metronidazole has been researched along with Amnionitis in 15 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate whether intrapartum antibiotic therapy with cefazolin versus the current standard clindamycin or metronidazole decreases the risk of postpartum infectious morbidity among women delivering by cesarean delivery who were receiving a base regimen of ampicillin or penicillin with gentamicin for chorioamnionitis." | 7.96 | Preoperative cefazolin rather than clindamycin or metronidazole is associated with lower postpartum infection among women with chorioamnionitis delivering by cesarean delivery. ( Dotters-Katz, SK; Grotegut, CA; Heine, RP; Hughes, BL; Stamilio, DM; Strauss, RA; Venkatesh, KK, 2020) |
| " After 8 days of prophylactic pivampicillin and metronidazol, culture from the cervix showed profuse growth of Group B Streptococci (GBS) and the patient developed symptoms of chorioamnionitis." | 7.68 | Group B streptococcal chorioamnionitis and neonatal septicemia following 8 days pivampicillin and metronidazol prophylaxis after premature rupture of membranes; a case report. ( Andersen, LF; Bruun, BB; Jensen, ET; Langhoff-Roos, J; Madsen, H; Svare, J, 1991) |
| "To investigate whether intrapartum antibiotic therapy with cefazolin versus the current standard clindamycin or metronidazole decreases the risk of postpartum infectious morbidity among women delivering by cesarean delivery who were receiving a base regimen of ampicillin or penicillin with gentamicin for chorioamnionitis." | 3.96 | Preoperative cefazolin rather than clindamycin or metronidazole is associated with lower postpartum infection among women with chorioamnionitis delivering by cesarean delivery. ( Dotters-Katz, SK; Grotegut, CA; Heine, RP; Hughes, BL; Stamilio, DM; Strauss, RA; Venkatesh, KK, 2020) |
| "A new antibiotic combination consisting of ceftriaxone, clarithromycin, and metronidazole prolonged the latency period, reduced acute histologic chorioamnionitis/funisitis, and improved neonatal outcomes in patients with preterm PROM." | 3.83 | A new anti-microbial combination prolongs the latency period, reduces acute histologic chorioamnionitis as well as funisitis, and improves neonatal outcomes in preterm PROM. ( Chaemsaithong, P; Jun, JK; Kim, SM; Lee, J; Park, CW; Park, JS; Romero, R; Yoon, BH, 2016) |
| " After 8 days of prophylactic pivampicillin and metronidazol, culture from the cervix showed profuse growth of Group B Streptococci (GBS) and the patient developed symptoms of chorioamnionitis." | 3.68 | Group B streptococcal chorioamnionitis and neonatal septicemia following 8 days pivampicillin and metronidazol prophylaxis after premature rupture of membranes; a case report. ( Andersen, LF; Bruun, BB; Jensen, ET; Langhoff-Roos, J; Madsen, H; Svare, J, 1991) |
| "Once the diagnosis of clinical chorioamnionitis has been established, delivery should be considered, regardless of the gestational age." | 2.66 | Management of clinical chorioamnionitis: an evidence-based approach. ( Conde-Agudelo, A; Garcia Sánchez, ÁJ; Jung, EJ; Romero, R, 2020) |
| "Bacterial vaginosis is associated with adverse sequelae, including late miscarriage, preterm prelabour rupture of the membranes, chorioamnionitis, postpartum endometritis and preterm labour and delivery." | 1.30 | Bacterial vaginosis: its importance in obstetrics. ( Lamont, RF; Woodrow, N, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (33.33) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 6 (40.00) | 24.3611 |
| 2020's | 3 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Germano, C | 1 |
| Messina, A | 1 |
| Massaro, A | 1 |
| Attini, R | 1 |
| Leo, L | 1 |
| Manzoni, P | 1 |
| Masturzo, B | 1 |
| Conde-Agudelo, A | 3 |
| Romero, R | 5 |
| Jung, EJ | 1 |
| Garcia Sánchez, ÁJ | 1 |
| Venkatesh, KK | 1 |
| Hughes, BL | 1 |
| Grotegut, CA | 1 |
| Strauss, RA | 1 |
| Stamilio, DM | 1 |
| Heine, RP | 1 |
| Dotters-Katz, SK | 1 |
| Dinglas, C | 1 |
| Chavez, M | 1 |
| Vintzileos, A | 1 |
| Oh, KJ | 2 |
| Park, JY | 2 |
| Lee, J | 4 |
| Hong, JS | 2 |
| Yoon, BH | 4 |
| Kim, SM | 2 |
| Chaemsaithong, P | 2 |
| Park, CW | 1 |
| Park, JS | 1 |
| Jun, JK | 1 |
| Treszezamsky, AD | 1 |
| Feldman, D | 1 |
| Sarabanchong, VO | 1 |
| Taha, TE | 1 |
| Brown, ER | 1 |
| Hoffman, IF | 1 |
| Fawzi, W | 1 |
| Read, JS | 1 |
| Sinkala, M | 1 |
| Martinson, FE | 1 |
| Kafulafula, G | 1 |
| Msamanga, G | 1 |
| Emel, L | 1 |
| Adeniyi-Jones, S | 1 |
| Goldenberg, R | 1 |
| Oyarzún, E | 1 |
| Gómez, R | 1 |
| Montiel, F | 1 |
| Kyle, P | 1 |
| Turner, DP | 1 |
| Woodrow, N | 1 |
| Lamont, RF | 1 |
| Jensen, LM | 1 |
| Jørgensen, JS | 1 |
| Lidegaard, O | 1 |
| Brinsden, PR | 1 |
| Weber, T | 1 |
| Andersen, LF | 1 |
| Svare, J | 1 |
| Madsen, H | 1 |
| Langhoff-Roos, J | 1 |
| Jensen, ET | 1 |
| Bruun, BB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of the Efficacy of Emergency Double-level and Single Cervical Cerclage in Cervical Insufficiency in the Second Trimester of Pregnancy - Multicenter Prospective Randomized Trial[NCT05268640] | 78 participants (Anticipated) | Interventional | 2022-03-11 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for metronidazole and Amnionitis
| Article | Year |
|---|---|
Maternal Origins of Neonatal Infections: What Do Obstetrician-Gynecologist Should/Could Do?
Topics: Ampicillin; Anti-Bacterial Agents; Bacteriuria; Cesarean Section; Chorioamnionitis; Clindamycin; Com | 2022 |
Management of clinical chorioamnionitis: an evidence-based approach.
Topics: Acetylcysteine; Adrenal Cortex Hormones; Ampicillin; Anti-Bacterial Agents; Anti-Infective Agents, L | 2020 |
[Bacterial vaginosis II. Related pathology and therapy].
Topics: Anti-Bacterial Agents; Chorioamnionitis; Clindamycin; Endometritis; Female; Humans; Metronidazole; O | 1995 |
1 trial available for metronidazole and Amnionitis
| Article | Year |
|---|---|
A phase III clinical trial of antibiotics to reduce chorioamnionitis-related perinatal HIV-1 transmission.
Topics: Adult; Anti-Bacterial Agents; Chorioamnionitis; Developing Countries; Disease-Free Survival; Double- | 2006 |
11 other studies available for metronidazole and Amnionitis
| Article | Year |
|---|---|
Preoperative cefazolin rather than clindamycin or metronidazole is associated with lower postpartum infection among women with chorioamnionitis delivering by cesarean delivery.
Topics: Cefazolin; Chorioamnionitis; Clindamycin; Female; Humans; Metronidazole; Postpartum Period; Pregnanc | 2020 |
Resolution of intra-amniotic sludge after antibiotic administration in a patient with short cervix and recurrent mid-trimester loss.
Topics: Abortion, Habitual; Adult; Anti-Bacterial Agents; Cerclage, Cervical; Cervix Uteri; Chorioamnionitis | 2019 |
Evidence that antibiotic administration is effective in the treatment of a subset of patients with intra-amniotic infection/inflammation presenting with cervical insufficiency.
Topics: Adult; Amniocentesis; Amniotic Fluid; Anti-Bacterial Agents; Biomarkers; Candida albicans; Ceftriaxo | 2019 |
Antibiotic administration can eradicate intra-amniotic infection or intra-amniotic inflammation in a subset of patients with preterm labor and intact membranes.
Topics: Adult; Amniocentesis; Amniotic Fluid; Anti-Bacterial Agents; Biomarkers; Ceftriaxone; Chorioamnionit | 2019 |
A new anti-microbial combination prolongs the latency period, reduces acute histologic chorioamnionitis as well as funisitis, and improves neonatal outcomes in preterm PROM.
Topics: Adult; Anti-Bacterial Agents; Ceftriaxone; Chorioamnionitis; Clarithromycin; Drug Therapy, Combinati | 2016 |
A new antibiotic regimen treats and prevents intra-amniotic inflammation/infection in patients with preterm PROM.
Topics: Adult; Anti-Bacterial Agents; Antibiotic Prophylaxis; Ceftriaxone; Chorioamnionitis; Clarithromycin; | 2016 |
Concurrent postpartum uterine and abdominal wall dehiscence and Streptococcus anginosus infection.
Topics: Abdominal Wall; Acute Disease; Adolescent; Anti-Bacterial Agents; Ascitic Fluid; Cefazolin; Cesarean | 2011 |
Chorioamnionitis due to pseudomonas aeruginosa: a complication of prolonged antibiotic therapy for premature rupture of membranes.
Topics: Adult; Cephalexin; Chorioamnionitis; Drug Therapy, Combination; Female; Fetal Membranes, Premature R | 1996 |
Bacterial vaginosis: its importance in obstetrics.
Topics: Abortion, Spontaneous; Anti-Infective Agents; Chorioamnionitis; Endometritis; Female; Humans; Metron | 1998 |
Spontaneous abortion of one twin with Down's syndrome followed by delivery of the second twin 14 weeks later; a case report.
Topics: Abortion, Spontaneous; Adult; Chorioamnionitis; Diseases in Twins; Down Syndrome; Embryo Transfer; F | 1991 |
Group B streptococcal chorioamnionitis and neonatal septicemia following 8 days pivampicillin and metronidazol prophylaxis after premature rupture of membranes; a case report.
Topics: Adult; Cervix Uteri; Chorioamnionitis; Female; Fetal Membranes, Premature Rupture; Humans; Infant, N | 1991 |