metronidazole has been researched along with Sterility, Female in 11 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "One hundred forty-six consecutive inpatients with acute pelvic inflammatory disease (PID) were randomly treated either with the combination of doxycycline and metronidazole or with the combination of penicillin G/amoxicillin and metronidazole." | 5.05 | Factors predicting abnormal hysterosalpingographic findings in patients treated for acute pelvic inflammatory disease. ( Aantaa, K; Paavonen, J; Räsänen, J; Vesterinen, E, 1985) |
| "Chronic endometritis was found in one-third of infertile women with RIF." | 1.46 | Live birth rate following oral antibiotic treatment for chronic endometritis in infertile women with repeated implantation failure. ( Ishikawa, T; Kitaya, K; Matsubayashi, H; Nishiyama, R; Takaya, Y; Takeuchi, T; Yamaguchi, K, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (63.64) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Lan, J | 1 |
| Chen, C | 1 |
| Kitaya, K | 1 |
| Matsubayashi, H | 1 |
| Takaya, Y | 1 |
| Nishiyama, R | 1 |
| Yamaguchi, K | 1 |
| Takeuchi, T | 1 |
| Ishikawa, T | 1 |
| Bohbot, JM | 1 |
| Heinonen, PK | 1 |
| Leinonen, M | 1 |
| Järnerot, G | 1 |
| Fredricsson, B | 1 |
| Hagström, B | 1 |
| Evaldson, G | 1 |
| Nord, CE | 1 |
| Korelitz, BI | 1 |
| Paavonen, J | 1 |
| Vesterinen, E | 1 |
| Aantaa, K | 1 |
| Räsänen, J | 1 |
| Walther, H | 1 |
| Schmör, J | 1 |
| Bánk, EB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparative Effectiveness Clinical Early of Transvaginal and Laparoscopic Approaches for Drainage of Tubo -Ovarian Abscess. Randomized Noninferiority[NCT03166982] | 80 participants (Anticipated) | Interventional | 2016-10-26 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metronidazole and Sterility, Female
| Article | Year |
|---|---|
Fertility, sterility, and pregnancy in chronic inflammatory bowel disease.
Topics: Adrenal Cortex Hormones; Colitis, Ulcerative; Crohn Disease; Female; Fertility; Humans; Infant, Newb | 1982 |
1 trial available for metronidazole and Sterility, Female
| Article | Year |
|---|---|
Factors predicting abnormal hysterosalpingographic findings in patients treated for acute pelvic inflammatory disease.
Topics: Acute Disease; Adolescent; Adult; Amoxicillin; Chlamydia Infections; Clinical Trials as Topic; Doxyc | 1985 |
9 other studies available for metronidazole and Sterility, Female
| Article | Year |
|---|---|
The role of lactic acid bacteria in maintaining vaginal internal environment homeostasis in patients with infertility.
Topics: Female; Humans; Hydrogen Peroxide; Infertility, Female; Lactobacillales; Metronidazole; Pregnancy; V | 2023 |
Live birth rate following oral antibiotic treatment for chronic endometritis in infertile women with repeated implantation failure.
Topics: Administration, Oral; Adult; Birth Rate; Chronic Disease; Ciprofloxacin; Endometritis; Female; Human | 2017 |
[Chlamydia trachomatis: The enemy of the Fallopian tube].
Topics: Adolescent; Adult; Ceftriaxone; Chlamydia Infections; Chlamydia trachomatis; Doxycycline; Fallopian | 2011 |
Fecundity and morbidity following acute pelvic inflammatory disease treated with doxycycline and metronidazole.
Topics: Abortion, Induced; Abortion, Spontaneous; Adolescent; Adult; Anti-Infective Agents; Bacteroides; Bio | 2003 |
Gardnerella-associated vaginitis and anaerobic bacteria.
Topics: Adult; Bacteria, Anaerobic; Bacterial Infections; Female; Gardnerella vaginalis; Haemophilus Infecti | 1984 |
Pregnancy, fertility, and inflammatory bowel disease.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Azathioprine; Colitis, Ulcerative; Crohn Disease; Fe | 1985 |
[Trichomonas infection in clinical picture, therapy and significance to fertility and sterility].
Topics: Adult; Child; Female; Humans; Infertility, Female; Infertility, Male; Male; Metronidazole; Trichomon | 1973 |
[Sterility in urogenital trichomoniasis].
Topics: Adult; Capsules; Colposcopy; Diagnosis, Differential; Female; Fertilization; Humans; Infertility, Fe | 1970 |
[On the role of trichomonas infection of the sperm in sterility].
Topics: Female; Humans; Infertility, Female; Infertility, Male; Male; Metronidazole; Spermatozoa; Trichomona | 1966 |