1,2-cyclohexanediol profile

1,2-Cyclohexanediol is a cyclic diol with two hydroxyl groups on adjacent carbons. It exists as two stereoisomers: cis-1,2-cyclohexanediol and trans-1,2-cyclohexanediol. It can be synthesized through various methods, including the hydroxylation of cyclohexene with osmium tetroxide or the reduction of 1,2-cyclohexanedione with lithium aluminum hydride. 1,2-cyclohexanediol is a versatile building block in organic synthesis and has applications in the pharmaceutical and fragrance industries. It is also a component of various natural products, including some antibiotics. The study of 1,2-cyclohexanediol is important due to its potential applications in various fields and its unique stereochemistry. The compound exhibits interesting properties, such as its ability to form hydrogen bonds and its chiral nature, which are crucial for its diverse applications.'

1,2-cyclohexanediol: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

cyclohexane-1,2-diol : A diol that consists of a cyclohexane skeleton carrying two hydroxy substituents. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	13601
CHEBI ID	24567
SCHEMBL ID	33549
MeSH ID	M0177979

Synonym
nsc52143
nsc-52143
1,2-trans-cyclohexanediol
trans-1,2-dihydroxycyclohexane
nsc-34836
nsc34836
cyclohexane-1,2-diol
1,2-dihydroxycyclohexane
1,2-benzenediol, hexahydro-
brenzkatechin [german]
nsc 10110
2-hydroxycyclohexanol
brn 2036627
ai3-06457
einecs 213-229-8
pyrocatechitol
nsc10110
nsc-10110
1,2-cyclohexanediol
931-17-9
1,2-cyclohexanediol, trans-
inchi=1/c6h12o2/c7-5-3-1-2-4-6(5)8/h5-8h,1-4h
54383-22-1
nsc-150568
nsc150568
C1802
A844452
AKOS009156389
unii-p27v53mh26
2-06-00-00744 (beilstein handbook reference)
p27v53mh26 ,
brenzkatechin
STL257460
FT-0633564
FT-0606325
FT-0623878
trans-2-hydroxycyclohexanol
BBL027442
SCHEMBL33549
1,2-cyclohexane-diol
CHEBI:24567
1,2-cyclohexanediol,c&t
1,2-cyclohexanediol cis-trans
J-660044
J-660004
1,2 cyclohexanediol, mix of cis and trans
(+/-)-trans-1,2-cyclohexanediol
FT-0696716
1,2-trans-dihydroxycyclohexane
trans-1,2-cyclohexandiol
1,2-cyclohexanediol, cis + trans
mfcd00003861
FT-0773257
(cis/trans)-cyclohexane-1,2-diol
Q15410906
i+/--cyclohexandiol-(1,2)
3-(3,4-dichlorophenyl)-1-hydroxy-1-phenylurea
DTXSID50871843
EN300-96148
FD9018
hexahydrocatechol
AS-57309
SB45386
SB46763
CS-0155355
SY048834
Z600453486

Class	Description
diol	A compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic. Aliphatic diols are also called glycols.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	5 (22.73)	18.2507
2000's	11 (50.00)	29.6817
2010's	6 (27.27)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	22 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
propylene glycol Propylene Glycol: A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.. propane-1,2-diol : The simplest member of the class of propane-1,2-diols, consisting of propane in which a hydrogen at position 1 and a hydrogen at position 2 are substituted by hydroxy groups. A colourless, viscous, hygroscopic, low-melting (-59degreeC) and high-boiling (188degreeC) liquid with low toxicity, it is used as a solvent, emulsifying agent, and antifreeze.	2.01	1	glycol; propane-1,2-diols	allergen; human xenobiotic metabolite; mouse metabolite; protic solvent
1-anilino-8-naphthalenesulfonate 1-anilino-8-naphthalenesulfonate: RN given refers to parent cpd. 8-anilinonaphthalene-1-sulfonic acid : A naphthalenesulfonic acid that is naphthalene-1-sulfonic acid substituted by a phenylamino group at position 8.	2.03	1	aminonaphthalene; naphthalenesulfonic acid	fluorescent probe
candesartan cilexetil candesartan cilexetil: a prodrug which is metabolized to an active form candesartan to exert its biological effects	7.01	1	biphenyls
metronidazole Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.. metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.	2.1	1	C-nitro compound; imidazoles; primary alcohol	antiamoebic agent; antibacterial drug; antimicrobial agent; antiparasitic agent; antitrichomonal drug; environmental contaminant; prodrug; radiosensitizing agent; xenobiotic
galactose galactopyranose : The pyranose form of galactose.	2.08	1	D-galactose; galactopyranose	Escherichia coli metabolite; mouse metabolite
cyclopropane cyclopropane : A cycloalkane composed of three carbon atoms to form a ring.	2	1	cycloalkane; cyclopropanes	inhalation anaesthetic
2-methylpentane Hexanes: Six-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives. Various polyneuropathies are caused by hexane poisoning.	2.1	1	alkane
cyclohexanol Cyclohexanols: Monohydroxy derivatives of cyclohexanes that contain the general formula R-C6H11O. They have a camphorlike odor and are used in making soaps, insecticides, germicides, dry cleaning, and plasticizers.. cyclohexanols : An alcohol in which one or more hydroxy groups are attached to a cyclohexane skeleton.	4.46	22	cyclohexanols; secondary alcohol	solvent
cyclohexanone [no description available]	2.39	2	cyclohexanones	human xenobiotic metabolite
cyclohexane Cyclohexane: C6H12. cyclohexane : An alicyclic hydrocarbon comprising a ring of six carbon atoms; the cyclic form of hexane, used as a raw material in the manufacture of nylon.	2.07	1	cycloalkane; volatile organic compound	non-polar solvent
cyclohexene cyclohexene : A cycloalkene that is cylohexane with a single double bond.	2	1	cycloalkene
cyclohexane-1,3-diol cyclohexane-1,3-diol: RN given refers to cpd without isomeric designation; structure	1.97	1
1,4-cyclohexanediol [no description available]	3.11	5
mannose mannopyranose : The pyranose form of mannose.	2.08	1	D-aldohexose; D-mannose; mannopyranose	metabolite
ruthenium Ruthenium: A hard, brittle, grayish-white rare earth metal with an atomic symbol Ru, atomic number 44, and atomic weight 101.07. It is used as a catalyst and hardener for PLATINUM and PALLADIUM.	2.06	1	iron group element atom; platinum group metal atom
chromium Chromium: A trace element that plays a role in glucose metabolism. It has the atomic symbol Cr, atomic number 24, and atomic weight 52. According to the Fourth Annual Report on Carcinogens (NTP85-002,1985), chromium and some of its compounds have been listed as known carcinogens.. chromium ion : An chromium atom having a net electric charge.. chromium atom : A chromium group element atom that has atomic number 24.	2.08	1	chromium group element atom; metal allergen	micronutrient
tiletamine hydrochloride Cyclohexanones: Cyclohexane ring substituted by one or more ketones in any position.. cyclohexanones : Any alicyclic ketone based on a cyclohexane skeleton and its substituted derivatives thereof.	2.39	2
chromium chromium hexavalent ion: a human respiratory carcinogen	2.08	1	chromium cation; monoatomic hexacation
diazodiphenylmethane diphenyldiazomethane: structure in first source	7.01	1
1,2-hexanediol [no description available]	2.1	1
tris(2-pyridylmethyl)amine tris(2-pyridylmethyl)amine: structure in first source	2.06	1
12-tungstophosphoric acid [no description available]	2.05	1
digoxin Digoxin: A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666). digoxin : A cardenolide glycoside that is digitoxin beta-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, Digitalis lanata, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small.	7.01	1	cardenolide glycoside; steroid saponin	anti-arrhythmia drug; cardiotonic drug; EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor; epitope
ribose ribopyranose : The pyranose form of ribose.	2.08	1	D-ribose; ribopyranose
lipofectamine Lipofectamine: mediates gene transfer; a polycationic lipid reagent	2.07	1

Condition	Relationship Strength	Studies
Benign Neoplasms [description not available]	2.08	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.08	1
Arrhythmia [description not available]	7.01	1
Cardiac Failure [description not available]	2.01	1
Arrhythmias, Cardiac Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.	2.01	1
Heart Failure A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.	2.01	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.03	1

1,2-cyclohexanediol

Description

Cross-References

Synonyms (67)

Drug Classes (1)

Research

Studies (22)

Market Indicators

Research Demand Index: 45.92

Study Types