metronidazole has been researched along with Alveolalgia in 22 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Evaluation of the postoperative signs of alveolar osteitis and infection was made by a dental surgeon five days postoperatively." | 7.11 | A Comparison of Pre-Emptive Co-Amoxiclav, Postoperative Amoxicillin, and Metronidazole for Prevention of Postoperative Complications in Dentoalveolar Surgery: A Randomized Controlled Trial. ( Al-Samadani, KH; Alharbi, AM; Alsaidalani, HM; Gazal, G; Karbouji, GA, 2022) |
| " Amoxicillin was the most frequently prescribed antibiotic used for most clinical conditions apart from pericoronitis, acute ulcerative gingivitis and dry sockets where metronidazole was the drug of choice." | 3.70 | A study of therapeutic antibiotic prescribing in National Health Service general dental practice in England. ( Ireland, RS; Martin, MV; Palmer, NA; Pealing, R, 2000) |
| "Evaluation of the postoperative signs of alveolar osteitis and infection was made by a dental surgeon five days postoperatively." | 3.11 | A Comparison of Pre-Emptive Co-Amoxiclav, Postoperative Amoxicillin, and Metronidazole for Prevention of Postoperative Complications in Dentoalveolar Surgery: A Randomized Controlled Trial. ( Al-Samadani, KH; Alharbi, AM; Alsaidalani, HM; Gazal, G; Karbouji, GA, 2022) |
| "Incidence of dry socket in amoxicillin group was 3 (5." | 3.01 | Prevention of dry socket in mandibular 3rd molars with single preoperative oral dose of metronidazole and amoxicillin compared to conventional therapy. ( Hassan, SU; Khooharo, TS; Shaikh, AH, 2021) |
| "Dry socket was the most common complication in the antibiotics group (six subjects), while acutely inflamed sockets was the most common in the placebo group (five subjects)." | 2.82 | Are systemic antibiotics necessary in the prevention of wound healing complications after intra-alveolar dental extraction? ( Adetoye, JO; Dipo-Fagbemi, IM; Ebigwei, S; Gbotolorun, OM; Olojede, AO, 2016) |
| "The difference in the incidence of alveolar osteitis between the placebo and the active gel groups was not significant and it was concluded that 25% topical metronidazole gel was not effective in reducing the incidence of alveolar osteitis." | 2.72 | The prevention of 'dry socket' with topical metronidazole in general dental practice. ( Devlin, CV; Devlin, H; Downes, P; Nixon, GM; Reekie, D, 2006) |
| "In relation to postoperative wound infection, this practise was of no benefit." | 2.67 | The effect of pre-operative perioral skin preparation with aqueous povidone-iodine on the incidence of infection after third molar removal. ( Loukota, RA, 1991) |
| " The drug appears to be free from side effects when a dosage of 200 mgs eight hourly for three days is given." | 2.65 | Metronidazole in the prevention of 'dry socket'. ( Murgatroyd, J; Rood, JP, 1979) |
| "Alveolar osteitis is a complication that can occur after tooth extraction, whereby exposed bone results in severe throbbing pain for the patient and can be prone to infection." | 1.56 | A novel dual action monolithic thermosetting hydrogel loaded with lidocaine and metronidazole as a potential treatment for alveolar osteitis. ( Bender, L; Boostrom, HM; Celiksoy, V; Cowpe, J; Heard, CM; Sloan, A; Varricchio, C; Zuanon, M, 2020) |
| "To evaluate two treatment modalities of dry socket in rats and to discuss the first findings of the molecular analysis in this experimental model." | 1.37 | Experimental dry socket: microscopic and molecular evaluation of two treatment modalities. ( Cardoso, CL; Carvalho, PS; Cestari, TM; Dionísio, TJ; Ferreira Júnior, O; Garlet, GP, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (22.73) | 18.7374 |
| 1990's | 4 (18.18) | 18.2507 |
| 2000's | 6 (27.27) | 29.6817 |
| 2010's | 2 (9.09) | 24.3611 |
| 2020's | 5 (22.73) | 2.80 |
| Authors | Studies |
|---|---|
| Gazal, G | 1 |
| Al-Samadani, KH | 1 |
| Alsaidalani, HM | 1 |
| Karbouji, GA | 1 |
| Alharbi, AM | 1 |
| Falci, SGM | 1 |
| Galvão, EL | 1 |
| de Souza, GM | 1 |
| Fernandes, IA | 1 |
| Souza, MRF | 1 |
| Al-Moraissi, EA | 1 |
| Yan, M | 1 |
| Pan, Y | 1 |
| Lu, S | 1 |
| Li, X | 1 |
| Wang, D | 1 |
| Shao, T | 1 |
| Wu, Z | 1 |
| Zhou, Q | 1 |
| Bender, L | 1 |
| Boostrom, HM | 1 |
| Varricchio, C | 1 |
| Zuanon, M | 1 |
| Celiksoy, V | 1 |
| Sloan, A | 1 |
| Cowpe, J | 1 |
| Heard, CM | 1 |
| Khooharo, TS | 1 |
| Hassan, SU | 1 |
| Shaikh, AH | 1 |
| Gbotolorun, OM | 1 |
| Dipo-Fagbemi, IM | 1 |
| Olojede, AO | 1 |
| Ebigwei, S | 1 |
| Adetoye, JO | 1 |
| Williams, PR | 1 |
| Glen, PT | 1 |
| Cardoso, CL | 1 |
| Ferreira Júnior, O | 1 |
| Carvalho, PS | 1 |
| Dionísio, TJ | 1 |
| Cestari, TM | 1 |
| Garlet, GP | 1 |
| Bergdahl, M | 1 |
| Hedström, L | 2 |
| Reekie, D | 1 |
| Downes, P | 1 |
| Devlin, CV | 1 |
| Nixon, GM | 1 |
| Devlin, H | 1 |
| Falcon, H | 1 |
| Crosse, A | 1 |
| Donaghy, J | 1 |
| Harrison, V | 1 |
| Hillman, L | 1 |
| Lawrence, A | 1 |
| Smith, M | 1 |
| White, S | 1 |
| Mitchell, L | 1 |
| Rood, JP | 2 |
| Danford, M | 1 |
| Palmer, NA | 1 |
| Pealing, R | 1 |
| Ireland, RS | 1 |
| Martin, MV | 1 |
| Murgatroyd, J | 1 |
| Ritzau, M | 1 |
| Hillerup, S | 1 |
| Branebjerg, PE | 1 |
| Ersbøl, BK | 1 |
| Loukota, RA | 1 |
| Barclay, JK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of the Application of Moxifloxacin and Cefixime in Reduction of Inflammatory Sequelae and Complications After Mandibular Third Molar Surgery[NCT05027893] | 157 participants (Actual) | Interventional | 2019-06-07 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metronidazole and Alveolalgia
| Article | Year |
|---|---|
Do antibiotics prevent infection after third molar surgery? A network meta-analysis.
Topics: Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Antibiotic Prophy | 2022 |
10 trials available for metronidazole and Alveolalgia
| Article | Year |
|---|---|
A Comparison of Pre-Emptive Co-Amoxiclav, Postoperative Amoxicillin, and Metronidazole for Prevention of Postoperative Complications in Dentoalveolar Surgery: A Randomized Controlled Trial.
Topics: Adult; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Dry Socket | 2022 |
Prevention of dry socket in mandibular 3rd molars with single preoperative oral dose of metronidazole and amoxicillin compared to conventional therapy.
Topics: Amoxicillin; Dry Socket; Female; Humans; Male; Metronidazole; Molar; Molar, Third; Tooth Extraction; | 2021 |
Are systemic antibiotics necessary in the prevention of wound healing complications after intra-alveolar dental extraction?
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Double-Blind Method; Dry Socket; Female; Humans; Male; Me | 2016 |
Metronidazole for the prevention of dry socket after removal of partially impacted mandibular third molar: a randomised controlled trial.
Topics: Administration, Oral; Adolescent; Adult; Anti-Infective Agents; Chi-Square Distribution; Contracepti | 2004 |
The prevention of 'dry socket' with topical metronidazole in general dental practice.
Topics: Administration, Topical; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anti-Infective Age | 2006 |
Topical metronidazole in the treatment of 'dry socket'.
Topics: Administration, Topical; Clinical Trials as Topic; Double-Blind Method; Dry Socket; Humans; Metronid | 1984 |
Metronidazole in the prevention of 'dry socket'.
Topics: Adult; Age Factors; Aged; Bacteria; Blood Coagulation; Double-Blind Method; Drug Evaluation; Dry Soc | 1979 |
Does metronidazole prevent alveolitis sicca dolorosa? A double-blind, placebo-controlled clinical study.
Topics: Adult; Double-Blind Method; Dry Socket; Female; Humans; Male; Metronidazole; Molar, Third; Placebos; | 1992 |
The effect of pre-operative perioral skin preparation with aqueous povidone-iodine on the incidence of infection after third molar removal.
Topics: Administration, Cutaneous; Adult; Dry Socket; Female; Humans; Incidence; Male; Metronidazole; Molar, | 1991 |
[Open, noncomparative multicenter study of the efficacy and tolerance of a spiramycin-metronidazole combination used in infectious oral pathology].
Topics: Bacterial Infections; Cellulitis; Drug Combinations; Dry Socket; Edema; Humans; Metronidazole; Mouth | 1991 |
11 other studies available for metronidazole and Alveolalgia
| Article | Year |
|---|---|
Chitosan-CaP microflowers and metronidazole loaded calcium alginate sponges with enhanced antibacterial, hemostatic and osteogenic properties for the prevention of dry socket after tooth removal.
Topics: Alginates; Anti-Bacterial Agents; Chitosan; Dry Socket; Escherichia coli; Hemostatics; Humans; Metro | 2022 |
A novel dual action monolithic thermosetting hydrogel loaded with lidocaine and metronidazole as a potential treatment for alveolar osteitis.
Topics: Acrylates; Anesthetics, Local; Anti-Infective Agents; Cells, Cultured; Drug Delivery Systems; Drug L | 2020 |
A single dose.
Topics: Anti-Infective Agents; Dry Socket; Humans; Metronidazole; Tooth Extraction | 2008 |
Unsuitable prescribing.
Topics: Adult; Anti-Infective Agents; Antibiotic Prophylaxis; Clinical Governance; Dry Socket; Guideline Adh | 2009 |
Experimental dry socket: microscopic and molecular evaluation of two treatment modalities.
Topics: Animals; Anti-Infective Agents; Bone Density; Dry Socket; Hydrogen Peroxide; Male; Metronidazole; Os | 2011 |
CASP and CONSORT.
Topics: Anti-Infective Agents, Local; Dry Socket; Guidelines as Topic; Humans; Metronidazole; Randomized Con | 2006 |
Topical metronidazole in the treatment of "dry socket".
Topics: Administration, Topical; Dry Socket; Female; Humans; Metronidazole; Pregnancy | 1984 |
Metronidazole in the treatment of "dry socket".
Topics: Dry Socket; Humans; Metronidazole | 1981 |
A study of therapeutic antibiotic prescribing in National Health Service general dental practice in England.
Topics: Abscess; Acute Disease; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Infecti | 2000 |
[Effect of metronidazole on development of dry socket following removal of lower third molars].
Topics: Adolescent; Adult; Double-Blind Method; Dry Socket; Female; Humans; Male; Metronidazole; Molar, Thir | 1990 |
Metronidazole and dry socket: prophylactic use in mandibular third molar removal complicated by non-acute pericoronitis.
Topics: Adolescent; Adult; Dry Socket; Female; Humans; Male; Metronidazole; Middle Aged; Molar, Third; Peric | 1987 |