metronidazole has been researched along with Gingivostomatitis, Herpetic in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Periodontal diseases are common oral diseases that afflict all humans to some degree." | 2.37 | Current concepts in periodontal diseases. ( Higgins, TJ; Hunter, N; Knox, KW, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Asensio Sánchez, T | 1 |
| Dávila, I | 1 |
| Moreno, E | 1 |
| Laffond, E | 1 |
| Macías, E | 1 |
| Ruiz, A | 1 |
| Lorente, F | 1 |
| Higgins, TJ | 1 |
| Hunter, N | 1 |
| Knox, KW | 1 |
1 review available for metronidazole and Gingivostomatitis, Herpetic
| Article | Year |
|---|---|
Current concepts in periodontal diseases.
Topics: Acute Disease; Adult; Child; Chronic Disease; Dental Plaque; Gingivitis; Gingivitis, Necrotizing Ulc | 1985 |
1 other study available for metronidazole and Gingivostomatitis, Herpetic
| Article | Year |
|---|---|
Anaphylaxis due to metronidazole with positive skin prick test.
Topics: Anaphylaxis; Angioedema; Drug Hypersensitivity; Female; Humans; Metronidazole; Middle Aged; Skin Tes | 2008 |