metronidazole has been researched along with Ileal Diseases in 11 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Ileal Diseases: Pathological development in the ILEUM including the ILEOCECAL VALVE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A patient had Crohn's disease in relapse with multiple small bowel fistulae and mesenteric abscesses." | 1.30 | Relative sensitivity of Tc-99m WBC versus In-111 WBC in a patient with Crohn's disease on steroids. ( Broekelschen, P; Challa, S; Lyons, KP; Milne, N, 1997) |
| "Whilst colonic amoebiasis and its complications are well-documented, ileal amoebiasis has not been described in the literature." | 1.30 | Ileal amoebiasis. ( Haffejee, AA; Moodley, J; Ramdial, P; Singh, B, 1997) |
| "The postoperative complications were suppuration of the wall (n = 4), intestinal fistula (n = 3), evisceration, and residual abscess." | 1.29 | [Typhoid perforations: experiences in a surgical setting in Cameroon. Apropos of 49 cases]. ( Ibile, A; Malonga, E; Masso-Misse, P; Yao, JG, 1994) |
| "Forty cases of typhoid ileal perforation were treated surgically in three years." | 1.29 | Typhoid perforation treated with and without metronidazole along with chloramphenicol, gentamycin. ( Ahmad, G; Dab, RH; Javaid, K; Rathore, AH, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 6 (54.55) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Castiglione, F | 1 |
| Rispo, A | 1 |
| Di Girolamo, E | 1 |
| Cozzolino, A | 1 |
| Manguso, F | 1 |
| Grassia, R | 1 |
| Mazzacca, G | 1 |
| Park, JH | 1 |
| Chung, MH | 1 |
| Kim, JY | 1 |
| Lee, HJ | 1 |
| Kang, YN | 1 |
| Kim, AS | 1 |
| Hwang, JB | 1 |
| Raina, A | 1 |
| Kiss, L | 1 |
| Yadav, D | 1 |
| Yao, JG | 1 |
| Masso-Misse, P | 1 |
| Ibile, A | 1 |
| Malonga, E | 1 |
| Hurst, RD | 1 |
| Molinari, M | 1 |
| Chung, TP | 1 |
| Rubin, M | 1 |
| Michelassi, F | 1 |
| Javaid, K | 1 |
| Dab, RH | 1 |
| Rathore, AH | 1 |
| Ahmad, G | 1 |
| Lyons, KP | 2 |
| Challa, S | 2 |
| Broekelschen, P | 2 |
| Milne, N | 2 |
| Singh, B | 1 |
| Moodley, J | 1 |
| Ramdial, P | 1 |
| Haffejee, AA | 1 |
| Fitzgerald, J | 1 |
| Troncone, R | 1 |
| Cole, CR | 1 |
| Kaul, A | 1 |
| Brower, RA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study of the Safety and Efficacy of AST-120 in the Treatment of Antibiotic-Refractory Pouchitis[NCT00583531] | Phase 2 | 2 participants (Actual) | Interventional | 2007-03-31 | Terminated (stopped due to Lack of enrollment) | ||
| "A Phase 1b/2 Study to Demonstrate the Safety and Efficacy of EXE-346 Live Biotherapeutic to Reduce High Bowel Movement Frequency in Subjects With an Ileal Pouch-Anal Anastomosis (PROF). The PROF Study."[NCT05938465] | Phase 1/Phase 2 | 50 participants (Anticipated) | Interventional | 2023-10-11 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for metronidazole and Ileal Diseases
| Article | Year |
|---|---|
Antibiotic treatment of small bowel bacterial overgrowth in patients with Crohn's disease.
Topics: Adult; Aged; Anti-Infective Agents; Bacterial Infections; Breath Tests; Ciprofloxacin; Colonic Disea | 2003 |
10 other studies available for metronidazole and Ileal Diseases
| Article | Year |
|---|---|
Intussusception associated with pseudomembranous colitis.
Topics: Amoxicillin; Anti-Bacterial Agents; Child; Colonoscopy; Diagnosis, Differential; Enterocolitis, Pseu | 2008 |
Electronic clinical challenges and images in GI. Ileal diverticulitis.
Topics: Aged, 80 and over; Anti-Infective Agents; Ciprofloxacin; Digestive System Surgical Procedures; Diver | 2008 |
[Typhoid perforations: experiences in a surgical setting in Cameroon. Apropos of 49 cases].
Topics: Adult; Aged; Ampicillin; Anastomosis, Surgical; Cameroon; Chloramphenicol; Colon; Combined Modality | 1994 |
Prospective study of the incidence, timing and treatment of pouchitis in 104 consecutive patients after restorative proctocolectomy.
Topics: Adenomatous Polyposis Coli; Adolescent; Adult; Aged; Anti-Infective Agents; Ciprofloxacin; Colitis, | 1996 |
Prospective study of the incidence, timing and treatment of pouchitis in 104 consecutive patients after restorative proctocolectomy.
Topics: Adenomatous Polyposis Coli; Adolescent; Adult; Aged; Anti-Infective Agents; Ciprofloxacin; Colitis, | 1996 |
Prospective study of the incidence, timing and treatment of pouchitis in 104 consecutive patients after restorative proctocolectomy.
Topics: Adenomatous Polyposis Coli; Adolescent; Adult; Aged; Anti-Infective Agents; Ciprofloxacin; Colitis, | 1996 |
Prospective study of the incidence, timing and treatment of pouchitis in 104 consecutive patients after restorative proctocolectomy.
Topics: Adenomatous Polyposis Coli; Adolescent; Adult; Aged; Anti-Infective Agents; Ciprofloxacin; Colitis, | 1996 |
Typhoid perforation treated with and without metronidazole along with chloramphenicol, gentamycin.
Topics: Adolescent; Child; Chloramphenicol; Drug Therapy, Combination; Female; Gentamicins; Humans; Ileal Di | 1996 |
Relative sensitivity of Tc-99m WBC versus In-111 WBC in a patient with Crohn's disease on steroids.
Topics: Abdominal Abscess; Adult; Ampicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammator | 1997 |
Ileal amoebiasis.
Topics: Adult; Amebiasis; Amebicides; Colitis; Constriction, Pathologic; Female; Humans; Ileal Diseases; Int | 1997 |
Relative sensitivity of Tc-99m WBC versus In-111 WBC in a patient with Crohn disease and steroid use.
Topics: Abdominal Abscess; Adult; Ampicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammator | 1997 |
Clinical quiz. An ileocolonic intussusception associated with C. difficile infection.
Topics: Abdominal Pain; Anti-Bacterial Agents; Clostridioides difficile; Diagnosis, Differential; Diarrhea; | 2001 |
Hydrostatic balloon dilation of a terminal ileal stricture secondary to Crohn's disease.
Topics: Adult; Crohn Disease; Dilatation; Female; Follow-Up Studies; Humans; Ileal Diseases; Intestinal Obst | 1986 |