cassine: RN given for (2S-(2alpha,5alpha,6alpha))-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Cassine | genus | RN given for (2S-(2alpha,5alpha,6alpha))-isomer[MeSH] | Celastraceae | A plant family of the order Celastrales, subclass Rosidae, class Magnoliopsida.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 193405 |
| CHEMBL ID | 2262843 |
| CHEBI ID | 3456 |
| MeSH ID | M0388166 |
| Synonym |
|---|
| 5227-24-7 |
| cassine |
| 12-(5-hydroxy-6-methylpiperidin-2-yl)dodecan-2-one |
| AC1L4W78 , |
| AC1Q5CI5 , |
| CHEMBL2262843 |
| chebi:3456 , |
| 12-[(2s,5r,6r)-5-hydroxy-6-methyl-2-piperidyl]dodecan-2-one |
| Q5756672 |
| DTXSID90966641 |
| Class | Description |
|---|---|
| citraconoyl group | |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1419048 | Selectivity index, ratio of CC50 for African green monkey Vero cells to IC50 for Leishmania amazonensis PH8 promastigotes | 2018 | Bioorganic & medicinal chemistry, 12-01, Volume: 26, Issue:22 | Isolation, leishmanicidal evaluation and molecular docking simulations of piperidine alkaloids from Senna spectabilis. |
| AID1419046 | Leishmanicidal activity against Leishmania amazonensis PH8 promastigotes after 48 hrs by spectrophotometric analysis | 2018 | Bioorganic & medicinal chemistry, 12-01, Volume: 26, Issue:22 | Isolation, leishmanicidal evaluation and molecular docking simulations of piperidine alkaloids from Senna spectabilis. |
| AID1419047 | Cytotoxicity against African green monkey Vero cells after 48 hrs by resazurin dye-based spectrophotometric analysis | 2018 | Bioorganic & medicinal chemistry, 12-01, Volume: 26, Issue:22 | Isolation, leishmanicidal evaluation and molecular docking simulations of piperidine alkaloids from Senna spectabilis. |
| AID1419049 | Leishmanicidal activity against Leishmania major MHOM/SU/1973/5-ASKH promastigotes after 48 hrs by cell counting method | 2018 | Bioorganic & medicinal chemistry, 12-01, Volume: 26, Issue:22 | Isolation, leishmanicidal evaluation and molecular docking simulations of piperidine alkaloids from Senna spectabilis. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 8 (61.54) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 13 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Article | Year |
|---|---|
| Anti-staphylococcal, anti-HIV and cytotoxicity studies of four South African medicinal plants and isolation of bioactive compounds from Cassine transvaalensis (Burtt. Davy) codd. BMC complementary and alternative medicine, Dec-18, Volume: 14 | 2014 |
| [information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | |