metronidazole has been researched along with Ileitis in 13 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Ileitis: Inflammation of any segment of the ILEUM and the ILEOCECAL VALVE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The incidence of PPI in patients with ulcerative colitis/indeterminate colitis is 5." | 1.35 | Incidence and short-term implications of prepouch ileitis following restorative proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis. ( Bell, AJ; Ciclitira, PJ; Clark, SK; McLaughlin, SD; Nicholls, RJ; Tekkis, PP, 2009) |
| "Records of 217 patients with mucosal ulcerative colitis who underwent restorative proctocolectomy with a stapled ileal pouch-anal anastomosis without anal mucosectomy from 1987 through 1990 were retrospectively reviewed." | 1.29 | Anal canal inflammation after ileal pouch-anal anastomosis. The need for treatment. ( Fazio, VW; Lavery, IC; Sirimarco, MT; Ziv, Y, 1995) |
| "A 28-year-old man with chronic ulcerative colitis had a proctocolectomy with creation of a continent ileostomy." | 1.27 | Pouch ileitis: report of a case with severe systemic manifestations. ( Katon, RM; Klein, K; Stenzel, P, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (30.77) | 18.7374 |
| 1990's | 7 (53.85) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McLaughlin, SD | 1 |
| Clark, SK | 1 |
| Bell, AJ | 1 |
| Tekkis, PP | 1 |
| Ciclitira, PJ | 1 |
| Nicholls, RJ | 1 |
| Bamias, G | 1 |
| Marini, M | 1 |
| Moskaluk, CA | 1 |
| Odashima, M | 1 |
| Ross, WG | 1 |
| Rivera-Nieves, J | 1 |
| Cominelli, F | 1 |
| Klein, K | 1 |
| Stenzel, P | 1 |
| Katon, RM | 1 |
| Lavery, IC | 1 |
| Sirimarco, MT | 1 |
| Ziv, Y | 1 |
| Fazio, VW | 1 |
| Solheim, K | 1 |
| Keighley, MR | 2 |
| Kelly, KA | 1 |
| Mignon, M | 1 |
| Stettler, C | 1 |
| Phillips, SF | 1 |
| Kmiot, WA | 1 |
| Youngs, D | 1 |
| Tudor, R | 1 |
| Thompson, H | 1 |
| Dubé, S | 1 |
| Heyen, F | 1 |
| Meuwissen, SG | 1 |
| Hoitsma, H | 1 |
| Boot, H | 1 |
| Seldenrijk, CA | 1 |
| Tsang, TK | 1 |
| Levin, BS | 1 |
| Morse, SR | 1 |
| Fagan, TC | 1 |
| Johnson, DG | 1 |
| Grosso, DS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study of the Safety and Efficacy of AST-120 in the Treatment of Antibiotic-Refractory Pouchitis[NCT00583531] | Phase 2 | 2 participants (Actual) | Interventional | 2007-03-31 | Terminated (stopped due to Lack of enrollment) | ||
| A Pilot Study of the Safety and Efficacy of AST-120 in the Treatment of Active Pouchitis[NCT00583076] | Phase 2 | 19 participants (Actual) | Interventional | 2007-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for metronidazole and Ileitis
| Article | Year |
|---|---|
["Pouchitis"; histology].
Topics: Crohn Disease; Diagnosis, Differential; Diarrhea; Fecal Incontinence; Humans; Ileitis; Ileum; Inflam | 1993 |
[Ileo-anal "pouchitis": a still misunderstood pathology].
Topics: Adrenal Cortex Hormones; Colitis, Ulcerative; Glutamine; Humans; Ileitis; Inflammation; Metronidazol | 1993 |
Pouchitis (pouch ileitis).
Topics: Anastomosis, Surgical; Humans; Ileitis; Ileostomy; Inflammatory Bowel Diseases; Metronidazole; Posto | 1989 |
10 other studies available for metronidazole and Ileitis
| Article | Year |
|---|---|
Incidence and short-term implications of prepouch ileitis following restorative proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis.
Topics: Adult; Aged; Anti-Infective Agents; Anti-Inflammatory Agents; Budesonide; Ciprofloxacin; Colitis, Ul | 2009 |
Down-regulation of intestinal lymphocyte activation and Th1 cytokine production by antibiotic therapy in a murine model of Crohn's disease.
Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Cells, Cultured; Ciprofloxacin; Crohn Disease; | 2002 |
Pouch ileitis: report of a case with severe systemic manifestations.
Topics: Adult; Colitis, Ulcerative; Endoscopy; Humans; Ileitis; Ileostomy; Intestinal Mucosa; Male; Metronid | 1983 |
Anal canal inflammation after ileal pouch-anal anastomosis. The need for treatment.
Topics: Administration, Rectal; Adolescent; Adult; Aged; Anal Canal; Biopsy; Ciprofloxacin; Colitis, Ulcerat | 1995 |
["Pouchitis" (inflammation of the ieal reservoir)].
Topics: Humans; Ileitis; Metronidazole; Proctocolectomy, Restorative; Risk Factors | 1995 |
["Pouchitis": new routes of research and signification].
Topics: Bacterial Infections; Diarrhea; Fatty Acids, Volatile; Glutamine; Humans; Ileitis; Inflammation; Met | 1993 |
Mucosal morphology, cell proliferation and faecal bacteriology in acute pouchitis.
Topics: Adult; Cell Division; Colony Count, Microbial; Feces; Female; Humans; Ileitis; Intestinal Mucosa; Lo | 1993 |
Mucosal morphology, cell proliferation and faecal bacteriology in acute pouchitis.
Topics: Adult; Cell Division; Colony Count, Microbial; Feces; Female; Humans; Ileitis; Intestinal Mucosa; Lo | 1993 |
Mucosal morphology, cell proliferation and faecal bacteriology in acute pouchitis.
Topics: Adult; Cell Division; Colony Count, Microbial; Feces; Female; Humans; Ileitis; Intestinal Mucosa; Lo | 1993 |
Mucosal morphology, cell proliferation and faecal bacteriology in acute pouchitis.
Topics: Adult; Cell Division; Colony Count, Microbial; Feces; Female; Humans; Ileitis; Intestinal Mucosa; Lo | 1993 |
Pouchitis and gastric hyposecretion: cause or effect?
Topics: Adenomatous Polyposis Coli; Adult; Anal Canal; Anastomosis, Surgical; Cimetidine; Colitis, Ulcerativ | 1990 |
Terminal ileitis associated with Blastocystis hominis infection.
Topics: Adult; Animals; Eukaryota; Feces; Humans; Ileitis; Male; Metronidazole; Protozoan Infections | 1989 |
Metronidazole-induced gynecomastia.
Topics: Adult; Binding, Competitive; Colectomy; Dihydrotestosterone; Estradiol; Gynecomastia; Humans; Ileiti | 1985 |