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metronidazole and Hematologic Diseases

metronidazole has been researched along with Hematologic Diseases in 2 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Hematologic Diseases: Disorders of the blood and blood forming tissues.

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's0 (0.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Allam, MA1
El-Shafie, AM1
Elwan, AM1
Soliman, GM1
Abu-Alfotuh, A1
Al Shabrawi, H1
Zander, AR1
Zabelina, T1
Kröger, N1
Renges, H1
Krüger, W1
Löliger, C1
Dürken, M1
Stockschläder, M1
de Wit, M1
Wacker-Backhaus, G1
Bielack, S1
Jaburg, N1
Rüssmann, B1
Erttmann, R1
Kabisch, H1

Trials

1 trial available for metronidazole and Hematologic Diseases

ArticleYear
Use of a five-agent GVHD prevention regimen in recipients of unrelated donor marrow.
    Bone marrow transplantation, 1999, Volume: 23, Issue:9

    Topics: Adolescent; Adult; Anti-Infective Agents; Antilymphocyte Serum; Bone Marrow Transplantation; Child;

1999

Other Studies

1 other study available for metronidazole and Hematologic Diseases

ArticleYear
Haematological side effect of Helicobacter pylori eradication.
    Journal of the Egyptian Society of Parasitology, 2010, Volume: 40, Issue:3

    Topics: Adult; Anti-Bacterial Agents; Clarithromycin; Enzyme Inhibitors; Female; Helicobacter Infections; He

2010