metronidazole has been researched along with Infections, Pasteurellaceae in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Eighty participants with Aggregatibacter actinomycetemcomitans-associated moderate to advanced periodontitis were randomized into two treatment groups: group A, antibiotics (500 mg metronidazole plus 375 mg amoxicillin three times per day for 7 days) during the first, non-surgical phase of periodontal therapy (T1) and placebo during the second, surgical phase (T2); and group B, placebo during T1 and antibiotics during T2." | 5.20 | Differential benefits of amoxicillin-metronidazole in different phases of periodontal therapy in a randomized controlled crossover clinical trial. ( Almaghlouth, A; Cionca, N; Courvoisier, DS; Giannopoulou, C; Mombelli, A, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| van Winkelhoff, AJ | 1 |
| Rurenga, P | 1 |
| Singadji, Z | 1 |
| Wekema-Mulder, G | 1 |
| Mombelli, A | 2 |
| Almaghlouth, A | 2 |
| Cionca, N | 2 |
| Courvoisier, DS | 2 |
| Giannopoulou, C | 2 |
| Bogdan, M | 1 |
| Zujić Atalić, V | 1 |
| Hećimović, I | 1 |
| Vuković, D | 1 |
| Décaillet, F | 1 |
2 trials available for metronidazole and Infections, Pasteurellaceae
| Article | Year |
|---|---|
Differential benefits of amoxicillin-metronidazole in different phases of periodontal therapy in a randomized controlled crossover clinical trial.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Combined Mod | 2015 |
Are there specific benefits of amoxicillin plus metronidazole in Aggregatibacter actinomycetemcomitans-associated periodontitis? Double-masked, randomized clinical trial of efficacy and safety.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Anti-Infecti | 2013 |
2 other studies available for metronidazole and Infections, Pasteurellaceae
| Article | Year |
|---|---|
Metronidazole and amoxicillin susceptibility of Aggregatibacter actinomycetemcomitans.
Topics: Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Humans; Metronidazole; Mi | 2014 |
Brain abscess due to Aggregatibacter aphrophilus and Bacteroides uniformis.
Topics: Adolescent; Aggregatibacter aphrophilus; Anti-Bacterial Agents; Bacteroides; Bacteroides Infections; | 2015 |