metronidazole has been researched along with Alcohol Abuse in 64 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The diagnosis of actinomycosis is problematic because it is an uncommon infection and microbiological identification is often difficult and delayed." | 1.33 | [Disseminated actinomycosis]. ( Biron, F; Depagne, C; Guerin, JC; Louerat, C; Nesme, P, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 58 (90.63) | 18.7374 |
| 1990's | 1 (1.56) | 18.2507 |
| 2000's | 3 (4.69) | 29.6817 |
| 2010's | 1 (1.56) | 24.3611 |
| 2020's | 1 (1.56) | 2.80 |
| Authors | Studies |
|---|---|
| Schattner, A | 1 |
| Uliel, L | 1 |
| Finn, T | 1 |
| Dubin, I | 1 |
| Le Falher, G | 1 |
| Makinson, A | 1 |
| Eden, A | 1 |
| Lesnik, A | 1 |
| Le Moing, V | 1 |
| Reynes, J | 1 |
| TAYLOR, JA | 1 |
| Spies, CD | 1 |
| von Dossow, V | 1 |
| Eggers, V | 1 |
| Jetschmann, G | 1 |
| El-Hilali, R | 1 |
| Egert, J | 1 |
| Fischer, M | 1 |
| Schröder, T | 1 |
| Höflich, C | 1 |
| Sinha, P | 1 |
| Paschen, C | 1 |
| Mirsalim, P | 1 |
| Brunsch, R | 1 |
| Hopf, J | 1 |
| Marks, C | 1 |
| Wernecke, KD | 1 |
| Pragst, F | 1 |
| Ehrenreich, H | 1 |
| Müller, C | 1 |
| Tonnesen, H | 1 |
| Oelkers, W | 1 |
| Rohde, W | 1 |
| Stein, C | 1 |
| Kox, WJ | 1 |
| Louerat, C | 1 |
| Depagne, C | 1 |
| Nesme, P | 1 |
| Biron, F | 1 |
| Guerin, JC | 1 |
| Cole, JO | 1 |
| Goodwin, DW | 1 |
| Sogliani, G | 1 |
| Miliani, B | 1 |
| Edwards, JA | 1 |
| Price, J | 1 |
| Campbell, B | 1 |
| Taylor, JT | 1 |
| Haslett, WL | 1 |
| Matthew, JR | 1 |
| Fried, R | 1 |
| Petersen, DR | 1 |
| Hjelle, JJ | 1 |
| Okomé-Nkoumou, M | 1 |
| Kombila, M | 1 |
| Ban, TA | 4 |
| Kitson, TM | 1 |
| Bieder, L | 1 |
| Solms, H | 1 |
| Grabovskiĭ, IaA | 1 |
| Uppal, R | 1 |
| Lateef, SK | 1 |
| Korsten, MA | 1 |
| Paronetto, F | 1 |
| Lieber, CS | 1 |
| Mottin, JL | 1 |
| Kissin, B | 2 |
| Gross, MM | 1 |
| Wilson, CW | 1 |
| O'Brien, C | 1 |
| MacAirt, JG | 1 |
| Kaplan, R | 1 |
| Blume, S | 1 |
| Rosenberg, S | 1 |
| Pitrelli, J | 1 |
| Turner, WJ | 1 |
| Lysloff, GO | 1 |
| Goldberg, A | 1 |
| Krasner, N | 1 |
| Dow, J | 1 |
| MacDonald, CM | 1 |
| Moore, MR | 1 |
| Linton, PH | 1 |
| Hain, JD | 1 |
| Gelder, MG | 1 |
| Edwards, G | 1 |
| Chaftez, ME | 1 |
| Egan, WP | 1 |
| Goetz, R | 1 |
| Lal, S | 1 |
| Rothstein, E | 2 |
| Clancy, DD | 2 |
| Tyndel, M | 1 |
| Fraser, JG | 1 |
| Hartleib, CJ | 1 |
| Penick, SB | 2 |
| Carrier, RN | 2 |
| Sheldon, JB | 2 |
| Fischer, PA | 1 |
| Jensen, E | 1 |
| Nimb, M | 1 |
| Platz, A | 1 |
| Panepinto, WC | 1 |
| Charnoff, SM | 1 |
| Templer, DI | 1 |
| Seinson, RP | 1 |
| Lehmann, HE | 3 |
| Gallant, DM | 1 |
| Bishop, MP | 1 |
| Camp, E | 1 |
| Tisdale, C | 1 |
| Ewing, JA | 1 |
| Leger, JM | 1 |
| Daudet, G | 1 |
| Kardos, G | 1 |
| Soóky, A | 1 |
| Szabados, P | 1 |
| Szollár, E | 1 |
| Matveev, VF | 1 |
| Vorob'ev, VS | 1 |
| Madalena, JC | 1 |
| de Mattos, HG | 1 |
| Coelho Filho, H | 1 |
| Neves, OR | 1 |
| Sonenreich, C | 1 |
| Corrèa, Rde S | 1 |
| Martins, C | 1 |
| de Mattos, H | 1 |
| Leite, DA | 1 |
| Blom, A | 1 |
| Sansoy, OM | 1 |
| Lingjaerde, O | 1 |
| Pazukhanich, EI | 1 |
| Borg, V | 1 |
| Lund, J | 1 |
| Friedland, P | 2 |
| Vaisberg, M | 2 |
| Merry, J | 1 |
| Whitehead, A | 1 |
| Winter, D | 2 |
| Sauvard, S | 2 |
| Stănescu, C | 2 |
| Theodorescu, M | 1 |
| Winter, J | 1 |
| Nitelea, I | 1 |
| Roy, P | 1 |
| Semer, JM | 1 |
| Greenberg, A | 1 |
| Naltchayan, E | 1 |
| Elosuo, R | 1 |
| Montanini, R | 1 |
| Giovannucci, M | 1 |
| Paltrinieri, E | 1 |
4 reviews available for metronidazole and Alcohol Abuse
| Article | Year |
|---|---|
Biochemical actions of anti-alcoholic agents.
Topics: Alcoholism; Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Animals; Behavior; Carbon Disulfide; C | 1980 |
Alcoholism and schizophrenia: diagnostic and therapeutic considerations.
Topics: Alcoholism; Brain; Disulfiram; Dopamine; Humans; Methyltyrosines; Metronidazole; NAD; Norepinephrine | 1977 |
Drug-induced attenuation of alcohol consumption. A review and evaluation of claimed, potential or current therapies.
Topics: Alcohol Deterrents; Alcohol Drinking; Alcoholism; Aversive Therapy; Conditioning, Classical; Conditi | 1973 |
Drugs in the treatment of alcoholism.
Topics: Alcohol Deterrents; Alcoholic Intoxication; Alcoholism; Amitriptyline; Antidepressive Agents; Chlord | 1967 |
20 trials available for metronidazole and Alcohol Abuse
| Article | Year |
|---|---|
Metronidazole in the treatment of alcoholism: a negative report.
Topics: Adult; Alcoholism; Drinking; Humans; Male; Metronidazole; Middle Aged; Placebos; Prognosis; Thirst | 1967 |
Chronic alcoholic gastritis. Roles of alcohol and Helicobacter pylori.
Topics: Adult; Alcoholism; Aluminum Hydroxide; Amoxicillin; Bismuth; Gastritis; Helicobacter Infections; Hel | 1991 |
Phenytoin, Metronidazole and multivitamins in the treatment of alcoholism.
Topics: Adult; Affect; Alcohol Drinking; Alcoholism; Clinical Trials as Topic; Evaluation Studies as Topic; | 1972 |
Anti-addictive chemotherapy--metronidazole and alcohol aversion.
Topics: Alcoholism; Aversive Therapy; Behavior; Blood Urea Nitrogen; Clinical Trials as Topic; Humans; Male; | 1972 |
Metronidazole in the treatment of alcoholism.
Topics: Alcoholism; Clinical Trials as Topic; Humans; Metronidazole | 1967 |
Metronidazole in the treatment of alcohol addiction. A controlled trial.
Topics: Alcoholism; Blood Pressure; Clinical Trials as Topic; Humans; Metronidazole; Placebos; Pulse; Semant | 1968 |
Effect of metronidazole on drinking by alcoholics.
Topics: Adult; Aged; Alcohol Drinking; Alcoholism; Clinical Trials as Topic; Humans; Male; Metronidazole; Mi | 1968 |
Metronidazole in the treatment of alcoholism. A clinical trial and review of the literature.
Topics: Adult; Alcohol Drinking; Alcoholism; Clinical Trials as Topic; Humans; Male; Metronidazole; Middle A | 1969 |
Toxicity of disulfiram combined with metronidazole.
Topics: Alcoholism; Clinical Trials as Topic; Disulfiram; Drug Synergism; Humans; Male; Metronidazole; Psych | 1969 |
Metronidazole as an adjuvant in the treatment of alcoholism.
Topics: Adult; Aged; Alcohol Drinking; Alcoholism; Clinical Trials as Topic; Female; Humans; Male; Metronida | 1969 |
Metronidazole in the treatment of alcoholism.
Topics: Adult; Aged; Alcohol Drinking; Alcoholism; Chronic Disease; Clinical Trials as Topic; Female; Hospit | 1969 |
[Metronidazole in the treatment of alcoholics].
Topics: Adult; Alcoholism; Clinical Trials as Topic; Denmark; Female; Humans; Male; Methods; Metronidazole; | 1970 |
Metronidazole and alcoholism. (An evaluation of specific and non specific factors in drug treatment).
Topics: Adult; Alcoholism; Clinical Trials as Topic; Female; Humans; Male; Metronidazole; Placebos; Racial G | 1970 |
Combined use of disulfiram and metronidazole in treatment of alcoholism.
Topics: Alcoholism; Clinical Trials as Topic; Disulfiram; Hospitalization; Hospitals, Psychiatric; Humans; M | 1970 |
Four year follow-up of metronidazole treatment program for alcoholism.
Topics: Adult; Aged; Alcoholism; Clinical Trials as Topic; Female; Follow-Up Studies; Humans; Male; Metronid | 1971 |
Long term trial of metronidazole in male alcoholics.
Topics: Alcoholism; Anorexia Nervosa; Clinical Trials as Topic; Follow-Up Studies; Humans; Male; Metronidazo | 1971 |
Chemical reduction of the compulsion to drink with metronidazole: a new treatment modality in the therapeutic program of the alcoholic.
Topics: Adult; Alcoholism; Clinical Trials as Topic; Female; Humans; Male; Metronidazole; Middle Aged | 1967 |
A six-month controlled evaluation of metronidazole (Flagyl) in chronic alcoholic patients.
Topics: Adult; Age Factors; Alcoholism; Black People; Chlordiazepoxide; Clinical Trials as Topic; Female; Hu | 1968 |
[Experience with metronidazol in alcoholism].
Topics: Adult; Alcoholism; Clinical Trials as Topic; Female; Humans; Male; Metronidazole; Middle Aged; Place | 1967 |
[Metronidazole in the treatment of alcoholism].
Topics: Alcoholism; Humans; Metronidazole | 1966 |
40 other studies available for metronidazole and Alcohol Abuse
| Article | Year |
|---|---|
'Giant' pyogenic liver abscess and
Topics: Alcoholism; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Ceftriaxone; Diabe | 2020 |
[Two cases of pulmonary gangrene in HIV-infected patients: favorable outcome without surgery].
Topics: Acetamides; Adult; Alcoholism; Amoxicillin; Anti-Bacterial Agents; Drug Therapy, Combination; Gangre | 2011 |
METRONIDAZOLE--A NEW AGENT FOR COMBINED SOMATIC AND PSYCHIC THERAPY OF ALCOHOLISM. A CASE STUDY AND PRELIMINARY REPORT.
Topics: Alcoholism; Angina Pectoris; Diabetes Mellitus; Drug Therapy; Female; Hair; Humans; Metronidazole; N | 1964 |
Altered cell-mediated immunity and increased postoperative infection rate in long-term alcoholic patients.
Topics: Alcoholism; Antibiotic Prophylaxis; Cefuroxime; Cytokines; Female; Humans; Immunity, Cellular; Male; | 2004 |
[Disseminated actinomycosis].
Topics: Actinomyces; Actinomycosis; Alcoholism; Amoxicillin; Brain Abscess; Brain Neoplasms; Bronchoalveolar | 2005 |
Alcoholism.
Topics: Alcohol Drinking; Alcoholism; Chlormethiazole; District of Columbia; Humans; Metronidazole; Reinforc | 1966 |
[Metronidazole in the treatment of alcoholism].
Topics: Adult; Aged; Alcoholism; Disulfiram; Humans; Metronidazole; Middle Aged; Psychoses, Alcoholic | 1967 |
Metronidazole and human alcohol dehydrogenase.
Topics: Alcohol Oxidoreductases; Alcoholism; Humans; In Vitro Techniques; Liver; Metronidazole; Spectrophoto | 1967 |
Anti-alcohol properties of metronidazole in rats.
Topics: Alcoholism; Animals; Drinking; Ethanol; Humans; Metronidazole; Rats | 1967 |
An addition to the somatic treatment of alcoholism.
Topics: Alcoholism; Disulfiram; Humans; Male; Metronidazole; Middle Aged | 1967 |
Metabolic interactions of aldehyde dehydrogenase with therapeutic and toxic agents.
Topics: Alcohol Oxidoreductases; Alcoholism; Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Animals; Anti | 1982 |
[Pulmonary amebiasis and tuberculosis association. Two case reports in Libreville, Gabon].
Topics: Adult; Alcoholism; Amebiasis; Anti-Infective Agents; Antitubercular Agents; Causality; Drug Therapy, | 2000 |
Drugs which interfere with alcohol metabolism.
Topics: Alcohol Deterrents; Alcoholism; Amines; Chloral Hydrate; Cyanides; Disulfiram; Ethanol; Humans; Hypo | 1977 |
[Overconsumption of alcohol as a component of eating habits (proceedings)].
Topics: Alcohol Drinking; Alcoholism; Europe; Feeding Behavior; Humans; Metronidazole; Socioeconomic Factors | 1976 |
[Sensitization treatment of alcoholism in the out-patient narcological practice].
Topics: Adult; Alcoholism; Ambulatory Care; Disulfiram; Furazolidone; Humans; Metronidazole; Middle Aged | 1975 |
Drug therapy in alcoholism.
Topics: Adult; Alcoholic Intoxication; Alcoholism; Antidepressive Agents; Anxiety; Carbamates; Chlordiazepox | 1970 |
The effect of metronidazole on the human taste threshold to alcohol.
Topics: Adolescent; Adult; Alcoholism; Ethanol; Female; Humans; Male; Metronidazole; Middle Aged; Taste | 1973 |
Clinical and experimental studies on alcoholism.
Topics: Alcohol Deterrents; Alcoholism; Animals; Disulfiram; Ethanol; Fenfluramine; Humans; Liver Diseases; | 1973 |
How to help the chronic alcoholic.
Topics: Alcohol Drinking; Alcoholism; Antidepressive Agents; Chronic Disease; Disulfiram; Humans; Metronidaz | 1972 |
[Craving for alcohol and its treatment].
Topics: Alcohol Drinking; Alcoholism; Ambulatory Care; Ethanol; Humans; Metronidazole; Parent-Child Relation | 1971 |
[Some details on new methods and problems in treating alcoholics].
Topics: Alcoholism; Humans; Hypnosis; Methods; Metronidazole | 1968 |
[Experience with treatment of chronic alcoholism patients with large doses of metronidazole in psychoneurologic dispensaries].
Topics: Adult; Alcoholism; Apomorphine; Chronic Disease; Fatigue; Feeding and Eating Disorders; Humans; Male | 1969 |
[Use of metronidazole in alcoholism].
Topics: Alcoholism; Humans; Metronidazole | 1967 |
[Metronidazole in the treatment of alcoholism].
Topics: Adult; Alcoholism; Humans; Male; Metronidazole | 1967 |
[Metronidazole in the management of alcoholism].
Topics: Adolescent; Adult; Age Factors; Aged; Alcoholism; Brazil; Female; Humans; Male; Metronidazole; Middl | 1968 |
[Relations between alcoholism and the gastrointestinal system. Experience using Metronidazole].
Topics: Adolescent; Adult; Alcoholism; Child; Ethanol; Gastrointestinal Diseases; Humans; Metronidazole; Mid | 1968 |
[Treatment of chronic alcoholism with metronidazole].
Topics: Adolescent; Adult; Alcoholism; Ambulatory Care; Child; Humans; Male; Metronidazole; Middle Aged | 1970 |
Evaluation of metronidazole in the treatment of alcoholism. A comprehensive three-year study comprising 60 cases.
Topics: Adult; Aged; Alcoholism; Female; Humans; Male; Metronidazole; Middle Aged | 1970 |
[Metronidazole (Flagyl) in alcoholism--a mistake].
Topics: Alcoholism; Humans; Metronidazole | 1971 |
[Treatment of chronic alcoholism patients with metronidazole under ambulatory conditions].
Topics: Alcoholism; Ambulatory Care; Humans; Metronidazole; Substance Withdrawal Syndrome | 1971 |
[A few observations on the use of metronidazole in the treatment of alcoholism from the Blaakors Clinic, Oslo].
Topics: Adult; Alcoholism; Female; Humans; Male; Metronidazole; Middle Aged | 1967 |
[Metronidazole in the treatment of alcoholism].
Topics: Aged; Alcoholism; Humans; Male; Metronidazole | 1967 |
The use of metronidazole in the treatment of alchoholism. (A further study).
Topics: Adult; Aged; Alcoholism; Female; Humans; Male; Metronidazole; Middle Aged | 1968 |
Metronidazole and alcoholism.
Topics: Adult; Alcoholism; Humans; Male; Metronidazole; Middle Aged | 1968 |
The influence of metronidazol and disulfiram on the pharmacologic action of ethanol.
Topics: Alcoholism; Animals; Disulfiram; Ethanol; Female; Humans; Lipids; Liver; Male; Metronidazole; Rabbit | 1969 |
The effect of metronidazol on the toxicity of ethanol.
Topics: Alcoholism; Animals; Disulfiram; Ethanol; Humans; Male; Metronidazole; Rats | 1969 |
[Preliminary report on the therapeutic action of flagyl in alcoholism].
Topics: Adult; Alcoholism; Humans; Male; Metronidazole; Middle Aged | 1966 |
The use of metronidazole in the treatment of alcoholism: a pilot study.
Topics: Adult; Aged; Alcoholism; Female; Humans; Male; Metronidazole; Middle Aged | 1966 |
Metronidazole in the treatment of the alcoholic.
Topics: Adult; Alcoholism; Blood Pressure; Humans; Male; Metronidazole; Middle Aged | 1966 |
[Changes in blood alcohol levels caused by administration of metronidazole].
Topics: Adult; Alcoholism; Ethanol; Humans; Male; Metronidazole; Middle Aged | 1966 |