Page last updated: 2024-11-11

robenidine

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Description

Robenidine: An anticoccidial agent mainly for poultry. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID9570438
CHEMBL ID97137
SCHEMBL ID571509
SCHEMBL ID23858311
MeSH IDM0019227
PubMed CID18527351
MeSH IDM0019227

Synonyms (63)

Synonym
CHEMBL97137
khimkoktsid
khimkoktside
carbonimidic dihydrazide, bis((4-chlorophenyl)methylene)-
guanidine, 1,3-bis((p-chlorobenzylidene)amino)-
1,3-bis((p-chlorobenzylidene)amino)guanidine
chimcoccide
einecs 247-308-3
robenidina [inn-spanish]
brn 2222647
khimcoccid
robenidinum [inn-latin]
NCGC00181026-01
1,3-bis[(e)-(4-chlorophenyl)methyleneamino]guanidine
bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride
robenidine (inn)
D08486
dtxsid9046813 ,
tox21_112676
cas-25875-51-8
dtxcid7026813
1,2-bis[(e)-(4-chlorophenyl)methylideneamino]guanidine
A818058
MLS004774077
smr003500746
robenidina
4888me6c4e ,
unii-4888me6c4e
robenidinum
bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide hydrochloride
robenidine [mi]
robenidine [inn]
SCHEMBL571509
tox21_112676_1
NCGC00181026-02
chimcoccid
2-(4-chlorobenzylidene)-n'-[(4-chlorophenyl)methylidene]hydrazinecarboximidohydrazide #
1,3-bis[p-chlorobenzylidene]amino]guanidine
chemcoccide
carbonimidic dihydrazide, bis[(4-chlorophenyl)methylene]-
sr-01000872601
SR-01000872601-1
n',2-bis(4-chlorobenzylidene)hydrazine-1-carboximidhydrazide
1,3-bis(4-chlorobenzylideneamino)guanidine
SCHEMBL23858311
robenidina (inn-spanish)
robenidinum (inn-latin)
HY-116724
CS-0066386
AKOS040744665
robenzidene
robenidine
robenz
robenidine [inn:ban]
25875-51-8
(2e)-2-(4-chlorobenzylidene)-n'-[(e)-(4-chlorophenyl)methylidene]hydrazinecarboximidohydrazide
3-[(e)-[(4-chlorophenyl)methylidene]amino]-1-[(z)-[(4-chlorophenyl)methylidene]amino]guanidine
bis((4-chlorophenyl)methylene)-carbonimidic dihydrazide
bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide, 9ci
1,3-bis((p-chlorobenzylidene)amino)-guanidine
1,3-bis[(p-chlorobenzylidene)amino]guanidine, 8ci
bis[(4-chlorophenyl)methylene]-carbonimidic dihydrazide
1-[(e)-(4-chlorophenyl)methylideneamino]-2-[(z)-(4-chlorophenyl)methylideneamino]guanidine

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" In the present study, we aimed to evaluate the effect of three coccidiostats, sulfaquinoxaline (SUL), robenidine (ROB), and toltrazuril (TOL), as feed additives on the pharmacokinetic profile of FFC in rabbits."( Influence of three coccidiostats on the pharmacokinetics of florfenicol in rabbits.
Liu, C; Shao, YX; Wang, SJ; Zhang, Q, 2015
)
0.42

Compound-Compound Interactions

ExcerptReferenceRelevance
"In this study, the potential of using the novel antibiotic NCL195 combined with subinhibitory concentrations of colistin against infections caused by Gram-negative bacteria (GNB) was investigated."( In vitro synergistic activity of NCL195 in combination with colistin against Gram-negative bacterial pathogens.
McCluskey, A; Nguyen, HT; O'Donovan, LA; Ogunniyi, AD; Page, SW; Russell, CC; Trott, DJ; Veltman, T; Venter, H; Williams, R, 2021
)
0.62

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019
)
0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (38)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
LuciferasePhotinus pyralis (common eastern firefly)Potency9.97660.007215.758889.3584AID1224835; AID624030
phosphopantetheinyl transferaseBacillus subtilisPotency79.43280.141337.9142100.0000AID1490
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency20.78633.189029.884159.4836AID1224846; AID1224894
RAR-related orphan receptor gammaMus musculus (house mouse)Potency34.14660.006038.004119,952.5996AID1159521; AID1159523
USP1 protein, partialHomo sapiens (human)Potency56.23410.031637.5844354.8130AID504865
TDP1 proteinHomo sapiens (human)Potency33.49830.000811.382244.6684AID686979
GLI family zinc finger 3Homo sapiens (human)Potency23.36670.000714.592883.7951AID1259369; AID1259392
AR proteinHomo sapiens (human)Potency36.52700.000221.22318,912.5098AID1259243; AID1259247
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency26.60320.000657.913322,387.1992AID1259378
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency6.96420.001022.650876.6163AID1224838; AID1224893
progesterone receptorHomo sapiens (human)Potency28.60080.000417.946075.1148AID1346784; AID1346795
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency3.46710.01237.983543.2770AID1645841
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency33.49150.003041.611522,387.1992AID1159552
retinoid X nuclear receptor alphaHomo sapiens (human)Potency10.69370.000817.505159.3239AID1159527; AID1159531
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency29.84930.001530.607315,848.9004AID1224848; AID1224849; AID1259403
pregnane X nuclear receptorHomo sapiens (human)Potency11.88320.005428.02631,258.9301AID1346982
estrogen nuclear receptor alphaHomo sapiens (human)Potency30.16200.000229.305416,493.5996AID1259248; AID743075
GVesicular stomatitis virusPotency13.80290.01238.964839.8107AID1645842
cytochrome P450 2D6Homo sapiens (human)Potency15.48710.00108.379861.1304AID1645840
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency21.58960.001024.504861.6448AID743212; AID743227
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency26.83250.023723.228263.5986AID743223
aryl hydrocarbon receptorHomo sapiens (human)Potency15.72890.000723.06741,258.9301AID743085; AID743122
activating transcription factor 6Homo sapiens (human)Potency19.62360.143427.612159.8106AID1159516; AID1159519
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency12.065219.739145.978464.9432AID1159509; AID1159518
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency6.07720.057821.109761.2679AID1159526; AID1159528
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency89.12510.354828.065989.1251AID504847
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency3.54810.01789.637444.6684AID588834
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency22.84790.000323.4451159.6830AID743065; AID743067
heat shock protein beta-1Homo sapiens (human)Potency31.10610.042027.378961.6448AID743210; AID743228
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency19.24170.000627.21521,122.0200AID743202; AID743219
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency14.12540.00798.23321,122.0200AID2551
gemininHomo sapiens (human)Potency13.33590.004611.374133.4983AID624296
Interferon betaHomo sapiens (human)Potency13.80290.00339.158239.8107AID1645842
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency13.80290.01238.964839.8107AID1645842
Cellular tumor antigen p53Homo sapiens (human)Potency28.22630.002319.595674.0614AID651631; AID720552
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency0.31620.009610.525035.4813AID1479145
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency13.80290.01238.964839.8107AID1645842
cytochrome P450 2C9, partialHomo sapiens (human)Potency13.80290.01238.964839.8107AID1645842
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (168)

Processvia Protein(s)Taxonomy
cell surface receptor signaling pathway via JAK-STATInterferon betaHomo sapiens (human)
response to exogenous dsRNAInterferon betaHomo sapiens (human)
B cell activation involved in immune responseInterferon betaHomo sapiens (human)
cell surface receptor signaling pathwayInterferon betaHomo sapiens (human)
cell surface receptor signaling pathway via JAK-STATInterferon betaHomo sapiens (human)
response to virusInterferon betaHomo sapiens (human)
positive regulation of autophagyInterferon betaHomo sapiens (human)
cytokine-mediated signaling pathwayInterferon betaHomo sapiens (human)
natural killer cell activationInterferon betaHomo sapiens (human)
positive regulation of peptidyl-serine phosphorylation of STAT proteinInterferon betaHomo sapiens (human)
cellular response to interferon-betaInterferon betaHomo sapiens (human)
B cell proliferationInterferon betaHomo sapiens (human)
negative regulation of viral genome replicationInterferon betaHomo sapiens (human)
innate immune responseInterferon betaHomo sapiens (human)
positive regulation of innate immune responseInterferon betaHomo sapiens (human)
regulation of MHC class I biosynthetic processInterferon betaHomo sapiens (human)
negative regulation of T cell differentiationInterferon betaHomo sapiens (human)
positive regulation of transcription by RNA polymerase IIInterferon betaHomo sapiens (human)
defense response to virusInterferon betaHomo sapiens (human)
type I interferon-mediated signaling pathwayInterferon betaHomo sapiens (human)
neuron cellular homeostasisInterferon betaHomo sapiens (human)
cellular response to exogenous dsRNAInterferon betaHomo sapiens (human)
cellular response to virusInterferon betaHomo sapiens (human)
negative regulation of Lewy body formationInterferon betaHomo sapiens (human)
negative regulation of T-helper 2 cell cytokine productionInterferon betaHomo sapiens (human)
positive regulation of apoptotic signaling pathwayInterferon betaHomo sapiens (human)
response to exogenous dsRNAInterferon betaHomo sapiens (human)
B cell differentiationInterferon betaHomo sapiens (human)
natural killer cell activation involved in immune responseInterferon betaHomo sapiens (human)
adaptive immune responseInterferon betaHomo sapiens (human)
T cell activation involved in immune responseInterferon betaHomo sapiens (human)
humoral immune responseInterferon betaHomo sapiens (human)
positive regulation of T cell mediated cytotoxicityHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
adaptive immune responseHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independentHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
regulation of T cell anergyHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
defense responseHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
immune responseHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
detection of bacteriumHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
regulation of interleukin-12 productionHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
regulation of interleukin-6 productionHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
protection from natural killer cell mediated cytotoxicityHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
innate immune responseHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
regulation of dendritic cell differentiationHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
antigen processing and presentation of endogenous peptide antigen via MHC class IbHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
negative regulation of cell population proliferationCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycleCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycle G2/M phase transitionCellular tumor antigen p53Homo sapiens (human)
DNA damage responseCellular tumor antigen p53Homo sapiens (human)
ER overload responseCellular tumor antigen p53Homo sapiens (human)
cellular response to glucose starvationCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
positive regulation of miRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
negative regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
mitophagyCellular tumor antigen p53Homo sapiens (human)
in utero embryonic developmentCellular tumor antigen p53Homo sapiens (human)
somitogenesisCellular tumor antigen p53Homo sapiens (human)
release of cytochrome c from mitochondriaCellular tumor antigen p53Homo sapiens (human)
hematopoietic progenitor cell differentiationCellular tumor antigen p53Homo sapiens (human)
T cell proliferation involved in immune responseCellular tumor antigen p53Homo sapiens (human)
B cell lineage commitmentCellular tumor antigen p53Homo sapiens (human)
T cell lineage commitmentCellular tumor antigen p53Homo sapiens (human)
response to ischemiaCellular tumor antigen p53Homo sapiens (human)
nucleotide-excision repairCellular tumor antigen p53Homo sapiens (human)
double-strand break repairCellular tumor antigen p53Homo sapiens (human)
regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
protein import into nucleusCellular tumor antigen p53Homo sapiens (human)
autophagyCellular tumor antigen p53Homo sapiens (human)
DNA damage responseCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorCellular tumor antigen p53Homo sapiens (human)
transforming growth factor beta receptor signaling pathwayCellular tumor antigen p53Homo sapiens (human)
Ras protein signal transductionCellular tumor antigen p53Homo sapiens (human)
gastrulationCellular tumor antigen p53Homo sapiens (human)
neuroblast proliferationCellular tumor antigen p53Homo sapiens (human)
negative regulation of neuroblast proliferationCellular tumor antigen p53Homo sapiens (human)
protein localizationCellular tumor antigen p53Homo sapiens (human)
negative regulation of DNA replicationCellular tumor antigen p53Homo sapiens (human)
negative regulation of cell population proliferationCellular tumor antigen p53Homo sapiens (human)
determination of adult lifespanCellular tumor antigen p53Homo sapiens (human)
mRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
rRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
response to salt stressCellular tumor antigen p53Homo sapiens (human)
response to inorganic substanceCellular tumor antigen p53Homo sapiens (human)
response to X-rayCellular tumor antigen p53Homo sapiens (human)
response to gamma radiationCellular tumor antigen p53Homo sapiens (human)
positive regulation of gene expressionCellular tumor antigen p53Homo sapiens (human)
cardiac muscle cell apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of cardiac muscle cell apoptotic processCellular tumor antigen p53Homo sapiens (human)
glial cell proliferationCellular tumor antigen p53Homo sapiens (human)
viral processCellular tumor antigen p53Homo sapiens (human)
glucose catabolic process to lactate via pyruvateCellular tumor antigen p53Homo sapiens (human)
cerebellum developmentCellular tumor antigen p53Homo sapiens (human)
negative regulation of cell growthCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
negative regulation of transforming growth factor beta receptor signaling pathwayCellular tumor antigen p53Homo sapiens (human)
mitotic G1 DNA damage checkpoint signalingCellular tumor antigen p53Homo sapiens (human)
negative regulation of telomere maintenance via telomeraseCellular tumor antigen p53Homo sapiens (human)
T cell differentiation in thymusCellular tumor antigen p53Homo sapiens (human)
tumor necrosis factor-mediated signaling pathwayCellular tumor antigen p53Homo sapiens (human)
regulation of tissue remodelingCellular tumor antigen p53Homo sapiens (human)
cellular response to UVCellular tumor antigen p53Homo sapiens (human)
multicellular organism growthCellular tumor antigen p53Homo sapiens (human)
positive regulation of mitochondrial membrane permeabilityCellular tumor antigen p53Homo sapiens (human)
cellular response to glucose starvationCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
entrainment of circadian clock by photoperiodCellular tumor antigen p53Homo sapiens (human)
mitochondrial DNA repairCellular tumor antigen p53Homo sapiens (human)
regulation of DNA damage response, signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of neuron apoptotic processCellular tumor antigen p53Homo sapiens (human)
transcription initiation-coupled chromatin remodelingCellular tumor antigen p53Homo sapiens (human)
negative regulation of proteolysisCellular tumor antigen p53Homo sapiens (human)
negative regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
positive regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
positive regulation of RNA polymerase II transcription preinitiation complex assemblyCellular tumor antigen p53Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
response to antibioticCellular tumor antigen p53Homo sapiens (human)
fibroblast proliferationCellular tumor antigen p53Homo sapiens (human)
negative regulation of fibroblast proliferationCellular tumor antigen p53Homo sapiens (human)
circadian behaviorCellular tumor antigen p53Homo sapiens (human)
bone marrow developmentCellular tumor antigen p53Homo sapiens (human)
embryonic organ developmentCellular tumor antigen p53Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylationCellular tumor antigen p53Homo sapiens (human)
protein stabilizationCellular tumor antigen p53Homo sapiens (human)
negative regulation of helicase activityCellular tumor antigen p53Homo sapiens (human)
protein tetramerizationCellular tumor antigen p53Homo sapiens (human)
chromosome organizationCellular tumor antigen p53Homo sapiens (human)
neuron apoptotic processCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycleCellular tumor antigen p53Homo sapiens (human)
hematopoietic stem cell differentiationCellular tumor antigen p53Homo sapiens (human)
negative regulation of glial cell proliferationCellular tumor antigen p53Homo sapiens (human)
type II interferon-mediated signaling pathwayCellular tumor antigen p53Homo sapiens (human)
cardiac septum morphogenesisCellular tumor antigen p53Homo sapiens (human)
positive regulation of programmed necrotic cell deathCellular tumor antigen p53Homo sapiens (human)
protein-containing complex assemblyCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressCellular tumor antigen p53Homo sapiens (human)
thymocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of thymocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
necroptotic processCellular tumor antigen p53Homo sapiens (human)
cellular response to hypoxiaCellular tumor antigen p53Homo sapiens (human)
cellular response to xenobiotic stimulusCellular tumor antigen p53Homo sapiens (human)
cellular response to ionizing radiationCellular tumor antigen p53Homo sapiens (human)
cellular response to gamma radiationCellular tumor antigen p53Homo sapiens (human)
cellular response to UV-CCellular tumor antigen p53Homo sapiens (human)
stem cell proliferationCellular tumor antigen p53Homo sapiens (human)
signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
cellular response to actinomycin DCellular tumor antigen p53Homo sapiens (human)
positive regulation of release of cytochrome c from mitochondriaCellular tumor antigen p53Homo sapiens (human)
cellular senescenceCellular tumor antigen p53Homo sapiens (human)
replicative senescenceCellular tumor antigen p53Homo sapiens (human)
oxidative stress-induced premature senescenceCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathwayCellular tumor antigen p53Homo sapiens (human)
oligodendrocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of execution phase of apoptosisCellular tumor antigen p53Homo sapiens (human)
negative regulation of mitophagyCellular tumor antigen p53Homo sapiens (human)
regulation of mitochondrial membrane permeability involved in apoptotic processCellular tumor antigen p53Homo sapiens (human)
regulation of intrinsic apoptotic signaling pathway by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of miRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
negative regulation of G1 to G0 transitionCellular tumor antigen p53Homo sapiens (human)
negative regulation of miRNA processingCellular tumor antigen p53Homo sapiens (human)
negative regulation of glucose catabolic process to lactate via pyruvateCellular tumor antigen p53Homo sapiens (human)
negative regulation of pentose-phosphate shuntCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to hypoxiaCellular tumor antigen p53Homo sapiens (human)
regulation of fibroblast apoptotic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of stem cell proliferationCellular tumor antigen p53Homo sapiens (human)
positive regulation of cellular senescenceCellular tumor antigen p53Homo sapiens (human)
positive regulation of intrinsic apoptotic signaling pathwayCellular tumor antigen p53Homo sapiens (human)
inositol phosphate metabolic processInositol hexakisphosphate kinase 1Homo sapiens (human)
phosphatidylinositol phosphate biosynthetic processInositol hexakisphosphate kinase 1Homo sapiens (human)
negative regulation of cold-induced thermogenesisInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol phosphate biosynthetic processInositol hexakisphosphate kinase 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (50)

Processvia Protein(s)Taxonomy
cytokine activityInterferon betaHomo sapiens (human)
cytokine receptor bindingInterferon betaHomo sapiens (human)
type I interferon receptor bindingInterferon betaHomo sapiens (human)
protein bindingInterferon betaHomo sapiens (human)
chloramphenicol O-acetyltransferase activityInterferon betaHomo sapiens (human)
TAP bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
signaling receptor bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
protein bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
peptide antigen bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
TAP bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
protein-folding chaperone bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
transcription cis-regulatory region bindingCellular tumor antigen p53Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
cis-regulatory region sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
core promoter sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
TFIID-class transcription factor complex bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
protease bindingCellular tumor antigen p53Homo sapiens (human)
p53 bindingCellular tumor antigen p53Homo sapiens (human)
DNA bindingCellular tumor antigen p53Homo sapiens (human)
chromatin bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription factor activityCellular tumor antigen p53Homo sapiens (human)
mRNA 3'-UTR bindingCellular tumor antigen p53Homo sapiens (human)
copper ion bindingCellular tumor antigen p53Homo sapiens (human)
protein bindingCellular tumor antigen p53Homo sapiens (human)
zinc ion bindingCellular tumor antigen p53Homo sapiens (human)
enzyme bindingCellular tumor antigen p53Homo sapiens (human)
receptor tyrosine kinase bindingCellular tumor antigen p53Homo sapiens (human)
ubiquitin protein ligase bindingCellular tumor antigen p53Homo sapiens (human)
histone deacetylase regulator activityCellular tumor antigen p53Homo sapiens (human)
ATP-dependent DNA/DNA annealing activityCellular tumor antigen p53Homo sapiens (human)
identical protein bindingCellular tumor antigen p53Homo sapiens (human)
histone deacetylase bindingCellular tumor antigen p53Homo sapiens (human)
protein heterodimerization activityCellular tumor antigen p53Homo sapiens (human)
protein-folding chaperone bindingCellular tumor antigen p53Homo sapiens (human)
protein phosphatase 2A bindingCellular tumor antigen p53Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor bindingCellular tumor antigen p53Homo sapiens (human)
14-3-3 protein bindingCellular tumor antigen p53Homo sapiens (human)
MDM2/MDM4 family protein bindingCellular tumor antigen p53Homo sapiens (human)
disordered domain specific bindingCellular tumor antigen p53Homo sapiens (human)
general transcription initiation factor bindingCellular tumor antigen p53Homo sapiens (human)
molecular function activator activityCellular tumor antigen p53Homo sapiens (human)
promoter-specific chromatin bindingCellular tumor antigen p53Homo sapiens (human)
inositol-1,3,4,5,6-pentakisphosphate kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol hexakisphosphate kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol heptakisphosphate kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol hexakisphosphate 5-kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
protein bindingInositol hexakisphosphate kinase 1Homo sapiens (human)
ATP bindingInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol hexakisphosphate 1-kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol hexakisphosphate 3-kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol 5-diphosphate pentakisphosphate 5-kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol diphosphate tetrakisphosphate kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (37)

Processvia Protein(s)Taxonomy
extracellular spaceInterferon betaHomo sapiens (human)
extracellular regionInterferon betaHomo sapiens (human)
Golgi membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
endoplasmic reticulumHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
Golgi apparatusHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
plasma membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
cell surfaceHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
ER to Golgi transport vesicle membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
secretory granule membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
phagocytic vesicle membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
early endosome membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
recycling endosome membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
extracellular exosomeHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
lumenal side of endoplasmic reticulum membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
MHC class I protein complexHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
extracellular spaceHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
external side of plasma membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
nuclear bodyCellular tumor antigen p53Homo sapiens (human)
nucleusCellular tumor antigen p53Homo sapiens (human)
nucleoplasmCellular tumor antigen p53Homo sapiens (human)
replication forkCellular tumor antigen p53Homo sapiens (human)
nucleolusCellular tumor antigen p53Homo sapiens (human)
cytoplasmCellular tumor antigen p53Homo sapiens (human)
mitochondrionCellular tumor antigen p53Homo sapiens (human)
mitochondrial matrixCellular tumor antigen p53Homo sapiens (human)
endoplasmic reticulumCellular tumor antigen p53Homo sapiens (human)
centrosomeCellular tumor antigen p53Homo sapiens (human)
cytosolCellular tumor antigen p53Homo sapiens (human)
nuclear matrixCellular tumor antigen p53Homo sapiens (human)
PML bodyCellular tumor antigen p53Homo sapiens (human)
transcription repressor complexCellular tumor antigen p53Homo sapiens (human)
site of double-strand breakCellular tumor antigen p53Homo sapiens (human)
germ cell nucleusCellular tumor antigen p53Homo sapiens (human)
chromatinCellular tumor antigen p53Homo sapiens (human)
transcription regulator complexCellular tumor antigen p53Homo sapiens (human)
protein-containing complexCellular tumor antigen p53Homo sapiens (human)
virion membraneSpike glycoproteinSevere acute respiratory syndrome-related coronavirus
fibrillar centerInositol hexakisphosphate kinase 1Homo sapiens (human)
nucleoplasmInositol hexakisphosphate kinase 1Homo sapiens (human)
cytosolInositol hexakisphosphate kinase 1Homo sapiens (human)
nucleusInositol hexakisphosphate kinase 1Homo sapiens (human)
cytoplasmInositol hexakisphosphate kinase 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (111)

Assay IDTitleYearJournalArticle
AID504749qHTS profiling for inhibitors of Plasmodium falciparum proliferation2011Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043
Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.
AID1347092qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347094qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1347407qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Pharmaceutical Collection2020ACS chemical biology, 07-17, Volume: 15, Issue:7
High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
AID1347425Rhodamine-PBP qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1)2019The Journal of biological chemistry, 11-15, Volume: 294, Issue:46
Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.
AID1347424RapidFire Mass Spectrometry qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1)2019The Journal of biological chemistry, 11-15, Volume: 294, Issue:46
Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID1347086qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347082qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347091qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347101qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347089qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347103qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347096qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347100qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347090qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347083qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347104qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347098qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347099qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1508630Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay2021Cell reports, 04-27, Volume: 35, Issue:4
A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1347108qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347095qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347154Primary screen GU AMC qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1347107qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347102qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347093qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347105qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347097qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347106qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1286505Cytotoxicity against human HepG2 cells after 24 hrs by WST-1 based colorimetric assay2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286456Bactericidal activity against Methicillin-sensitive Staphylococcus aureus clinical isolate USA300 assessed as log reduction in bacterial cell number at 4 times MIC after 8 hrs by time-kill curve analysis2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286500Bactericidal activity against methicillin-sensitive Staphylococcus aureus ATCC 29213 after 24 and 48 hrs2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID51255The compound was tested for anti-coccidial activity in chicken against E. maxima(DP-776) measured at dose 33(ppm in diet)1991Journal of medicinal chemistry, Sep, Volume: 34, Issue:9
Benzylated 1,2,3-triazoles as anticoccidiostats.
AID1286501Ratio of MBC for methicillin-sensitive Staphylococcus aureus ATCC 25923 to MIC90 for methicillin-sensitive Staphylococcus aureus ATCC 259232016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286487Selectivity index, ratio of GI50 for human HepG2 cells to MIC50 for methicillin-sensitive Staphylococcus aureus clinical isolate2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286465Bactericidal activity against Methicillin-sensitive Staphylococcus aureus clinical isolate USA300 assessed as log reduction in bacterial cell number at 8 times MIC after 24 hrs by time-kill curve analysis2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286504Ratio of MBC for methicillin-sensitive Staphylococcus aureus ATCC 29213 to MIC90 for methicillin-sensitive Staphylococcus aureus ATCC 292132016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286479Metabolic stability in human liver microsomes assessed as compound loss after 60 mins2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286525Bactericidal activity against Methicillin-sensitive Staphylococcus aureus clinical isolate USA300 assessed as log reduction in bacterial cell number at 2 times MIC after 8 hrs by time-kill curve analysis2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286483Toxicity in po dosed male rabbit2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286486Selectivity index, ratio of GI50 for human HEL299 cells to MIC50 for methicillin-resistant Staphylococcus aureus clinical isolate2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286496Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 29213 after 20 to 24 hrs in presence of 50% heat inactivated bovine serum2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286467Inhibition of biofilm formation in methicillin-resistant Staphylococcus aureus assessed as log reduction at > 43.2 uM after 24 hrs by MBEC assay relative to control2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286488Selectivity index, ratio of GI50 for human HepG2 cells to MIC50 for methicillin-resistant Staphylococcus aureus clinical isolate2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286515Ratio of MBC for methicillin-resistant Staphylococcus aureus clinical isolate to MIC90 for methicillin-resistant Staphylococcus aureus clinical isolate2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286521Bactericidal activity against methicillin-sensitive Staphylococcus aureus ATCC 29213 assessed as log reduction in bacterial cell number at 2 times MIC after 8 hrs by time-kill curve analysis2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286499Bactericidal activity against methicillin-sensitive Staphylococcus aureus ATCC 49775 after 24 and 48 hrs2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286477Intrinsic clearance in human liver microsomes assessed per mg of protein2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286461Bactericidal activity against Methicillin-sensitive Staphylococcus aureus ATCC 29213 assessed as log reduction in bacterial cell number at 8 times MIC after 24 hrs by time-kill curve analysis2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286508Antibacterial activity against vancomycin-resistant Enterococcus after 20 to 24 hrs2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286523Bactericidal activity against methicillin-sensitive Staphylococcus aureus ATCC 29213 assessed as log reduction in bacterial cell number at 8 times MIC after 8 hrs by time-kill curve analysis2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286516Antibacterial activity against Escherichia coli ATCC 25922 after 20 to 24 hrs in presence of polymyxin B nonapeptide2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID51241The compound was tested for anti-coccidial activity in chicken against E. brunetti (FS-103) measured at dose 33(ppm in diet)1991Journal of medicinal chemistry, Sep, Volume: 34, Issue:9
Benzylated 1,2,3-triazoles as anticoccidiostats.
AID1286476Half life of compound in mouse liver microsomes2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286495Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 49775 after 20 to 24 hrs in presence of 50% heat inactivated bovine serum2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286462Bactericidal activity against Methicillin-sensitive Staphylococcus aureus clinical isolate USA300 assessed as log reduction in bacterial cell number at MIC after 24 hrs by time-kill curve analysis2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286513Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate after 20 to 24 hrs in presence of 50% heat inactivated bovine serum2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286519Ratio of MIC90 for Pseudomonas aeruginosa ATCC 27853 to MIC90 for Pseudomonas aeruginosa ATCC 27853 in presence of polymyxin B nonapeptide2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286468Toxicity in sheep erythrocytes assessed as hemolysis after 30 mins2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286497Bactericidal activity against methicillin-sensitive Staphylococcus aureus ATCC 25923 after 24 and 48 hrs2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286471Lipophilicity, logD of the compound at pH 32016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286510Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 20 to 24 hrs2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID51261The compound was tested for anti-coccidial activity in chicken against E. mitis(LS-84) measured at dose 33(ppm in diet)1991Journal of medicinal chemistry, Sep, Volume: 34, Issue:9
Benzylated 1,2,3-triazoles as anticoccidiostats.
AID1286484Toxicity in po dosed female rabbit2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286466Inhibition of biofilm formation in methicillin-resistant Staphylococcus aureus after 24 hrs by MBEC assay2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286506Antiprotozoal activity against Babesia microti ATCC PRA-99 infected in BALB/c mouse assessed as suppression of parasitemia at 25 and 50 mg/kg, administered 4 times daily2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286459Bactericidal activity against Methicillin-sensitive Staphylococcus aureus ATCC 29213 assessed as log reduction in bacterial cell number at 2 times MIC after 24 hrs by time kill curve analysis2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID51092Anticoccidial activity in chicken against Eimeria acervulina.1991Journal of medicinal chemistry, Sep, Volume: 34, Issue:9
Benzylated 1,2,3-triazoles as anticoccidiostats.
AID1286457Bactericidal activity against Methicillin-sensitive Staphylococcus aureus clinical isolate USA300 assessed as log reduction in bacterial cell number at 8 times MIC after 8 hrs by time-kill curve analysis2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286460Bactericidal activity against Methicillin-sensitive Staphylococcus aureus ATCC 29213 assessed as log reduction in bacterial cell number at 4 times MIC after 24 hrs by time kill curve analysis2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286492Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 29213 after 20 to 24 hrs2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286524Bactericidal activity against methicillin-sensitive Staphylococcus aureus clinical isolate USA300 assessed as log reduction in bacterial cell number at MIC after 8 hrs by time-kill curve analysis2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID51411The compound was tested for anti-coccidial activity in chicken against E. praecox(DP-785) measured at dose 33(ppm in diet)1991Journal of medicinal chemistry, Sep, Volume: 34, Issue:9
Benzylated 1,2,3-triazoles as anticoccidiostats.
AID1286491Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 49775 after 20 to 24 hrs2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286485Selectivity index, ratio of GI50 for human HEL299 cells to MIC50 for methicillin-sensitive Staphylococcus aureus clinical isolate2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID51422The compound was tested for anti-coccidial activity in chicken against E. tenella(DP-761) measured at dose 33(ppm in diet)1991Journal of medicinal chemistry, Sep, Volume: 34, Issue:9
Benzylated 1,2,3-triazoles as anticoccidiostats.
AID1286512Antibacterial activity against Staphylococcus aureus ATCC 29213 after 20 to 24 hrs in presence of 2% heat inactivated bovine serum2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286482Toxicity in po dosed rat2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286503Ratio of MBC for methicillin-sensitive Staphylococcus aureus ATCC 49775 to MIC90 for methicillin-sensitive Staphylococcus aureus ATCC 497752016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286478Intrinsic clearance in mouse liver microsomes assessed per mg of protein2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286493Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 25923 after 20 to 24 hrs in presence of 50% heat inactivated bovine serum2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286502Ratio of MBC for methicillin-sensitive Staphylococcus aureus ATCC 6538 to MIC90 for methicillin-sensitive Staphylococcus aureus ATCC 65382016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286474Solubility of the compound at pH 6.52016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286464Bactericidal activity against Methicillin-sensitive Staphylococcus aureus clinical isolate USA300 assessed as log reduction in bacterial cell number at 4 times MIC after 24 hrs by time-kill curve analysis2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286522Bactericidal activity against methicillin-sensitive Staphylococcus aureus ATCC 29213 assessed as log reduction in bacterial cell number at 4 times MIC after 8 hrs by time-kill curve analysis2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286509Antibacterial activity against Escherichia coli ATCC 25922 after 20 to 24 hrs2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286494Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 6538 after 20 to 24 hrs in presence of 50% heat inactivated bovine serum2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286520Bactericidal activity against methicillin-sensitive Staphylococcus aureus ATCC 29213 assessed as log reduction in bacterial cell number at MIC after 8 hrs by time-kill curve analysis2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286480Metabolic stability in mouse liver microsomes assessed as compound loss after 60 mins2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286507Antibacterial activity against methicillin-resistant Staphylococcus aureus after 20 to 24 hrs2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286514Bactericidal activity against methicillin-resistant Staphylococcus aureus clinical isolate after 24 and 48 hrs2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286473Solubility of the compound at pH 22016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286463Bactericidal activity against Methicillin-sensitive Staphylococcus aureus clinical isolate USA300 assessed as log reduction in bacterial cell number at 2 times MIC after 24 hrs by time-kill curve analysis2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286470Cytotoxicity against human HEL299 cells after 24 hrs by WST-1 based colorimetric assay2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286490Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 6538 after 20 to 24 hrs2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID51412Anticoccidial activity in chicken against E. tenella1991Journal of medicinal chemistry, Sep, Volume: 34, Issue:9
Benzylated 1,2,3-triazoles as anticoccidiostats.
AID1286472Lipophilicity, logD of the compound at pH 7.42016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286517Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 20 to 24 hrs in presence of polymyxin B nonapeptide2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286458Bactericidal activity against Methicillin-sensitive Staphylococcus aureus ATCC 29213 assessed as log reduction in bacterial cell number at MIC after 24 hrs by time kill curve analysis2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286511Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate after 20 to 24 hrs2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286498Bactericidal activity against methicillin-sensitive Staphylococcus aureus ATCC 6538 after 24 and 48 hrs2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286518Ratio of MIC90 for Escherichia coli ATCC 25922 to MIC90 for Escherichia coli ATCC 25922 in presence of polymyxin B nonapeptide2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID1286475Half life of compound in human liver microsomes2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
AID51231The compound was tested for anti-coccidial activity in chicken against E. acervulina (DP-761) measured at dose 33(ppm in diet)1991Journal of medicinal chemistry, Sep, Volume: 34, Issue:9
Benzylated 1,2,3-triazoles as anticoccidiostats.
AID51246The compound was tested for anti-coccidial activity in chicken against E. hagani(DP-786) measured at dose 33(ppm in diet)1991Journal of medicinal chemistry, Sep, Volume: 34, Issue:9
Benzylated 1,2,3-triazoles as anticoccidiostats.
AID1286489Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 25923 after 20 to 24 hrs2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Robenidine Analogues as Gram-Positive Antibacterial Agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (89)

TimeframeStudies, This Drug (%)All Drugs %
pre-199044 (49.44)18.7374
1990's7 (7.87)18.2507
2000's11 (12.36)29.6817
2010's16 (17.98)24.3611
2020's11 (12.36)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 39.04

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index39.04 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.37 (4.65)
Search Engine Demand Index52.26 (26.88)
Search Engine Supply Index2.03 (0.95)

This Compound (39.04)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Trials2 (2.35%)5.53%
Reviews0 (0.00%)6.00%
Reviews3 (3.53%)6.00%
Case Studies0 (0.00%)4.05%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
Other80 (94.12%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]