metronidazole has been researched along with Ataxia in 10 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Ataxia: Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronidazole-induced central nervous system (CNS) toxicity causes a spectrum of neurological symptoms including ataxia, encephalopathy and peripheral neuropathy." | 3.75 | Reversible metronidazole-induced cerebellar toxicity in a multiple transplant recipient. ( Condon, M; Graves, TD; Loucaidou, M; Perry, RJ, 2009) |
| "We describe a patient with a liver abscess due to Entamoeba histolytica, in whom metronidazole therapy (total dose, 21 g over 14 days) was complicated by reversible deafness, tinnitus, and ataxia and who relapsed 5 months later with a splenic abscess." | 3.69 | Amebic abscess of the spleen complicated by metronidazole-induced neurotoxicity: case report. ( Lawford, R; Sorrell, TC, 1994) |
| " Mostly, metronidazole is a tolerable drug but rarely presents serious adverse effects on the nervous system." | 2.49 | A rare adverse effect of metronidazole: nervous system symptoms. ( Kafadar, I; Klç, BA; Moustafa, F; Yalçın, K, 2013) |
| "Encefalopathy as a side effect of metronidazole therapy - a case report Neurological symptoms as side effects of pharmacological treatment generally tend to remain underdiagnosed." | 1.46 | [Encefalopathy as a side effect of metronidazole therapy – a case report]. ( Karayianni, M; Laska, AC; von Heijne, A, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Muir, RT | 1 |
| Mercado, M | 1 |
| Walter, VR | 1 |
| Singhal, N | 1 |
| Kwan, P | 1 |
| Kucharczyk, W | 1 |
| Stall, NM | 1 |
| Carlen, PL | 1 |
| John, KJ | 1 |
| P Pillai, D | 1 |
| Pillai, V | 1 |
| John, JK | 1 |
| Karayianni, M | 1 |
| von Heijne, A | 1 |
| Laska, AC | 1 |
| Rizvi, I | 1 |
| Garg, RK | 1 |
| Kumar, N | 1 |
| Pandey, S | 1 |
| Malhotra, HS | 1 |
| Kafadar, I | 1 |
| Moustafa, F | 1 |
| Yalçın, K | 1 |
| Klç, BA | 1 |
| Vivas, LLY | 1 |
| Gold, WL | 1 |
| Mandell, DM | 1 |
| Wu, PE | 1 |
| Kuriyama, A | 1 |
| Graves, TD | 1 |
| Condon, M | 1 |
| Loucaidou, M | 1 |
| Perry, RJ | 1 |
| Lawford, R | 1 |
| Sorrell, TC | 1 |
| Woodruff, BK | 1 |
| Wijdicks, EF | 1 |
| Marshall, WF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| To Determine the Effect of Honey Enema in the Treatment of Patients With Acute Pouchitis (Pilot Study)[NCT02201186] | Phase 2 | 10 participants (Actual) | Interventional | 2014-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metronidazole and Ataxia
| Article | Year |
|---|---|
A rare adverse effect of metronidazole: nervous system symptoms.
Topics: Anti-Infective Agents; Ataxia; Child, Preschool; Convalescence; Dizziness; Dysentery, Amebic; Headac | 2013 |
9 other studies available for metronidazole and Ataxia
| Article | Year |
|---|---|
Ataxia and Parkinsonism in Metronidazole Neurotoxicity.
Topics: Ataxia; Brain Diseases; Cerebellar Ataxia; Humans; Magnetic Resonance Imaging; Metronidazole; Neurot | 2021 |
Metronidazole-induced reversible cerebellar dysfunction.
Topics: Aged; Anti-Bacterial Agents; Ataxia; Cerebellar Diseases; Cerebellar Nuclei; Duration of Therapy; Dy | 2021 |
[Encefalopathy as a side effect of metronidazole therapy – a case report].
Topics: Abscess; Aged; Anti-Infective Agents; Ataxia; Brain Diseases; Dysarthria; Female; Gait Disorders, Ne | 2017 |
Metronidazole-associated encephalopathy: a reversible condition.
Topics: Anti-Bacterial Agents; Ataxia; Brain Diseases; Confusion; Humans; Magnetic Resonance Imaging; Male; | 2018 |
An 82-year-old man with ataxia and dysarthria.
Topics: Aged, 80 and over; Anti-Infective Agents; Ataxia; Brain; Cerebellar Nuclei; Diabetes Mellitus, Type | 2016 |
Chestnut Sign: Metronidazole-Induced Encephalopathy.
Topics: Abdominal Abscess; Aged; Anti-Bacterial Agents; Ataxia; Brain Diseases; Ciprofloxacin; Depression; D | 2017 |
Reversible metronidazole-induced cerebellar toxicity in a multiple transplant recipient.
Topics: Anti-Infective Agents; Ataxia; Brain; Follow-Up Studies; Humans; Kidney Transplantation; Magnetic Re | 2009 |
Amebic abscess of the spleen complicated by metronidazole-induced neurotoxicity: case report.
Topics: Adult; Amebiasis; Ataxia; Central Nervous System Diseases; Humans; Liver Abscess, Amebic; Male; Metr | 1994 |
Reversible metronidazole-induced lesions of the cerebellar dentate nuclei.
Topics: Aged; Anti-Infective Agents; Ataxia; Cerebellar Nuclei; Dysarthria; Humans; Magnetic Resonance Imagi | 2002 |