPase family AAA domain-containing protein 5Homo sapiens (human)
DNA clamp unloader activityATPase family AAA domain-containing protein 5Homo sapiens (human)
DNA bindingATPase family AAA domain-containing protein 5Homo sapiens (human)
RNA bindingAtaxin-2Homo sapiens (human)
epidermal growth factor receptor bindingAtaxin-2Homo sapiens (human)
protein bindingAtaxin-2Homo sapiens (human)
mRNA bindingAtaxin-2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (27)

Processvia Protein(s)Taxonomy
nuclear bodyCellular tumor antigen p53Homo sapiens (human)
nucleusCellular tumor antigen p53Homo sapiens (human)
nucleoplasmCellular tumor antigen p53Homo sapiens (human)
replication forkCellular tumor antigen p53Homo sapiens (human)
nucleolusCellular tumor antigen p53Homo sapiens (human)
cytoplasmCellular tumor antigen p53Homo sapiens (human)
mitochondrionCellular tumor antigen p53Homo sapiens (human)
mitochondrial matrixCellular tumor antigen p53Homo sapiens (human)
endoplasmic reticulumCellular tumor antigen p53Homo sapiens (human)
centrosomeCellular tumor antigen p53Homo sapiens (human)
cytosolCellular tumor antigen p53Homo sapiens (human)
nuclear matrixCellular tumor antigen p53Homo sapiens (human)
PML bodyCellular tumor antigen p53Homo sapiens (human)
transcription repressor complexCellular tumor antigen p53Homo sapiens (human)
site of double-strand breakCellular tumor antigen p53Homo sapiens (human)
germ cell nucleusCellular tumor antigen p53Homo sapiens (human)
chromatinCellular tumor antigen p53Homo sapiens (human)
transcription regulator complexCellular tumor antigen p53Homo sapiens (human)
protein-containing complexCellular tumor antigen p53Homo sapiens (human)
virion membraneSpike glycoproteinSevere acute respiratory syndrome-related coronavirus
Elg1 RFC-like complexATPase family AAA domain-containing protein 5Homo sapiens (human)
nucleusATPase family AAA domain-containing protein 5Homo sapiens (human)
cytoplasmAtaxin-2Homo sapiens (human)
Golgi apparatusAtaxin-2Homo sapiens (human)
trans-Golgi networkAtaxin-2Homo sapiens (human)
cytosolAtaxin-2Homo sapiens (human)
cytoplasmic stress granuleAtaxin-2Homo sapiens (human)
membraneAtaxin-2Homo sapiens (human)
perinuclear region of cytoplasmAtaxin-2Homo sapiens (human)
ribonucleoprotein complexAtaxin-2Homo sapiens (human)
cytoplasmic stress granuleAtaxin-2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID504749qHTS profiling for inhibitors of Plasmodium falciparum proliferation2011Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043
Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (33.33)18.7374
1990's2 (22.22)18.2507
2000's0 (0.00)29.6817
2010's3 (33.33)24.3611
2020's1 (11.11)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
metronidazole[no description available]medium10C-nitro compound;
imidazoles;
primary alcohol		antiamoebic agent;
antibacterial drug;
antimicrobial agent;
antiparasitic agent;
antitrichomonal drug;
environmental contaminant;
prodrug;
radiosensitizing agent;
xenobiotic
fumagillin[no description available]medium10antibiotic antifungal drug;
carboxylic ester;
dicarboxylic acid monoester;
meroterpenoid;
organooxygen heterocyclic antibiotic;
spiro-epoxide		angiogenesis inhibitor;
antibacterial drug;
antimicrobial agent;
antiprotozoal drug;
fungal metabolite;
methionine aminopeptidase 2 inhibitor
carbadox[no description available]medium10quinoxaline derivative
sesquiterpenes[no description available]medium10
thiazoles[no description available]medium601,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
carbamates[no description available]medium30amino-acid anion
benzothiazole[no description available]medium10benzothiazolesenvironmental contaminant;
plant metabolite;
xenobiotic
oxibendazole[no description available]medium10benzimidazoles;
carbamate ester
albendazole[no description available]medium10aryl sulfide;
benzimidazoles;
benzimidazolylcarbamate fungicide;
carbamate ester		anthelminthic drug;
microtubule-destabilising agent;
tubulin modulator
ethoxzolamide[no description available]low00aromatic ether;
benzothiazoles;
sulfonamide		antiglaucoma drug;
diuretic;
EC 4.2.1.1 (carbonic anhydrase) inhibitor
riluzole[no description available]low00benzothiazoles
tiaramide[no description available]low00benzothiazoles
ticlatone[no description available]low00benzothiazoles
dibenzothiazyl disulfide[no description available]low00benzothiazoles;
organic disulfide		allergen
2-aminobenzothiazole[no description available]low00benzothiazoles
diamthazole[no description available]low00benzothiazoles
dithiazanine[no description available]low00benzothiazoles;
benzothiazolium ion		anthelminthic drug;
fluorochrome
2-(methylthio)benzothiazole[no description available]low00benzothiazoles;
methyl sulfide		aryl hydrocarbon receptor agonist;
xenobiotic metabolite
2-(2-hydroxyphenyl)benzothiazole[no description available]low00benzothiazoles;
phenols		geroprotector
methabenzthiazuron[no description available]low00benzothiazoles
sabeluzole[no description available]low00benzothiazoles
lubeluzole[no description available]low00benzothiazoles
2-benzothiazolesulfonamide[no description available]low00benzothiazoles;
sulfonamide
2-(4-Morpholinyl)benzothiazole[no description available]low00benzothiazoles
mefenacet[no description available]low00benzothiazoles;
tertiary carboxamide		antimitotic;
herbicide
firefly luciferin[no description available]low001,3-thiazolemonocarboxylic acid;
benzothiazoles;
imidothioate		luciferin
pramipexole[no description available]low00benzothiazoles;
diamine		antidyskinesia agent;
antiparkinson drug;
dopamine agonist;
radical scavenger
N-(4-methoxyphenyl)-1,3-benzothiazol-2-amine[no description available]low00benzothiazoles
2-pyridin-4-yl-1,3-benzothiazole[no description available]low00benzothiazoles
6-methoxy-3-methyl-1,3-benzothiazol-2-imine[no description available]low00benzothiazoles
6-Fluoro-1,3-benzothiazol-2-amine[no description available]low00benzothiazoles
N-[2-(1-azepanyl)-1,3-benzothiazol-6-yl]carbamic acid ethyl ester[no description available]low00benzothiazoles
e 3040[no description available]low00benzothiazoles;
organic hydroxy compound;
pyridines;
secondary amino compound		anti-inflammatory drug;
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor;
uricosuric drug
E3040 glucuronide[no description available]low00benzothiazoles;
beta-D-glucosiduronic acid;
pyridines;
secondary amino compound		xenobiotic metabolite
3-(3,5-dimethyl-1-pyrazolyl)-1,2-benzothiazole 1,1-dioxide[no description available]low00benzothiazoles
6-ethoxy-2-[(4-fluorophenyl)methylthio]-1,3-benzothiazole[no description available]low00benzothiazoles
6-propan-2-yl-1,3-benzothiazol-2-amine[no description available]low00benzothiazoles
3-(2-phenoxyethyl)-1,3-benzothiazol-2-one[no description available]low00benzothiazoles
3-[3-(2-methoxyphenoxy)propyl]-1,3-benzothiazol-2-one[no description available]low00benzothiazoles
2-(2-oxo-1,3-benzothiazol-3-yl)-N-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)acetamide[no description available]low00benzothiazoles
N-(1,3-benzothiazol-2-yl)-N-methylbenzamide[no description available]low00benzothiazoles
2-[(1-cyclohexyl-5-tetrazolyl)thio]-N-(6-ethoxy-1,3-benzothiazol-2-yl)acetamide[no description available]low00benzothiazoles
2-(1,3-benzothiazol-2-yl)-3-methyl-2-butenenitrile[no description available]low00benzothiazoles
5-[(4-chloro-1-pyrazolyl)methyl]-N-(6-methyl-1,3-benzothiazol-2-yl)-2-furancarboxamide[no description available]low00benzothiazoles
N-(2-furanylmethyl)-2-(2-oxo-1,3-benzothiazol-3-yl)acetamide[no description available]low00benzothiazoles
N-(6-ethoxy-1,3-benzothiazol-2-yl)-2-methoxyacetamide[no description available]low00benzothiazoles
N-(5-methoxy-1,3-benzothiazol-2-yl)-3-methylbutanamide[no description available]low00benzothiazoles
2-(4,5-dihydrothiazol-2-ylthio)-N-(6-methoxy-1,3-benzothiazol-2-yl)acetamide[no description available]low00benzothiazoles
2-(beta-D-glucosyl)benzothiazole[no description available]low00benzothiazoles;
C-glycosyl compound
1-[(1,3-benzothiazol-2-ylthio)methyl]-2-azepanone[no description available]low00benzothiazoles
2-[[3-[4-(dimethylamino)phenyl]-4,5-dihydroisoxazol-5-yl]methyl]-1,1-dioxo-1,2-benzothiazol-3-one[no description available]low00benzothiazoles
5-[(1,3-benzothiazol-2-ylthio)methyl]-2-furancarboxylic acid methyl ester[no description available]low00benzothiazoles
N-(4,6-dimethyl-2-pyrimidinyl)-1,3-benzothiazol-2-amine[no description available]low00benzothiazoles
captax[no description available]low00aryl thiol;
benzothiazoles		carcinogenic agent;
metabolite
1,3-benzothiazol-2-yl(thiomorpholin-4-yl)methanone[no description available]low00benzothiazoles
N-[[(6-methyl-1,3-benzothiazol-2-yl)amino]-sulfanylidenemethyl]-2-thiophenecarboxamide[no description available]low00benzothiazoles
2-(1,3-benzothiazol-2-ylmethoxy)phenol[no description available]low00benzothiazoles
N-[2-(1-cyclohexenyl)ethyl]-3-(2-oxo-1,3-benzothiazol-3-yl)propanamide[no description available]low00benzothiazoles
N-(4-methyl-2-thiazolyl)-3-(2-oxo-1,3-benzothiazol-3-yl)propanamide[no description available]low00benzothiazoles
N-(1,3-benzothiazol-2-yl)-2-cyclohexylacetamide[no description available]low00benzothiazoles
N-(3-phenyl-1,3-benzothiazol-2-ylidene)-2-propenamide[no description available]low00benzothiazoles
N-(4-methoxyphenyl)-3-methyl-1,3-benzothiazol-2-imine[no description available]low00benzothiazoles
N-(6-ethoxy-1,3-benzothiazol-2-yl)butanamide[no description available]low00benzothiazoles
N-[[(6-methoxy-1,3-benzothiazol-2-yl)amino]-sulfanylidenemethyl]-2-furancarboxamide[no description available]low00benzothiazoles
2-[(2-chlorophenyl)methylthio]-6-nitro-1,3-benzothiazole[no description available]low00benzothiazoles
N-(1,3-benzothiazol-2-yl)-2-[(1-methyl-2-imidazolyl)thio]acetamide[no description available]low00benzothiazoles
N-[4,6-bis(4-morpholinyl)-1,3,5-triazin-2-yl]-2-(methylthio)-1,3-benzothiazol-6-amine[no description available]low00benzothiazoles
2-[[cyclohexyl(oxo)methyl]amino]-1,3-benzothiazole-6-carboxylic acid methyl ester[no description available]low00benzothiazoles
N-(2-methyl-1,3-benzothiazol-6-yl)-2-furancarboxamide[no description available]low00benzothiazoles
2-(2,4,5-trimethoxyphenyl)-1,3-benzothiazole[no description available]low00benzothiazoles
3-[2-(3-methylphenoxy)ethyl]-1,3-benzothiazol-2-one[no description available]low00benzothiazoles
3-[2-(4-methylphenoxy)ethyl]-1,3-benzothiazol-2-one[no description available]low00benzothiazoles
3-methoxy-N-(6-methylsulfonyl-1,3-benzothiazol-2-yl)benzamide[no description available]low00benzothiazoles
N-(6-ethoxy-1,3-benzothiazol-2-yl)-1,3-dimethyl-2-oxo-5-benzimidazolesulfonamide[no description available]low00benzothiazoles
N-[6-(diethylsulfamoyl)-1,3-benzothiazol-2-yl]-2-thiophenecarboxamide[no description available]low00benzothiazoles
2-[(3-bromo-2-imidazo[1,2-a]pyrimidinyl)methylthio]-1,3-benzothiazole[no description available]low00benzothiazoles
N-(6-chloro-1,3-benzothiazol-2-yl)-2-diphenylphosphorylacetamide[no description available]low00benzothiazoles
3-[(1,3-benzothiazol-2-ylthio)methyl]-4-cyclohexyl-1H-1,2,4-triazole-5-thione[no description available]low00benzothiazoles
6-fluoro-2-phenyl-1,2-benzothiazol-3-one[no description available]low00benzothiazoles
6-fluoro-2-(2-methylphenyl)-1,2-benzothiazol-3-one[no description available]low00benzothiazoles
1-[[2-(1,3-benzothiazol-2-ylthio)-1-oxoethyl]amino]-3-phenylthiourea[no description available]low00benzothiazoles
1-(4-amino-1,2,5-oxadiazol-3-yl)-5-[(1,3-benzothiazol-2-ylthio)methyl]-4-triazolecarboxylic acid methyl ester[no description available]low00benzothiazoles
[4-methoxy-6-(propan-2-ylamino)-1,3,5-triazin-2-yl]-[(1,1,3-trioxo-1,2-benzothiazol-2-yl)methyl]cyanamide[no description available]low00benzothiazoles
[4-chloro-6-(propan-2-ylamino)-1,3,5-triazin-2-yl]-[(1,1,3-trioxo-1,2-benzothiazol-2-yl)methyl]cyanamide[no description available]low00benzothiazoles
(4,7-dichloro-1,3-benzothiazol-2-yl)hydrazine[no description available]low00benzothiazoles
3,4,5-trimethoxy-N-(3-methyl-1,3-benzothiazol-2-ylidene)benzamide[no description available]low00benzothiazoles
4-(1,3-benzothiazol-2-ylthio)butanoic acid [2-[(3-cyano-2-thiophenyl)amino]-2-oxoethyl] ester[no description available]low00benzothiazoles
N-[2-(1,3-benzothiazol-2-ylthio)-1-oxoethyl]-1-methyl-2-pyrrolecarboxamide[no description available]low00benzothiazoles
3-(1,3-benzothiazol-2-yl)propanoic acid (3,5-dimethyl-4-isoxazolyl)methyl ester[no description available]low00benzothiazoles
1-(1,3-benzothiazol-2-yl)-3-propylurea[no description available]low00benzothiazoles
5-bromo-N-(6-sulfamoyl-1,3-benzothiazol-2-yl)-2-furancarboxamide[no description available]low00benzothiazoles
N-(4,7-dimethoxy-3-methyl-1,3-benzothiazol-2-ylidene)butanamide[no description available]low00benzothiazoles
N-(4-fluoro-3-methyl-1,3-benzothiazol-2-ylidene)-2-nitrobenzamide[no description available]low00benzothiazoles
5-bromo-N-(4,7-dimethoxy-1,3-benzothiazol-2-yl)-2-thiophenecarboxamide[no description available]low00benzothiazoles
N-[2-(methylthio)-1,3-benzothiazol-6-yl]-2-furancarboxamide[no description available]low00benzothiazoles
1-cyclohexyl-3-(6-ethoxy-1,3-benzothiazol-2-yl)urea[no description available]low00benzothiazoles
5-bromo-N-(4-methoxy-1,3-benzothiazol-2-yl)-2-thiophenecarboxamide[no description available]low00benzothiazoles
2-(1,3-benzothiazol-2-yl)-5-methyl-3-pyrazolamine[no description available]low00benzothiazoles
2-[5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl(oxo)methyl]-1,1-dioxo-1,2-benzothiazol-3-one[no description available]low00benzothiazoles
N-(6-methylsulfonyl-1,3-benzothiazol-2-yl)-4-oxo-4-thiophen-2-ylbutanamide[no description available]low00benzothiazoles
N-(2-phenylethyl)-1,3-benzothiazol-2-amine[no description available]low00benzothiazoles
N-(4,5,6-trifluoro-1,3-benzothiazol-2-yl)-2-furancarboxamide[no description available]low00benzothiazoles
4-[[5-(1,3-benzothiazol-2-yl)-2-thiophenyl]-oxomethyl]-1-piperazinecarboxaldehyde[no description available]low00benzothiazoles
1,3-benzothiazole-6-carboxylic acid (2-benzamido-2-oxoethyl) ester[no description available]low00benzothiazoles
1,3-benzothiazole-6-carboxylic acid [2-[(3,5-dichloro-4-methyl-2-pyridinyl)amino]-2-oxoethyl] ester[no description available]low00benzothiazoles
1,3-benzothiazole-6-carboxylic acid [2-(2-furanyl)-2-oxoethyl] ester[no description available]low00benzothiazoles
1-(1,1-dioxo-1,2-benzothiazol-3-yl)-N-(2-methylphenyl)-4-piperidinecarboxamide[no description available]low00benzothiazoles
N-(2-methyl-1,3-benzothiazol-6-yl)benzamide[no description available]low00benzothiazoles
2-(2-chloro-3-pyridinyl)-1,3-benzothiazole[no description available]low00benzothiazoles
2-[[5-[(1,3-benzothiazol-2-ylthio)methyl]-4-methyl-1,2,4-triazol-3-yl]thio]-N-[2-(4-morpholinyl)ethyl]acetamide[no description available]low00benzothiazoles
N-[6-(dimethylsulfamoyl)-1,3-benzothiazol-2-yl]-2-thiophenecarboxamide[no description available]low00benzothiazoles
1,3-benzothiazole-6-carboxylic acid [2-[1-(1-methoxypropan-2-yl)-2,5-dimethyl-3-pyrrolyl]-2-oxoethyl] ester[no description available]low00benzothiazoles
N-(3-methyl-1,3-benzothiazol-2-ylidene)-2-pyrazinecarboxamide[no description available]low00benzothiazoles
2-(6-imidazo[2,1-b]thiazolyl)acetic acid [2-(1,3-benzothiazol-2-ylamino)-2-oxoethyl] ester[no description available]low00benzothiazoles
N-(1,3-benzothiazol-2-yl)-2-oxolanecarboxamide[no description available]low00benzothiazoles
1-(2-furanylmethyl)-N-[2-(methylthio)-1,3-benzothiazol-6-yl]-5-oxo-3-pyrrolidinecarboxamide[no description available]low00benzothiazoles
1-thiophen-2-ylsulfonyl-4-piperidinecarboxylic acid 1,3-benzothiazol-2-ylmethyl ester[no description available]low00benzothiazoles
N-(1,3-benzothiazol-2-yl)-2-methoxy-N-[2-(1-methyl-2-pyrrolidinyl)ethyl]benzamide[no description available]low00benzothiazoles
4-[[2-(4-methyl-1-piperidinyl)-1,3-benzothiazol-6-yl]-oxomethyl]-1-piperazinecarboxylic acid ethyl ester[no description available]low00benzothiazoles
2-[(6-fluoro-1,3-benzothiazol-2-yl)amino]-4-thiazolecarboxylic acid ethyl ester[no description available]low00benzothiazoles
4-(4,6-difluoro-1,3-benzothiazol-2-yl)morpholine[no description available]low00benzothiazoles
5-bromo-2-thiophenecarboxylic acid 1,3-benzothiazol-2-ylmethyl ester[no description available]low00benzothiazoles
N-(6-acetamido-3-prop-2-enyl-1,3-benzothiazol-2-ylidene)cyclohexanecarboxamide[no description available]low00benzothiazoles
N-(6-acetamido-3-prop-2-enyl-1,3-benzothiazol-2-ylidene)-2-thiophenecarboxamide[no description available]low00benzothiazoles
2-chloro-N-(3-methyl-1,3-benzothiazol-2-ylidene)acetamide[no description available]low00benzothiazoles
2-(1,3-benzothiazol-2-ylmethylthio)-1-butyl-5-benzimidazolesulfonamide[no description available]low00benzothiazoles
N-(5-phenyl-1,3,4-oxadiazol-2-yl)-1,3-benzothiazole-2-carboxamide[no description available]low00benzothiazoles
3-methoxy-N-(3-methyl-6-methylsulfonyl-1,3-benzothiazol-2-ylidene)benzamide[no description available]low00benzothiazoles
[4-(butan-2-ylamino)-6-chloro-1,3,5-triazin-2-yl]-[(1,1,3-trioxo-1,2-benzothiazol-2-yl)methyl]cyanamide[no description available]low00benzothiazoles
N-[3-(2-methoxyethyl)-6-methylsulfonyl-1,3-benzothiazol-2-ylidene]-2-nitrobenzamide[no description available]low00benzothiazoles
N'-(4,6-difluoro-1,3-benzothiazol-2-yl)benzohydrazide[no description available]low00benzothiazoles
3-chloro-N-[3-(2-methoxyethyl)-6-sulfamoyl-1,3-benzothiazol-2-ylidene]-1-benzothiophene-2-carboxamide[no description available]low00benzothiazoles
N-(7-methyl-2-thiazolo[4,5-g][1,3]benzothiazolyl)propanamide[no description available]low00benzothiazoles
N-[3-(2-methylcyclohexyl)-2,4-dihydro-1H-1,3,5-triazin-6-yl]-1,3-benzothiazol-2-amine[no description available]low00benzothiazoles
N-(6-fluoro-1,3-benzothiazol-2-yl)-2-oxolanecarboxamide[no description available]low00benzothiazoles
N-(6-methyl-1,3-benzothiazol-2-yl)-6-oxo-1-phenyl-4,5-dihydropyridazine-3-carboxamide[no description available]low00benzothiazoles
4-[[1-(6-ethoxy-1,3-benzothiazol-2-yl)-3-piperidinyl]-oxomethyl]-1-piperazinecarboxylic acid ethyl ester[no description available]low00benzothiazoles
2-[[4-methyl-5-[(2-oxo-1,3-benzothiazol-3-yl)methyl]-1,2,4-triazol-3-yl]thio]-N-(phenylmethyl)acetamide[no description available]low00benzothiazoles
N-(2-oxolanylmethyl)-2-(1-piperidinyl)-1,3-benzothiazole-6-carboxamide[no description available]low00benzothiazoles
N-(6-methyl-1,3-benzothiazol-2-yl)-2-(5,6,7,8-tetrahydro-4H-cyclohepta[c]pyrazol-2-yl)acetamide[no description available]low00benzothiazoles
N-(4-methyl-1,3-benzothiazol-2-yl)-2-(1-pyrrolyl)acetamide[no description available]low00benzothiazoles
dithiazanine iodide[no description available]low00benzothiazoles;
organic iodide salt		anthelminthic drug;
fluorochrome
3,3'-diethylthiacarbocyanine iodide[no description available]low00benzothiazoles;
cyanine dye		fluorochrome
tyrphostin ag825[no description available]low00aromatic ether;
benzothiazoles;
enamide;
nitrile;
organic sulfide;
phenols;
primary carboxamide		epidermal growth factor receptor antagonist
2-(1,3-benzothiazol-2-yl)-4-chloro-5-(3-chloroanilino)-3-pyridazinone[no description available]low00benzothiazoles
5-[(6-methoxy-1,3-benzothiazol-2-yl)amino]-3-methyl-2-thiophenecarboxylic acid ethyl ester[no description available]low00benzothiazoles
6-bromo-2-(1-pyrrolidinyl)-1,3-benzothiazole[no description available]low00benzothiazoles
6-fluoro-N-phenyl-1,3-benzothiazol-2-amine[no description available]low00benzothiazoles
N'-(4-fluoro-1,3-benzothiazol-2-yl)-2-phenoxyacetohydrazide[no description available]low00benzothiazoles
N'-(4,5-dimethyl-1,3-benzothiazol-2-yl)propanehydrazide[no description available]low00benzothiazoles
N'-(4,6-difluoro-1,3-benzothiazol-2-yl)propanehydrazide[no description available]low00benzothiazoles
4-fluoro-N-(4-fluoro-1,3-benzothiazol-2-yl)-1,3-benzothiazol-2-amine[no description available]low00benzothiazoles
N-[3-(dimethylamino)propyl]-N-(6-methyl-1,3-benzothiazol-2-yl)-1,3-benzothiazole-6-carboxamide[no description available]low00benzothiazoles
2-(3,5-dimethyl-1H-pyrrol-2-yl)-1,3-benzothiazole[no description available]low00benzothiazoles
N-(6-methoxy-1,3-benzothiazol-2-yl)-1-thiophen-2-ylsulfonyl-4-piperidinecarboxamide[no description available]low00benzothiazoles
r 115866[no description available]low00aromatic amine;
benzothiazoles;
secondary amino compound;
triazoles
as 601245[no description available]low00benzothiazoles
2-(4-methoxyphenyl)-1,2-benzothiazol-3-one[no description available]low00benzothiazoles
2-(4-chlorophenyl)-1,2-benzothiazol-3-one[no description available]low00benzothiazoles
tozadenant[no description available]low00benzothiazoles
3-(benzenesulfonyl)-N-[4-(6-methyl-1,3-benzothiazol-2-yl)phenyl]propanamide[no description available]low00benzothiazoles
2-(4-fluorophenyl)-6-methoxy-1,3-benzothiazole[no description available]low00benzothiazoles
2-(3-chlorophenyl)-1,2-benzothiazol-3-one[no description available]low00benzothiazoles
vizamyl[no description available]low00(18)F radiopharmaceutical;
aromatic amine;
benzothiazoles;
secondary amino compound		radioactive imaging agent
picogreen[no description available]low00benzothiazoles;
cyanine dye;
quinolines;
tertiary amine		fluorescent dye
N-[3-(3,5-dimethyl-1-piperidinyl)propyl]-2-(1-piperidinyl)-1,3-benzothiazole-6-carboxamide[no description available]low00benzothiazoles
5-fluoro-2-phenyl-1,2-benzothiazol-3-one[no description available]low00benzothiazoles
2-(2-fluorophenyl)-1,2-benzothiazol-3-one[no description available]low00benzothiazoles
2-(4-fluorophenyl)-1,2-benzothiazol-3-one[no description available]low00benzothiazoles
INDY[no description available]low00benzothiazoles;
enone;
organic hydroxy compound		antineoplastic agent;
drug metabolite;
EC 2.7.12.1 (dual-specificity kinase) inhibitor
2-(3-oxo-1,2-benzothiazol-2-yl)-N-phenylacetamide[no description available]low00benzothiazoles
tak-632[no description available]low00(trifluoromethyl)benzenes;
aromatic ether;
benzothiazoles;
cyclopropylcarboxamide;
monofluorobenzenes;
nitrile;
secondary carboxamide		antineoplastic agent;
apoptosis inducer;
B-Raf inhibitor;
EC 2.7.11.26 (tau-protein kinase) inhibitor;
necroptosis inhibitor
N-[3-(1,3-benzothiazol-2-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-2-yl]acetamide[no description available]low00benzothiazoles
ML355[no description available]low00benzothiazoles;
monomethoxybenzene;
phenols;
secondary amino compound;
substituted aniline;
sulfonamide		EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor;
platelet aggregation inhibitor
dehydroluciferin[no description available]low001,3-thiazolemonocarboxylic acid;
benzothiazoles;
biaryl;
phenols		animal metabolite;
luciferin
ConditionIndicatedRelationship StrengthStudiesTrials
Aspiculariasis0low10
Bertielliasis0low10
Cenuriasis0low10
Cestode Infections0low10
Cholera Infantum0low10
Coenuriasis0low10
Dipylidiasis0low10
Equine Diseases0low20
Equine Strongyle Infections0low10
Functional Gastrointestinal Disorders0low10
Gastrointestinal Diseases0low10
Gastrointestinal Disorders0low10
Gastrointestinal Disorders, Functional0low10
Giardia duodenalis Infection0low10
Giardia Infection0low10
Giardia intestinalis Infection0low10
Giardia lamblia Infection0low10
Giardiasis0low10
Horse Diseases0low20
Hymenolepiasis0low20
Hymenolepis Infection0low20
Infections, Equine Strongyle0low10
Infections, Nematode0low20
Lambliasis0low10
Nematode Infections0low20
Oxyuriasis0low10
Parasite Infections0low10
Parasitic Diseases0low10
Parasitic Diseases, Animal0low10
Parasitic Infections0low10
Parasitic Infections, Animal0low10
Raillietiniasis0low10
Strongyle Infections, Equine0low10
Strongylosis, Equine0low10
Tapeworm Infection0low10

Research Highlights

Bioavailability (1)

ArticleYear
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology, Volume: 96, Issue: 5		2019
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (1)

ArticleYear
Critical tests of new benzothiazole anthelmintic tioxidazole in the horse.
American journal of veterinary research, Volume: 41, Issue: 9		1980
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]