Deoxybenzoin is a pale-yellow solid organic compound with the formula C14H12O. It is a diphenyl ketone that can be synthesized via various methods, including the Friedel-Crafts acylation of benzene with benzoyl chloride. Deoxybenzoin is a versatile building block in organic synthesis, serving as a precursor to various pharmaceutical compounds and natural products. It exhibits biological activity, acting as a ligand for certain enzymes and demonstrating potential applications in cancer therapy and drug development. Deoxybenzoin is also used in the synthesis of chalcones, which are important intermediates in the synthesis of flavonoids, a class of naturally occurring compounds with various pharmacological properties. Its ability to undergo photochemical reactions and its potential applications in the development of novel materials have also led to its study.'
deoxybenzoin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 9948 |
| CHEMBL ID | 3182695 |
| SCHEMBL ID | 24800 |
| MeSH ID | M0475081 |
| Synonym |
|---|
| EU-0066752 |
| brn 1072876 |
| einecs 207-193-2 |
| ai3-10583 |
| nsc 131456 |
| EN300-17086 |
| nsc131456 |
| nsc-131456 |
| benzyl phenyl ketone |
| 2-phenylacetophenone , |
| phenyl benzyl ketone |
| 451-40-1 |
| desoxybenzoin |
| nsc6097 |
| nsc-6097 |
| 1,2-diphenylethanone |
| deoxybenzoin |
| acetophenone, 2-phenyl- |
| benzoin, deoxy- |
| 1,2-diphenylethan-1-one |
| wln: rv1r |
| ENAMINE_004883 |
| ethanone, 1,2-diphenyl- |
| inchi=1/c14h12o/c15-14(13-9-5-2-6-10-13)11-12-7-3-1-4-8-12/h1-10h,11h |
| 2-phenylacetophenone, 97% |
| nsc-249236 |
| nsc249236 |
| AC-11645 |
| B0435 |
| HMS1407N21 |
| AKOS001050203 |
| tox21_302159 |
| dtxsid6044430 , |
| cas-451-40-1 |
| dtxcid4024430 |
| NCGC00255911-01 |
| 1,2-diphenylethanone;deoxybenzoin |
| A826725 |
| 1,2-diphenyl-ethanone |
| CCG-103088 |
| unii-f17v6c9pzx |
| f17v6c9pzx , |
| 4-07-00-01393 (beilstein handbook reference) |
| FT-0624508 |
| F3297-0011 |
| STL264189 |
| 1,2-di(phenyl)ethanone |
| SCHEMBL24800 |
| benzylphenylketone |
| 1,2 diphenyl ethanone |
| 1,2 diphenyl-ethanone |
| 1,2-diphenyl-1-ethanone |
| bzbn |
| desoxybenzoine |
| 1, 2-diphenylethanone |
| deoxy benzoin |
| a-phenylacetophenone |
| W-106163 |
| AH-034/32462010 |
| CHEMBL3182695 |
| mfcd00003081 |
| sr-01000388911 |
| SR-01000388911-1 |
| Z56876371 |
| SY010613 |
| d-(+)-fucose;6-deoxy-d-galactose |
| AS-11947 |
| AMY39030 |
| Q27277503 |
| HY-Y1777 |
| ?2-phenylacetophenone |
| CS-0019389 |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 70.9799 | 0.0072 | 15.7588 | 89.3584 | AID1224835 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 28.9719 | 0.0060 | 38.0041 | 19,952.5996 | AID1159521; AID1159523 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 38.2017 | 0.0010 | 22.6508 | 76.6163 | AID1224838; AID1224839; AID1224893 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 32.0195 | 0.0030 | 41.6115 | 22,387.1992 | AID1159552; AID1159553; AID1159555 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 50.9664 | 0.0015 | 30.6073 | 15,848.9004 | AID1224841; AID1224848; AID1224849 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 61.1306 | 0.0054 | 28.0263 | 1,258.9301 | AID1346982 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 56.3396 | 0.0002 | 29.3054 | 16,493.5996 | AID1259244; AID743078 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 61.1306 | 0.0007 | 23.0674 | 1,258.9301 | AID743122 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 34.3762 | 0.0003 | 23.4451 | 159.6830 | AID743065 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 26.7920 | 0.0376 | 17.0823 | 61.1927 | AID1259364; AID1259388 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 54.4827 | 0.0015 | 57.7890 | 15,848.9004 | AID1259244 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 76.9588 | 0.0023 | 19.5956 | 74.0614 | AID651631 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 54.4827 | 0.0015 | 51.7393 | 15,848.9004 | AID1259244 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3 | High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (35.29) | 29.6817 |
| 2010's | 11 (64.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| This Compound (53.26) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 17 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||