metronidazole has been researched along with Abdominal Epilepsy in 1 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Five patients had apparently drug-induced seizures while simultaneously receiving theophylline and either imipenem (three patients), ciprofloxacin (one patient), or ciprofloxacin and metronidazole (one patient)." | 7.68 | Seizures in patients simultaneously receiving theophylline and imipenem or ciprofloxacin or metronidazole. ( Allen, N; Semel, JD, 1991) |
| "Five patients had apparently drug-induced seizures while simultaneously receiving theophylline and either imipenem (three patients), ciprofloxacin (one patient), or ciprofloxacin and metronidazole (one patient)." | 3.68 | Seizures in patients simultaneously receiving theophylline and imipenem or ciprofloxacin or metronidazole. ( Allen, N; Semel, JD, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Semel, JD | 1 |
| Allen, N | 1 |
1 other study available for metronidazole and Abdominal Epilepsy
| Article | Year |
|---|---|
Seizures in patients simultaneously receiving theophylline and imipenem or ciprofloxacin or metronidazole.
Topics: Aged; Ciprofloxacin; Drug Interactions; Drug Therapy, Combination; Epilepsies, Partial; Female; Huma | 1991 |