Compounds > octenidine hydrochloride
Page last updated: 2024-11-06

octenidine hydrochloride

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Octenidine hydrochloride is a bisbiguanide antiseptic agent. It is synthesized by reacting 4-chlorophenylguanidine with 4-chloro-N-(4-chlorophenyl)-2-methylpentanediamide. Octenidine hydrochloride has a broad spectrum of antimicrobial activity against bacteria, fungi, and viruses. It is used in a variety of medical and personal care products, including antiseptic solutions, wound dressings, and skin disinfectants. Octenidine hydrochloride is effective against a wide range of microorganisms, including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecium (VRE), and Candida albicans. It is also effective against viruses, including influenza A and B viruses. Octenidine hydrochloride is well-tolerated and has a low risk of sensitization. It is often used in healthcare settings to prevent and treat infections. The compound is also effective against Pseudomonas aeruginosa, an opportunistic pathogen that can cause serious infections in people with weakened immune systems. Octenidine hydrochloride is also a potent inhibitor of biofilm formation. This makes it a valuable tool for preventing infections in patients with implanted medical devices, such as catheters and prosthetic joints. Octenidine hydrochloride is a safe and effective antiseptic agent that is used in a variety of medical and personal care products. It is an important tool for preventing and treating infections. Research on octenidine hydrochloride is ongoing to further understand its mechanism of action and to develop new and improved formulations. '

Cross-References

ID SourceID
PubMed CID51166
CHEMBL ID36342
SCHEMBL ID126065
MeSH IDM0320024

Synonyms (39)

Synonym
win-414642
octenidine hydrochloride
octenidine hydrochloride (usan)
D05222
70775-75-6
win 41464-2
octenidine hcl
las-189962
CHEMBL36342
win-41464-2
octenidine dihydrochloride
sensidin do
las189962
O0388
1-octanamine, n,n'-(1,10-decanediyldi-1(4h)-pyridinyl-4-ylidene)bis-, dihydrochloride
octenidine hydrochloride [usan]
1,1'-decamethylenebis(1,4-dihydro-4-(octylimino)pyridine) dihydrochloride
unii-u84956nu4b
einecs 274-861-8
u84956nu4b ,
n,n'-(1,10-decanediyldi-1(4h)-pyridinyl-4-ylidene)bis(1-octanamine) dihydrochloride
S5012
SCHEMBL126065
octenidine hydrochloride [who-dd]
octenidine dihydrochloride [mi]
octenidine hcl [inci]
octenidine hydrochloride [mart.]
DTXSID90221025
mfcd01938808
HY-B2170A
CS-6224
BCP22785
1,1'-(decane-1,10-diyl)bis(n-octylpyridin-4(1h)-imine) dihydrochloride
Q1409243
CCG-270262
n-octyl-1-[10-(4-octyliminopyridin-1-yl)decyl]pyridin-4-imine;dihydrochloride
D86682
A847887
B2692-013330
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (51)

Assay IDTitleYearJournalArticle
AID1726848Antibacterial activity against Pseudomonas aeruginosa after 24 hrs by microdilution method2021RSC medicinal chemistry, Jun-23, Volume: 12, Issue:6
Sulfonium-based liposome-encapsulated antibiotics deliver a synergistic antibacterial activity.
AID287949Inhibition of lysophospholipase activity of PLB1 in Cryptococcus neoformans var. grubii H99 assessed as loss of 1-[14C]palmitoyl lyso phosphatidylcholine at 0.25 uM2007Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
Synthesis, antifungal and haemolytic activity of a series of bis(pyridinium)alkanes.
AID95887Minimum inhibitory concentration against Klebsiella pneumonia 396451984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque.
AID201926Compound is evaluated for the effect of saliva upon the antiplaque activity of the compound at 0% of saliva and at 0.05 percentage of compound; - = No plaque accumulation1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque.
AID201925Compound is evaluated for the effect of saliva upon the antiplaque activity of the compound at 0% of saliva and at 0.025 percentage of compound; - = No plaque accumulation1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque.
AID287941Inhibition of lysophospholipase transacylase activity of PLB1 in Cryptococcus neoformans var. grubii H99 assessed as rate of formation of 1-[14C]palmitoyl lyso phosphatidylcholine at 250 uM2007Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
Synthesis, antifungal and haemolytic activity of a series of bis(pyridinium)alkanes.
AID201929Compound is evaluated for the effect of saliva upon the antiplaque activity of the compound at 50% of saliva and at 0.05 percentage of compound; - = No plaque accumulation1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque.
AID287950Inhibition of lysophospholipase transacylase activity of PLB1 in Cryptococcus neoformans var. grubii H99 assessed as rate of formation of 1-[14C]palmitoyl lyso phosphatidylcholine at 0.25 uM2007Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
Synthesis, antifungal and haemolytic activity of a series of bis(pyridinium)alkanes.
AID70083Antimicrobial minimum inhibitory concentration against Escherichia coli AB1932-11984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque.
AID201762Compound is evaluated for plaque-bactericidal index (PBI) against Streptococcus mitis 905571984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque.
AID207630Minimum antimicrobial inhibitory concentration against Staphylococcus aureus1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque.
AID287943Inhibition of lysophospholipase activity of PLB1 in Cryptococcus neoformans var. grubii H99 assessed as loss of 1-[14C]palmitoyl lyso phosphatidylcholine at 25 uM2007Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
Synthesis, antifungal and haemolytic activity of a series of bis(pyridinium)alkanes.
AID30567Compound is evaluated for plaque-bactericidal index (PBI) against Actinomyces naeslundii 6311984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque.
AID201924Compound is evaluated for the effect of saliva upon the antiplaque activity of the compound at 0% of saliva and at 0.01 percentage of compound; - = No plaque accumulation1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque.
AID287944Inhibition of lysophospholipase transacylase activity of PLB1 in Cryptococcus neoformans var. grubii H99 assessed as rate of formation of 1-[14C]palmitoyl lyso phosphatidylcholine at 25 uM2007Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
Synthesis, antifungal and haemolytic activity of a series of bis(pyridinium)alkanes.
AID201945Compound is evaluated for the effect of saliva upon the antiplaque activity of the compound at 50% of saliva and at 0.025 percentage of compound; - = No staining1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque.
AID287946Inhibition of lysophospholipase activity of PLB1 in Cryptococcus neoformans var. grubii H99 assessed as loss of 1-[14C]palmitoyl lyso phosphatidylcholine at 2.5 uM2007Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
Synthesis, antifungal and haemolytic activity of a series of bis(pyridinium)alkanes.
AID1635009Induction of cell permeabilization in Pseudomonas aeruginosa assessed as propidium iodide uptake at 4 uM after 10 mins2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics.
AID287951Antifungal activity against Cryptococcus neoformans ATCC 901122007Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
Synthesis, antifungal and haemolytic activity of a series of bis(pyridinium)alkanes.
AID1348169Anti-Trichomonas activity against metronidazole-resistant Trichomonas vaginalis IR78 ATCC 50138 cultured in TYI-S-33 media assessed as reduction in parasite growth after 30 mins by haemocytometry2018European journal of medicinal chemistry, Jan-01, Volume: 143Recent developments in anti-Trichomonas research: An update review.
AID201761Compound is evaluated for the growth inhibition of Streptococcus mutans OMZ-611984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque.
AID9429Compound is evaluated for minimal bactericidal concentration against plaque formation for Actinomyces viscosus1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque.
AID287939Inhibition of phospholipase B activity of PLB1 in Cryptococcus neoformans var. grubii H99 assessed as loss of 1,2-di[1-14C]palmitoyl phosphatidylcholine at 250 uM2007Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
Synthesis, antifungal and haemolytic activity of a series of bis(pyridinium)alkanes.
AID287959Cytotoxicity against human erythrocytes assessed as hemolytic activity at 50 uM2007Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
Synthesis, antifungal and haemolytic activity of a series of bis(pyridinium)alkanes.
AID30580Compound is evaluated for plaque-bactericidal index (PBI) against Actinomyces viscosus T14V1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque.
AID209593Compound is evaluated for minimal bactericidal concentration against plaque formation for Streptococcus mutans1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque.
AID287948Inhibition of phospholipase B activity of PLB1 in Cryptococcus neoformans var. grubii H99 assessed as loss of 1,2-di[1-14C]palmitoyl phosphatidylcholine at 0.25 uM2007Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
Synthesis, antifungal and haemolytic activity of a series of bis(pyridinium)alkanes.
AID1348170Anti-Trichomonas activity against metronidazole-resistant Trichomonas vaginalis IR78 ATCC 50138 cultured in PBS/BSA media assessed as reduction in parasite growth after 30 mins by haemocytometry2018European journal of medicinal chemistry, Jan-01, Volume: 143Recent developments in anti-Trichomonas research: An update review.
AID201944Compound is evaluated for the effect of saliva upon the antiplaque activity of the compound at 50% of saliva and at 0.01 percentage of compound; - = No staining1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque.
AID201927Compound is evaluated for the effect of saliva upon the antiplaque activity of the compound at 50% of saliva and at 0.01 percentage of compound; - = No plaque accumulation1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque.
AID209594Minimum plaque inhibitory concentration using a standard test organism, Streptococcus mutans OMZ-611984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque.
AID201942Compound is evaluated for the effect of saliva upon the antiplaque activity of the compound at 0% of saliva and at 0.025 percentage of compound; - = No staining1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque.
AID201949Compound is evaluated for the effect of saliva upon the staining potential of the compound at 0% of saliva and at 0.01 percentage of compound; - = No staining1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque.
AID201763Compound is evaluated for plaque-bactericidal index (PBI) against Streptococcus mutans 104491984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque.
AID201946Compound is evaluated for the effect of saliva upon the antiplaque activity of the compound at 50% of saliva and at 0.05 percentage of compound; + = Slight staining1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque.
AID30579Compound is evaluated for plaque-bactericidal index (PBI) against Actinomyces viscosus M-1001984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque.
AID201760Compound is evaluated for the inhibition of plaque-forming enzyme of Streptococcus mutans OMZ-611984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque.
AID287947Inhibition of lysophospholipase transacylase activity of PLB1 in Cryptococcus neoformans var. grubii H99 assessed as rate of formation of 1-[14C]palmitoyl lyso phosphatidylcholine at 2.5 uM2007Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
Synthesis, antifungal and haemolytic activity of a series of bis(pyridinium)alkanes.
AID162736Minimum antimicrobial inhibitory concentration against Proteus mirabilis MGH-11984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque.
AID201943Compound is evaluated for the effect of saliva upon the antiplaque activity of the compound at 0% of saliva and at 0.05 percentage of compound; + = Slight staining1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque.
AID287960Cytotoxicity against human erythrocytes assessed as hemolytic activity at 5 uM2007Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
Synthesis, antifungal and haemolytic activity of a series of bis(pyridinium)alkanes.
AID201764Compound is evaluated for plaque-bactericidal index (PBI) against Streptococcus sanguis 105581984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque.
AID234118Compound is evaluated for stain index1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque.
AID287940Inhibition of lysophospholipase activity of PLB1 in Cryptococcus neoformans var. grubii H99 assessed as loss of 1-[14C]palmitoyl lyso phosphatidylcholine at 250 uM2007Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
Synthesis, antifungal and haemolytic activity of a series of bis(pyridinium)alkanes.
AID164401Minimum antimicrobial inhibitory concentration against Pseudomonas aeruginosa MGH-21984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque.
AID70080Minimum inhibitory concentration against Escherichia coli (Vogel)1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque.
AID287945Inhibition of phospholipase B activity of PLB1 in Cryptococcus neoformans var. grubii H99 assessed as loss of 1,2-di[1-14C]palmitoyl phosphatidylcholine at 2.5 uM2007Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
Synthesis, antifungal and haemolytic activity of a series of bis(pyridinium)alkanes.
AID70081Antimicrobial minimum inhibitory concentration against Escherichia coli 100/B221984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque.
AID287942Inhibition of phospholipase B activity of PLB1 in Cryptococcus neoformans var. grubii H99 assessed as loss of 1,2-di[1-14C]palmitoyl phosphatidylcholine at 25 uM2007Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
Synthesis, antifungal and haemolytic activity of a series of bis(pyridinium)alkanes.
AID287952Antifungal activity against Candida albicans ATCC 102312007Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
Synthesis, antifungal and haemolytic activity of a series of bis(pyridinium)alkanes.
AID201928Compound is evaluated for the effect of saliva upon the antiplaque activity of the compound at 50% of saliva and at 0.025 percentage of compound; - = No plaque accumulation1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (20.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's2 (40.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 33.46

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index33.46 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.73 (4.65)
Search Engine Demand Index61.55 (26.88)
Search Engine Supply Index3.00 (0.95)

This Compound (33.46)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
palmitic acid
Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.. hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.		3.2710long-chain fatty acid;
straight-chain saturated fatty acid		algal metabolite;
Daphnia magna metabolite;
EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor;
plant metabolite
miltefosine
miltefosine: hexadecyl phosphocholine derivative of cisplatin; did not substantially activate HIV long terminal repeat; less toxic than cisplatin. miltefosine : A phospholipid that is the hexadecyl monoester of phosphocholine.		3.2710phosphocholines;
phospholipid		anti-inflammatory agent;
anticoronaviral agent;
antifungal agent;
antineoplastic agent;
antiprotozoal drug;
apoptosis inducer;
immunomodulator;
protein kinase inhibitor
lansoprazole
Lansoprazole: A 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of (R)- and (S)-isomers.		3.2710benzimidazoles;
pyridines;
sulfoxide		anti-ulcer drug;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor
metronidazole
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.. metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.		3.2710C-nitro compound;
imidazoles;
primary alcohol		antiamoebic agent;
antibacterial drug;
antimicrobial agent;
antiparasitic agent;
antitrichomonal drug;
environmental contaminant;
prodrug;
radiosensitizing agent;
xenobiotic
monocrotaline
[no description available]		3.2710pyrrolizines
omeprazole
Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.. omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.. 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.		3.2710aromatic ether;
benzimidazoles;
pyridines;
sulfoxide
pantoprazole
Pantoprazole: 2-pyridinylmethylsulfinylbenzimidazole proton pump inhibitor that is used in the treatment of GASTROESOPHAGEAL REFLUX and PEPTIC ULCER.. pantoprazole : A member of the class of benzimidazoles that is 1H-benzimidazole substituted by a difluoromethoxy group at position 5 and a [(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl group at position 2.		3.2710aromatic ether;
benzimidazoles;
organofluorine compound;
pyridines;
sulfoxide		anti-ulcer drug;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
environmental contaminant;
xenobiotic
rabeprazole
Rabeprazole: A 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.		3.2710benzimidazoles;
pyridines;
sulfoxide		anti-ulcer drug;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor
triclosan
[no description available]		2.3110aromatic ether;
dichlorobenzene;
monochlorobenzenes;
phenols		antibacterial agent;
antimalarial;
drug allergen;
EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
fungicide;
persistent organic pollutant;
xenobiotic
dequalinium chloride
dequalinium chloride : An organic chloride salt that is the dichloride salt of dequalinium.		2.0310organic chloride saltantifungal agent;
antineoplastic agent;
antiseptic drug;
mitochondrial NADH:ubiquinone reductase inhibitor
tetracosane
tetracosane: a pure alkane compound. tetracosane : A straight-chain alkane containing 24 carbon atoms.		3.2710long-chain alkaneplant metabolite;
volatile oil component
tomatine
alpha-tomatine: in tomato fruits and vegetative plant tissues; structure in first source		3.2710alkaloid antibiotic;
glycoalkaloid;
glycoside;
steroid alkaloid;
tetrasaccharide derivative		antifungal agent;
immunological adjuvant;
phytotoxin
cetylpyridinium chloride anhydrous
tserigel: according to first source contains polyvinylbutyral & cetylpyridinium chloride; UD only lists cetylpyridinium chloride as constituent. cetylpyridinium chloride : A pyridinium salt that has N-hexadecylpyridinium as the cation and chloride as the anion. It has antiseptic properties and is used in solutions or lozenges for the treatment of minor infections of the mouth and throat.		1.9610chloride salt;
organic chloride salt		antiseptic drug;
surfactant
amoxicillin
Amoxicillin: A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.. amoxicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-(4-hydroxyphenyl)acetamido group.		2.5920penicillin allergen;
penicillin		antibacterial drug
alexidine dihydrchloride
[no description available]		1.9610
n-chlorotaurine
N-chlorotaurine: inhibits both inducible nitric oxide synthase and IkappaB kinase		3.2710
arbutin
hydroquinone O-beta-D-glucopyranoside : A monosaccharide derivative that is hydroquinone attached to a beta-D-glucopyranosyl residue at position 4 via a glycosidic linkage.		3.2710beta-D-glucoside;
monosaccharide derivative		Escherichia coli metabolite;
plant metabolite
geraniol
[no description available]		3.27103,7-dimethylocta-2,6-dien-1-ol;
monoterpenoid;
primary alcohol		allergen;
fragrance;
plant metabolite;
volatile oil component
curcumin
Curcumin: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.. curcumin : A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.		3.2710aromatic ether;
beta-diketone;
diarylheptanoid;
enone;
polyphenol		anti-inflammatory agent;
antifungal agent;
antineoplastic agent;
biological pigment;
contraceptive drug;
dye;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor;
EC 1.8.1.9 (thioredoxin reductase) inhibitor;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
flavouring agent;
food colouring;
geroprotector;
hepatoprotective agent;
immunomodulator;
iron chelator;
ligand;
lipoxygenase inhibitor;
metabolite;
neuroprotective agent;
nutraceutical;
radical scavenger
zephiran
[no description available]		2.3110
amphotericin b
Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.		2.4720antibiotic antifungal drug;
macrolide antibiotic;
polyene antibiotic		antiamoebic agent;
antiprotozoal drug;
bacterial metabolite
rosmarinic acid
rosmarinic acid: RN given refers to parent cpd; promote OT project. (R)-rosmarinic acid : A stereoisomer of rosmarinic acid having (R)-configuration.. rosmarinic acid : The 1-carboxy-2-(2,4-dihydroxyphenyl)ethyl ester of trans-caffeic acid.		3.2710rosmarinic acidgeroprotector;
plant metabolite
chlorhexidine
Chlorhexidine: A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.. chlorhexidine : A bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge.		1.9610biguanides;
monochlorobenzenes		antibacterial agent;
antiinfective agent
3-(biphenyl-4-yl)-3-hydroxyquinuclidine
3-(biphenyl-4-yl)-3-hydroxyquinuclidine: structure given in first source		3.2710
tetracycline
Tetracycline: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.. tetracycline : A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria.		2.5920
rifampin
Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)		2.1310cyclic ketal;
hydrazone;
N-iminopiperazine;
N-methylpiperazine;
rifamycins;
semisynthetic derivative;
zwitterion		angiogenesis inhibitor;
antiamoebic agent;
antineoplastic agent;
antitubercular agent;
DNA synthesis inhibitor;
EC 2.7.7.6 (RNA polymerase) inhibitor;
Escherichia coli metabolite;
geroprotector;
leprostatic drug;
neuroprotective agent;
pregnane X receptor agonist;
protein synthesis inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials
Dental Plaque
A film that attaches to teeth, often causing DENTAL CARIES and GINGIVITIS. It is composed of MUCINS, secreted from salivary glands, and microorganisms.		01.9610
Fungal Diseases
[description not available]		02.0310
Mycoses
Diseases caused by FUNGI.		02.0310
Infections, Trichomonas
[description not available]		03.0910
Trichomonas Infections
Infections in birds and mammals produced by various species of Trichomonas.		03.0910