Page last updated: 2024-10-31

metronidazole and Autosomal Dominant Juvenile Parkinson Disease

metronidazole has been researched along with Autosomal Dominant Juvenile Parkinson Disease in 1 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's1 (100.00)2.80

Authors

AuthorsStudies
Muir, RT1
Mercado, M1
Walter, VR1
Singhal, N1
Kwan, P1
Kucharczyk, W1
Stall, NM1
Carlen, PL1

Other Studies

1 other study available for metronidazole and Autosomal Dominant Juvenile Parkinson Disease

ArticleYear
Ataxia and Parkinsonism in Metronidazole Neurotoxicity.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2021, Volume: 48, Issue:2

    Topics: Ataxia; Brain Diseases; Cerebellar Ataxia; Humans; Magnetic Resonance Imaging; Metronidazole; Neurot

2021