metronidazole has been researched along with Blepharitis in 12 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Blepharitis: Inflammation of the eyelids.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the efficacy of topical ivermectin-metronidazole combined therapy in the management of Demodex-associatedblepharitis." | 9.41 | Topical ivermectin-metronidazole gel therapy in the treatment of blepharitis caused by Demodex spp.: A randomized clinical trial. ( Ávila, MY; Martínez-Pulgarín, DF; Rizo Madrid, C, 2021) |
| "Metronidazole topical gel may be a safe and effective means of treating rosacea blepharitis." | 9.08 | The efficacy of topical metronidazole in the treatment of ocular rosacea. ( Barnhorst, DA; Chern, KC; Foster, JA; Meisler, DM, 1996) |
| "To evaluate the efficacy of topical ivermectin-metronidazole combined therapy in the management of Demodex-associatedblepharitis." | 5.41 | Topical ivermectin-metronidazole gel therapy in the treatment of blepharitis caused by Demodex spp.: A randomized clinical trial. ( Ávila, MY; Martínez-Pulgarín, DF; Rizo Madrid, C, 2021) |
| "Metronidazole topical gel may be a safe and effective means of treating rosacea blepharitis." | 5.08 | The efficacy of topical metronidazole in the treatment of ocular rosacea. ( Barnhorst, DA; Chern, KC; Foster, JA; Meisler, DM, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 3 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yanchenko, SV | 1 |
| Malishev, AV | 1 |
| Teshaev, SZ | 1 |
| Sapharov, ZO | 1 |
| Petrosyan, LM | 1 |
| Odilova, GR | 1 |
| Ramazonova, SS | 1 |
| Ávila, MY | 1 |
| Martínez-Pulgarín, DF | 1 |
| Rizo Madrid, C | 1 |
| Hedberg, ML | 1 |
| Chibnall, RJ | 1 |
| Compton, LA | 1 |
| Navel, V | 1 |
| Mulliez, A | 1 |
| Benoist d'Azy, C | 1 |
| Baker, JS | 1 |
| Malecaze, J | 1 |
| Chiambaretta, F | 1 |
| Dutheil, F | 1 |
| Franco-Álvarez de Luna, F | 1 |
| Santos Rosa, C | 1 |
| Fernández-Villalón, JÁ | 1 |
| Arrúa, M | 1 |
| Samudio, M | 1 |
| Fariña, N | 1 |
| Cibils, D | 1 |
| Laspina, F | 1 |
| Sanabria, R | 1 |
| Carpinelli, L | 1 |
| Mino de Kaspar, H | 1 |
| Stacey, MJ | 1 |
| Blanch, RJ | 1 |
| Cheikhrouhou, F | 1 |
| Makni, F | 1 |
| Neji, S | 1 |
| Sellami, H | 1 |
| Masmoudi, A | 1 |
| Turki, H | 1 |
| Ben Zina, Z | 1 |
| Fki, J | 1 |
| Ayadi, A | 1 |
| Nath, AK | 1 |
| Timshina, DK | 1 |
| Thappa, DM | 1 |
| Sinclair, R | 1 |
| Chamaillard, M | 1 |
| Mortemousque, B | 1 |
| Boralevi, F | 1 |
| Marques da Costa, C | 1 |
| Aitali, F | 1 |
| Taïeb, A | 1 |
| Léauté-Labrèze, C | 1 |
| Barnhorst, DA | 1 |
| Foster, JA | 1 |
| Chern, KC | 1 |
| Meisler, DM | 1 |
| Junk, AK | 1 |
| Lukacs, A | 1 |
| Kampik, A | 1 |
2 reviews available for metronidazole and Blepharitis
| Article | Year |
|---|---|
Symptomatic vulvar demodicosis: A case report and review of the literature.
Topics: Administration, Oral; Administration, Topical; Adult; Animals; Antiparasitic Agents; Antiprotozoal A | 2020 |
Efficacy of treatments for Demodex blepharitis: A systematic review and meta-analysis.
Topics: Animals; Anti-Infective Agents, Local; Antiparasitic Agents; Blepharitis; Eye Infections, Parasitic; | 2019 |
3 trials available for metronidazole and Blepharitis
| Article | Year |
|---|---|
Topical ivermectin-metronidazole gel therapy in the treatment of blepharitis caused by Demodex spp.: A randomized clinical trial.
Topics: Blepharitis; Eyelashes; Humans; Ivermectin; Metronidazole; Mite Infestations | 2021 |
Comparative study of the efficacy of different treatment options in patients with chronic blepharitis.
Topics: Administration, Ophthalmic; Adolescent; Adult; Aged; Aged, 80 and over; Animals; Anti-Bacterial Agen | 2015 |
The efficacy of topical metronidazole in the treatment of ocular rosacea.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Blepharitis; Double-Blind Method; Female; G | 1996 |
7 other studies available for metronidazole and Blepharitis
| Article | Year |
|---|---|
[Acaricidal therapy in chronic demodex blepharitis and meibomian gland dysfunctions].
Topics: Acaricides; Blepharitis; Dry Eye Syndromes; Eyelid Diseases; Humans; Meibomian Gland Dysfunction; Me | 2023 |
[Resistance to routine ophthalmological treatments in a patient with chronic blepharitis].
Topics: Acaricides; Adolescent; Animals; Blepharitis; Boric Acids; Chronic Disease; Drug Resistance; Eyelash | 2014 |
A case of external ophthalmomyiasis in a deployed U.K. soldier.
Topics: Adolescent; Afghan Campaign 2001-; Animals; Antinematodal Agents; Antiprotozoal Agents; Blepharitis; | 2008 |
[Human demodicidosis in Sfax area (Tunisia)].
Topics: Adolescent; Adult; Aged; Animals; Antiprotozoal Agents; Blepharitis; Child; Ear; Female; Forehead; H | 2010 |
Demodex in an aerobic environment on the eyelashes.
Topics: Acari; Adult; Animals; Anti-Infective Agents; Antiparasitic Agents; Blepharitis; Eyelashes; Humans; | 2012 |
Cutaneous and ocular signs of childhood rosacea.
Topics: Adolescent; Blepharitis; Chalazion; Child; Child, Preschool; Conjunctivitis; Corneal Ulcer; Eye Dise | 2008 |
[Topical administration of metronidazole gel as an effective therapy alternative in chronic Demodex blepharitis--a case report].
Topics: Administration, Topical; Adult; Animals; Anti-Infective Agents; Blepharitis; Female; Follow-Up Studi | 1998 |