metronidazole has been researched along with Osteolysis in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Osteolysis: Dissolution of bone that particularly involves the removal or loss of calcium.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Circumscribed osteitis of a child's mandibula, with no dental etiology occurs around 7-years of age, adjacent to a healthy first molar." | 1.30 | [Circumscribed mandibular osteitis in children due to hematogenous dissemination. Apropos of 5 clinical cases]. ( Buis, J; Diner, PA; Franchi, G; Karcenty, B; Soupre, V; Vazquez, MP, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Franchi, G | 1 |
| Soupre, V | 1 |
| Karcenty, B | 1 |
| Buis, J | 1 |
| Diner, PA | 1 |
| Vazquez, MP | 1 |
| Ogutcen-Toller, M | 1 |
| Alkan, A | 1 |
| Baris, S | 1 |
| Cakir, N | 1 |
2 other studies available for metronidazole and Osteolysis
| Article | Year |
|---|---|
[Circumscribed mandibular osteitis in children due to hematogenous dissemination. Apropos of 5 clinical cases].
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Bacteremia; Child; Curettage; Focal Infec | 1999 |
An unusual form of Actinomycosis of the mandible with a resultant gross sequester in a 4-year-old child: a case report.
Topics: Actinomycosis; Ampicillin; Anti-Bacterial Agents; Anti-Infective Agents; Child, Preschool; Follow-Up | 2001 |