metronidazole has been researched along with Ear Diseases in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Ear Diseases: Pathological processes of the ear, the hearing, and the equilibrium system of the body.
| Excerpt | Relevance | Reference |
|---|---|---|
| "As otogenic cerebral abscesses constitute a major proportion of all cerebral abscesses, the use of metronidazole against obligate anaerobic bacteria, which tend to dominate in such abscesses, should reduce the high mortality from this condition." | 1.26 | Bacteriological study of otogenic cerebral abscesses: chemotherapeutic role of metronidazole. ( Ingham, HR; Roxby, CM; Slekon, JB, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ingham, HR | 1 |
| Slekon, JB | 1 |
| Roxby, CM | 1 |
| Kristensen, S | 1 |
| Juul, A | 1 |
| Rosetzsky, A | 1 |
2 other studies available for metronidazole and Ear Diseases
| Article | Year |
|---|---|
Bacteriological study of otogenic cerebral abscesses: chemotherapeutic role of metronidazole.
Topics: Adolescent; Adult; Bacteroides fragilis; Bacteroides Infections; Brain Abscess; Ear Diseases; Female | 1977 |
Metronidazole uptake in the cholesteatomatous membrane in chronic otitis media.
Topics: Adult; Aged; Cholesteatoma; Chromatography, High Pressure Liquid; Ear Diseases; Ear, Middle; Female; | 1986 |