metronidazole has been researched along with Microbial Superinvasion in 7 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Relapse is frequent and must be distinguished from reinfection." | 2.45 | [Clostridium-difficile-associated diarrhea]. ( Bujanda, L; Cosme, A, 2009) |
| "The literature on the prevalence of superinfection of pancreatic tissue by S." | 1.32 | Streptococcus pneumoniae as an uncommon cause of superinfected pancreatic pseudocysts. ( Bauerfeind, P; Gubler, C; Ossola, N; Zinkernagel, A, 2003) |
| "Necrotizing fasciitis is a potentially fatal, acute bacterial infection characterized by extensive fascial and subcutaneous tissue necrosis." | 1.28 | Fatal necrotizing fasciitis of dental origin. ( Beecroft, WA; Cogan, AG; Stoykewych, AA, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Smith, S | 1 |
| Bujanda, L | 1 |
| Cosme, A | 1 |
| Gubler, C | 1 |
| Zinkernagel, A | 1 |
| Ossola, N | 1 |
| Bauerfeind, P | 1 |
| Levenga, H | 1 |
| Donnelly, P | 1 |
| Blijlevens, N | 1 |
| Verweij, P | 1 |
| Shirango, H | 1 |
| de Pauw, B | 1 |
| Trenschel, R | 1 |
| Peceny, R | 1 |
| Runde, V | 1 |
| Elmaagacli, A | 1 |
| Dermoumi, H | 1 |
| Heintschel von Heinegg, E | 1 |
| Müller, KD | 1 |
| Schaefer, UW | 1 |
| Beelen, DW | 1 |
| Stoykewych, AA | 1 |
| Beecroft, WA | 1 |
| Cogan, AG | 1 |
| Brook, I | 1 |
2 reviews available for metronidazole and Microbial Superinvasion
| Article | Year |
|---|---|
[Clostridium-difficile-associated diarrhea].
Topics: Aged; Anti-Bacterial Agents; Bacterial Toxins; Biological Therapy; Clostridioides difficile; Colecto | 2009 |
Fatal hemorrhagic pneumonia caused by infection due to Kytococcus sedentarius--a pathogen or passenger?
Topics: Actinomycetales; Actinomycetales Infections; Acyclovir; Antineoplastic Combined Chemotherapy Protoco | 2004 |
1 trial available for metronidazole and Microbial Superinvasion
| Article | Year |
|---|---|
Fungal colonization and invasive fungal infections following allogeneic BMT using metronidazole, ciprofloxacin and fluconazole or ciprofloxacin and fluconazole as intestinal decontamination.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Antibiotic Prophylaxis; Antifungal Agents; Aspergillosis; | 2000 |
4 other studies available for metronidazole and Microbial Superinvasion
| Article | Year |
|---|---|
Intestinal microbiota transplantation: a case of Crohn's colitis with superimposed Clostridium difficile infection.
Topics: Addison Disease; Adult; Anti-Infective Agents; Clostridioides difficile; Crohn Disease; Enterocoliti | 2013 |
Streptococcus pneumoniae as an uncommon cause of superinfected pancreatic pseudocysts.
Topics: Amoxicillin; Drug Therapy, Combination; Follow-Up Studies; Humans; Infusions, Intravenous; Male; Met | 2003 |
Fatal necrotizing fasciitis of dental origin.
Topics: Adult; Bacteroides Infections; Candidiasis; Cefotaxime; Clindamycin; Cloxacillin; Fasciitis; Female; | 1992 |
The effect of antimicrobial therapy on mixed infections with Bacteroides species. Is eradication of the anaerobes important?
Topics: Abscess; Animals; Bacteria, Anaerobic; Bacterial Infections; Bacteroides; Drug Therapy, Combination; | 1991 |