metronidazole has been researched along with Pneumonia in 29 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Pneumonia: Infection of the lung often accompanied by inflammation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this prospective, multicenter, open-label, randomized controlled trial, 77 patients with mild-to-moderate community-acquired pneumonia with aspiration factors were enrolled and randomly assigned to receive moxifloxacin or levofloxacin plus metronidazole." | 9.19 | Clinical efficacy and safety of moxifloxacin versus levofloxacin plus metronidazole for community-acquired pneumonia with aspiration factors. ( Li, F; Liu, Y; Pu, C; Ren, X; Ren, Y; Sui, DJ; Sun, L; Sun, T; Wang, R; Yang, Z, 2014) |
| "The effect of metronidazole in experimental anaerobic pneumonia in guinea pigs infected with peptostreptococci has been studied." | 7.67 | [Effect of metronidazole on the course of experimental anaerobic streptococcal pneumonia]. ( Anisimova, LA; Bukova, VE; Khodyreva, GD; Kozliuk, AS; Shroĭt, IG, 1986) |
| "Three hundred and ten patients with chronic destructive pneumonia (CDP), a necrotizing pneumonia probably caused by aerobic and anaerobic bacterial synergism, were treated with cephalosporins (80 of these with cephalosporins, penicillin and metronidazole)." | 7.66 | Treatment of chronic destructive pneumonia with cephalosporins, penicillin and metronidazole. ( Cameron, EW, 1978) |
| "In this prospective, multicenter, open-label, randomized controlled trial, 77 patients with mild-to-moderate community-acquired pneumonia with aspiration factors were enrolled and randomly assigned to receive moxifloxacin or levofloxacin plus metronidazole." | 5.19 | Clinical efficacy and safety of moxifloxacin versus levofloxacin plus metronidazole for community-acquired pneumonia with aspiration factors. ( Li, F; Liu, Y; Pu, C; Ren, X; Ren, Y; Sui, DJ; Sun, L; Sun, T; Wang, R; Yang, Z, 2014) |
| " In this randomized study, the efficacy of metronidazole was compared with clindamycin in the treatment of patients with anaerobic lung abscess or necrotizing pneumonia." | 5.05 | Metronidazole vs clindamycin treatment of anerobic pulmonary infection. Failure of metronidazole therapy. ( Perlino, CA, 1981) |
| "The majority of the enteric bacteria and aerobic and anaerobic cocci causing postventilation pneumonia in newborns were susceptible to gentamicin, carbenicillin, ampicillin and cephalosporins." | 3.69 | [Sensitivity of pathogens of post-ventilation pneumonia in newborns to antibacterial drugs]. ( Abrosimova, NA; Kushnareva, MV; Nisan, LG, 1994) |
| "The effect of metronidazole in experimental anaerobic pneumonia in guinea pigs infected with peptostreptococci has been studied." | 3.67 | [Effect of metronidazole on the course of experimental anaerobic streptococcal pneumonia]. ( Anisimova, LA; Bukova, VE; Khodyreva, GD; Kozliuk, AS; Shroĭt, IG, 1986) |
| "Three hundred and ten patients with chronic destructive pneumonia (CDP), a necrotizing pneumonia probably caused by aerobic and anaerobic bacterial synergism, were treated with cephalosporins (80 of these with cephalosporins, penicillin and metronidazole)." | 3.66 | Treatment of chronic destructive pneumonia with cephalosporins, penicillin and metronidazole. ( Cameron, EW, 1978) |
| "Several new approaches to treatment of pneumonia in the critical care setting are being evaluated, including single-agent empiric coverage using a broad-spectrum beta-lactam agent; broad-spectrum quinolones, such as ciprofloxacin; intrabronchial aminoglycoside instillation therapy; and passive immune therapy with immunoglobulins and monoclonal antibodies." | 2.38 | Approach to therapy of respiratory infections in the critical care setting. ( Pennington, JE, 1990) |
| "Neonatal pneumonia is mostly bacterial and other etiology is considered less frequently." | 1.56 | Neonatal pneumonia caused by Trichomonas vaginalis. ( Burčková, H; Mrázek, J; Pavlíček, J; Pokrývková, M; Wiedermannová, H; Zárubová, P, 2020) |
| "We report an unusual presentation of pulmonary embolism (PE) where a 58-year-old man first developed symptoms of community-acquired pneumonia." | 1.48 | An unusual presentation of pulmonary embolism leading to infarction, cavitation, abscess formation and bronchopleural fistulation. ( Banerjee, A; Bennett, L; Morelli, T; Teng, E, 2018) |
| "The patient was initially treated for tetanus and aspiration pneumonia with a guarded prognosis." | 1.33 | Tetanus, pneumonia, and malaria in a tsunami victim in Banda Aceh, Indonesia. ( Hanley, MR; O'Regan, W; Squires, S; Tate, C, 2006) |
| "Anaerobic bacterial meningitis due to this pathogen is rarely diagnosed and if present, a predisposing source of infection should be actively sought for." | 1.29 | Bacteroides fragilis meningitis. ( Ngan, CC; Tan, AL, 1994) |
| "Metronidazole also has been used either alone or in combination, most frequently with amoxicillin, to treat many other anaerobic infections: head and neck, pleuropulmonary, genital tract, bone and joint, skin and soft tissue, and cases of fusobacterial septicemia (necrobacillosis)." | 1.27 | The therapeutic use of metronidazole in anaerobic infection: six years' experience in a London hospital. ( Eykyn, SJ, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (37.93) | 18.7374 |
| 1990's | 5 (17.24) | 18.2507 |
| 2000's | 4 (13.79) | 29.6817 |
| 2010's | 8 (27.59) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Pokrývková, M | 1 |
| Zárubová, P | 1 |
| Wiedermannová, H | 1 |
| Burčková, H | 1 |
| Mrázek, J | 1 |
| Pavlíček, J | 1 |
| Teng, E | 1 |
| Bennett, L | 1 |
| Morelli, T | 1 |
| Banerjee, A | 1 |
| Dev, YP | 1 |
| Goyal, OP | 1 |
| Sun, T | 1 |
| Sun, L | 1 |
| Wang, R | 1 |
| Ren, X | 1 |
| Sui, DJ | 1 |
| Pu, C | 1 |
| Ren, Y | 1 |
| Liu, Y | 1 |
| Yang, Z | 1 |
| Li, F | 1 |
| Compain, F | 1 |
| Rossi, B | 1 |
| Richaud, C | 1 |
| Guerot, E | 1 |
| Rostane, H | 1 |
| Jarraud, S | 1 |
| Podglajen, I | 1 |
| Evans, D | 1 |
| Shakur, R | 1 |
| Scott, D | 1 |
| Rao, S | 1 |
| Solaymani-Mohammadi, S | 1 |
| Petri, WA | 1 |
| Parker, SK | 1 |
| Davaus Gasparetto, T | 1 |
| Marchiori, E | 1 |
| Menezes, P | 1 |
| Zanetti, G | 1 |
| Daoud, E | 1 |
| Guzman, J | 1 |
| Altın, C | 1 |
| Kanyılmaz, S | 1 |
| Baysal, S | 1 |
| Özin, B | 1 |
| Kim, SM | 1 |
| Shin, HW | 1 |
| Han, HJ | 1 |
| Park, JH | 1 |
| Gibbons, FK | 1 |
| Branda, JA | 1 |
| Shepard, JA | 1 |
| Hanley, MR | 1 |
| O'Regan, W | 1 |
| Squires, S | 1 |
| Tate, C | 1 |
| Kvist Poulsen, H | 1 |
| Borel, J | 1 |
| Chandrasekar, PH | 1 |
| Rolston, KV | 1 |
| Chokkavelu, V | 1 |
| Le Frock, JL | 1 |
| Kannangara, DW | 1 |
| Vogel, F | 1 |
| Eykyn, SJ | 1 |
| Perlino, CA | 1 |
| Ngan, CC | 1 |
| Tan, AL | 1 |
| Abrosimova, NA | 1 |
| Kushnareva, MV | 1 |
| Nisan, LG | 1 |
| Baldwin, L | 1 |
| Henderson, A | 1 |
| Wright, M | 1 |
| Whitby, M | 1 |
| Cameron, EW | 1 |
| Watt, B | 1 |
| Collee, JG | 1 |
| Pennington, JE | 1 |
| Segreti, J | 1 |
| Trenholme, GM | 1 |
| Schwigon, CD | 1 |
| Hulla, FW | 1 |
| Schulze, B | 1 |
| Maslak, A | 1 |
| Shroĭt, IG | 1 |
| Anisimova, LA | 1 |
| Khodyreva, GD | 1 |
| Kozliuk, AS | 1 |
| Bukova, VE | 1 |
| Opferkuch, W | 1 |
| McCulloch, AJ | 1 |
| McEvoy, A | 1 |
| Jackson, JD | 1 |
| Jarvis, EH | 1 |
4 reviews available for metronidazole and Pneumonia
| Article | Year |
|---|---|
Bacterial challenges and evolving antibacterial drug strategy.
Topics: 4-Quinolones; Aminoglycosides; Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Infections; C | 1992 |
Approach to therapy of respiratory infections in the critical care setting.
Topics: Aminoglycosides; Anti-Bacterial Agents; Cephalosporins; Ciprofloxacin; Cross Infection; Humans; Inte | 1990 |
Respiratory pharmacology. Antibiotics. I. Beta-lactam antibiotics, the tetracyclines, chloramphenicol, erythromycin, clindamycin, metronidazole, and the quinolones.
Topics: Anti-Bacterial Agents; beta-Lactams; Chloramphenicol; Clindamycin; Erythromycin; Humans; Metronidazo | 1986 |
[Classification, diagnosis and therapy of pneumonia].
Topics: Aminoglycosides; Amoxicillin; Anti-Bacterial Agents; Antibodies, Bacterial; Antibody Specificity; Bi | 1985 |
3 trials available for metronidazole and Pneumonia
| Article | Year |
|---|---|
Clinical efficacy and safety of moxifloxacin versus levofloxacin plus metronidazole for community-acquired pneumonia with aspiration factors.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Community-Acquired Infections; Female; Fluoroquinolo | 2014 |
T-tube suction drainage and/or prophylactic two-dose metronidazole in abdominal hysterectomy.
Topics: Adult; Aged; Bacterial Infections; Clinical Trials as Topic; Dose-Response Relationship, Drug; Femal | 1984 |
Metronidazole vs clindamycin treatment of anerobic pulmonary infection. Failure of metronidazole therapy.
Topics: Adult; Bacterial Infections; Clindamycin; Clinical Trials as Topic; Female; Humans; Lung Abscess; Lu | 1981 |
22 other studies available for metronidazole and Pneumonia
| Article | Year |
|---|---|
Neonatal pneumonia caused by Trichomonas vaginalis.
Topics: Humans; Infant, Newborn; Metronidazole; Multiplex Polymerase Chain Reaction; Pneumonia; Trichomonas | 2020 |
An unusual presentation of pulmonary embolism leading to infarction, cavitation, abscess formation and bronchopleural fistulation.
Topics: Abscess; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bronchial Fistula; Di | 2018 |
Recurrent lung infection due to chronic peri-odontitis.
Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Anti-Infective Agents; Diagnos | 2013 |
Photo Quiz: A 44-Year-Old Kidney Transplant Patient with Pneumonia.
Topics: Acute Kidney Injury; Adult; Anti-Bacterial Agents; Bacterial Proteins; Bacterial Toxins; beta-Lactam | 2017 |
Antibiotic prescribing.
Topics: Anti-Bacterial Agents; Cellulitis; Clindamycin; Clostridioides difficile; Diarrhea; Humans; Medical | 2008 |
Hepatic amebiasis: a reminder of the complications.
Topics: Animals; Antiprotozoal Agents; Diagnosis, Differential; Drainage; Entamoeba histolytica; Genotype; H | 2009 |
Pulmonary toxicity associated with sirolimus following kidney transplantation: computed tomography findings.
Topics: Adrenal Cortex Hormones; Adult; Azathioprine; Bronchoalveolar Lavage Fluid; Diagnosis, Differential; | 2010 |
Q: Are antibiotics indicated for the treatment of aspiration pneumonia?
Topics: Anti-Bacterial Agents; beta-Lactams; Clindamycin; Humans; Metronidazole; Pneumonia; Pneumonia, Aspir | 2010 |
QT interval prolongation due to metronidazole administration.
Topics: Aged; Anti-Infective Agents; Cross Infection; Drug Therapy, Combination; Electrocardiography; Female | 2011 |
Serially changing metronidazole-induced encephalopathy.
Topics: Anti-Infective Agents; Brain Diseases; Corpus Callosum; Diffusion Magnetic Resonance Imaging; Follow | 2011 |
Case records of the Massachusetts General Hospital. Case 12-2006. A 37-year-old man with hemoptysis and a pulmonary infiltrate.
Topics: Adult; Anti-Infective Agents; Diagnosis, Differential; Hemoptysis; Humans; Lung; Lung Neoplasms; Mal | 2006 |
Tetanus, pneumonia, and malaria in a tsunami victim in Banda Aceh, Indonesia.
Topics: Adult; Ceftriaxone; Diazepam; Disasters; Female; Humans; Indonesia; Malaria; Metronidazole; Pneumoni | 2006 |
Comparative efficacy of four antibiotics in anaerobic pulmonary infection. An experimental model in rabbits.
Topics: Animals; Anti-Bacterial Agents; Bacteria, Anaerobic; Bacteroides fragilis; Bacteroides Infections; C | 1984 |
[Antibiotic therapy in severe infections].
Topics: Aminoglycosides; Anti-Bacterial Agents; Bacterial Infections; Cephalosporins; Humans; Infections; Me | 1983 |
The therapeutic use of metronidazole in anaerobic infection: six years' experience in a London hospital.
Topics: Adult; Aged; Bacterial Infections; Bone Diseases; Empyema; Female; Fusobacterium Infections; Gastroi | 1983 |
Bacteroides fragilis meningitis.
Topics: Adult; Bacteroides fragilis; Bacteroides Infections; Cholesteatoma, Middle Ear; Ear Neoplasms; Human | 1994 |
[Sensitivity of pathogens of post-ventilation pneumonia in newborns to antibacterial drugs].
Topics: Anti-Bacterial Agents; Carbenicillin; Ceftazidime; Gentamicins; Humans; Infant, Newborn; Lincomycin; | 1994 |
Spontaneous Clostridium perfringens lung abscess unresponsive to penicillin.
Topics: Clostridium Infections; Clostridium perfringens; Humans; Injections, Intravenous; Lung Abscess; Male | 1993 |
Treatment of chronic destructive pneumonia with cephalosporins, penicillin and metronidazole.
Topics: Administration, Oral; Adolescent; Adult; Aged; Bacterial Infections; Cephalexin; Cephalothin; Child; | 1978 |
Timentin in the treatment of nosocomial bronchopulmonary infections in intensive care units.
Topics: Adult; Aged; Aminoglycosides; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Bronchitis; Cla | 1986 |
[Effect of metronidazole on the course of experimental anaerobic streptococcal pneumonia].
Topics: Acute Disease; Animals; Bacterial Infections; Drug Evaluation, Preclinical; Guinea Pigs; Immunity, C | 1986 |
Severe steroid responsive pneumonitis associated with pyoderma gangrenosum and ulcerative colitis.
Topics: Ampicillin; Colitis, Ulcerative; Erythromycin; Female; Gentamicins; Humans; Metronidazole; Middle Ag | 1985 |